Study on the molecular mechanism of psychiatric disorders that targets PACAP signaling pathways and aimed at the development of therapeutic drug

• Project/Area Number: 26293020
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Pharmacology in pharmacy
• Research Institution: Osaka University
• Principal Investigator: Hashimoto Hitoshi 大阪大学, 薬学研究科, 教授 (30240849)
• Co-Investigator(Kenkyū-buntansha): 早田 敦子 大阪大学, 連合小児発達学研究科, 助教 (70390812)
• Co-Investigator(Renkei-kenkyūsha): HASHIMOTO Ryota 大阪大学, 大学院連合小児発達学研究科, 准教授 (10370983)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000); Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
• Keywords: PACAP / 精神疾患 / 創薬 / 薬学 / 国際情報交換

Outline of Final Research Achievements

Pathophysiological mechanisms for psychiatric disorders remain poorly understood, which need to be urgently addressed. Recent studies have suggested that PACAP is implicated in neuropsychological functions and the risk and pathogenesis of psychiatric disorders. In this study, in order to obtain insights relevant to drug development, we examined brain signaling pathways as well as intracellular signaling pathways that are relevant to PACAP-dependent signaling. We obtained the data showing that the implication of noradrenaline in PACAP-deficient mouse phenotypes, involvement of BDNF signaling in PACAP-dependent axon outgrowth, necessity of β-arrestin2 for PACAP-induced 5-HT2A receptor internalization, and interaction and internalization of PACAP receptor PAC1 with β-arrestin2, which induces prolonged ERK1/2 activation. The present observations as well as the assay systems generated are expected to contribute to future drug discovery research.

Research Products

• [Int'l Joint Research] カリフォルニア大学ロサンゼルス校(米国)
• [Int'l Joint Research] カリフォルニア大学ロサンゼルス校(米国)
• [Journal Article] Targeted knockdown of the mitochondria-localized protein p13 protects against experimental parkinsonism (2018)
  • Author(s): Inoue N, Ogura S, Kasai A, Nakazawa T, Ikeda K, Higashi S, Isotani A, Baba K, Mochizuki H, Fujimura H, Ago Y, Hayata-Takano A, Seiriki K, Shintani N, Hashimoto H
  • Journal Title: EMBO Rep Volume: 19(3)
  • DOI: 10.15252/embr.201744860
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Unbiased compound screening with a reporter gene assay highlights the role of p13 in the cardiac cellular stress response (2018)
  • Author(s): Inoue N, Hirouchi T, Kasai A, Higashi S, Hiraki N, Tanaka S, Nakazawa T, Nunomura K, Lin B, Omori A, Hayata-Takano A, Kim YJ, Doi T, Baba A, Hashimoto H, Shintani N
  • Journal Title: Biochem Biophys Res Commun Volume: 495(2) Pages: 1992-1997
  • DOI: 10.1016/j.bbrc.2017.11.116
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Disturbed spermatogenic signaling in pituitary adenylate cyclase activating polypeptide-deficient mice (2018)
  • Author(s): Reglodi D, Cseh S, Somoskoi B, Fulop BD, Szentleleky E, Szegeczki V, Kovacs A, Varga A, Kiss P, Hashimoto H, Tamas A, Bardosi A, Manavalan S, Bako E, Zakany R, Juhasz T
  • Journal Title: Reproduction Volume: 155(2) Pages: 129-139
  • DOI: 10.1530/rep-17-0470
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Construct and face validity of a new model for the three-hit theory of depression using PACAP mutant mice on CD1 background (2018)
  • Author(s): Farkas J, Kovacs LA, Gaspar L, Nafz A, Gaszner T, Ujvari B, Kormos V, Csernus V, Hashimoto H, Reglodi D, Gaszner B
  • Journal Title: Neuroscience Volume: 354 Pages: 11-29
  • DOI: 10.1016/j.neuroscience.2017.04.019
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Impaired extinction of cued fear memory and abnormal dendritic morphology of the prelimbic and infralimbic cortices in VPAC2 receptor (VIPR2)-deficient mice (2017)
  • Author(s): Ago Y, Hayata-Takano A, Kawanai T, Yamauchi R, Takeuchi S, Cushman JD, Rajbhandari AK, Fanselow MS, Hashimoto H, Waschek JA
  • Journal Title: Neurobiol. Learn Mem. Volume: 145 Pages: 222-231
  • DOI: 10.1016/j.nlm.2017.10.010
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Aging-Induced Modulation of Pituitary Adenylate Cyclase-Activating Peptide- and Vasoactive Intestinal Peptide-Induced Vasomotor Responses in the Arteries of Mice (2017)
  • Author(s): Ivic I, Solymar M, Fulop BD, Hashimoto H, Toth G, Tamas A, Juhasz T, Koller A, Reglodi D
  • Journal Title: J. Vasc. Res. Volume: 54(6) Pages: 359-366
  • DOI: 10.1159/000481781
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Risperidone and aripiprazole alleviate prenatal valproic acid-induced abnormalities in behaviors and dendritic spine density in mice (2017)
  • Author(s): Hara Y, Ago Y, Taruta A, Hasebe S, Kawase H, Tanabe W, Tsukada S, Nakazawa T, Hashimoto H, Matsuda T, Takuma K
  • Journal Title: Psychopharmacology (Berl) Volume: 234(21) Pages: 3217-3228
  • DOI: 10.1007/s00213-017-4703-9
  • Peer Reviewed / Open Access
• [Journal Article] Oxytocin attenuates deficits in social interaction but not recognition memory in a prenatal valproic acid-induced mouse model of autism (2017)
  • Author(s): Hara Y, Ago Y, Higuchi M, Hasebe S, Nakazawa T, Hashimoto H, Matsuda T, Takuma K
  • Journal Title: Horm Behav Volume: 96 Pages: 130-136
  • DOI: 10.1016/j.yhbeh.2017.09.013
  • Peer Reviewed / Open Access
• [Journal Article] High-specd and scalable whole-brain imaging in rodents and primates. (2017)
  • Author(s): Seiriki K, Kasai A, Hashimoto T, Schulze W, Niu M, Yamaguchi S, Nakazawa T, Inoue K, Uezono S, Takada M, Naka Y, Igarashi H, Tanuma M, Wascheck JA, Ago Y, Tanaka KF, Hayata-Takano A, Nagayasu K, Shintani N, Hashimoto R, Kunii Y, Hino M, Matsumoto J, Yabe
  • Journal Title: Neuron Volume: 94 Issue: 6 Pages: 1085-1100
  • DOI: 10.1016/j.neuron.2017.05.017
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Psychopharmacology of combined activation of the serotonin1A and σ1 receptors (2017)
  • Author(s): Ago Y, Hasebe S, Hiramatsu N, Hashimoto H, Takuma K, Matsuda T
  • Journal Title: Eur. J. Pharmacol. Volume: 809 Pages: 172-177
  • DOI: 10.1016/j.ejphar.2017.05.035
  • Peer Reviewed
• [Journal Article] Environmental enrichment attenuates behavioral abnormalities in valproic acid-exposed autism model mice (2017)
  • Author(s): Yamaguchi H, Hara Y, Ago Y, Takano E, Hasebe S, Nakazawa T, Hashimoto H, Matsuda T, Takuma K
  • Journal Title: Behav Brain Res Volume: 333 Pages: 67-73
  • DOI: 10.1016/j.bbr.2017.06.035
  • Peer Reviewed / Open Access
• [Journal Article] Prenatal exposure to valproic acid increases miR-132 levels in the mouse embryonic brain. (2017)
  • Author(s): Hara Y, Ago Y, Takano E, Hasebe S, Nakazawa T, Hashimoto H, Matsuda T, Takuma K.
