| Budget Amount *help |
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
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| Outline of Final Research Achievements |
In a nematode Caenorhabditis elegans, initiation of axon regeneration in injured neuron is positively regulated by SVH-1, which activates a JNK MAP kinase cascade via a c-Met-like receptor tyrosine kinase SVH-2. In this study, we demonstrated that SVH-4, a receptor tyrosine kinase that is activated by collagen, acts upstream of the SVH-2-JNK pathway. We also found that SVH-1 controls larval growth via an extracellular matrix component FBL-1. Furthermore, we showed that HIF-1-mediated activation of 5-HT signaling promotes axon regeneration by activating both the RhoA and cAMP pathways.
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