Analysis on molecular mechanisms of antiviral innate immune regulation via RNA sensors
| Project/Area Number |
26293107
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
Kawai Taro 奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授 (50456935)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | 自然免疫 / ウイルス感染 / シグナル伝達 / サイトカイン / 免疫学 |
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| Outline of Final Research Achievements |
Virus infection is usually sensed by innate immune receptors for foreign RNAs such as RIG-I-like receptors (RLRs). In this research, we have identified Arl5b as a negative regulator for RLRs signaling. Moreover, we have discovered a lipid kinase PIKfyve as a positive regulator for RLRs. Moreover, we have identified RNA-binding protein HuR as a positive regulator for RLR signaling. We found that HuR binds to mRNA encoding the kinase Plk2 and it plays a critical roles in induction of type I interferon during RLR signaling. These findings demonstrate that HuR-mediated stabilization of Plk2 mRNA regulates antiviral innate immunity.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Identification of an atypical monocyte and committed progenitor involved in fibrosis.2017
Author(s)
Kozaki T, Komano J, Kanbayashi D, Takahama M, Misawa T, Satoh T, Takeuchi O, Kawai T, Shimizu S, Matsuura Y, Akira S, Saitoh T
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Journal Title
PNAS
Volume: 114
Pages: 96-101
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] IPS-1 differentially induces TRAIL, BCL2, BIRC3 and PRKCE in type I interferons-dependent and -independent anticancer activity.2015
Author(s)
Kumar S, Ingle H, Mishra S, Mahla RS, Kumar A, Kawai T, Akira S, Takaoka A, Raut AA, Kumar H.
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Journal Title
Cell Death Dis.
Volume: 6
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] RIG-I detects mRNA of intracellular Salmonella enterica serovar Typhimurium during bacterial infection.2014
Author(s)
Schmolke M, Patel JR, de Castro E, Sánchez-Aparicio MT, Uccellini MB, Miller JC, Manicassamy B, Satoh T, Kawai T, Akira S, Merad M, García-Sastre A.
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Journal Title
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Nucleic acids sensing by T cells initiates Th2 cell differentiation2014
Author(s)
Imanishi T, Ishihara C, Badr Mel S, Hashimoto-Tane A, Kimura Y, Kawai T, Takeuchi O, Ishii KJ, Taniguchi S, Noda T, Hirano H, Brombacher F, Barber GN, Akira S, Saito T
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Journal Title
Nat Commun.
Volume: 10
Pages: 3566-3566
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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