The molecular epidemiological study of DNA repair-related genes in post-Chernobyl radiation-induced thyroid cancers
Project/Area Number |
26293142
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Epidemiology and preventive medicine
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Research Institution | Nagasaki University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
サエンコ ウラジミール 長崎大学, 原爆後障害医療研究所, 准教授 (30343346)
荻 朋男 名古屋大学, 環境医学研究所, 教授 (80508317)
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Project Period (FY) |
2014-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
|
Keywords | 甲状腺癌 / 甲状腺がん |
Outline of Final Research Achievements |
Mutation data were obtained by next-generation sequencing using genomic DNA of 56 post-Chernobyl radiation-induced pediatric thyroid cancer cases and 55 controls who were also lived in the same area and exposed but without development of thyroid cancer. Although several candidate genes related to carcinogenesis were found, further research is needed. No obvious accumulation of mutations was identified among DNA repair genes. Through this project, we were able to acquire comprehensive genomic data of the invaluable samples and established the basis of continuous research in future.
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Academic Significance and Societal Importance of the Research Achievements |
チェルノブイリ原発事故後の小児甲状腺癌は、放射線被ばくによって発癌したということが非常に明確な貴重な症例である。この地域では多くの人が被ばくしたが、限られたごく一部の人のみが癌を発症した。この癌発症に関連する遺伝的な背景(個人の体質)を明らかにすることがこの研究の目的であった。明確な原因となる遺伝子を発見することは出来なかったが、これらの非常に貴重なサンプルについて多数の網羅的ゲノムデータを取得することが出来、今後の研究基盤として大いに役立つものと考える。
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Report
(6 results)
Research Products
(26 results)
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[Journal Article] Sporadic pediatric papillary thyroid carcinoma harboring the ETV6/NTRK3 fusion oncogene in a 7-year-old Japanese girl: a case report and review of literature.2018
Author(s)
Otsubo R, Mussazhanova Z, Akazawa Y, Sato A, Matsuda K, Matsumoto M, Yano H, Matsuse M, Mitsutake N, Ando T, Niino D, Nagayasu T, Nakashima M.
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Journal Title
Endocrinol Metab
Volume: 31
Issue: 4
Pages: 461-467
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Identification of Three Novel Fusion Oncogenes, SQSTM1/NTRK3, AFAP1L2/RET, and PPFIBP2/RET, in Thyroid Cancers of Young Patients in Fukushima.2017
Author(s)
Iyama K, Matsuse M, Mitsutake N, Rogounovitch T, Saenko V, Suzuki K, Ashizawa M, Ookouchi C, Suzuki S, Mizunuma H, Fukushima T, Suzuki S, Yamashita S.
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Journal Title
Thyroid
Volume: 印刷中
Issue: 6
Pages: 811-818
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Genotype Analyses in the Japanese and Belarusian Populations Reveal Independent Effects of rs965513 and rs1867277 but Do Not Support the Role of FOXE1 Polyalanine Tract Length in Conferring Risk for Papillary Thyroid Carcinoma.2017
Author(s)
Nikitski AV, Rogounovitch TI, Bychkov A, Takahashi M, Yoshiura KI, Mitsutake N, Kawaguchi T, Matsuse M, Drozd VM, Demidchik Y, Nishihara E, Hirokawa M, Miyauchi A, Rubanovich AV, Matsuda F, Yamashita S, Saenko VA.
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Journal Title
Thyroid
Volume: 27
Issue: 2
Pages: 224-235
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Targeted Foxe1 overexpression in mouse thyroid causes the development of multinodular goiter but does not promote carcinogenesis.2016
Author(s)
Nikitski A, Saenko V, Shimamura M, Nakashima M, Matsuse M, Suzuki K, Rogounovitch T, Bogdanova T, Shibusawa N, Yamada M, Nagayama Y, Yamashita S, Mitsutake N
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Journal Title
Endocrinology
Volume: 印刷中
Issue: 5
Pages: 2182-2195
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Association between p53-binding protein 1 expression and genomic instability in oncocytic follicular adenoma of the thyroid2016
Author(s)
Mussazhanova Z, Akazawa Y, Matsuda K, Shichijo K, Miura S, Otsubo R, Oikawa M, Yoshiura K, Mitsutake N, Rogounovitch T, Saenko V, Kozykenova Z, Zhetpisbaev B, Shabdarbaeva D, Sayakenov N, Amntayev B, Kondo H, Ito M, Nakashima M.
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Journal Title
Endocrine Journal
Volume: 63
Issue: 5
Pages: 457-467
DOI
NAID
ISSN
0918-8959, 1348-4540
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] TCUKIN and CORGI Consortiums, Carmona LG; JTCMS Consortium: The 8q24 rs6983267G variant is associated with increased thyroid cancer risk.2015
Author(s)
Sahasrabudhe R, Estrada A, Lott P, Martin L, Polanco Echeverry G, Velez A, Neta G, Takahasi M, Saenko V, Mitsutake N, Jaeguer E, Duque CS, Rios A, Bohorquez M, Prieto R, Criollo A, Echeverry M, Tomlinson I
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Journal Title
Endocr Relat Cancer
Volume: 22
Issue: 5
Pages: 841-849
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The common genetic variant rs944289 on chromosome 14q13.3 associates with risk of both malignant and benign thyroid tumors in the Japanese population.2015
Author(s)
Rogounovitch TI, Bychkov A, Takahashi M, Mitsutake N, Nakashima M, Nikitski AV, Hayashi T, Hirokawa M, Ishigaki K, Shigematsu K, Bogdanova T, Matsuse M, Nishihara E, Minami S, Yamanouchi K, Ito M, Kawaguchi T, Kondo H, Takamura N, Ito Y, Miyauchi A, Matsuda F, Yamashita S, Saenko VA.
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Journal Title
Thyroid
Volume: 25
Issue: 3
Pages: 333-340
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 福島の小児および思春期の甲状腺乳頭癌における新規融合癌遺伝子の同定2017
Author(s)
井山慶大, 光武範吏, 松瀬美智子, タチアナ ログノビッチ, ウラジミール サエンコ, 鈴木啓司, 芦澤 舞, 大河内千代, 鈴木 聡, 水沼 廣, 福島俊彦, 鈴木眞一, 山下俊一
Organizer
第90回 日本内分泌学会学術総会
Related Report
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[Presentation] 甲状腺乳頭癌における分子マーカーによるリスク分類2016
Author(s)
光武範吏, 松瀬美智子, 薮田智範, Vladimir Saenko, 西原永潤, 廣川満良, 宮内 昭, 山下俊一
Organizer
日本甲状腺外科学会学術集会
Place of Presentation
甲府富士屋ホテル(山梨県・甲府市)
Year and Date
2016-10-27
Related Report
Invited
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[Presentation] Genotype analyses in the Japanese and Belarusian populations reveal independent effects of rs965513 and rs1867277 but do not support the role of FOXE1 polyalanine tract length in conferring risk for papillary thyroid carcinoma2016
Author(s)
ニキツキ アリャクサンドル, サエンコ ウラジミル, ログノビッチ タチアナ,ビチコブ アンドレイ, 高橋めい子, 吉浦孝一郎, 光武範吏, 川口喬久, 松瀬美智子, ドロズド ワレンチナ, デミドチック ユリ, 西原永潤, 廣川満良, 宮内 昭, ルバノビッチ アレクサンドル, 松田文彦, 山下俊一
Organizer
日本内分泌学会学術総会
Place of Presentation
京都国際会議場(京都府・京都市)
Year and Date
2016-04-21
Related Report
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