| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Outline of Final Research Achievements |
We previously showed that rRNA degradation occurs in Bombyx cells (BM-N cells) as an antiviral immune response during abortive infection with heterologous nucleopolyhedroviruses (NPVs). In the present study, we examined the induction mechanisms of rRNA degradation in Autographa californica NPV (AcMNPV) infected BM-N cells. We identified AcMNPV p143 (ac-p143) as an inducer of rRNA degradation. And then, we investigated the domain of Ac-P143 responsible for rRNA degradation, the cellular factors interacting with Ac-P143, and the signal transduction factors responsible for induction of rRNA degradation.
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