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The origin of endogenous pluripotent Muse cells and their role in tissue homeostasis

Research Project

Project/Area Number 26293058
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field General medical chemistry
Research InstitutionTohoku University

Principal Investigator

Dezawa Mari  東北大学, 医学系研究科, 教授 (50272323)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2017: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Keywords再生医学 / 多能性幹細胞 / 間葉系幹細胞 / 再生医療
Outline of Final Research Achievements

Mammalian Muse cells are endogenous pluripotent stem cells. On the other hand, planarians who have high regenerative capacity also hold endogenous pluripotent stem cells called neoblast in the connective tissue. Focusing on this similarity, we explored distribution, mobility and functionality of Muse cells in vivo. Muse cells distributed in the bone marrow, peripheral blood and, similar to planarians, the connective tissue of nearly every organ. Muse cells were mobilized from the bone marrow to the peripheral blood in response to S1P signal produced by damaged tissue, preferentially migrated to and homed into the damaged site, and repair the tissue by spontaneous differentiation into tissue-compatible cells. Thus, they are contributing to daily tissue homeostasis as well as to reparative function after tissue damage.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (109 results)

All 2018 2017 2016 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (27 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 22 results,  Open Access: 14 results) Presentation (81 results) (of which Int'l Joint Research: 18 results,  Invited: 78 results)

  • [Int'l Joint Research] ナポリ第2大学(イタリア)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Mobilized Muse Cells After Acute Myocardial Infarction Predict Cardiac Function and Remodeling in the Chronic Phase2018

    • Author(s)
      Tanaka T, Nishigaki K, Minatoguchi S, Nawa T, Yamada Y, Kanamori H, Mikami A, Ushikoshi H, Kawasaki M, Dezawa M, Minatoguchi S.
    • Journal Title

      Circulation Journal

      Volume: 82 Issue: 2 Pages: 561-571

    • DOI

      10.1253/circj.CJ-17-0552

    • NAID

      130006321864

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] S1P-S1PR2 Axis Mediates Homing of Muse Cells into Damaged Heart for Long Lasting Tissue Repair and Functional Recovery After Acute Myocardial Infarction2018

    • Author(s)
      Yamada, Y. Wakao, S. Kushida, Y. Minatoguchi, S. Mikami, A. Higashi, K. Baba, S. Shigemoto, T. Kuroda, Y. Kanamori, H. Amin, M. Kawasaki, M. Nishigaki, K. Taoka, M. Isobe, T. Muramatsu, C. Dezawa, M. Minatoguchi, S.
    • Journal Title

      Circulation research

      Volume: 122 Issue: 8 Pages: 1069-1083

    • DOI

      10.1161/circresaha.117.311648

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Intravenously injected human multilineage-differentiating stress-enduring cells selectively engraft into mouse aortic aneurysms and attenuate dilatation by differentiating into multiple cell types2018

    • Author(s)
      Hosoyama, K. Wakao, S. Kushida, Y. Ogura, F. Maeda, K. Adachi, O. Kawamoto, S. Dezawa, M. Saiki, Y.
    • Journal Title

      The Journal of thoracic and cardiovascular surgery

      Volume: - Issue: 6 Pages: 2301-2313.e4

    • DOI

      10.1016/j.jtcvs.2018.01.098

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cardiotrophic Growth Factor-Driven Induction of Human Muse Cells Into Cardiomyocyte-Like Phenotype.2018

    • Author(s)
      Amin M, Kushida Y, Wakao S, Kitada M, Tatsumi K, Dezawa M.
    • Journal Title

      Cell Transplant.

      Volume: 27(2) Issue: 2 Pages: 285-298

    • DOI

      10.1177/0963689717721514

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Human Muse Cells Reconstruct Neuronal Circuitry in Subacute Lacunar Stroke Model.2017

    • Author(s)
      Uchida H, Niizuma K, Kushida Y, Wakao S, Tominaga T, Borlongan CV, Dezawa M.
    • Journal Title

      Stroke.

