|Budget Amount *help
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2017: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
|Outline of Final Research Achievements
Mammalian Muse cells are endogenous pluripotent stem cells. On the other hand, planarians who have high regenerative capacity also hold endogenous pluripotent stem cells called neoblast in the connective tissue. Focusing on this similarity, we explored distribution, mobility and functionality of Muse cells in vivo. Muse cells distributed in the bone marrow, peripheral blood and, similar to planarians, the connective tissue of nearly every organ. Muse cells were mobilized from the bone marrow to the peripheral blood in response to S1P signal produced by damaged tissue, preferentially migrated to and homed into the damaged site, and repair the tissue by spontaneous differentiation into tissue-compatible cells. Thus, they are contributing to daily tissue homeostasis as well as to reparative function after tissue damage.