Elucidation of the genetic factors and the mechanisms of adverse effects by anti-rheumatic drugs.
Project/Area Number |
26293123
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Applied pharmacology
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Research Institution | University of Tsukuba (2015-2016) Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital (2014) |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
當間 重人 独立行政法人国立病院機構(相模原病院臨床研究センター), リウマチ性疾患研究部, 部長 (50207528)
|
Co-Investigator(Renkei-kenkyūsha) |
TSUCHIYA Naoyuki 筑波大学, 医学医療系, 教授 (60231437)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
|
Keywords | 遺伝子診断・治療 / 遺伝子診断治療 |
Outline of Final Research Achievements |
It was tried to detect the genetic factors and the mechanisms of adverse effects by anti-rheumatic drugs. The genome wide association study was performed, but the results were not confirmed by the replication analysis. No specific micro RNA was detected in the plasma from the rheumatoid arthritis patients with methotrexate-induced interstitial lung diseases. The transgenic mouse of HLA-A*31:01, a susceptibility allele for methotrexate-induced interstitial lung diseases, was not more susceptible for the model of methotrexate-induced induced interstitial lung disease.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis.2017
Author(s)
Terao C, Kawaguchi T, Dieude P, Varga J, Kuwana M, Hudson M, Kawaguchi Y, Matucci-Cerinic M, Ohmura K, Riemekasten G, Kawasaki A, Airo P, Horita T, Oka A, Hachulla E, Yoshifuji H, Caramaschi P, Hunzelmann N, Baron M, Atsumi T, Hassoun P, Torii T, Takahashi M, et al.
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Journal Title
Ann Rheum Dis.
Volume: 印刷中
Issue: 6
Pages: 1150-1158
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] The 23-valent pneumococcal polysaccharide vaccine in patients with rheumatoid arthritis: a double-blinded, randomized, placebo-controlled trial.2017
Author(s)
Izumi Y, Akazawa M, Akeda Y, Tohma S, Hirano F, Ideguchi H, Matsumura R, Miyamura T, Mori S, Fukui T, Iwanaga N, Jiuchi Y, Kozuru H, Tsutani H, Saisyo K, Sugiyama T, Suenaga Y, Okada Y, Katayama M, Ichikawa K, Furukawa H, Kawakami K, Oishi K, Migita K.
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Journal Title
Arthritis Res Ther.
Volume: 19
Issue: 1
Pages: 15-15
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Association of a single nucleotide polymorphism upstream of ICOS with Japanese autoimmune hepatitis type 1.2017
Author(s)
Higuchi T, Oka S, Furukawa H, Nakamura M, Komori A, Abiru S, Nagaoka S, Hashimoto S, Naganuma A, Naeshiro N, Yoshizawa K, Shimada M, Nishimura H, Tomizawa M, Kikuchi M, Makita F, Yamashita H, Ario K, Yatsuhashi H, Tohma S, Kawasaki A, Ohira H, Tsuchiya N, Migita K.
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Journal Title
J Hum Genet.
Volume: in press
Issue: 4
Pages: 481-484
DOI
NAID
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Independent Association of HLA-G 3’ Untranslated Region 14bp Indel Polymorphism with Systemic Lupus Erythematosus in a Japanese Population: a Case-control Association Study.2016
Author(s)
Hachiya Y, Kawasaki A, Oka S, Kondo Y, Ito S, Matsumoto I, Kusaoi M, Amano H, Suda A, Setoguchi K, Nagai T,Shimada K, Sugii S, Okamoto A, Chiba N, Suematsu E, Ohno S, Katayama M, Kono H, Hirohata S, Takasaki Y, Hashimoto H, Sumida T, Nagaoka S, Tohma S, Furukawa H, Tsuchiya N.
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Journal Title
PLoS ONE.
Volume: 11
Issue: 6
Pages: 22-22
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Protective role of HLA-DRB1*13:02 against microscopic polyangiitis and MPO-ANCA positive vasculitis in a Japanese population: a case-control study.2016
Author(s)
Kawasaki A, Hasebe N, Hidaka M, Hirano F, Sada K, Kobayashi S, Yamada H, Furukawa H, Yamagata K, Sumida T, Miyasaka N, Tohma S, Ozaki S, Matsuo S, Hashimoto H, Makino H, Arimura Y, Harigai M, Tsuchiya N.
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Journal Title
PLoS ONE.
Volume: 11
Issue: 5
Pages: e0154393-e0154393
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Neutrophil CD64 is upregulated in RA patients with lymphoma but not in other solid cancers.2016
Author(s)
Komiya A, Matsui T, Horie K, Fukuda H, Iwata K, Tsuno H, Ogihara H, Ikenaka T, Kawakami M, Furukawa H, Hashimoto A, Hirai K, Tohma S.
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Journal Title
Mod Rheumatol.