  • Journal Title: Mol Autism Volume: 8 Pages: 33-33
  • DOI: 10.1186/s13229-017-0149-5
  • Peer Reviewed / Open Access
• [Journal Article] Backup mechanisms maintain PACAP/VIP-induced arterial relaxations in pituitary adenylate cyclase-activating polypeptide-deficient mice (2017)
  • Author(s): Ivic I, Fulop BD, Juhasz T, Reglodi D, Toth G, Hashimoto H, Tamas A, Koller A
  • Journal Title: J. Vasc. Res. Volume: 54 Pages: 180-192
  • DOI: 10.1159/000457798
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Decreased cohesin in the brain leads to defective synapse devclopmont and anxicty-related behavior. (2017)
  • Author(s): Fujita Y, Masuda K, Bando M, Nakato R, Katou Y, Tanaka T, Nakayama M, Takao K, Miyakawa T, Tanaka T, Ago Y, Hashimoto H, Shirahige K, Yamashita T
  • Journal Title: The Journal of Experiment Medicine Volume: 印刷中 Issue: 5 Pages: 1431-1452
  • DOI: 10.1084/jem.20161517
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effect of Clozapine on DNA Methylation in Peripheral Leukocytes from Patients with Treatment-Resistant Schizophrenia. (2017)
  • Author(s): Kinoshita M, Numata S, Tajima A, Yamamori H, Yasuda Y, Fujimoto M, Watanabe S, Umehara H, Shimodera S, Nakazawa T, Kikuchi M, Nakaya A, Hashimoto H, Imoto I, Hashimoto R, Ohmori T.
  • Journal Title: International Journal of Molecular Sciences Volume: 18 Pages: 632-632
  • DOI: 10.3390/ijms18030632
  • NAID: 120006535029
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells from monozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine. (2017)
  • Author(s): Nakazawa T, Kikuchi M, Ishikawa M, Yamamori H, Nagayasu K, Matsumoto T, Fujimoto M, Yasuda Y, Fujiwara M, Okada S, Matsumura K, Kasai A, Hayata-Takano A, Shintani N, Numata S, Takuma K, Akamatsu W, Okano H, Nakaya A, Hashimoto H, Hashimoto R.
  • Journal Title: Schizophrenia Research Volume: 181 Pages: 75-82
  • DOI: 10.1016/j.schres.2016.10.012
  • NAID: 120007037467
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Implantable optogenetic device with CMOS IC technology for simultaneous optical measurement and stimulation (2017)
  • Author(s): Makito Haruta,Naoya Kamiyama,Shun Nakajima,Mayumi Motoyama,Mamiko Kawahara Yasumi Ohta,Atsushi Yamasaki,Hiroaki Takehara,Toshihiko Noda,Kiyotaka Sasagawa,Yasuyuki Ishikawa,Takashi Tokuda,Hitoshi Hashimoto,Jun Ohta
  • Journal Title: Japanese Journal of Applied Physics Volume: 56 Issue: 5 Pages: 057001-057001
  • DOI: 10.7567/jjap.56.057001
  • NAID: 210000147741
  • ISSN: 0021-4922, 1347-4065
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Early Neurobehavioral Development of Mice Lacking Endogenous PACAP (2017)
  • Author(s): Farkas J, Sandor B, Tamas A, Kiss P, Hashimoto H, Nagy AD, Fulop BD, Juhasz T, Manavalan S, Reglodi D.
  • Journal Title: J. Mol. Neurobiol. Volume: 61(4) Pages: 468-478
  • DOI: 10.1007/s12031-017-0887-z
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Role of prefrontal serotonergic and dopaminergic systems in encounter-induced hyperactivity in methamphetamine-sensitized mice (2017)
  • Author(s): Tanaka T, Ago Y, Umehara C, Imoto E, Hasebe S, Hashimoto H, Takuma K, Matsuda T.
  • Journal Title: International Journal of Neuropsychopharmacology Volume: 20 Pages: 1-12
  • DOI: 10.1093/ijnp/pyw115
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Anti-anhedonic effect of selective serotonin reuptake inhibitors with affinity for sigma-1 receptors in picrotoxin-treated mice (2017)
  • Author(s): Hasebe S, Ago Y, Watabe Y, Oka S, Hiramatsu N, Tanaka T, Umehara C, Hashimoto H, Takuma K, Matsuda T
  • Journal Title: Br. J. Pharmacol. Volume: 174 Pages: 314-327
  • DOI: 10.1111/bph.13692
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Pituitary adenylate cyclase-activating polypeptide (PACAP) contributes to the proliferation of hematopoietic progenitor cells in murine bone marrow via PACAP-specific receptor. (2017)
  • Author(s): Xu Z, Ohtaki H, Watanabe J, Miyamoto K, Murai N, Sasaki S, Matsumoto M, Hashimoto H, Hiraizumi Y, Numazawa S, Shioda S.
  • Journal Title: Sci Rep. Volume: 6 Pages: 1-12
  • DOI: 10.1038/srep22373
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders (2017)
  • Author(s): Nakazawa T, Hashimoto R, Sakoori K, Sugaya Y, Tanimura A, Hashimotodani Y, Ohi K, Yamamori H, Yasuda Y, Umeda-Yano S, Kiyama Y, Konno K, Inoue T, Yokoyama K, Inoue T, Numata S, Ohnuma T, Iwata N, Ozaki N, Hashimoto H, Watanabe M, Manabe T, Yamamoto T, Takeda M, Kano M.
  • Journal Title: Neurodegenerative Diseases 17, 103-109, 2017 Volume: 7 Pages: 10594-10594
  • DOI: 10.1038/ncomms11466
  • NAID: 120006535052
  • Peer Reviewed / Open Access
• [Journal Article] Critical involvement of the orbitofrontal cortex in hyperlocomotion induced by NMDA receptor blockade in mice. (2016)
  • Author(s): Seiriki K, Kasai A, Kuwaki T, Nakazawa T, Yamaguchi S, Hashimoto H.
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 480 Pages: 558-563
  • DOI: 10.1016/j.bbrc.2016.10.089
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Double In situ Hybridization for MicroRNAs and mRNAs in Brain Tissues. (2016)
  • Author(s): Kasai A, Kakihara S, Miura H, Okada R, Hayata-Takano A, Hazama K, Niu M, Shintani N, Nakazawa T, Hashimoto H.
