Elucidation of the functions of microRNA-33 in homeostasis in vivo

• Project/Area Number: 26293186
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Kyoto University
• Principal Investigator: Ono Koh 京都大学, 医学(系)研究科(研究院), 准教授 (00359275)
• Co-Investigator(Kenkyū-buntansha): 堀江 貴裕 京都大学, 医学(系)研究科(研究院), 助教 (20565577)
• Co-Investigator(Renkei-kenkyūsha): NAKAMURA Tomoyuki 関西医科大学, 薬理学, 教授 (20362527) ; MARUSAWA Hiroyuki 京都大学, 大学院医学研究科, 准教授 (80324630)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000); Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2014: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
• Keywords: マイクロRNA / 動脈硬化 / 線維化 / ナノ粒子 / HDL-C / 炎症 / コレステロール / 慢性炎症 / 骨髄

Outline of Final Research Achievements

MicroRNAs (miRNAs; miRs) are small non-protein-coding RNAs that negatively regulate gene expression. They bind to the 3’UTR of specific mRNAs and inhibit translation or promote mRNA degradation. There is emerging evidence linking miR-33a/b to lipid homoeostasis, targeting ABCA1, SREBF1, etc. Such functions of miR-33a/b appear to serve as “thrifty genes” during evolution to maintain cholesterol levels both at cellular and whole body levels. As we are now living in a “satiation period,” miR-33a/b no longer seem to be useful and could be potential therapeutic targets for lipid disorders and/or atherosclerosis. In fact, we have found that existence of miR-33a/b can lead to the occurrence of atherosclerosis, chronic inflammation, and cardiac fibrosis in vivo. Fine regulation of miR-33a/b could be a promising new approach for the prevention or treatment of cardiovascular diseases in the future.

