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Genetic anthropology of skin functions and microbiome in Asian populations

Research Project

Project/Area Number 26291095
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Physical anthropology
Research InstitutionUniversity of the Ryukyus

Principal Investigator

Kimura Ryosuke  琉球大学, 医学(系)研究科(研究院), 准教授 (00453712)

Co-Investigator(Kenkyū-buntansha) 大橋 順  東京大学, 理学(系)研究科(研究院), 准教授 (80301141)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Keywords細菌叢 / 皮膚 / 多様性 / ヒト / ゲノム
Outline of Final Research Achievements

Previous population genomics studies have revealed that Asian-specific strong positive selections occurred on nonsynonymous variants in ABCC11 and EDAR, which are involved in the functions of sweat glands. In this study, we aimed to clarify the associations of these variants with the individual variation in skin functions and skin microbiome. As a result, we observed that both of the Asian-type variants are associated with a decreased amount of porphyrin on facial surface, which is mainly produced by Propionibacterium acnes. Moreover, an interaction between the effects of the two variants suggests that these variants co-evolved in Asia. Further functional studies and population genetics studies will be needed to elucidate the epistasis between the variants of ABCC11 and EDAR.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(13 results)

All 2017 2016 2015 2014 Other

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (4 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Remarks (2 results)

  • [Journal Article] Polymorphisms associated with a tropical climate and root crop diet induce susceptibility to metabolic and cardiovascular diseases in Solomon Islands2017

    • Author(s)
      Takuro Furusawa, Izumi Naka, Taro Yamauchi, Kazumi Natsuhara, Ricky Eddie, Ryosuke Kimura, Minato Nakazawa, Takafumi Ishida, Ryutaro Ohtsuka, Jun Ohashi
    • Journal Title

      PLoS One

      Volume: 12

    • DOI

      10.1371/journal.pone.0172676

    • NAID

      120006027074

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Whole-body patterns of the range of joint motion in young adults: masculine type and feminine type.2016

    • Author(s)
      Moromizato K, Kimura R, Fukase H, Yamaguchi K, Ishida H
    • Journal Title

      Journal of Physiological Anthropology

      Volume: 35 Pages: 23-23

    • DOI

      10.1186/s40101-016-0112-8

    • NAID

      120006892749

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mapping the genetic diversity of HLA haplotypes in the Japanese populations.2015

    • Author(s)
      W. Y. Saw, X. Liu, C. C. Khor, F. Takeuchi, T. Katsuya, R. Kimura, T. Nabika, T. Ohkubo, Y. Tabara, K. Yamamoto, M. Yokota, Japanese Genome Variation Consortium, Y. Y. Teo, and N. Kato
    • Journal Title

      Sci Rep.

      Volume: 5 Pages: 17855-17855

    • DOI

      10.1038/srep17855

    • NAID

      120006892738

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] ゲノム情報から古代人の姿を探る2015

    • Author(s)
      木村亮介
    • Journal Title

      細胞工学

      Volume: 34 Pages: 1172-1176

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Genome-wide SNP analysis reveals population structure and demographic history of the Ryukyu Islanders in the southern part of the Japanese Archipelago2014

    • Author(s)
      Sato T., Nakagome S., Watanabe C., Yamaguchi K., Kawaguchi A., Koganebuchi K., Haneji K., Yamaguchi T., Hanihara T., Yamamoto K., Ishida H., Mano S., Kimura R., Oota H.
    • Journal Title

      Mol Biol Evol.

      Volume: 31(11) Pages: 2929-2940

    • DOI

      10.1093/molbev/msu230

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 集団ゲノム学の方法論①-集団史を推定する-2014

    • Author(s)
      木村亮介
    • Journal Title

      医学のあゆみ

      Volume: 249 Pages: 207-210

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 集団ゲノム学の方法論②-遺伝適応の痕跡を探索する-2014

    • Author(s)
      木村亮介
    • Journal Title

      医学のあゆみ

      Volume: 249 Pages: 279-282

    • Related Report
      2014 Annual Research Report
  • [Presentation] Interpopulation differentiation and neutrality in the human face.2017

    • Author(s)
      Kimura R
    • Organizer
      Workshop Human evolution in Eurasia elucidated through Genetics, Archeology, and Linguistics
    • Place of Presentation
      National Institute of Genetics, Shizuoka
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] アジア・オセアニア集団で観察される古代人ハプロタイプの適応的遺伝子移入2016

    • Author(s)
      中 伊津美, 木村亮介, 古澤拓郞, 山内太郎, 夏原和美, 中澤港, 安高雄治, 石田貴文, 稲岡司, 松村康弘, 大塚柳太郎, 大橋順
    • Organizer
      第70回日本人類学会大会
    • Place of Presentation
      NSG学生総合プラザSTEP(新潟県新潟市)
    • Year and Date
      2016-10-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] Analysis of polymorphisms associated with skin pigmentation in Oceanic populations2016

    • Author(s)
      NAKA, I., NISHIDA, N., KIMURA, R., YAMAGUCHI, K., FURUSAWA, T., YAMAUCHI, T., NATSUHARA, K., ATAKA, Y., ISHIDA, T., INAOKA, T., MATSUMURA, Y. , OHTSUKA, R., OHASHI, J.
    • Organizer
      第13回国際人類遺伝学会
    • Place of Presentation
      国立京都国際会館,京都
    • Year and Date
      2016-04-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] メラネシア地域集団の皮膚色素関連遺伝子多型の集団遺伝学的解析2015

    • Author(s)
      中伊津美,西田奈央,木村亮介,山口今日子,古澤拓郎,山内太郎,夏原和美,中澤港,安高雄治,石田貴文,稲岡司,松村康弘,大塚柳太郎,大橋順
    • Organizer
      第69回日本人類学会大会
    • Place of Presentation
      産業技術総合研究所・臨海副都心センター,東京
    • Year and Date
      2015-10-10
    • Related Report
      2015 Annual Research Report
  • [Remarks] 琉球大学大学院医学研究科人体解剖学講座

    • URL

      http://w3.u-ryukyu.ac.jp/anatomy1/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 亜熱帯島嶼の時空間ゲノミクス -環境・微生物・家畜・ヒトの相互作用から疾病の内因と外因を探る-

    • URL

      http://w3.u-ryukyu.ac.jp/anthropology/jikuukan/

    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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