  • Journal Title: Frontiers in Molecular Neuroscience Volume: 9 Pages: 126-126
  • DOI: 10.3389/fnmol.2016.00126
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] PACAP Protects the Adolescent and Adult Mice Brain from Ethanol Toxicity and Modulates Distinct Sets of Genes Regulating Similar Networks (2016)
  • Author(s): Lacaille H, Duterte-Boucher D, Vaudry H, Zerdoumi Y, Flaman JM, Hashimoto H, Vaudry D.
  • Journal Title: Mol. Neurobiol. Volume: 印刷中
  • DOI: 10.1007/s12035-016-0204-9
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Prenatal Exposure to Histone Deacetylase Inhibitors Affects Gene Expression of Autism-Related Molecules and Delays Neuronal Maturation (2016)
  • Author(s): Kawanai T, Ago Y, Watanabe R, Inoue A, Taruta A, Onaka Y, Hasebe S, Hashimoto H, Matsuda T, Takuma K.
  • Journal Title: Neurochem Res. Volume: 41(10) Pages: 2574-2584
  • DOI: 10.1007/s11064-016-1969-y
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Improvement by methylphenidate and atomoxetine of social interaction deficits and recognition memory impairment in a mouse model of valproic acid-induced autism (2016)
  • Author(s): Hara Y, Ago Y, Taruta A, Katashiba K, Hasebe S, Takano E, Onaka Y, Hashimoto H, Matsuda T, Takuma K
  • Journal Title: Autism Res. Volume: - Pages: 926-39
  • DOI: 10.1002/aur.1596
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Involvement of GABAA receptors in 5-HT1A and σ1 receptor synergism on prefrontal dopaminergic transmission under circulating neurosteroid deficiency (2016)
  • Author(s): Ago Y, Hasebe S, Hiramatsu N, Mori K, Watabe Y, Onaka Y, Hashimoto H, Takuma K, Matsuda T.
  • Journal Title: Psychopharmacology Volume: 233(17) Pages: 3125-3134
  • DOI: 10.1007/s00213-016-4353-3
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Reduced response to chronic mild stress in PACAP mutant mice is associated with blunted FosB expression in limbic forebrain and brainstem centers (2016)
  • Author(s): Kormos V, Gaspar L, Kovacs, Farkas J, Gaszner T, Csernus V, Balogh A, Hashimoto H, Reglodi D, Helyes Z, Gaszner B.
  • Journal Title: Neuroscience Volume: 330 Pages: 335-358
  • DOI: 10.1016/j.neuroscience.2016.06.004
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] PACAP suppresses dry eye signs by stimulating tear secretion (2016)
  • Author(s): Nakamachi T, Ohtaki H, Seki T, Yofu S, Kagami N, Hashimoto H, Shintani N, Baba A, Mark L, Lanekoff I, Kiss P, Farkas J, Reglodi D, Shioda S.
  • Journal Title: Nat Commun Volume: 7 Pages: 12034-12034
  • DOI: 10.1038/ncomms12034
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] De novo POGZ mutations in sporadic autism disrupt the DNA-binding activity of POGZ (2016)
  • Author(s): Matsumura K, Nakazawa T, Nagayasu K, Gotoda-Nishimura N, Kasai A, Hayata-Takano A, Shintani N, Yamamori H, Yasuda Y, Hashimoto R, Hashimoto H.
  • Journal Title: J Mol Psychiatry. Volume: 4 Pages: 1-1
  • DOI: 10.1186/s40303-016-0016-x
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Whole-exome sequencing and neurite outgrowth analysis in autism spectrum disorder. (2016)
  • Author(s): Hashimoto R, Nakazawa T, Tsurusaki Y, Yasuda Y, Nagayasu K, Matsumura K, Kawashima H, Yamamori H, Fujimoto M, Ohi K, Umeda-Yano S, Fukunaga M, Fujino H, Kasai A, Hayata-Takano A, Shintani N, Takeda M, Matsumoto N, Hashimoto H.
  • Journal Title: J. Hum. Genet. Volume: 61 Pages: 199-206
  • DOI: 10.1038/jhg.2015.141
  • NAID: 40020766278
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Pituitary adenylate cyclase-activating polypeptide (PACAP) is involved in adult mouse hippocampal neurogenesis after stroke (2016)
  • Author(s): Matsumoto M, Nakamachi T, Watanabe J, Sugiyama K, Ohtaki H, Murai N, Sasaki S, Xu Z, Hashimoto H, Seki T, Miyazaki A, Shioda S.
  • Journal Title: J Mol Neurosci. Volume: 未定
  • Peer Reviewed
• [Journal Article] Rivastigmine improves isolation rearing-induced prepulse inhibition deficits via muscarinic acetylcholine receptors in mice (2016)
  • Author(s): Higashino K, Ago Y, Umeki T, Hasebe S, Onaka Y, Hashimoto H, Takuma K, Matsuda T.
  • Journal Title: Psychopharmacology Volume: 233(3) Pages: 521-528
  • DOI: 10.1007/s00213-015-4123-7
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Structured line illumination Raman microscopy (2015)
  • Author(s): Watanabe K, Palonpon AF, Smith NI, Chiu LD, Kasai A, Hashimoto H, Kawata S, Fujita K.
  • Journal Title: Nat. Commun. Volume: 6 Pages: 10095-10095
  • DOI: 10.1038/ncomms10095
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The female encounter test, a novel method for evaluating reward-seeking behavior or motivation in mice (2015)
  • Author(s): Ago Y, Hasebe S, Nishiyama S, Oka S, Onaka Y, Hashimoto H, Takuma K, Matsuda T.
  • Journal Title: The International Journal of Neuropsychopharmacology Volume: 18(11)
  • DOI: 10.1093/ijnp/pyv062
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Pharmacological profile of encounter-induced hyperactivity in isolation-reared mice (2015)
  • Author(s): Hasebe S, Ago Y, Nishiyama S, Oka S, Hashimoto H, Takuma K, Matsuda T.
  • Journal Title: Behav Pharmacol. Volume: 26(7) Pages: 681-690
  • DOI: 10.1097/fbp.0000000000000140
  • Peer Reviewed
• [Journal Article] Reductions in synaptic proteins and selective alteration of prepulse inhibition in male C57BL/6 mice after postnatal administration of a VIP receptor (VIPR2) agonist (2015)
  • Author(s): Ago Y, Condro MC, Tan YV, Ghiani CA, Colwell CS, Cushman JD, Fanselow MS, Hashimoto H, Waschek JA.
  • Journal Title: Psychopharmacology (Berl). Volume: 232(12) Pages: 2181-2189
  • DOI: 10.1007/s00213-014-3848-z
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Atomoxetine reverses locomotor hyperactivity, impaired novel object recognition, and prepulse inhibition impairment in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP). (2015)
  • Author(s): hibasaki Y, Hayata-Takano A, Hazama K, Nakazawa T, Shintani N, Kasai A, Nagayasu K, Hashimoto R, Tanida M, Katayama T, Matsuzaki S, Yamada K, Taniike M, Onaka Y, Ago Y, Waschek JA, Köves K, Reglődi D, Tamas A, Matsuda T, Baba A, Hashimoto H.