Volume: 26
Issue: 2
Pages: 216-23
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Autoantibody Profiles in Collagen Disease Patients with Interstitial Lung Disease (ILD): Antibodies to Major Histocompatibility Complex Class I-Related Chain A (MICA) as Markers of ILD.2015
Author(s)
Furukawa H, Oka S, Shimada K, Masuo K, Nakajima F, Funano S, Tanaka Y, Komiya A, Fukui N, Sawasaki T, Tadokoro K, Nose M, Tsuchiya N, Tohma S.
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Journal Title
Biomark Insights.
Volume: 16
Pages: 63-73
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Circulating microRNA Profiles in Patients with Type-1 Autoimmune Hepatitis.2015
Author(s)
Migita K, Komori A, Kozuru H, Jiuchi Y, Nakamura M, Yasunami M, Furukawa H, Abiru S, Yamasaki K, Nagaoka S, Hashimoto S, Bekki S, Kamitsukasa H, Nakamura Y, Ohta H, Shimada M, Takahashi H, et al.
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Journal Title
PLoS One
Volume: 10
Issue: 11
Pages: e0136908-e0136908
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Predictors of mortality in patients with interstitial lung disease treated with corticosteroids: results from a cohort study.2014
Author(s)
Migita K, Arai T, Jiuchi Y, Izumi Y, Iwanaga N, Kawahara C, Suematsu E, Miyamura T, Tsutani H, Kawabe Y, Matsumura R, Mori S, Ohshima S, Yoshizawa S, Suenaga Y, Ogushi F, Kawabata M, Furukawa H, Matsui T, Bito S, Tohma S.
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Journal Title
Medicine (Baltimore).
Volume: 93
Issue: 26
Pages: e175-e175
DOI
Related Report
Peer Reviewed
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[Journal Article] Protective effect of the HLA-DRB1*13:02 allele in Japanese rheumatoid arthritis patients.2014
Author(s)
Oka S, Furukawa H, Kawasaki A, Shimada K, Sugii S, Hashimoto A, Komiya A, Fukui N, Ito S, Nakamura T, Saisho K, Katayama M, Tsunoda S, Sano H, Migita K, Suda A, Nagaoka S, Tsuchiya N, Tohma S.
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Journal Title
PLoS One.
Volume: 9
Issue: 6
Pages: e99453-e99453
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] HLA-DRB1*08:02 is associated with bucillamine-induced proteinuria in Japanese rheumatoid arthritis patients.2014
Author(s)
Furukawa H, Oka S, Shimada K, Sugii S, Hashimoto A, Komiya A, Fukui N, Miyashita T, Migita K, Suda A, Nagaoka S, Tsuchiya N, Tohma S.
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Journal Title
Biomark Insights.
Volume: 9
Pages: 23-8
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] HLAクラスIIと強皮症2017
Author(s)
古川宏,岡笑美,川崎綾,島田浩太,杉井章二,松下貴史,橋本篤,小宮明子,福井尚志,小林幸司,長田侑,井畑淳,近藤裕也,永井立夫,瀬戸口京吾,岡本明子,岡本享,千葉実行,末松栄一,河野肇,片山雅夫,廣畑俊成,住田孝之,右田清志,長谷川稔,藤本学,佐藤伸一,長岡章平,竹原和彦,當間重人,土屋尚之
Organizer
第20回強皮症研究会議
Place of Presentation
アステラス製薬 本社(東京都中央区)
Year and Date
2017-01-14
Related Report
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[Presentation] 日本人全身性エリテマトーデスとHLA-G多型の関連2016
Author(s)
川崎綾,八谷有紀,古川宏,近藤裕也,伊藤聡,松本功,草生真規雄,天野浩文,須田昭子,長岡章平,瀬戸口京吾,永井立夫,廣畑俊成,島田浩太,杉井章二,岡本享,千葉実行,末松栄一,大野滋,片山雅夫,河野肇,髙崎芳成,橋本博史,住田孝之,當間重人,土屋尚之
Organizer
第60回日本リウマチ学会
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Year and Date
2016-04-21
Related Report
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[Presentation] Association of HLA-G and Leukocyte Immunoglobulin-like Receptor A3 Polymorphisms with the Susceptibility to Pulmonary Hypertention in Systemic Sclerosis.2015
Author(s)
Hachiya Y, Kawasaki A, Matsushita T, Furukawa H, Nagaoka S, Shimada K, Sugii S, Setoguchi K, Okamoto A, Chiba N, Suematsu E, Katayama M, Hirohata S, Kono H, Migita K, Sumida T, Tohma S, Hasegawa M, Fujimoto M, Sato S, Takehara K, Tsuchiya N.
Organizer
Seventy-second Annual Scientific Meeting of American College of Rheumatology
Place of Presentation
San Francisco
Year and Date
2015-11-06
Related Report
Int'l Joint Research
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