• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of transcriptional regulation by histone modification pattern

Research Project

Project/Area Number 26293059
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field General medical chemistry
Research InstitutionTohoku University

Principal Investigator

NAKAYAMA Keiko  東北大学, 医学(系)研究科(研究院), 教授 (60294972)

Co-Investigator(Kenkyū-buntansha) 舟山 亮  東北大学, 医学(系)研究科(研究院), 助教 (20452295)
細金 正樹  東北大学, 医学(系)研究科(研究院), 助手 (30734347)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2014: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Keywordsヒストン修飾 / Bリンパ球 / ChIPシークエンス / 乳癌細胞株 / リンパ球 / Bリンパ球 / インスリン分泌細胞
Outline of Final Research Achievements

TGF-β treatment to breast cancer cell lines induces epithelial-mesenchymal transition. We confirmed suppression of EZH2 expression by shRNA decreased modification levels of Histone H3K27me3. With this method, we analyzed the effect of suppression of H3K27me3 modification on transcript. Contrary to expectations, suppression of H3K27me3 did not cause a major effect.
Next to breast cancer cell lines, we analyzed EZH2 deficient B lymphocytes. As we expected, modification of H3K27me3 in these downregulated and we obtained list of transcriptional activated genes. We also analyzed the modification level of H3K4me1 as a marker of enhancer activity. We identified the region where H3K4me1 increased after EZH2 deletion. However, we could not recognize which genes were regulated by corresponding enhancers.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (45 results)

All 2017 2016 2015 2014 Other

All Journal Article (29 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 29 results,  Open Access: 22 results,  Acknowledgement Compliant: 14 results) Presentation (14 results) (of which Invited: 1 results) Remarks (2 results)

  • [Journal Article] Geminin is an indispensable inhibitor of Cdt1 in mouse embryonic stem cells.2017

    • Author(s)
      Hosogane, M., Bosu, L., Fukumoto, E., Yamada, H., Sato, S., Nakayama, K.
    • Journal Title

      Genes Cells

      Volume: 印刷中 Issue: 4 Pages: 360-375

    • DOI

      10.1111/gtc.12482

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A Bach2-Cebp gene regulatory network for the commitment of multipotent hematopoietic progenitors.2017

    • Author(s)
      Itoh-Nakadai, A., Matsumoto, M., Kato, H., Sasaki, J., Uehara, Y., Sato, Y., Ebina-Shibuya, R., Morooka, M., Funayama, R., Nakayama, K., Ochiai, K., Muto, A. and Igarashi, K.
    • Journal Title

      Cell Reports

      Volume: 18 Issue: 10 Pages: 2401-2414

    • DOI

      10.1016/j.celrep.2017.02.029

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A large-scale targeted proteomics assay resource based on an in vitro human proteome.2017

    • Author(s)
      Matsumoto M, Matsuzaki F, Oshikawa K, Goshima N, Mori M, Kawamura Y, Ogawa K, Fukuda E, Nakatsumi H, Natsume T, Fukui K, Horimoto K, Nagashima T, Funayama R, Nakayama K, Nakayama KI.
    • Journal Title

      Nat Methods

      Volume: 14 Issue: 3 Pages: 251-258

    • DOI

      10.1038/nmeth.4116

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Regulatory signatures of liver regeneration distilled by integrative analysis of mRNA, histone methylation, and proteomics.2017

    • Author(s)
      Sato, Y., Katoh, Y., Matsumoto, M., Sato, M., Ebina, M., Itoh-Nakadai, A., Funayama, R., Nakayama, K., Unno, M., Igarashi, K.
    • Journal Title

      J.Biol.Chem.

      Volume: 印刷中 Issue: 19 Pages: 8019-8037

    • DOI

      10.1074/jbc.m116.774547

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exome sequencing deciphers a germline MET mutation in familial epidermal growth factor receptor-mutant lung cancer.2017

    • Author(s)
      Tode N, Kikuchi T, Sakakibara T, Hirano T, Inoue A, Ohkouchi S, Tamada T, Okazaki T, Koarai A, Sugiura H, Niihori T, Aoki Y, Nakayama K, Matsumoto K, Matsubara Y, Yamamoto M, Watanabe A, Nukiwa T, Ichinose M.
    • Journal Title

      Cancer Sci

      Volume: 印刷中 Issue: 6 Pages: 1263-1270

    • DOI

      10.1111/cas.13233

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin.2017

    • Author(s)
      Hidaka, T., Ogawa, E., Kobayashi, E.H., Suzuki, T., Funayama, R., Nagashima, T., Fujimura, T., Aiba, S., Nakayama, K., Okuyama, R., Yamamoto, M.
    • Journal Title

      Nat. Immunol.