      Volume: 48(2) Issue: 2 Pages: 428-35

    • DOI

      10.1161/strokeaha.116.014950

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Beneficial Effects of Systemically Administered Human Muse Cells in Adriamycin Nephropathy.2017

    • Author(s)
      Uchida N, Kushida Y, Kitada M, Wakao S, Kumagai N, Kuroda Y, Kondo Y, Hirohara Y, Kure S, Chazenbalk G, Dezawa M
    • Journal Title

      J Am Soc Nephrol

      Volume: 28 Issue: 10 Pages: 2946-2960

    • DOI

      10.1681/asn.2016070775

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genetically Engineered Multilineage-Differentiating Stress-Enduring Cells as Cellular Vehicles against Malignant Gliomas.2017

    • Author(s)
      Tomohiro Yamasaki
    • Journal Title

      Morecular Therapy oncolytics

      Volume: 6 Pages: 45-56

    • DOI

      10.1016/j.omto.2017.06.001

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prolonged but non-permanent expression of a transgene in ependymal cells of adult rats using an adenovirus-mediated transposon gene transfer system2017

    • Author(s)
      Suzuki JI, Dezawa M, Kitada M.
    • Journal Title

      Brain Res.

      Volume: 1675 Pages: 20-27

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Therapeutic Potential of Multilineage-Differentiating Stress-Enduring Cells for Osteochondral Repair in a Rat Model.2017

    • Author(s)
      Mahmoud EE, Kamei N, Shimizu R, Wakao S, Dezawa M, Adachi N, Ochi M.
    • Journal Title

      Stem Cells Int

      Volume: 2017 Pages: 8154569-8154569

    • DOI

      10.1155/2017/8154569

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Human Muse cells, non-tumorigenic pluripotent-like stem cells, have the capacity for liver regeneration by specific homing and replenishment of new hepatocytes in liver fibrosis mouse model.2016

    • Author(s)
      Iseki M, Kushida Y, Wakao S, Akimoto T, Mizuma M, Motoi F, Asada R, Shimizu S, Unno M, Chazenbalk G, Dezawa M.
    • Journal Title

      Cell Transplantation

      Volume: - Issue: 5 Pages: 821-840

    • DOI

      10.3727/096368916x693662

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Muse cells provide the pluripotency of mesenchymal stem cells: direct contribution of Muse cells to tissue regeneration.2016

    • Author(s)
      Mari Dezawa.
    • Journal Title

      Cell Transplant.

      Volume: Epub ahead of print Issue: 5 Pages: 849-61

    • DOI

      10.3727/096368916x690881

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A distinct subpopulation of bone marrow mesenchymal stem cells, Muse cells, directly commit to the replacement of liver components.2016

    • Author(s)
      Katagiri H, Kushida Y, Nojima M, Kuroda Y, Wakao S, Ishida K, Endo F, Kume K, Takahara T, Nitta H, Tsuda H, Dezawa M, Nishizuka SS.
    • Journal Title

      American Journal of Transplantation

      Volume: 16 Issue: 2 Pages: 468-483

    • DOI

      10.1111/ajt.13537

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transplantation of Unique Subpopulation of Fibroblasts, Muse Cells, Ameliorates Experimental2016

    • Author(s)
      Satow, T., Kawase, T., Kitamura, A. , Kajitani ,Y. , Yamaguchi, T. , Tanabe, N. , Otoi, R. , Komuro, T. , Kobayashi, A. , Nagata, H. , Mima, T.,
    • Journal Title

      Stem Cells

      Volume: 34 Issue: 1 Pages: 160-173

    • DOI

      10.1002/stem.2206

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 生体内多能性幹細胞:Muse細胞2015

    • Author(s)
      出澤真理
    • Journal Title

      脳神経系の再生医学

      Volume: なし Pages: 19-26

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 体性幹細胞とMuse細胞の位置づけ2015

    • Author(s)
      若尾昌平、出澤真理
    • Journal Title

      膵島の再生医療

      Volume: なし Pages: 73-78

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Therapeutic Effects of Human Multilineage-Differentiating Stress Enduring (MUSE) Cell Transplantation into Infarct Brain of Mice.2015

