Research Project
Grant-in-Aid for Scientific Research (B)
Recent advance in sequence technology has enabled comprehensive analyses of genetic mutations in human colorectal cancer. In this study, we combined organoid culture technology and CRISPR-Cas9 technology to establish gene engineered organoids for analysis of genetic mutations in human colorectal cancers. The engineered organoids were xenotransplanted into immune-deficient mice and pathologically examined for their invasive and metastatic capacity. The functional analysis platform for driver genetic mutations are instrumental and holds a promise for applying to drug screening.
All 2017 2016 2015 2014
All Journal Article (18 results) (of which Int'l Joint Research: 4 results, Peer Reviewed: 16 results, Open Access: 11 results, Acknowledgement Compliant: 12 results) Presentation (35 results) Book (5 results)
Nature
Volume: 印刷中
Nat Cell Biol
Volume: 印刷中 Pages: 530-41
10.1038/ncb3509
J Exp Med
Science Translational Medicine
Inflamm Bowel Dis
Volume: 22 Pages: 2802-2810
10.1097/mib.0000000000000972
nature
Volume: 238 Pages: 260-264
10.1038/nature19768
PLoS Genet.
Volume: 12
10.1371/journal.pgen.1006349
Cell Stem Cell
Volume: 19 Pages: 205-216
10.1016/j.stem.2016.04.002
Cell stem cell
Volume: 18 Pages: 827-38
10.1016/j.stem.2016.04.003
Developmental Cell
Volume: 37 Pages: 47-57
10.1016/j.devcel.2016.03.002
Elife.
Volume: 5 Pages: 1-19
10.7554/elife.11621
The Journal of Cell Biology.
Volume: 3 Pages: 1474-1485
Nature protocol
Digestion
Volume: 91 Pages: 233-238
10.1159/000375302
Cancer prevention research
Volume: 8:492-501 Pages: 492-501
10.1158/1940-6207.capr-15-0025-t
Nat Med
Volume: 21(3) Pages: 256-262
10.1038/nm.3802
Inflamm Bowel Dis.
Volume: 20 Pages: 1820-1827
10.1097/mib.0000000000000149
Volume: 20(8) Pages: 1426-1434
10.1097/mib.0000000000000105