      Volume: 18 Issue: 1 Pages: 64-73

    • DOI

      10.1038/ni.3614

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis.2017

    • Author(s)
      Shimizu K, Fukushima H, Ogura K, Lien EC, Nihira NT, Zhang J, North BJ, Guo A, Nagashima K, Nakagawa T, Hoshikawa S, Watahiki A, Okabe K, Yamada A, Toker A, Asara JM, Fukumoto S, Nakayama KI, Nakayama K, Inuzuka H, Wei W.
    • Journal Title

      Sci Signal. doi: 10.1126/scisignal.aah4117.

      Volume: 10 Issue: 460 Pages: 1-15

    • DOI

      10.1126/scisignal.aah4117

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Homeostatic Shift Facilitates Endoplasmic Reticulum Proteostasis through Transcriptional Integration of Proteostatic Stress Response Pathways.2017

    • Author(s)
      Baird L, Tsujita T, Kobayashi E, Funayama R, Nagashima T, Nakayama K, and Yamamoto M.
    • Journal Title

      Mol Cell Biol

      Volume: 37 Issue: 4

    • DOI

      10.1128/mcb.00439-16

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dramatic response after functional hemispherectomy in a patient with epileptic encephalopathy carrying a de novo COL4A1 mutation.2017

    • Author(s)
      Hino-Fukuyo, N., Kikuchi, A., Iwasaki, M., Sato, Y., Kubota, Y., Kobayashi, T., Nakayama, T., Haginoya, K., Arai-Ichinoi, N., Niihori, T., Sato, R., Suzuki, T., Kudo, H., Funayama, R., Nakayama, K., Aoki, Y., Kure, S.
    • Journal Title

      Brain Dev.

      Volume: 39 Issue: 4 Pages: 337-340

    • DOI

      10.1016/j.braindev.2016.11.006

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ubiquitylation of Ku80 by RNF126 Promotes Completion of Nonhomologous End Joining-Mediated DNA Repair.2017

    • Author(s)
      Ishida N, Nakagawa T, Iemura SI, Yasui A, Shima H, Katoh Y, Nagasawa Y, Natsume T, Igarashi K, Nakayama K.
    • Journal Title

      Mol Cell Biol

      Volume: 37 Issue: 4

    • DOI

      10.1128/mcb.00347-16

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Wnt-beta-catenin signaling regulates ABCC3 (MRP3) transporter expression in colorectal cancer.2016

    • Author(s)
      Kobayashi, M., Funayama, R., Ohnuma, S., Unno, M., Nakayama, K.
    • Journal Title

      Cancer Sci.

      Volume: 107 Issue: 12 Pages: 1776-1784

    • DOI

      10.1111/cas.13097

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Lack of genetic variation prevents adaptation at the geographic range margin in a damselfly.2016

    • Author(s)
      Takahashi, Y., Suyama, Y., Matsuki, Y., Funayama, R., Nakayama, K., Kawata, M.
    • Journal Title

      Mol. Ecol.

      Volume: 25 Issue: 18 Pages: 4450-4460

    • DOI

      10.1111/mec.13782

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Tohoku Medical Megabank Project: Design and Mission2016

    • Author(s)
      Kuriyama S, Yaegashi N, et al. (Tamiya G; 11th in 58 authors)
    • Journal Title

      Journal of Epidemiology

      Volume: 26 Issue: 9 Pages: 493-511

    • DOI

      10.2188/jea.JE20150268

    • NAID

      130005409018

    • ISSN
      0917-5040, 1349-9092
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lack of Transcription Triggers H3K27me3 Accumulation in the Gene Body.2016

    • Author(s)
      Hosogane, M., Funayama, R., Shirota, M., Nakayama, K.
    • Journal Title

      Cell Rep.

      Volume: 16 Issue: 3 Pages: 696-706

    • DOI

      10.1016/j.celrep.2016.06.034

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The double knockout of Bach1 and Bach2 in mice reveals shared compensatory mechanisms in regulating alveolar macrophage function and lung surfactant homeostasis.2016

    • Author(s)
      Ebina-Shibuya, R., Watanabe-Matsui, M., Matsumoto, M., Itoh-Nakadai, A., Funayama, R., Nakayama, K., Muto, A., Igarashi, K.
    • Journal Title

      J. Biochem.

      Volume: 160 Pages: 333-344

    • NAID

      40021050454

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genomewide approaches for BACH1 target genes in mouse embryonic fibroblasts showed BACH1-Pparg pathway in adipogenesis.2016

    • Author(s)
      Matsumoto M, Kondo K, Shiraki T, Brydun A, Funayama R, Nakayama K, Yaegashi N, Katagiri H, Igarashi K.
    • Journal Title

      Genes Cells.