    • Author(s)
      Yamauchi T, Kuroda Y, Morita T, Shichinohe H, Houkin K, Dezawa M, Kuroda S.
    • Journal Title

      PLoS One

      Volume: 10(3) Issue: 3 Pages: e0116009-e0116009

    • DOI

      10.1371/journal.pone.0116009

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Current status and future prospects of Muse cell research2015

    • Author(s)
      Wakao S, Dezawa M.
    • Journal Title

      Folia Pharmacologica Japonica

      Volume: 145 Issue: 6 Pages: 299-305

    • DOI

      10.1254/fpj.145.299

    • NAID

      130005075728

    • ISSN
      0015-5691, 1347-8397
    • Related Report
      2015 Annual Research Report
  • [Journal Article] Mesenchymal Stem Cells as a Source of Schwann Cells: Their Anticipated Use in Peripheral Nerve Regeneration.2015

    • Author(s)
      Wakao S, Matsuse D, Dezawa M.
    • Journal Title

      Cells Tissues Organs.

      Volume: Epub ahead of print

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 「生体内多能性幹細胞:Muse細胞」2015

    • Author(s)
      出澤真理
    • Journal Title

      脳神経系の再生医療

      Volume: なし Pages: 19-26

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 「体性幹細胞とMuse細胞の位置づけ」2015

    • Author(s)
      若尾昌平、出澤真理
    • Journal Title

      膵島の再生医療

      Volume: なし Pages: 73-78

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Human adipose tissue possesses a unique population of pluripotent stem cells with non-tumorigenic and low telomerase activities : potential implications in regenerative medicine2014

    • Author(s)
      Ogura F, Wakao S, Kuroda Y, Tsuchiyama K, Bagheri M, Heneidi S, Chazenbalk G, Aiba S, Dezawa M
    • Journal Title

      Stem Cells Dev

      Volume: 23(7) Issue: 7 Pages: 717-28

    • DOI

      10.1089/scd.2013.0473

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mesenchymal stem cells and their subpopulation, pluripotent Muse cells, in basic research and regenerative medicine2014

    • Author(s)
      Kuroda Y, Dezawa M
    • Journal Title

      Anat Rec

      Volume: 297(1) Issue: 1 Pages: 98-110

    • DOI

      10.1002/ar.22798

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Muse cells, a novel type of non-tumorigenic pluripotent stem cells, reside in human mesenchymal tissues2014

    • Author(s)
      Wakao S, Akashi H, Kushida Y, Dezawa M.
    • Journal Title

      Pathol Int

      Volume: 64(1) Issue: 1 Pages: 1-9

    • DOI

      10.1111/pin.12129

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new age of regenerative medicine: fusion of tissue engineering and stem cell research.2014

    • Author(s)
      Albertine KH, Dezawa M.
    • Journal Title

      Anat. Rec (Hoboken).

      Volume: 297(1) Issue: 1 Pages: 1-3

    • DOI

      10.1002/ar.22796

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new age of regenerative medicine: fusion of tissue engineering and stem cell research.2014

    • Author(s)
      Okano T, Dezawa M.
    • Journal Title

      Anat. Rec (Hoboken).

      Volume: 297(1) Issue: 1 Pages: 4-5

    • DOI

      10.1002/ar.22811

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Muse cells, a novel type of non-tumorigenic pluripotent stem cells, that reside in human mesenchymal tissues.2014

    • Author(s)
      Wakao S, Akashi H, Dezawa M.
    • Journal Title

      Spinal Surgery

      Volume: 28(1) Pages: 17-23

    • NAID

      130006896077

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transplantation of human bone marrow stromal cell-derived neuroregenrative cells promotes functional recovery after spinal cord injury in mice.2014

    • Author(s)
      Mannoji C, Koda M, Kamiya K, Dezawa M, Hashimoto M, Furuya T, Okawa A, Takahashi K, Yamazaki M.
    • Journal Title

      Acta Neurobiol Exp (Wars).

