| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Outline of Final Research Achievements |
Distinct microRNAs are suggested to play a potential role in stress coping. Long non-coding RNAs and chromatin-binding proteins are also important epigenetic regulators. This study was designed to reveal a possible link between the vulnerability of stress and epigenetic regulators. First, we could show that a group of genes related to eukaryotic initiation factor 2 (EIF2)-dependent signals were potential biomarkers for chronic psychological stress in healthy young adults and IBS patients. We succeeded to identify stress microRNA markers in a group of people under distressed conditions and chronic fatigue syndrome-associated microRNAs in peripheral blood. We identified TRA2beta 4 RNA as a new long non-coding RNA facilitating oxidative stress-associated, mitogen responses. We also showed that homeodomain-interacting protein kinase 2, a DNA damage-responsive kinase, participates in the regulation of dynamic interaction between HP1gamma and histone H3K9me3 to promote DNA repair.
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