Research Products

• [Int'l Joint Research] Mayo Clinic College of Medicine/Washington University School of Medicine/Yale University School of Medicine(米国)
• [Journal Article] Incidence and Prognostic Impact of Heart Failure Hospitalization During Follow-up after Primary Percutaneous Coronary Intervention in ST-segment Elevation Myocardial Infarction. (2017)
  • Author(s): Taniguchi T, Horie M, et al.
  • Journal Title: American Journal of Cardiology Volume: 印刷中 Issue: 11 Pages: 1729-1739
  • DOI: 10.1016/j.amjcard.2017.03.013
  • Peer Reviewed
• [Journal Article] Prevention of neointimal formation using miRNA-126-containing nanoparticle-conjugated stents in a rabbit model. (2017)
  • Author(s): Izuhara M, Kuwabara Y, Saito N, Yamamoto E, Hakuno D, Nakashima Y, Horie T, Baba O, Nishiga M, Nakao T, Nishino T, Nakazeki F, Ide Y, Kimura M, Kimura T, Ono K.
  • Journal Title: PLoS One Volume: 12(3) Issue: 3 Pages: e0172798-e0172798
  • DOI: 10.1371/journal.pone.0172798
  • Peer Reviewed / Open Access
• [Journal Article] Ad hoc vs. Non-ad hoc Percutaneous Coronary Intervention Strategies in Patients With Stable Coronary Artery Disease (2017)
  • Author(s): Toyota T, Horie M, et al.
  • Journal Title: Circulation Journal Volume: 81 Issue: 4 Pages: 458-467
  • DOI: 10.1253/circj.CJ-16-0987
  • NAID: 130005475829
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Cardiac and Noncardiac Causes of Long-Term Mortality in ST-Segment-Elevation Acute Myocardial Infarction Patients Who Underwent Primary Percutaneous Coronary Intervention. (2017)
  • Author(s): Yamashita Y, Shiomi H, Morimoto T, Yaku H, Furukawa Y, Nakagawa Y, Ando K, Kadota K, Abe M, Nagao K, Shizuta S, Ono K, Kimura T; CREDO-Kyoto AMI Registry Investigators.
  • Journal Title: Circ Cardiovasc Qual Outcomes. Volume: 10 Issue: 1
  • DOI: 10.1161/circoutcomes.116.002790
  • Peer Reviewed / Open Access
• [Journal Article] Feasibility and diagnostic performance of fractional flow reserve measurement derived from coronary computed tomography angiography in real clinical practice. (2017)
  • Author(s): Kawaji T, Shiomi H, Morishita H, Morimoto T, Taylor CA, Kanao S, Koizumi K, Kozawa S, Morihiro K, Watanabe H, Tazaki J, Imai M, Saito N, Shizuta S, Ono K, Togashi K, Kimura T.
  • Journal Title: Int J Cardiovasc Imaging. Volume: 33 Issue: 2 Pages: 271-281
  • DOI: 10.1007/s10554-016-0995-9
  • Peer Reviewed
• [Journal Article] Short versus prolonged dual antiplatelet therapy duration after bare-metal stent implantation: 2-month landmark analysis from the CREDO-Kyoto registry cohort-2. (2017)
  • Author(s): Natsuaki M, Morimoto T, Furukawa Y, Nakagawa Y, Kadota K, Ando K, Shiomi H, Toyota T, Watanabe H, Ono K, Shizuta S, Tamura T, Inoko M, Inada T, Shirotani M, Matsuda M, Aoyama T, Onodera T, Suwa S, Takeda T, Inoue K, Kimura T; CREDO-Kyoto PCI/CABG registry cohort-2 investigators.
  • Journal Title: Cardiovasc Interv Ther. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] MicroRNA-33 Controls Adaptive Fibrotic Response in the Remodeling Heart by Preserving Lipid Raft Cholesterol. (2016)
  • Author(s): Nishiga M, Horie T, Kuwabara Y, Nagao K, Baba O, Nakao T, Nishino T, Hakuno D, Nakashima Y, Nishi H, Nakazeki F, Ide Y, Koyama S, Kimura M, Hanada R, Nakamura T, Inada T, Hasegawa K, Conway SJ, Kita T, Kimura T, Ono K.
  • Journal Title: Circ Res. Volume: - Issue: 5 Pages: 835-847
  • DOI: 10.1161/circresaha.116.309528
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A Novel Link between Plasma MicroRNA-33b Levels and Lipid Disorders in Diabetes Mellitus. (2016)
  • Author(s): Ono K.
  • Journal Title: J Atheroscler Thromb. Volume: 23 Pages: 1259-1260
• [Journal Article] MSH2 Dysregulation Is Triggered by Proinflammatory Cytokine Stimulation and Is Associated with Liver Cancer Development. (2016)
  • Author(s): Eso Y, Takai A, Matsumoto T, Inuzuka T, Horie T, Ono K, Uemoto S, Lee K, Edelmann W, Chiba T, Marusawa H.
  • Journal Title: Cancer Research Volume: 76 Issue: 15 Pages: 4383-93
  • DOI: 10.1158/0008-5472.can-15-2926
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Adaptive servoventilation versus oxygen therapy for sleep disordered breathing in patients with heart failure: a randomised trial. (2016)
  • Author(s): Murase K, Ono K, Yoneda T, Iguchi M, Yokomatsu T, Mizoguchi T, Izumi T, Akao M, Miki S, Nohara R, Ueshima K, Mishima M, Kimura T, White DP, Chin K.
  • Journal Title: Open Heart. Volume: 31 Issue: 1 Pages: e000366-e000366
  • DOI: 10.1136/openhrt-2015-000366
  • NAID: 120005997791
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of Age and Sex on Clinical Outcomes after Percutaneous Coronary Intervention Relative to Coronary Artery Bypass Grafting in Patients with Triple Vessel Coronary Artery Disease. (2016)