      Volume: 74(4) Pages: 479-88

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] 新しい医療を切り開くMuse細胞の可能性2018

    • Author(s)
      出沢真理
    • Organizer
      第45回日本膵・膵島移植研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Endogenous reparative Muse cells may provide novel therapeutic approaches.2018

    • Author(s)
      Mari Dezawa
    • Organizer
      Stem Cell Research 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 新しい医療を切り開くMuse細胞の特異性と可能性2018

    • Author(s)
      出沢真理
    • Organizer
      第17回日本再生医療学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Unique Reparative Mechanism of Muse Cells: Specific Homing by S1P-S1P Receptor System.2018

    • Author(s)
      Mari Dezawa
    • Organizer
      The 11th Pan Pacific Symposium on Stem Cells and Cancer Research (PPSSC) 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 成体に備わる修復幹細胞としてのMuse細胞:再生医療の一般普及を目指して2017

    • Author(s)
      出沢 真理
    • Organizer
      第16回日本再生医療学会総会(会長講演)
    • Place of Presentation
      仙台国際センター、仙台
    • Year and Date
      2017-03-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] Muse細胞:自然の修復機構を活用した新しい再生医療の可能性2017

    • Author(s)
      出沢 真理
    • Organizer
      第16回日本再生医療学会総会(シンポジウム 17)
    • Place of Presentation
      仙台国際センター、仙台
    • Year and Date
      2017-03-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] Muse細胞:自然の修復機構を活用した新しい再生医療の可能性2017

    • Author(s)
      出沢 真理
    • Organizer
      第14回日本免疫治療学研究会学術集会
    • Place of Presentation
      東京大学伊藤国際学術研究センター、東京
    • Year and Date
      2017-02-11
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Human Muse cells reconstruct neuronal circuitry in rodent acute and subacute stroke models.2017

    • Author(s)
      Mari Dezawa
    • Organizer
      The 10th Pan Pacific Symposium on Stem Cells and Cancer Research (PPSSC) 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 生体の修復を担うMuse細胞を活用した修復再生医学への展望2017

    • Author(s)
      出沢真理
    • Organizer
      第8回日本ニューロリハビリテーション学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Muse細胞:修復幹細胞を用いた新たな再生医療2017

    • Author(s)
      出沢真理
    • Organizer
      弘前大学医学部学部講義「整形外科学Ⅱ」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Muse cells may contribute to tissue homeostasis by reparative function.2017

    • Author(s)
      Mari Dezawa
    • Organizer
      TEXAS A&M University
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Direct Contribution of Bone Marrow Cells to Tissue Regeneration.2017

    • Author(s)
      Mari Dezawa
    • Organizer
      AMERICAN Transplant CONGRESS 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Discovery of endogenous pluripotent stem cells, Muse cells, may shift the paradigm of stem cell therapy.2017

    • Author(s)
      Mari Dezawa
    • Organizer
      Rutgers State University of New Jersey
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Muse細胞:自然の修復機構を活用した新しい再生医療の可能性2017

    • Author(s)
      出沢真理
    • Organizer
      第65回日本輸血・細胞治療学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Muse細胞を活用する次世代医療:修復医学の可能性2017

    • Author(s)
      出沢真理
    • Organizer
      第5回山梨医学フォーラム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 医療の未来を切り開くMuse細胞2017

    • Author(s)
      出沢真理
    • Organizer
      第10回 The KAITEKI FORUM
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Muse細胞:自然の修復機構を活用した新しい再生医学の可能性2017

    • Author(s)
      出沢真理
    • Organizer
      京都コモンズ第20回セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Unique Newly Discovered Muse Cells May Lead to the Paradigm Shift of Stem Cell Therapy.2017

    • Author(s)
      Mari Dezawa
    • Organizer
      Stem Cell Conference 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Endogenous reparative Muse cells may provide novel therapeutic approaches.2017

    • Author(s)
      Mari Dezawa
    • Organizer
      Johns Hopkins University School of Medicine
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Muse細胞:自然の修復機構を活用した新しい再生医学の可能性2017

    • Author(s)
      出沢真理
    • Organizer
      北海道大学皮膚科特別講演
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 生体に備わる修復幹細胞としての『Muse細胞』、新たな再生医療の世界2017

