Studies on molecular mechanism of the sensing system of novel orally active neuromodulating peptides
| Project/Area Number |
26292070
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kyoto University |
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Principal Investigator |
OHINATA KOUSAKU 京都大学, (連合)農学研究科(研究院), 准教授 (00361147)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2016: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | ペプチド / 中鎖 / 腸－脳軸 / 情動調節 / 食欲 / グレリン / 生理活性ペプチド / 腸ー脳連関 / 神経経路 / 腸－脳連関 / セロトニン5HT1A / ドーパミンD1 / GABAA / 経口投与 / 抗不安作用 / 脳腸相関 / 迷走神経 / 高架式十字迷路試験 / ダイズβ-コングリシニン / 消化管酵素 |
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| Outline of Final Research Achievements |
A number of molecules are produced from food composed of various components after digestion by enzymes present in the gastrointestinal tract. We found many bioactive peptides derived from enzymatic digests of food proteins based on structure-activity relationship of functional peptides. In this study, we found that orally administered mid-size peptide exhibits potent neuromodulating effect. The neuromodulating effect was blocked by vagotomy, and it increased c-Fos positive cell in the NTS, where the input from the vagus nerve is known to be received. There results suggest that the mid-size peptide acts on the gastrointestinal tract, and thereafter, the peptide signal from the gut is transferred to the central nervous system. Thus, we revealed that mid-size peptides derived from food proteins act via the novel gut-brain communication.
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Report
(5 results)
Research Products
(14 results)
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[Journal Article] Rational identification of a novel soy-derived anxiolytic-like undecapeptide acting via gut-brain axis after oral administration.2017
Author(s)
Ota A, Yamamoto A, Kimura S, Mori Y, Mizushige T, Nagashima Y, Sato M, Suzuki H, Odagiri S, Yamada D, Sekiguchi M, Wada K, Kanamoto R, Ohinata K.
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Journal Title
Neurochem Int.
Volume: 105
Pages: 51-57
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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