Anti-cancer therapies baesd on novel cancer stem cell-specific factors
| Project/Area Number |
26293173
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kyoto University |
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Principal Investigator |
Seno Hiroshi 京都大学, 医学(系)研究科(研究院), 教授 (90335266)
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| Co-Investigator(Renkei-kenkyūsha) |
FUKUDA Akihisa 京都大学, 大学院医学研究科, 助教 (70644897)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Keywords | 癌 / 幹細胞 / 消化器 / 大腸 / 膵臓 / 胃 |
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| Outline of Final Research Achievements |
In this study, we explored the nature of cancer stem cells, and sought the possibility of anti-cancer stem cell-targeting therapies. For that purpose, we performed the experiments as follows. 1) In the intestine, transcriptome of cancer stem cells was analyzed based on the expression of various stem cell markers, especially Dclk1. 2) The roles of Dclk1 and novel cancer stem cell-specific markers were investigated in mouse gastric, pancreatic, and gall bladder cancer models. 3) Therapeutic potentials of kinases and cell surface proteins in cancer stem cells were examined in mouse cancer models and cancer spheroids. Based on these experiments, basis for the development of anti-cancer stem cell therapies was established.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Diagnostic performance of a new “endoscopic scraper” for malignant biliary strictures: A multicenter prospective study.2017
Author(s)
Sakuma Y, Kodama Y, Sogabe Y, Nakai Y, Yamashita Y, Mikami S, Kajimura K, Ikeda K, Tamaki H, Iwamoto S, Matsuda F, Fujita K, Uza N, Kawamura T, Uemoto S, Seno H, Chiba T, Yazumi S; Kyoto Pancreatobiliary Study Group.
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Journal Title
Gastrointest Endosc
Volume: 85
Pages: 371-379
DOI
Related Report
Peer Reviewed
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[Journal Article] Pathogenicity of Immunoglobulin G in Patients with IgG4-related Disease.2016
Author(s)
Shiokawa M, Kodama Y, Kuriyama K, Yoshimura K, Tomono T, Morita T, Kakiuchi N, Matsumori T, Mima A, Nishikawa Y, Ueda T, Tsuda M, Yamauchi Y, Minami R, Sakuma Y, Ota Y, Maruno T, Kurita A, Sawai Y, Tsuji Y, Uza N, Matsumura K, Watanabe T, Notohara K, Tsuruyama T, Seno H, Chiba T.
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Journal Title
GUT
Volume: 未定
Pages: 1322-1322
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] EP4 receptor–associated protein in macrophages ameliorates colitis and colitis-associated tumorigenesis.2015
Author(s)
Nakatsuji, M., M. Minami*, H. Seno*, M. Yasui, H. Komekado, S. Higuchi, R. Fujikawa, Y. Nakanishi, A. Fukuda, K. Kawada, Y. Sakai, T. Kita, P. Libby, H. Ikeuchi, M. Yokode, and T. Chiba
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Journal Title
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Deletion of nardilysin prevents the development of steatohepatitis and liver fibrosis.2014
Author(s)
Ishizu-Higashi S, Seno H, Nishi E, Matsumoto Y, Ikuta K, Tsuda M, Kimura Y, Takada Y, Kimura Y, Nakanishi Y, Kanda K, Komekado H, Chiba T.
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Journal Title
10.1371/journal.pone.0098017
Volume: 9
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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