    • Author(s)
      出沢真理
    • Organizer
      Bio Japan 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 医療の未来を切り開くMuse細胞:糖尿病への応用の可能性2017

    • Author(s)
      出沢真理
    • Organizer
      弘前 Research Conference・特別講演
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Endogenous reparative Muse cells may provide novel therapeutic approaches.2017

    • Author(s)
      出沢真理
    • Organizer
      The 8th meeting of Asian Cellular Therapy Organization(ACTO)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Muse細胞:生体内修復機構を活用した新たな治療戦略2017

    • Author(s)
      出沢真理
    • Organizer
      第63回日本病理学会・秋期特別総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Muse細胞を活用する次世代医療:修復医学の可能性2017

    • Author(s)
      出沢真理
    • Organizer
      第60回日本脳循環代謝学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 成体に備わる修復幹細胞としてのMuse細胞:再生医療の一般普及を目指して2017

    • Author(s)
      出沢真理
    • Organizer
      ライフサイエンスサミット in TOPPAN 2017
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 新しい医療を切り開くMuse細胞の可能性2017

    • Author(s)
      出沢真理
    • Organizer
      第52回日本脊髄障害医学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] To look for which kind of biomarkers in the circulation we can add to the study protocol to reveal effects of autologous MSC treatment for emphysema.2017

    • Author(s)
      Mari Dezawa
    • Organizer
      Leiden University Medical Center
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] MUSE cell study in acute myocardial infarction to be conducted in Japan.2017

    • Author(s)
      Mari Dezawa
    • Organizer
      Leiden University Medical Center
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Wnt signalling in the lung.2017

    • Author(s)
      Mari Dezawa
    • Organizer
      Leiden University Medical Center
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Clinical development of MUSE treatment in Japan2017

    • Author(s)
      Mari Dezawa
    • Organizer
      Leiden University Medical Center
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Reparative endogenous pluripotent stem cells, Muse cells, may shift the paradigm of regenerative medicine.2017

    • Author(s)
      Mari Dezawa
    • Organizer
      Karolinska Institutet Department of Cell & Molecular Biology
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Endogenous non-tumorigenic pluripotent Muse cells enable Reparative Medicine, a novel therapeutic concept.2017

    • Author(s)
      Mari Dezawa
    • Organizer
      Warsaw Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Endogenous non-tumorigenic pluripotent Muse cells enable reparative medicine; a novel therapeutic concept.2017

    • Author(s)
      Mari Dezawa
    • Organizer
      Napoli University Dept. of Experimental Medicine
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Muse細胞を活用する次世代医療:修復医学の可能性2017

    • Author(s)
      出沢真理
    • Organizer
      障害者支援再生医療研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Unique Newly Discovered Muse Cells May Lead to the Paradigm Shift of Stem Cell Therapy2016

    • Author(s)
      出沢 真理
    • Organizer
      日本研究皮膚科学会 第41回年次学術大会・総会
    • Place of Presentation
      仙台国際センター、仙台
    • Year and Date
      2016-12-11
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Unique Newly Discovered Muse Cells May Lead to the Paradigm Shift of Stem Cell Therapy2016

    • Author(s)
      出沢 真理
    • Organizer
      第9回 アジア太平洋小児内分泌学会(APPES)
    • Place of Presentation
      東京国際フォーラム、東京
    • Year and Date
      2016-11-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 多能性幹細胞Muse細胞による障がいの機能回復の展望2016

    • Author(s)
      出沢 真理
    • Organizer
      スポーツ・文化・ワールド・フォーラム
    • Place of Presentation
      六本木アカデミーヒルズ、東京
    • Year and Date
      2016-10-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Unique Newly Discovered Muse Cells May Lead to the Paradigm Shift of Stem Cell Therapy2016

    • Author(s)
      Mari Dezawa
    • Organizer
      PACT Symposium:Designer Cells Go Clinic
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2016-09-23
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Muse cells as tissue repairing stem cells; a role of phagocytosis in their differentiation2016