  • Journal Title: Psychopharmacology (Berl). Volume: 297 Pages: 95-104
  • DOI: 10.1016/j.neuroscience.2015.03.062
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Reduced prefrontal dopaminergic activity in valproic acid-treated mouse autism model (2015)
  • Author(s): Hara Y, Takuma K, Takano E, Katashiba K, Taruta A, Higashino K, Hashimoto H, Ago Y, Matsuda T.
  • Journal Title: Behavioural Brain Research Volume: 289 Pages: 39-47
  • DOI: 10.1016/j.bbr.2015.04.022
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] CRTH2, a prostaglandin D2 receptor, mediates depression-related behavior in mice (2015)
  • Author(s): Yusuke Onaka, Norihito Shintani, Takanobu Nakazawa, Ryota Haba, Yukio Ago, Hyper Wang, Takuya Kanoh, Atsuko Hayata-Takano, Hiroyuki Hirai, Kin-ya Nagata, Masataka Nakamura, Ryota Hashimoto, Toshio Matsuda, James A. Waschek, Atsushi Kasai, Kazuki Nagayasu, Akemichi Baba, Hitoshi Hashimoto
  • Journal Title: Behav Brain Res Volume: 284 Pages: 131-137
  • DOI: 10.1016/j.bbr.2015.02.013
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Anxiolytic-like effects of restraint during the dark cycle in adolescent mice (2015)
  • Author(s): Ota Y, Ago Y, Tanaka T, Hasebe S, Toratani Y, Onaka Y, Hashimoto H, Takuma K, Matsuda T
  • Journal Title: Behav Brain Res Volume: 284 Pages: 103-111
  • DOI: 10.1016/j.bbr.2015.02.010
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A mouse model of human primitive neuroectodermal tumors resulting from microenvironmentally-driven malignant transformation of orthotopically transplanted radial glial cells. (2015)
  • Author(s): Malchenko S, Sredni ST, Hashimoto H, Kasai A, Nagayasu K, Xie J, Margaryan NV, Seiriki K, Lulla RR, Seftor RE, Pachman LM, Meltzer HY, Hendrix MJ, Soares MB.
  • Journal Title: PLoS One Volume: 10(3)
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] PACAP Enhances Axon Outgrowth in Cultured Hippocampal Neurons to a Comparable Extent as BDNF. (2015)
  • Author(s): Ogata K, Shintani N, Hayata-takano A, Kamo T, Higashi S, Seiriki K, Momosaki H, Vaudy D, Vaudy H, Galas L, Kasai A, Nagayasu K, Nakazawa T, Hashimoto R, Ago Y, Matsuda T, Baba A, Hashimoto H.
  • Journal Title: PLoS ONE Volume: 10
  • DOI: 10.1371/journal.pone.0120526
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Role of the 5-HT1A Autoreceptor in the Enhancement of Fluvoxamine-Induced Increases in Prefrontal Dopamine Release by Adrenalectomy/Castration in Mice. (2015)
  • Author(s): Hasebe S, Hiramatsu N, Ago Y, Mori K, Watabe Y, Hashimoto H, Takuma K, Matsuda T
  • Journal Title: J Pharmacol Sci. Volume: 127 Pages: 232-235
  • DOI: 10.1016/j.jphs.2015.01.001
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Simultaneous neuron- and astrocyte-specific fluorescent marking. (2015)
  • Author(s): Schulze W, Hayata-Takano A, Kamo T, Nakazawa T, Nagayasu K, Kasai A, Seiriki K, Shintani N, Ago Y, Farfan C, Hashimoto R, Baba A, Hashimoto H.
  • Journal Title: Biochemical and Biophysical Research Communications, Volume: 459 Pages: 81-86
  • DOI: 10.1016/j.bbrc.2015.02.073
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Identification of the role of BMP and TGF-β signaling in the trajectory of serotonergic differentiation in a rapid assay in mouse embryonic stem cells in vitro. (2015)
  • Author(s): Yamasaki A, Kasai A, Toi A, Kurita M, Kimoto S, Hayata-Takano A, Nakazawa T, Nagayasu K, Shintani N, Hashimoto R, Ito A, Meltzer HY, Ago Y, Waschek JA, Onaka Y, matsuda T, Baba A, Hashimoto H.
  • Journal Title: J Neurochem Volume: 132(4) Pages: 418-28
  • DOI: 10.1111/jnc.12999
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Behavioral characterization of mice overexpressing human dysbindin-1. (2014)
  • Author(s): Shintani N, Onaka Y, Hashimoto R, Takamura H, Nagata T, Umeda-Yano S, Mouri A, Mamiya T, Haba R, Matsuzaki S, Katayama T, Yamamori H, Nakazawa T, Nagayasu K, Ago Y, Yagasaki Y, Nabeshima T, Takeda M, Hashimoto H.
  • Journal Title: Mol Brain. Volume: 7(1) Pages: 74-74
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Structural and morphometric comparison of the molar teeth in pre-eruptive developmental stage of PACAP-deficient and wild-type mice. (2014)
  • Author(s): Sandor B, Fintor K, Felszeghy S, Juhasz T, Reglodi D, Mark L, Kiss P, Jungling A, Fulop BD, Nagy AD, Hashimoto H, Zakany R, Nagy A, Tamas A.
  • Journal Title: J Mol Neurosci Volume: 54(3) Pages: 331-341
  • DOI: 10.1007/s12031-014-0392-6
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] High-speed whole brain imaging with subcellular resolution and comparison analysis (2017)
  • Author(s): 笠井淳司、橋本均
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 仙台
  • Year and Date: 2017-03-24
• [Presentation] 精神的ストレスにより活性化する神経核の情動行動における役割 (2017)
  • Author(s): 丹生光咲、笠井淳司、勢力薫、五十嵐久人、山口瞬、山中章弘、中澤敬信、橋本均
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 仙台
  • Year and Date: 2017-03-24
• [Presentation] 全脳活動マッピングを用いたNMDA受容体拮抗薬誘発行動異常にかかわる脳部位の解析 (2017)
  • Author(s): 勢力薫、笠井淳司、桑木崇宏、丹生光咲、中雄一郎、五十嵐久人、中澤敬信、山口瞬、吾郷由希夫、橋本均
  • Organizer: 第90回薬理学会年会
  • Place of Presentation: 長崎
  • Year and Date: 2017-03-15
• [Presentation] CNS創薬を支援する疾患モデルの開発 (2017)
  • Author(s): 橋本均、笠井淳司、中澤敬信
  • Organizer: 日本安全性薬理研究会第8回学術年会
  • Place of Presentation: 東京
  • Year and Date: 2017-02-10
• [Presentation] Modeling VIPR2 linkages to schizophrenia in mice (2017)
  • Author(s): Ago Y, Hayata-Takano A, Rajbhandari A, Fanselow M, Hashimoto H, Waschek JA
  • Organizer: The 13th International Symposium on VIP, PACAP and Related Peptides
  • Int'l Joint Research
• [Presentation] Astrocyte-neuron lactate shuttle playes pivotal role in PACAP mediated fear memory acquisition or retrieval in mice (2017)
  • Author(s): Nakashima Y, Kambe Y, Trung NT, Shintani N, Hashimoto H, Miyata A
  • Organizer: The 13th International Symposium on VIP, PACAP and Related Peptides
  • Int'l Joint Research
• [Presentation] Comparative effects of ketamine isomers, R-ketamine and S-ketamine, in mouse models of depression (2017)
  • Author(s): Ago Y, Higuchi M, Tanabe W, Seiriki K, Igarashi H, Hashimoto K, Hashimoto H
  • Organizer: Neuroscience 2017
  • Int'l Joint Research
• [Presentation] Saturated Excitation Microscopy Using Image Subtraction (2017)
  • Author(s): Nawa Y, Yonemaru Y, Kasai A, Smith NI, Hashimoto H, Kawata S, Fujita K
  • Organizer: ICO24 (The 24th Congress of the International Commission for Optics)
  • Int'l Joint Research
• [Presentation] Whole-brain mapping analysis of the NMDAR antagonist-induced neuronal activity (2017)
  • Author(s): Seiriki K, Kasai A, Kuwaki T, Niu M, Naka Y, Igarashi H, Nakazawa T, Yamaguchi S, Ago Y, Hashimoto H
  • Organizer: Neuroscience 2017
  • Int'l Joint Research
• [Presentation] 高頻度にde novo変異が認められる自閉スペクトラム症関連遺伝子POGZの患者由来iPS細胞を用いた分子病態解析 (2017)
  • Author(s): 岡田翔太，松村憲佑，中澤敬信，永安一樹，馬場優志，笠井淳司，吾郷由希夫，田熊一敞，山森英長，安田由華，橋本亮太，橋本均
  • Organizer: 第132回 日本薬理学会 近畿部会
• [Presentation] 自閉スペクトラム症モデルマウスの社会性行動障害に有効な抗てんかん作用を有する医薬品の探索 (2017)
  • Author(s): 三浦大樹，笠井淳司，彌永祐輔，原雄大，中澤敬信，吾郷由希夫，田熊一敞, 橋本均
  • Organizer: 第132回 日本薬理学会 近畿部会
• [Presentation] ヒトiPS細胞からセロトニン神経細胞への分化誘導法の開発 (2017)
  • Author(s): 桝中このみ，永安一樹，中澤敬信，吾郷由希夫，田熊一敞, 橋本均
  • Organizer: 第132回 日本薬理学会 近畿部会
• [Presentation] Endogenous PACAP increases food intake by modulating the neuropeptides expression in the hypothalamus (2017)
  • Author(s): Trung NT, Kambe Y, Kurihara T, Shintani N, Hashimoto H, Miyata A
  • Organizer: 第70回日本薬理学会西南部会
• [Presentation] 自閉スペクトラム症に高頻度に認めるPOGZ遺伝子座の患者特異的de novo変異の表現型解析 (2017)
  • Author(s): 中澤敬信，田熊一敞, 橋本亮太，橋本均
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会
• [Presentation] ブチリルコリンエステラーゼ阻害によるグレリンシグナルの活性化を介した中枢ムスカリンM1受容体機能の亢進 (2017)
  • Author(s): 吾郷由希夫, 東野功典, 国本寿美子, 塚田信司, Nigel H. Greig, 松田敏夫, 橋本均
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会
• [Presentation] 全脳マッピングと神経活動操作による情動行動制御機構の解明 (2017)
  • Author(s): 笠井淳司, 丹生光咲, 勢力薫, 五十嵐久人, 桑木崇宏, 田沼将人, 中澤敬信, 山口瞬, 山中章宏, 橋本均
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会
• [Presentation] 全脳イメージング法を用いた精神疾患モデルマウスの機能評価 (2017)
  • Author(s): 橋本均
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会
• [Presentation] 精神疾患の病態解析と創薬へ向けたモデル研究 (2017)
  • Author(s): 橋本均
  • Organizer: 第61回薬学会関東支部大会
• [Presentation] 複数の自閉症患者にde novo変異が認められるPRKD2遺伝子産物の機能解析 (2017)
  • Author(s): 馬場優志，松村憲佑，中澤敬信，永安一樹，笠井淳司，田熊一敞, 橋本均
  • Organizer: 次世代を担う創薬・医療薬理シンポジウム2017
• [Presentation] 自閉スペクトラム症に高頻度に変異が認められる遺伝子POGZは神経細胞の分化制御に関与する (2017)
  • Author(s): 松村憲佑，中澤敬信，永安一樹，三浦大樹，笠井淳司，田熊一敞，山森英長，安田由華，橋本亮太，橋本均
  • Organizer: 第40回日本神経科学大会
• [Presentation] β-アレスチンを介する PACAP-PAC1 シグナルの解析 (2017)
  • Author(s): 新谷勇介，早田敦子, 橋本均
  • Organizer: 第131回 日本薬理学会 近畿部会
• [Presentation] VPAC2受容体を介する大脳皮質神経神経発達異常と精神疾患との関連 (2017)
  • Author(s): 吾郷由希夫、早田敦子、河内琢也、山内良介、James Waschek、橋本均
  • Organizer: 第90回薬理学会年会
  • Place of Presentation: 長崎
• [Presentation] ASD-associated de novo mutations in POGZ impair the DNA-binding activity of POGZ (2016)
  • Author(s): Nakazawa T, Matsumura K, Nagayasu K, Kasai A, Hayata-Takano A, Shintani N, Takuma K, Yamamori H, Yasuda Y, Hashimoto R, Hashimoto H.
  • Organizer: 55th Annual Meeting, ACNP
  • Place of Presentation: アメリカ
  • Year and Date: 2016-12-04
  • Int'l Joint Research
• [Presentation] Activation of the VPAC2 receptor inhibits neurite outgrowth and branching of cortical neurons by a PKA-dependent mechanism (2016)
  • Author(s): Hashimoto H, Ago Y, Hayata-Takano A, Kawanai T, Yamauchi R, Waschek JA.