      Volume: in press Issue: 6 Pages: 553-567

    • DOI

      10.1111/gtc.12365

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Human genetic variation database, a reference database of genetic variations in the Japanese population.2016

    • Author(s)
      Higasa K, Miyake N, Yoshimura J, Okamura K, Niihori T, Saitsu H, Doi K, Shimizu M, Nakabayashi K, Aoki Y, Tsurusaki Y, Morishita S, Kawaguchi T, Migita O, (中略), Matsumoto N, Matsuda F.
    • Journal Title

      J Hum Genet.

      Volume: advance online publication Issue: 6 Pages: 547-553

    • DOI

      10.1038/jhg.2016.12

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription.2016

    • Author(s)
      Kobayashi EH, Suzuki T, Funayama R, Nagashima T, Hayashi M, Sekine H, Tanaka N, Moriguchi T, Motohashi H, Nakayama K, Yamamoto M.
    • Journal Title

      Nat Commun

      Volume: 7 Issue: 1 Pages: 11624-11624

    • DOI

      10.1038/ncomms11624

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Genomic analysis identifies candidate pathogenic variants in 9 of 18 patients with unexplained West syndrome.2015

    • Author(s)
      Hino-Fukuyo N, Kikuchi A, Arai-Ichinoi N, Niihori T, Sato R, Suzuki T, Kudo H, Sato Y, Nakayama T, Kakisaka Y, Kubota Y, Kobayashi T, Funayama R, Nakayama K, Uematsu M, Aoki Y, Haginoya K, Kure S.
    • Journal Title

      Hum Genet.

      Volume: 134 Issue: 6 Pages: 649-658

    • DOI

      10.1007/s00439-015-1553-6

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mutations in PIGL in a patient with Mabry syndrome.2015

    • Author(s)
      Fujiwara I, Murakami Y, Niihori T, Kanno J, Hakoda A, Sakamoto O, Okamoto N, Funayama R, Nagashima T, Nakayama K, Kinoshita T, Kure S, Matsubara Y, Aoki Y.
    • Journal Title

      Am J Med Genet A.

      Volume: in press Issue: 4 Pages: 777-785

    • DOI

      10.1002/ajmg.a.36987

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protein monoubiquitylation: targets and diverse functions2015

    • Author(s)
      Nakagawa T, Nakayama K
    • Journal Title

      Genes to cells

      Volume: 7 Issue: 7 Pages: 543-562

    • DOI

      10.1111/gtc.12250

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of the Atg9a gene in intrauterine growth and survival of fetal mice.2015

    • Author(s)
      Kojima T, Yamada T, Akaishi R, Furuta I, Saitoh T, Nakabayashi K, Nakayama KI, Nakayama K, Akira S, Minakami H
    • Journal Title

      Reprod.Biol.

      Volume: 15 Issue: 3 Pages: 131-138

    • DOI

      10.1016/j.repbio.2015.05.001

    • NAID

      120005828503

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The artificial loss of Runx1 reduces the expression of quiescence-associated transcription factors in CD4(+) T lymphocytes.2015

    • Author(s)
      Wong WF, Kohu K, Nagashima T, Funayama R, Matsumoto M, Movahed E, Tan GM, Yeow TC, Looi CY, Kurokawa M, Osato M, Igarashi K, Nakayama K, Satake M.
    • Journal Title

      Mol Immunol.

      Volume: 68 Issue: 2 Pages: 223-33

    • DOI

      10.1016/j.molimm.2015.08.012

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Rho-kinase inhibition during early cardiac development causes arrhythmogenic right ventricular cardiomyopathy in mice2015

    • Author(s)
      Ellawindy A, Satoh K, Sunamura S, Kikuchi N, Suzuki K, Minami T, Ikeda S, Tanaka S, Shimizu T, Enkhjargal B, Miyata S, Taguchi Y, Handoh T, Kobayashi K, Kobayashi K, Nakayama K, Miura M, Shimokawa H.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 35 Issue: 10 Pages: 2172

    • DOI

      10.1161/atvbaha.115.305872

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] S6 Kinase- and beta-TrCP2-Dependent Degradation of p19Arf Is Required for Cell Proliferation2015

    • Author(s)
      Nakagawa T, Araki T, Nakagawa M, Hirao A, Unno M, Nakayama K
    • Journal Title

      Molecular and cellular biology

      Volume: 20 Issue: 20 Pages: 3517-3527

    • DOI

      10.1128/mcb.00343-15

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] CRL4 E3 Ligase Promotes Monoubiquitylation and Chromatin Binding of TET Dioxygenases2015

    • Author(s)
      Nakagawa, T., Lv, L., Nakagawa, M., Yu, Y., Yu, C., D'Alessio, A. C., Nakayama, K., Fan, H., Chen, X. & Xiong, Y.
    • Journal Title

      Mol Cell

      Volume: 57 Issue: 2 Pages: 247-260

    • DOI

      10.1016/j.molcel.2014.12.002

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Identification of acquired mutations by whole-genome sequencing in GATA-2 deficiency evolving into myelodysplasia and acute leukemia.2014