    • Author(s)
      Mari Dezawa
    • Organizer
      Cell Symposium 100 Years of Phagocytes
    • Place of Presentation
      Sicily, Italy
    • Year and Date
      2016-09-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 再生医学の現状とMuse細胞の将来展望2016

    • Author(s)
      出沢 真理
    • Organizer
      第57回日本組織細胞化学会総会・学術集会
    • Place of Presentation
      杏林大学井の頭キャンパス、東京
    • Year and Date
      2016-09-03
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 再生医学における組織細胞化学的アプローチ2016

    • Author(s)
      出沢 真理
    • Organizer
      第41回組織細胞化学講習会 講演会
    • Place of Presentation
      仙台市民会館、仙台
    • Year and Date
      2016-08-03
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Unique mitochondrial metabolism in Muse cells2016

    • Author(s)
      Mari Dezawa
    • Organizer
      the 9th Pan Pacific Symposium on Stem Cells and Cancer Research (PPSSC) 2016
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2016-05-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Transplantation of Unique, Newly Discovered Muse Cells May Lead to Promising Stroke Therapy2016

    • Author(s)
      Mari Dezawa
    • Organizer
      The American Society for Neural Therapy and Repair (ASNTR) 2016
    • Place of Presentation
      Tampa, USA
    • Year and Date
      2016-04-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Muse細胞:再生医療のおけるハードルの低い一般医療化を目指して2016

    • Author(s)
      出沢 真理
    • Organizer
      第15回日本再生医療学会総会
    • Place of Presentation
      大阪国際会議場、大阪
    • Year and Date
      2016-03-19
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Muse細胞によるハードルの低い再生医療の一般化を目指して2016

    • Author(s)
      出沢 真理
    • Organizer
      第15回再生心臓血管外科治療研究会
    • Place of Presentation
      名古屋国際会議場、名古屋
    • Year and Date
      2016-02-15
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 生体内に存在する多能性幹細胞Muse細胞の体内動態と組織修復機構2015

    • Author(s)
      出沢 真理
    • Organizer
      第38回分子生物学会
    • Place of Presentation
      神戸ポートアイランド、神戸
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 生体由来多能性幹細胞 Muse細胞の発見:再生医療にどれだけの変革をもたらすことができるか2015

    • Author(s)
      出沢 真理
    • Organizer
      第23回旭川心不全研究会
    • Place of Presentation
      旭川グランドホテル、旭川
    • Year and Date
      2015-11-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Muse細胞の発見:ハードルの低い再生医療の一般医療化を目指して2015

    • Author(s)
      出沢 真理
    • Organizer
      第1回弘前再生医療シンポジウム in 弘前
    • Place of Presentation
      弘前大学、弘前
    • Year and Date
      2015-10-31
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 生体内修復幹細胞としてのMuse細胞はどこまで脳梗塞を治せるのか2015

    • Author(s)
      出沢 真理
    • Organizer
      第27回日本脳循環代謝学会総会
    • Place of Presentation
      富山国際会議場、富山
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Muse細胞の発見:ハードルの高い再生医療の一般医療化を目指して2015

    • Author(s)
      出沢 真理
    • Organizer
      第16回日本分子脳神経外科学会
    • Place of Presentation
      アクトシティ浜松、浜松
    • Year and Date
      2015-08-28
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Muse細胞の発見によってもたらされる間葉系幹細胞移植のパラダイムシフト2015

    • Author(s)
      出沢 真理
    • Organizer
      第5回細胞再生医療研究会特別講演Ⅱ
    • Place of Presentation
      臨床研究情報センター(TRI)、神戸
    • Year and Date
      2015-07-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Muse細胞の発見によってもたらされる間葉系幹細胞移植のパラダイムシフト2015

    • Author(s)
      出沢 真理
    • Organizer
      日本耳鼻咽喉科学会東北連合学会特別講演
    • Place of Presentation
      ザ・セレクトン福島、福島
    • Year and Date
      2015-07-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Muse細胞の発見によってもたらされる間葉系幹細胞移植治療のパラダイムシフト2015