  • Organizer: Neuroscience 2016
  • Place of Presentation: アメリカ
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] 全脳イメージングによる脳機能・疾患機序の解析 (2016)
  • Author(s): 橋本均、勢力薫、丹生光咲、中雄一郎、笠井淳司
  • Organizer: 第38回日本生物学的精神医学会・第59回日本神経化学会大会 合同年会
  • Place of Presentation: 福岡
  • Year and Date: 2016-09-08
• [Presentation] 神経細胞の成熟におけるPACAPとBDNFの役割 (2016)
  • Author(s): 早田 敦子、加茂 俊彦、勢力 薫、尾形 勝弥、中澤 敬信、吾郷 由希夫、永安 一樹、笠井 淳司、新谷 紀人、橋本 均
  • Organizer: 第38回日本生物学的精神医学会・第59回日本神経化学会大会 合同年会
  • Place of Presentation: 福岡
  • Year and Date: 2016-09-08
• [Presentation] ドパミン神経賦活薬の慢性投与は胎仔期バルプロ酸曝露マウスの自閉症様行動を改善する (2016)
  • Author(s): 長谷部茂、原雄大、樋口桃子、吾郷由希夫、中澤敬信、橋本均、松田敏夫、田熊一敞
  • Organizer: 第38回日本生物学的精神医学会・第59回日本神経化学会大会 合同年会
  • Place of Presentation: 福岡
  • Year and Date: 2016-09-08
• [Presentation] Overactivation of the VPAC2 receptor during the early postnatal period causes prefrontal synaptic abnormalities and cognitive dysfundtion in mice (2016)
  • Author(s): Ago Y, Hayata A, Kawanai T, Yamauchi R, Waschek JA, Hashimoto H.
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: 韓国
  • Year and Date: 2016-07-03
  • Int'l Joint Research
• [Presentation] iPS細胞技術を用いた統合失調症患者のクロザピン応答性の個人間の相違の分子機構解析 (2016)
  • Author(s): 中澤敬信、橋本亮太、橋本均
  • Organizer: 第46回日本神経精神薬理学会年会
  • Place of Presentation: 韓国
  • Year and Date: 2016-07-02
• [Presentation] 精神的ストレスによる覚せい剤精神病の再燃現象におけるセロトニン受容体の関与 (2016)
  • Author(s): 田中辰典、吾郷由希夫、梅原千晶、長谷部 茂、橋本 均、田熊一敞、松田敏夫
  • Organizer: 第13回GPCR研究会
  • Place of Presentation: 東京
  • Year and Date: 2016-05-13
• [Presentation] 統合失調症におけるVIP/PACAP受容体VPAC2活性化の病態的意義 (2016)
  • Author(s): 吾郷由希夫、河内琢也、山内良介、早田敦子、James Waschek、橋本 均
  • Organizer: 第13回GPCR研究会
  • Place of Presentation: 東京
  • Year and Date: 2016-05-13
• [Presentation] 発育期の環境要因が精神・神経機能に及ぼす影響 (2016)
  • Author(s): 田熊一敞, 吾郷由希夫, 長谷部 茂, 橋本均, 松田敏夫
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜（神奈川・横浜市）
  • Year and Date: 2016-03-09
• [Presentation] 雌性マウスを用いた意欲・報酬探索行動評価試験 (2016)
  • Author(s): 川瀬啓生、吾郷由希夫、長谷部茂、岡智史、田熊一敞, 松田敏夫、橋本均
  • Organizer: 第129回日本薬理学会近畿部会
  • Place of Presentation: 広島
• [Presentation] 精神疾患の分子機構の解析と創薬に向けた疾患モデル研究 (2016)
  • Author(s): 橋本均
  • Organizer: 第61回脳の医学・生物学研究会
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] Whole Brain Imaging to Investigate Physiology and Pathophysiology of Brain Disorders (2016)
  • Author(s): Hashimoto H.
  • Organizer: VIMM Seminar (日伊国交150周年事業)
  • Place of Presentation: イタリア
  • Int'l Joint Research / Invited
• [Presentation] 自閉スペクトラム症関連遺伝子POGZの患者特異的de novo変異の表現型解析 (2016)
  • Author(s): 松村憲佑、中澤敬信、永安一樹、三浦大樹、笠井淳司、田熊一敞、山森英長、安田由華、橋本亮太、橋本均
  • Organizer: 次世代を担う創薬・医療薬理シンポジウム2016
  • Place of Presentation: 仙台
• [Presentation] 社会的敗北ストレスによる社会的忌避行動時の全脳神経活動マッピング (2016)
  • Author(s): 五十嵐久人、笠井淳司、勢力薫、丹生光咲、中雄一郎、山浦港生、中澤敬信、橋本均
  • Organizer: 第130回日本薬理学会近畿部会
  • Place of Presentation: 京都
• [Presentation] がん治療後に認められる高次脳機能障害におけるシクロオキシゲナーゼの関与 (2016)
  • Author(s): 尾中勇祐、新谷紀人、 中澤敬信、吾郷由希夫、木野村 元彦、田邊 航、荻田 喜代一、橋本 均
  • Organizer: 第130回日本薬理学会近畿部会
  • Place of Presentation: 京都
• [Presentation] 脳病態を解明するモデル動物の全脳イメージング (2015)
  • Author(s): 橋本均, 笠井淳司, 勢力薫, 丹生光咲, 中澤敬信
  • Organizer: 第6回脳表現型の分子メカニズム研究会
  • Place of Presentation: コンベンションルームAP品川アネックスIルーム（東京・品川区）
  • Year and Date: 2015-11-14
• [Presentation] A new block-face serial microscopy tomography for computational mapping of brain cells, and unbiased comparative analysis (2015)
  • Author(s): Seiriki K, Kasai A, Hashimoto T, Schulze W, Niu M, Nakazawa T, Hashimoto H.
  • Organizer: 45th Society for Neuroscience Annual meeting (Neuroscience2015)
  • Place of Presentation: シカゴ（アメリカ）
  • Year and Date: 2015-10-17
  • Int'l Joint Research
• [Presentation] Practical optimization of in situ hybridization procedure for the detection of microRNAs and mRNA expression in brain tissues (2015)
  • Author(s): Kasai A, Kakihara S, Okada R, Hazama K, Nakazawa T, Nagayasu K, Hayata-Takano A, Shintani N, Hashimoto H.
  • Organizer: 45th Society for Neuroscience Annual meeting (Neuroscience2015)
  • Place of Presentation: シカゴ（アメリカ）
  • Year and Date: 2015-10-17
  • Int'l Joint Research
• [Presentation] Overactivation of the VPAC2 receptor during postnatal brain development causes prefrontal synaptic abnormalities and cognitive dysfunction in mice (2015)
  • Author(s): Ago Y, Condro MC, Tan YV, Hayata A, Kawanai T, Cushman JD, Fanselow MS, Hashimoto H, Waschek JA.
  • Organizer: 12th International Symposium on VIP/PACAP and Related Peptides
  • Place of Presentation: カッパドキア（トルコ）
  • Year and Date: 2015-09-21
  • Int'l Joint Research
• [Presentation] Roles of PACAP in Depressopm-Like Behavior (2015)
  • Author(s): Hashimoto H, Shintani N, Ago Y, Hayata-Takano A, Waschek JA, Baba A.
