Project/Area Number |
26293094
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Bacteriology (including mycology)
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Research Institution | Chiba University |
Principal Investigator |
Saijo Shinobu 千葉大学, 真菌医学研究センター, 准教授 (60396877)
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Co-Investigator(Kenkyū-buntansha) |
岩倉 洋一郎 東京理科大学, 付置研究所, 教授 (10089120)
米山 光俊 千葉大学, 真菌医学研究センター, 教授 (40260335)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2015: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
|
Keywords | C-type lectin / 遺伝子改変動物 / サイトカイン / C型レクチン / 真菌感染 / 感染防御 / レクチン |
Outline of Final Research Achievements |
Myeloid cells act central roles in inflammatory responses. C-type lectin receptors (CLRs) are key players that are expressed mainly in these cells to orchestrate immune responses for maintaining immune homeostasis. These receptors recognize carbohydrate structures in microbes, including fungi, bacteria, viruses, and parasites, as pathogen-associated molecular patterns (PAMPs). Owing to the activities, the pleiotropic roles of CLRs has been suggested to have an important effect on homeostasis in the body. In this study, we found that collaboration of several C-type lectins are important in anti-fungal immunity.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Dectin-2-dependent host defense in mice infected with serotype 3 Streptococcus pneumoniae2016
Author(s)
Akahori Y, Miyasaka T, Toyama M, Matsumoto I, Miyahara A, Zong T, Ishii K, Kinjo Y, Miyazaki Y, Saijo S, Iwakura Y, Kawakami K.
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Journal Title
BMC Immunol
Volume: 17
Issue: 1
Pages: 1-1
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Dectin-2 Recognizes Mannosylated O-antigens of Human Opportunistic Pathogens and Augments Lipopolysaccharide Activation of Myeloid Cells.2016
Author(s)
Wittmann A, Lamprinaki D, Bowles KM, Katzenellenbogen E, Knirel YA, Whitfield C, Nishimura T, Matsumoto N, Yamamoto K, Iwakura Y, Saijo S, Kawasaki N.
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Journal Title
J Biol Chem.
Volume: 291
Issue: 34
Pages: 17629-38
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A critical role of Dectin-1 in hypersensitivity pneumonitis2015
Author(s)
Higashino-Kameda M, Yabe-Wada T, Matsuba S, Takeda K, Anzawa K, Mochizuki T, Makimura K, Saijo S, Iwakura Y, Toga H, Nakamura A
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Journal Title
Inflamm Res
Volume: 65
Issue: 3
Pages: 235-44
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis.2015
Author(s)
Murayama A.M, Kakuta S, Inoue A, Umeda N, Yonezawa T, Maruhashi T, Tateishi K, Ishigame H, Yabe R, Ikeda S, Seno A, Chi H-H, Hashiguchi Y, Kurata R, Tada T, Kubo S, Sato N, Liu Y, Hattori M, Saijo S, Matsushita M, Fujita T, Sumida T, Iwakura Y
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Journal Title
Nature Communications
Volume: 6
Issue: 1
Pages: 1-12
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2(+)Vγ6(+)γδ T cells.2015
Author(s)
Akitsu A, Ishigame H, Kakuta S, Chung SH, Ikeda S, Shimizu K, Kubo S, Liu Y, Umemura M, Matsuzaki G, Yoshikai Y, Saijo S, Iwakura Y.
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Journal Title
Nat Commun
Volume: 6
Issue: 1
Pages: 7464-7464
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] α-Mannan induces Th17-mediated pulmonary graft-versus-host disease in mice.2015
Author(s)
Uryu H, Hashimoto D, Kato K, Hayase E, Matsuoka S, Ogasawara R, Takahashi S, Maeda Y, Iwasaki H, Miyamoto T, Saijo S, Iwakura Y, Hill GR, Akashi K, Teshima T.:
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Journal Title
Blood
Volume: 125
Issue: 19
Pages: 3014-23
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] α-Mannan induces Th17-mediated pulmonary graft-versus-host disease in mice.2015
Author(s)
Uryu H, Hashimoto D, Kato K, Hayase E, Matsuoka S, Ogasawara R, Takahashi S, Maeda Y, Iwasaki H, Miyamoto T, Saijo S, Iwakura Y, Hill GR, Akashi K, Teshima T.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus.2015
Author(s)
Herbst S, Shah A, Mazon Moya M, Marzola V, Jensen B, Reed A, Birrell MA, Saijo S, Mostowy S, Shaunak S, Armstrong-James D.
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Journal Title
EMBO Mol Med.
Volume: 7
Issue: 3
Pages: 240-258
DOI
Related Report
Peer Reviewed
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[Journal Article] Dectin-2 deficiency promotes Th2 response and mucin production in the lungs after pulmonary infection with Cryptococcus neoformans.2015
Author(s)
Nakamura Y, Sato K, Yamamoto H, Matsumura K, Matsumoto I, Nomura T, Miyasaka T, Ishii K, Kanno E, Tachi M, Yamasaki S, Saijo S, Iwakura Y, Kawakami K.
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Journal Title
Infect Immun.
Volume: 83
Issue: 2
Pages: 671-681
DOI
Related Report
Peer Reviewed
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[Journal Article] The pH-responsive PacC transcription factor of Aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis.2014
Author(s)
Bertuzzi M, Schrettl M, Alcazar-Fuoli L, Cairns TC, Munoz A, Walker LA, Herbst S, Safari M, Cheverton AM, Chen D, Liu H, Saijo S, Fedorova ND, Armstrong-James D, Munro CA, Read ND, Filler SG, Espeso EA, Nierman WC, Haas H, Bignell EM.
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Journal Title
PLoS Pathog.
Volume: 10
Issue: 10
Pages: e1004413-e1004413
DOI
Related Report
Peer Reviewed
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[Journal Article] Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of mycobacteria.2014
Author(s)
Yonekawa A, Saijo S, Hoshino Y, Miyake Y, Ishikawa E, Suzukawa M, Inoue H, Tanaka M, Yoneyama M, Oh-Hora M, Akashi K, Yamasaki S.
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Journal Title
Immunity
Volume: 41
Issue: 3
Pages: 402-13
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses.2014
Author(s)
Chiba S, Ikushima H, Ueki H, Yanai H, Kimura Y, Hangai S, Nishio J, Negishi H, Tamura T, Saijo S, Iwakura Y, Taniguchi T.
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Journal Title
eLife
Volume: 04177
Pages: 04177-04177
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 自然免疫による病原体防御の新展開2016
Author(s)
西城 忍
Organizer
第8回日本インターフェロン・サイトカイン学術集会
Place of Presentation
長崎大学坂本キャンパス良準会館(長崎県長崎市)
Year and Date
2016-05-13
Related Report
Invited
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