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Novel cancer therapy for spontaneous animal tumor using ultrasound irradiation with microbubble

Research Project

Project/Area Number 26292155
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Veterinary medical science
Research InstitutionHokkaido University

Principal Investigator

TAKIGUCHI MITSUYOSHI  北海道大学, (連合)獣医学研究科, 教授 (70261336)

Co-Investigator(Kenkyū-buntansha) 中村 健介  北海道大学, (連合)獣医学研究科, 助教 (80625898)
佐々木 東  北海道大学, (連合)獣医学研究科, 助教 (00754532)
Co-Investigator(Renkei-kenkyūsha) KUDO Nobuki  北海道大学, 大学院情報科学研究科, 准教授 (30271638)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Keywords獣医学 / トランスレーショナルリサーチ / がん治療 / 超音波治療 / マイクロバブル / ソノポレーション / ドラッグデリバリー / がん / 膀胱がん / 甲状腺がん
Outline of Final Research Achievements

This study revealed that sonoporation, the combination of ultrasound and microbubbles, enhances the antitumor effect of a chemotherapeutic agent with minimum invasiveness in preclinical canine thyroid and bladder cancer models. Moreover, the results of this study clarified the mechanism of sonoporation. This preclinical study may contribute to establish sonoporation as a theranostic tool in cancer therapy.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(9 results)

All 2017 2016 2015

All Presentation (9 results) (of which Int'l Joint Research: 3 results)

  • [Presentation] Spatial and Temporal Window for cisplatin delivery in a 3D culture model2017

    • Author(s)
      Noboru Sasaki, Nobuki Kudo, Shouta MM Nakayama, Kensuke Nakamura, Keitaro Morishita, Hiroshi Ohta, Mitsuyoshi Takiguchi
    • Organizer
      The 22nd European Symposium on Ultrasound Contrast Imaging
    • Place of Presentation
      Rotterdam, The Netherlands, Hilton Hotel
    • Year and Date
      2017-01-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 超音波とマイクロバブルによるデリバリーの時間的制約2016

    • Author(s)
      佐々木東、石井和浩、工藤信樹、滝口満喜
    • Organizer
      第15回日本超音波治療研究会
    • Place of Presentation
      新宿区、東京、東京女子医科大学TWIns
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
  • [Presentation] Low intensity pulsed ultrasound and microbubbles increase cellular cisplatin and enhance cisplatin effect in a bladder cancer culture model2016

    • Author(s)
      Noboru Sasaki, Mitsuyoshi Takiguchi
    • Organizer
      5th International Symposium on Focused Ultrasound
    • Place of Presentation
      Bethesda, MD, USA, Bethesda North Marriot Hotel & Conference center
    • Year and Date
      2016-08-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 本当にソノポレーションか?2016

    • Author(s)
      佐々木東、工藤信樹、中山翔太、滝口満喜
    • Organizer
      日本超音波医学会平成28年度第1回超音波分子診断治療研究会
    • Place of Presentation
      札幌市、北海道、北海道大学大学院情報科学研究科
    • Year and Date
      2016-08-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] ドラッグデリバリーの効果が及ぶ距離2016

    • Author(s)
      佐々木東、工藤信樹、中村健介、森下啓太郎、大田寛、滝口満喜
    • Organizer
      日本超音波医学会第89回学術集会
    • Place of Presentation
      京都市、京都府、京都国際会議場
    • Year and Date
      2016-05-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 膀胱癌を模した3次元培養系でのシスプラチンデリバリー2015

    • Author(s)
      佐々木東、工藤信樹、滝口満喜
    • Organizer
      第14回日本超音波治療研究会
    • Place of Presentation
      高知市、高知県、かるぽーと(高知市文化プラザ)
    • Year and Date
      2015-11-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 3次元培養でのシスプラチンと超音波-マイクロバブルの併用2015

    • Author(s)
      佐々木東、Chrit Moonen、滝口満喜
    • Organizer
      日本超音波医学会平成27年度第1回超音波分子診断治療研究会
    • Place of Presentation
      札幌市、北海道、北海道大学大学院情報科学研究科
    • Year and Date
      2015-08-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] ドラッグデリバリーを可視化する培養系の開発2015

    • Author(s)
      佐々木東、滝口満喜、Clemens Bos、Chrit Moonen
    • Organizer
      日本超音波医学会第88回学術集会
    • Place of Presentation
      品川、東京都、品川プリンスホテル
    • Year and Date
      2015-05-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Noboru Sasaki, Clemens Bos, Jean-Michel Escoffre, Gert Storm, Chrit Moonen2015

    • Author(s)
      Noboru Sasaki, Clemens Bos, Jean-Michel Escoffre, Gert Storm, Chrit Moonen
    • Organizer
      15th International Symposium on Therapeutic Ultrasound
    • Place of Presentation
      ユトレヒト、ユトレヒト大学本部、オランダ
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research

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Published: 2014-04-04   Modified: 2018-03-22  

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