    • Author(s)
      出沢 真理
    • Organizer
      第13回日本臨床腫瘍学会
    • Place of Presentation
      ロイトン札幌、札幌
    • Year and Date
      2015-07-16
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Epithelial and Mesenchymal Stem Cells ; Tissue Engineering, Organ Development and Regeneration2015

    • Author(s)
      Mari Dezawa
    • Organizer
      ISSCR 2015
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2015-06-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 再生医療の現状とMuse細胞の将来展望2015

    • Author(s)
      出沢 真理
    • Organizer
      第2回新生児科指導医教育セミナー
    • Place of Presentation
      TKP仙台カンファレンスセンター、仙台
    • Year and Date
      2015-05-23
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Discovery of Muse cells shift the paradigm of mesenchymal stem cells2015

    • Author(s)
      出沢 真理
    • Organizer
      AsiaCORD_AHA2015 MEETING in KOBE
    • Place of Presentation
      シスメックス(株)テクノパーク、神戸
    • Year and Date
      2015-05-02
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Muse細胞の発見がもたらす再生医療の新たな可能性2015

    • Author(s)
      出沢 真理
    • Organizer
      日本内分泌学会イブニングセミナー
    • Place of Presentation
      ホテルニューオータニ、東京
    • Year and Date
      2015-04-23
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Discovery of Muse Cells shifts the Paradigm of Stem Cell Therapy2015

    • Author(s)
      Mari Dezawa
    • Organizer
      PPSSC 2015
    • Place of Presentation
      Hsinchu, Taiwan
    • Year and Date
      2015-04-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Muse cells and their possible application to both autologous and allogenic transplantation therapy2015

    • Author(s)
      Mari Dezawa
    • Organizer
      PPSSC 2015
    • Place of Presentation
      Hsinchu, Taiwan
    • Year and Date
      2015-04-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Muse細胞の発見によってもたらされる間葉系幹細胞移植のパラダイムシフト2015

    • Author(s)
      出澤真理
    • Organizer
      DSファーマバイオメディカル㈱ 2014年研究開発発表会
    • Place of Presentation
      大日本住友製薬株式会社、大阪市
    • Year and Date
      2015-03-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Discovery of Muse Cells shifts the Paradigm of Mesenchymal Stem Cells2015

    • Author(s)
      出澤真理
    • Organizer
      Clinical Applications of Stem Cells
    • Place of Presentation
      Singapore
    • Year and Date
      2015-02-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Muse細胞の発見によってもたらされる間葉系幹細胞移植のパラダイムシフト2014

    • Author(s)
      出澤真理
    • Organizer
      第5回先進医療開発コアセンターシンポジウム
    • Place of Presentation
      東北大学
    • Year and Date
      2014-12-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Discovery of Muse Cells shifts the Paradigm of Mesenchymal Stem Cells2014

    • Author(s)
      出澤真理
    • Organizer
      日仏再生医学シンポジウム
    • Place of Presentation
      在日フランス大使館、東京
    • Year and Date
      2014-11-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Muse細胞の発見によってもたらされる間葉系幹細胞移植のパラダイムシフト2014

    • Author(s)
      出澤真理
    • Organizer
      第56回日本先天代謝異常学会
    • Place of Presentation
      江陽グランドホテル、仙台市
    • Year and Date
      2014-11-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 再生医学の現状とMuse細胞の将来展望2014

    • Author(s)
      出澤真理
    • Organizer
      弘前大学整形外科学講義
    • Place of Presentation
      弘前大学
    • Year and Date
      2014-11-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Muse細胞の発見によってもたらされる間葉系幹細胞移植のパラダイムシフト2014

    • Author(s)
      出澤真理
    • Organizer
      弘前再生医療講演会
    • Place of Presentation
      弘前大学
    • Year and Date
      2014-11-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Muse細胞の発見によってもたらされる間葉系幹細胞移植のパラダイムシフト2014

    • Author(s)
      出澤真理
    • Organizer
      第31回細胞療法研究会
    • Place of Presentation
      愛知医科大学
    • Year and Date
      2014-11-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Muse細胞の発見によってもたらされる間葉系幹細胞移植のパラダイムシフト2014