  • Organizer: 12th International Symposium on VIP/PACAP and Related Peptides
  • Place of Presentation: カッパドキア（トルコ）
  • Year and Date: 2015-09-21
  • Int'l Joint Research
• [Presentation] ストレスにより活性化する神経細胞の全脳マッピングと定量的解析 (2015)
  • Author(s): 丹生光咲, 笠井淳司, 勢力薫, 山口瞬, 橋本岳, 中澤敬信, 橋本均
  • Organizer: 次世代を担う創薬・医療薬理シンポジウム2015
  • Place of Presentation: 東京大学薬学部（東京・文京区）
  • Year and Date: 2015-08-29
• [Presentation] 構造および神経活動の変化を定量的に検出する高精細三次元全脳形態計測システム (2015)
  • Author(s): 勢力薫, 笠井淳司, 丹生光咲, 山口瞬, 橋本岳, 中澤敬信, 橋本均
  • Organizer: 第38回日本神経科学会大会
  • Place of Presentation: 神戸国際会議場（兵庫・神戸市）
  • Year and Date: 2015-07-28
• [Presentation] 自閉症の疾患特異的候補遺伝子の機能的スクリーニング (2015)
  • Author(s): 松村憲佑, 橋本亮太, 中澤敬信, 鶴崎美徳, 安田由華, 永安一樹, 川島和, 山森英長, 藤本美智子, 大井一高, 梅田知美, 福永雅喜, 藤野陽生, 笠井淳司, 早田敦子, 新谷紀人, 武田雅俊, 松本直通, 橋本均
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場（兵庫・神戸市）
  • Year and Date: 2015-07-28
• [Presentation] 雌選択性試験：マウス間相互作用を基盤とした新規うつ様行動評価系 (2015)
  • Author(s): 長谷部茂, 岡智史, 尾中勇祐, 橋本均, 松田敏夫, 吾郷由希夫, 田熊一敞
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場（兵庫・神戸市）
  • Year and Date: 2015-07-28
• [Presentation] マウス活動期における拘束ストレスは抗不安様作用を示す (2015)
  • Author(s): 田中辰典, 太田友樹, 大住康晃, 長谷部茂, 尾中勇祐, 橋本均, 松田敏夫, 田熊一敞, 吾郷由希夫
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場（兵庫・神戸市）
  • Year and Date: 2015-07-28
• [Presentation] リバスチグミンのムスカリン受容体を介したプレパルスインヒビション障害改善作用 (2015)
  • Author(s): 東野功典, 梅木孝弘, 尾中勇祐, 橋本均, 松田敏夫, 田熊一敞, 吾郷由希夫
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場（兵庫・神戸市）
  • Year and Date: 2015-07-28
• [Presentation] がん治療後の脳機能障害の解明に有用な動物モデルの作製 (2015)
  • Author(s): 尾中勇祐, 木野村元彦, 新谷紀人, 平井博之, 永田欽也, 中村正孝, 長谷部茂, 永安一樹, 吾郷由希夫, 笠井淳司, 早田敦子, 中澤敬信, 田熊一敞, 松田敏夫, 馬場明道, 橋本均
  • Organizer: 第127回日本薬理学会近畿部会
  • Place of Presentation: 長良川国際会議場（岐阜・岐阜市）
  • Year and Date: 2015-06-26
• [Presentation] 慢性的な社会的敗北ストレスによる内側前頭前皮質におけるPACAP発現低下とエピジェネティクス関連因子の発現変化 (2015)
  • Author(s): 川瀬啓生、笠井淳司、小川純明、狭間啓佑、早田敦子、新谷紀人、馬場明道、橋本均
  • Organizer: 日本薬学会 第135年会
  • Place of Presentation: 神戸 神戸学院大学
  • Year and Date: 2015-03-25 – 2015-03-28
• [Presentation] 高精細三次元定量的全脳解析システムの構築と脳内変化の検出 (2015)
  • Author(s): 笠井淳司、勢力薫、丹生光咲、橋本岳、橋本均
  • Organizer: 日本薬学会 第135年会
  • Place of Presentation: 神戸 神戸学院大学
  • Year and Date: 2015-03-25 – 2015-03-28
• [Presentation] 高精細全脳形態計測システムの構築 (2015)
  • Author(s): 勢力薫、笠井淳司、丹生光咲、山口瞬、橋本岳、橋本均
  • Organizer: 第88回日本薬理学会年会
  • Place of Presentation: 名古屋 名古屋国際会議場
  • Year and Date: 2015-03-18 – 2015-03-20
• [Presentation] ゲノム科学による霊長類脳の多様性の解明 (2015)
  • Author(s): 橋本亮太、中澤敬信、今井啓雄、井上謙一、安田由華、山森英長、大井一高、 松村憲佑、 永安一樹、三浦健一郎、福永雅喜、高田 昌彦、武田雅俊、 橋本 均
  • Organizer: 平成26年度 京都大学霊長類研究所共同利用研究会「霊長類脳科学の新しい展開とゲノム科学との融合」
  • Place of Presentation: 京都 京都大学霊長類研究所
  • Year and Date: 2015-03-13 – 2015-03-14
• [Presentation] Mitophagy and inhibition of mitochondrial fusion. (2015)
  • Author(s): Shintani N, Hashimoto H, Scorrano L.