    • Author(s)
      Fujiwara, T., Fukuhara, N., Funayama, R., Nariai, N., Kamata, M., Nagashima, T., Kojima, K., Onishi, Y., Sasahara, Y., Ishizawa, K., Nagasaki, M., Nakayama, K. & Harigae, H
    • Journal Title

      Ann Hematol

      Volume: 93 Issue: 9 Pages: 1515-1522

    • DOI

      10.1007/s00277-014-2090-4

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] HCV infection enhances Th17 commitment, which could affect the pathogenesis of autoimmune diseases2014

    • Author(s)
      Kondo Y, Ninomiya M, Kimura O, Machida K, Funayama R, Nagashima T, Kobayashi K, Kakazu E, Kato T, Nakayama K, Lai MM, Shimosegawa T.
    • Journal Title

      PLoS One

      Volume: 9(6) Issue: 6 Pages: e98521-e98521

    • DOI

      10.1371/journal.pone.0098521

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] GNE myopathy associated with congenital thrombocytopenia: a report of two siblings.2014

    • Author(s)
      Izumi R, Niihori T, Suzuki N, Sasahara Y, Nishiyama A, Nishiyama S, Endo K, Kato M, Warita H, Konno H, Tateyama M, Nagashima T, Funayama R, Nakayama K, Kure S, Matsubara Y, Aoki Y, Aoki M.
    • Journal Title

      Neuromuscul. Disord.

      Volume: 24(12) Issue: 12 Pages: 1068-1072

    • DOI

      10.1016/j.nmd.2014.07.008

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Molecular analysis of Amyotrophic Lateral Sclerosis associated Cyclin F mutants.2016

    • Author(s)
      Yujiao Yu, Akane Morohoshi, Tadashi Nakagawa, Keiko Nakayama.
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-12-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] ユビキチン化によるFACT複合体の機能制御2016

    • Author(s)
      諸星茜、中川直、中山啓子
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-12-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] H3K27ヒストン修飾によるエンハンサー制御のゲノムワイド解析2016

    • Author(s)
      細金正樹、中山啓子
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-12-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] 大腸がんにおけるタンパク質シトルリン化酵素PADI2の役割2016

    • Author(s)
      舟山亮、谷口肇、水間正道、藤島史喜、小林実、大沼忍、海野倫明、中山啓子
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-12-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] Reactivation of cell proliferation by continuous TGF-β treatment.2016

    • Author(s)
      Tadashi Nakagawa, Masaki Hosogane, Ryo Funayama, Keiko Nakayama.
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 大腸癌で発現が抑制されるPeptidylarginine deiminase2の機能解析2016

    • Author(s)
      谷口肇、舟山亮、小林実、高館達之、阿部友哉、水間正道、藤島史喜、大沼忍、内藤剛、海野倫明、中山啓子
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] がん原遺伝子RASによる遺伝子サイレンシングの分子機構の解析2015

    • Author(s)
      舟山亮、細金正樹、長嶋剛史、中山啓子
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] TGF-β刺激によるTFIID構成因子TAF7の分解とその役割の解明2015

    • Author(s)
      中川直、細金正樹、舟山亮、中山啓子
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] セルトリ細胞特異的β-TrCPノックアウトマウスの解析2015

    • Author(s)
      諸星茜、中川直、中野星児、中山啓子.
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウスES細胞におけるgemininの細胞周期と分化に対する制御.2014

    • Author(s)
      福本恵美子, Kundu, Lena Rani, 佐藤聡一郎, 細金正樹 & 中山啓子
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] H3K27me3修飾パターン形成過程の時系列解析2014

    • Author(s)
      細金正樹, 舟山亮, 城田松之 & 中山啓子
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 精子形成におけるE3ユビキチンリガーゼβ-TrCPの新規基質の同定と解析2014

    • Author(s)
      久志瞭, 中川直, 中野星児, 遠藤尚博 & 中山啓子
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] TFIID complex changes accompany epithelial-mesenchymal transition (EMT).2014

    • Author(s)
      Nakagawa, Tadashi & Nakayama, Keiko
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] がん遺伝子による転写変化とエピゲノム変化2014

    • Author(s)
      中山啓子
    • Organizer
      第23回長崎障害者支援再生医療研究会
    • Place of Presentation
      長崎大学医学部良順会館(長崎県長崎市)
    • Year and Date
      2014-11-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Remarks] 東北大学がん医学コアセンター細胞増殖制御分野

    • URL

      http://www.devgen.med.tohoku.ac.jp/

    • Related Report
      2016 Annual Research Report
  • [Remarks] がん医学コアセンター 細胞増殖制御分野

    • URL

      http://www.devgen.med.tohoku.ac.jp/index.html

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi