| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Outline of Final Research Achievements |
In this study, we tried to reveal the mechanisms of immune regulation by CD169-positive macrophages. We analyze the localization and character of these CD169-positive macrophages in various tissues using CD169-Cre-YFP mice. We also examined the pathological roles of these macrophages in ischemic-reperfusion injury of kidney and DSS-induced colitis. In addition, we identified a CD169-positive macrophage-specific transcription factor. We found that this transcription factor not only promotes CCL8 production, but also suppresses gene expression related to anti-inflammation or tissue repair in these macrophages.
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