Establishment of research foundation on "objective pain assessment" using animal models suffering from neuropathic pain
| Project/Area Number |
26293129
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
UEDA Tadashi 九州大学, 薬学研究院, 教授 (90184928)
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| Co-Investigator(Kenkyū-buntansha) |
白石 充典 九州大学, 薬学研究院, 助教 (00380527)
阿部 義人 九州大学, 薬学研究院, 准教授 (60315091)
日下部 宜宏 九州大学, 農学研究院, 教授 (30253595)
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| Co-Investigator(Renkei-kenkyūsha) |
INOUE Kazuhide 九州大学, 大学院・薬学研究院, 教授 (80124379)
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| Research Collaborator |
TSUDA Makoto 九州大学, 大学院・薬学研究院, 教授 (40373394)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
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| Keywords | 神経障害性疼痛 / 蛋白質工学 / 抗原安定化 / P2X4受容体 / 抗体工学 / 痛みの定量 / イメージング / 蛋白質 / 薬理学 / P2X4 / モノクローナル抗体 / Fab |
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| Outline of Final Research Achievements |
There are more than 20 million patients suffering from neuropathic pain in the world. One of the proteins involved in neuropathic pain is P2X4 receptor. Pain develops from various causes. In general, pain assessment depends on individual subject. In order to develop novel medicines to cure neuropathic pain, objective pain assessment must be necessary. In this study, we prepared antibodies bound to conformational structure of rat P2X4 receptor, and then visualized rat P2X4 receptors expressed on 1321N1 culture cells using those antibodies. These results contribute to the fundamental research on the pain assessment caused by neuropathic pain.
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Report
(5 results)
Research Products
(6 results)
