Genetic anthropology of skin functions and microbiome in Asian populations
| Project/Area Number |
26291095
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical anthropology
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
Kimura Ryosuke 琉球大学, 医学(系)研究科(研究院), 准教授 (00453712)
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| Co-Investigator(Kenkyū-buntansha) |
大橋 順 東京大学, 理学(系)研究科(研究院), 准教授 (80301141)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | 細菌叢 / 皮膚 / 多様性 / ヒト / ゲノム |
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| Outline of Final Research Achievements |
Previous population genomics studies have revealed that Asian-specific strong positive selections occurred on nonsynonymous variants in ABCC11 and EDAR, which are involved in the functions of sweat glands. In this study, we aimed to clarify the associations of these variants with the individual variation in skin functions and skin microbiome. As a result, we observed that both of the Asian-type variants are associated with a decreased amount of porphyrin on facial surface, which is mainly produced by Propionibacterium acnes. Moreover, an interaction between the effects of the two variants suggests that these variants co-evolved in Asia. Further functional studies and population genetics studies will be needed to elucidate the epistasis between the variants of ABCC11 and EDAR.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Mapping the genetic diversity of HLA haplotypes in the Japanese populations.2015
Author(s)
W. Y. Saw, X. Liu, C. C. Khor, F. Takeuchi, T. Katsuya, R. Kimura, T. Nabika, T. Ohkubo, Y. Tabara, K. Yamamoto, M. Yokota, Japanese Genome Variation Consortium, Y. Y. Teo, and N. Kato
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Journal Title
Sci Rep.
Volume: 5
Pages: 17855-17855
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Genome-wide SNP analysis reveals population structure and demographic history of the Ryukyu Islanders in the southern part of the Japanese Archipelago2014
Author(s)
Sato T., Nakagome S., Watanabe C., Yamaguchi K., Kawaguchi A., Koganebuchi K., Haneji K., Yamaguchi T., Hanihara T., Yamamoto K., Ishida H., Mano S., Kimura R., Oota H.
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Journal Title
Mol Biol Evol.
Volume: 31(11)
Pages: 2929-2940
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] アジア・オセアニア集団で観察される古代人ハプロタイプの適応的遺伝子移入2016
Author(s)
中 伊津美, 木村亮介, 古澤拓郞, 山内太郎, 夏原和美, 中澤港, 安高雄治, 石田貴文, 稲岡司, 松村康弘, 大塚柳太郎, 大橋順
Organizer
第70回日本人類学会大会
Place of Presentation
NSG学生総合プラザSTEP（新潟県新潟市）
Year and Date
2016-10-08
Related Report
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[Presentation] Analysis of polymorphisms associated with skin pigmentation in Oceanic populations2016
Author(s)
NAKA, I., NISHIDA, N., KIMURA, R., YAMAGUCHI, K., FURUSAWA, T., YAMAUCHI, T., NATSUHARA, K., ATAKA, Y., ISHIDA, T., INAOKA, T., MATSUMURA, Y. , OHTSUKA, R., OHASHI, J.
Organizer
第13回国際人類遺伝学会
Place of Presentation
国立京都国際会館，京都
Year and Date
2016-04-03
Related Report
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