    • Author(s)
      出澤真理
    • Organizer
      未来医療開発プロジェクト(MIAST)シンポジウム
    • Place of Presentation
      岩手医科大学
    • Year and Date
      2014-08-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 腫瘍性の無い生体由来多能性幹細胞 Muse細胞の発見:ヒトは失われた機能を取り戻せるのか2014

    • Author(s)
      出澤真理
    • Organizer
      第14回日本外傷歯学会
    • Place of Presentation
      大阪歯科大学
    • Year and Date
      2014-07-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Muse細胞の基礎から将来展望まで2014

    • Author(s)
      出澤真理
    • Organizer
      知的ワイガヤ会
    • Place of Presentation
      東京大学
    • Year and Date
      2014-07-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Muse細胞の発見によってもたらされる間葉系幹細胞移植のパラダイムシフト2014

    • Author(s)
      出澤真理
    • Organizer
      第34回北斗最新医療セミナー
    • Place of Presentation
      北斗病院、帯広市
    • Year and Date
      2014-06-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 再生医療研究の現状とMuse細胞の将来展望2014

    • Author(s)
      出澤真理
    • Organizer
      特許庁 平成26年度先端技術研修
    • Place of Presentation
      虎の門三井ビルディング、東京
    • Year and Date
      2014-06-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 腫瘍性の無い新しい多能性幹細胞 Muse細胞の発見:ヒトは失われた機能を取り戻せるのか2014

    • Author(s)
      出澤真理
    • Organizer
      経和会総会
    • Place of Presentation
      学士会館、東京
    • Year and Date
      2014-06-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 生体に内在する多能性幹細胞 Muse細胞の担う機能;Regenerative homeostasisとstem cell failureの提唱2014

    • Author(s)
      出澤真理
    • Organizer
      第20回神戸全体会議
    • Place of Presentation
      神戸バイオテクノロジー研究・人材育成センター、神戸
    • Year and Date
      2014-06-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 骨髄と結合組織を足場とする多能性幹細胞 Muse細胞の担う生体内修復機能2014

    • Author(s)
      出澤真理
    • Organizer
      第46回日本結合組織学会学術大会、第61回マトリックス研究会大会合同学術集会
    • Place of Presentation
      ウィンクあいち、名古屋市
    • Year and Date
      2014-06-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Muse細胞発見のもたらす間葉系幹細胞のパラダイムシフト2014

    • Author(s)
      出澤真理
    • Organizer
      第55回日本神経学会
    • Place of Presentation
      福岡国際会議場、福岡市
    • Year and Date
      2014-05-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 腫瘍性の無い新しい多能性幹細胞 Muse細胞の発見:ヒトは失われた機能を取り戻せるのか2014

    • Author(s)
      出澤真理
    • Organizer
      Medical Cooperation Meeting of Hepatitis (MCH)
    • Place of Presentation
      飛翔閣、石巻市
    • Year and Date
      2014-05-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Discovery of Muse cells, novel pluripotent stem cells that reside in human mesenchymal tissues: implications for new concepts of regenerative homeostasis and stem cell failure.2014

    • Author(s)
      出澤真理
    • Organizer
      Seminar at Nelson Biological Labs in Rutgers
    • Place of Presentation
      Rutgers, The State University of New Jersey, USA
    • Year and Date
      2014-04-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Making three dimensional human colored skin by using Muse cells, a novel type of non-tumorigenic pluripotent stem cells2014

    • Author(s)
      出澤真理
    • Organizer
      Stem Cells andTissue Injury Platform Session at EB 2014
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-04-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Discovery of Muse Cells, Novel Pluripotent Stem Cells That Reside in Human Mesenchymal Tissues: Implications for New Concepts of Regenerative Homeostasis and Stem Cell Failure2014

    • Author(s)
      出澤真理
    • Organizer
      PPSSC 2014
    • Place of Presentation
      台北(台湾)
    • Year and Date
      2014-04-12
    • Related Report
      2014 Annual Research Report
    • Invited

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Published: 2014-04-04   Modified: 2019-03-29  

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