  • Organizer: 13 th Annual Retreat
  • Place of Presentation: Venetian Institute of Molecular Medicine
  • Year and Date: 2015-02-06 – 2015-02-07
• [Presentation] International collaborative research focusing on the oxidative stress hypothesis for novel drug development in psychiatric diseases. (2015)
  • Author(s): 橋本均
  • Organizer: 都医学研セミナー
  • Place of Presentation: 東京 東京都医学総合研究所
  • Year and Date: 2015-01-23
  • Invited
• [Presentation] 高精細三次元定量的全脳解析法の構築：マイクロエンドフェのタイプの探索へ (2014)
  • Author(s): 笠井淳司、勢力薫、丹生光咲、橋本岳、橋本均
  • Organizer: 2014年度包括脳ネットワーク冬のシンポジウム
  • Place of Presentation: 東京 東京医科歯科大学 湯島キャンパス
  • Year and Date: 2014-12-12 – 2014-12-13
• [Presentation] 自閉スペクトラム症関連候補遺伝子のハイスループット機能評価系による解析 (2014)
  • Author(s): 永安一樹、松村憲佑、中澤敬信、安田由華、山森英長、梅田知美、大井一高、橋本亮太、武田雅俊、橋本均
  • Organizer: 2014年度包括脳ネットワーク冬のシンポジウム
  • Place of Presentation: 東京 東京医科歯科大学 湯島キャンパス
  • Year and Date: 2014-12-12 – 2014-12-13
• [Presentation] Brain-enriched Sorting Nexin Family Proteins Regulate Spine Morphogenesisand Are Associated with Risk for Schizophrenia (2014)
  • Author(s): Nakazawa T, Hashimoto R, Tanimura A, Ohi K, Yamamori H, Yasuda Y, Umeda-Yano S, Kiyama Y, Konno K, Inoue T, Numata S, Ohnuma T, Iwata N, Ozaki N, Hashimoto H, Watanabe M, Manabe T, Yamamoto T, Takeda M, Kano M
  • Organizer: ACNP 53rd Annual Meeting
  • Place of Presentation: Phoenix, AZ , USA
  • Year and Date: 2014-12-07 – 2014-12-11
• [Presentation] アメリカにおける神経精神薬理学会の動向 (2014)
  • Author(s): 橋本均
  • Organizer: 第24回 日本臨床精神神経薬理学会 第44回日本神経精神薬理学会 合同年会 双方向性トランスレーショナル研究の実現
  • Place of Presentation: 名古屋 名古屋国際会議場
  • Year and Date: 2014-11-20 – 2014-11-22
  • Invited
• [Presentation] iPS細胞関連技術を用いた統合失調症研究 (2014)
  • Author(s): 中澤敬信、橋本亮太、永安一樹、安田由華、山森英長、梅田知美、藤本美智子、大井一高、石川充、赤松和土、岡野栄之、武田雅俊、橋本均
  • Organizer: 第24回 日本臨床精神神経薬理学会 第44回日本神経精神薬理学会 合同年会 双方向性トランスレーショナル研究の実現
  • Place of Presentation: 名古屋 名古屋国際会議場
  • Year and Date: 2014-11-20 – 2014-11-22
  • Invited
• [Presentation] 自閉症の疾患特異的候補遺伝子の機能的スクリーニング系の確立 (2014)
  • Author(s): 松村憲佑、永安一樹、中澤敬信、安田由華、山森英長、梅田知美、大井一高、橋本亮太、武田雅俊、橋本均
  • Organizer: 第24回 日本臨床精神神経薬理学会 第44回日本神経精神薬理学会 合同年会 双方向性トランスレーショナル研究の実現
  • Place of Presentation: 名古屋 名古屋国際会議場
  • Year and Date: 2014-11-20 – 2014-11-22
• [Presentation] LPS誘発炎症モデルにおいて発現変化する脳内miRNAの同定 (2014)
  • Author(s): 柿原素楽、笠井淳司、岡田遼、尾中勇祐、中澤敬信、永安一樹、早田敦子、新谷紀人、橋本均
  • Organizer: 第126回 日本薬理学会 近畿部会
  • Place of Presentation: 和歌山 和歌山県JAビル
  • Year and Date: 2014-10-24
• [Presentation] PRABβ（σ）遺伝子欠損マウスの行動表現型に関する検討 (2014)
  • Author(s): 本郷翔子、中田理恵子、尾中勇祐、新谷紀人、橋本均、井上裕康
  • Organizer: 第87回日本生化学会
  • Place of Presentation: 京都 京都国際会館
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] 神経ペプチドPACAPによる精神機能調節：創薬への展望 (2014)
  • Author(s): 橋本均、新谷紀人、早田敦子、笠井淳司、永安一樹、中澤敬信
  • Organizer: 第36回日本生物学的精神医学会 第57回日本神経化学会大会 合同年会
  • Place of Presentation: 奈良 奈良県文化会館
  • Year and Date: 2014-09-29 – 2014-10-01
• [Presentation] 精神・神経疾患モデル動物の病態解析のための三次元全脳形態計測法の構築 (2014)
  • Author(s): 勢力薫、笠井淳司、丹生光咲、早田敦子、永安一樹、中澤敬信、新谷紀人、橋本岳、橋本均
  • Organizer: 第36回日本生物学的精神医学会 第57回日本神経化学会大会 合同年会
  • Place of Presentation: 奈良 奈良県文化会館
  • Year and Date: 2014-09-29 – 2014-10-01
• [Presentation] A crosstalk between PACAP and serotonin 2A signaling (2014)
  • Author(s): 森口 啓太、早田 敦子、道添 瞳、円丁 直樹、新谷 紀人、馬場 明道、橋本 均
  • Organizer: 20th International Symposium on Regulatory Peptides (REGPEG2014)
  • Place of Presentation: 京都 京都ガーデンパレス
  • Year and Date: 2014-09-07 – 2014-09-10
• [Presentation] ミトコンドリア融合抑制因子MIFIの転写を調節する化合物の探索 (2014)
  • Author(s): 廣内大成、井上直紀、新谷紀人、田中翔太、笠井淳司、馬場明道、橋本均
  • Organizer: 次世代を担う創薬・医療薬理シンポジウム2014
  • Place of Presentation: 大阪 近畿大学薬学部 東大阪キャンパス
  • Year and Date: 2014-08-30
• [Presentation] コルチコステロン誘発性うつ病モデルを用いたプロスタノイド受容体DP2を介する情動制御機構の解析 (2014)
  • Author(s): 尾中勇祐、新谷紀人、木野村元彦、平井博之、長田欽也、中村正孝、早田敦子、笠井淳司、永安一樹、中澤敬信、馬場明道、橋本均
  • Organizer: 生体機能と創薬シンポジウム2014
  • Place of Presentation: 大阪 近畿大学薬学部 東大阪キャンパス
  • Year and Date: 2014-08-28 – 2014-08-29
• [Presentation] 細胞内タンパク質輸送と統合失調症 (2014)
  • Author(s): 中澤敬信、橋本亮太、橋本均
  • Organizer: 生体機能と創薬シンポジウム2014
  • Place of Presentation: 大阪 近畿大学薬学部 東大阪キャンパス
  • Year and Date: 2014-08-28 – 2014-08-29
• [Presentation] 脳内miRNA発現の高感度検出に向けたin situ hybridization法の最適化：炎症により発現変化する脳内miRNAの同定 (2014)
  • Author(s): 柿原素楽、笠井淳司、岡田遼、狭間啓佑、中澤敬信、永安一樹、早田敦子、新谷紀人、橋本均
  • Organizer: 生体機能と創薬シンポジウム2014
  • Place of Presentation: 大阪 近畿大学薬学部 東大阪キャンパス
  • Year and Date: 2014-08-28 – 2014-08-29
• [Presentation] PACAP-PAC1 signaling pathway regulates internalization of serotonin 2A receptor in a PKC and.b-arrestin2 dependent manner (2014)
  • Author(s): 早田 敦子、森口 啓太、円丁 直樹、新谷 紀人、馬場 明道、橋本 均
  • Organizer: 29th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2014-06-22 – 2014-06-26
• [Presentation] ミトコンドリア融合阻害因子MIFIによる心病態の増悪機序に関する解析：遺伝子発現プロフィール解析 (2014)
  • Author(s): 田中翔太、新谷紀人、中山博之、東信太朗、開菜摘、舎川洸太、藤尾慈、井上直紀、笠井淳司、早田敦子、橋本均、馬場明道
  • Organizer: 第125回 日本薬理学会 近畿部会
  • Place of Presentation: 岡山 岡山コンベンションセンター
  • Year and Date: 2014-06-20
• [Remarks] 大阪大学大学院 薬学研究科 神経薬理学分野
  • URL: http://molpharm.umin.jp/index.html
• [Remarks] 大阪大学大学院 薬学研究科 神経薬理学教室
  • URL: http://molpharm.umin.jp/index.html