  • Author(s): Yamaji K, Shiomi H, Morimoto T, Nakatsuma K, Toyota T, Ono K, Furukawa Y, Nakagawa Y, Kadota K, Ando K, Shirai S, Onodera T, Watanabe H, Natsuaki M, Sakata R, Hanyu M, Nishiwaki N, Komiya T, Kimura T.
  • Journal Title: Circulation Volume: 115 Issue: 19 Pages: 020955-020955
  • DOI: 10.1161/circulationaha.115.020955
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effects of Age and Sex on Clinical Outcomes after Percutaneous Coronary Intervention Relative to Coronary Artery Bypass Grafting in Patients with Triple Vessel Coronary Artery Disease. (2016)
  • Author(s): Yamaji K, Shiomi H, Morimoto T, Nakatsuma K, Toyota T, Ono K, Furukawa Y, Nakagawa Y, Kadota K, Ando K, Shirai S, Onodera T, Watanabe H, Natsuaki M, Sakata R, Hanyu M, Nishiwaki N, Komiya T, Kimura T.
  • Journal Title: Circulation. Volume: 115 Pages: 020955-020955
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Emerging Novel Biomarkers for Arteriosclerosis Obliterans (2016)
  • Author(s): Horie T, Kimura T, Ono K.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 23 Issue: 2 Pages: 171-172
  • DOI: 10.5551/jat.ED028
  • NAID: 130005122030
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] microRNAs and Cardiovascular Remodeling. (2015)
  • Author(s): Ono K
  • Journal Title: Adv Exp Med Biol. Volume: 888 Pages: 197-213
  • DOI: 10.1007/978-3-319-22671-2_10
  • ISBN: 9783319226705, 9783319226712
  • Acknowledgement Compliant
• [Journal Article] Functions of microRNA-33a/b and microRNA therapeutics. (2015)
  • Author(s): Ono K.
  • Journal Title: J Cardiol. Volume: 67 Issue: 1 Pages: 28-33
  • DOI: 10.1016/j.jjcc.2015.10.017
  • Acknowledgement Compliant
• [Journal Article] Expression Patterns of miRNA-423-5p in the Serum and Pericardial Fluid in Patients Undergoing Cardiac Surgery. (2015)
  • Author(s): Miyamoto S, Usami S, Kuwabara Y, Horie T, Baba O, Hakuno D, Nakashima Y, Nishiga M, Izuhara M, Nakao T, Nishino T, Ide Y, Nakazeki F, Wang J, Ueyama K, Kimura T, Ono K.
  • Journal Title: PLoS One. Volume: 10(11) Issue: 11 Pages: e0142904-e0142904
  • DOI: 10.1371/journal.pone.0142904
  • NAID: 120005749912
  • Peer Reviewed / Open Access
• [Journal Article] microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain. (2015)
  • Author(s): Kim J, Yoon H, Horie T, Burchett JM, Restivo JL, Rotllan N, Ramírez CM, Verghese PB, Ihara M, Hoe HS, Esau C, Fernández-Hernando C, Holtzman DM, Cirrito JR, Ono K, Kim J.
  • Journal Title: J Neurosci. Volume: 35(44) Issue: 44 Pages: 14717-26
  • DOI: 10.1523/jneurosci.2053-15.2015
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Influence of Sex on Long-Term Outcomes Afte Implantation of Bare-Metal Stent: A Multicenter Report From the Coronary Revascularization Demonstrating Outcome Study-Kyoto (CREDO-Kyoto) Registry Cohort-1. (2015)
  • Author(s): Yamaji K, Shiomi H, Morimoto T, Toyota T, Ono K, Furukawa Y, Nakagawa Y, Kadota K, Ando K, Shirai S, Kato M, Takatsu Y, Doi O, Kambara H, Suwa S, Onodera T, Watanabe H, Natsuaki M, Kimura T
  • Journal Title: Circulation. Volume: 132 Issue: 24 Pages: 2323-33
  • DOI: 10.1161/circulationaha.115.017168
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] MicroRNAs and High-Density Lipoprotein Cholesterol Metabolism. (2015)
  • Author(s): Ono K, Horie T, Nishino T, Baba O, Kuwabara Y, Kimura T.
  • Journal Title: Int Heart J. Volume: 56 Pages: 365-71
  • NAID: 130005087574
  • Acknowledgement Compliant
• [Journal Article] Long-Term Outcomes After Coronary Stent Implantation in Patients Presenting With Versus Without Acute Myocardial Infarction (an Observation from Coronary Revascularization Demonstrating Outcome Study-Kyoto Registry Cohort-2). (2015)
  • Author(s): Yamaji K, Natsuaki M, Morimoto T, Ono K, Furukawa Y, Nakagawa Y, Kadota K, Ando K, Shirai S, Watanabe H, Shiomi H, Kimura T.
  • Journal Title: Am J Cardiol. Volume: 116 Issue: 1 Pages: 15-23
  • DOI: 10.1016/j.amjcard.2015.03.036
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] MicroRNA-133a in the Development of Arteriosclerosis Obliterans (2015)
  • Author(s): Ono K
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 22 Issue: 4 Pages: 342-343
  • DOI: 10.5551/jat.ED006
  • NAID: 130005066047
  • ISSN: 1340-3478, 1880-3873
  • Acknowledgement Compliant
• [Journal Article] High-density lipoprotein cholesterol levels and cardiovascular outcomes in Japanese patients after percutaneous coronary intervention: a report from the CREDO-Kyoto registry cohort-2. (2015)
  • Author(s): Izuhara M, Ono K, Shiomi H, Morimoto T, Furukawa Y, Nakagawa Y, Shizuta S, Tada T, Tazaki J, Horie T, Kuwabara Y, Baba O, Nishino T, Kita T, Kimura T; CREDO-Kyoto PCI/CABG Registry Cohort-2 Investigators.
  • Journal Title: Atherosclerosis. Volume: 242(2) Issue: 2 Pages: 632-8
  • DOI: 10.1016/j.atherosclerosis.2015.05.010
  • NAID: 120005678183
  • Peer Reviewed / Open Access
• [Journal Article] MicroRNA-33a/b in Lipid Metabolism (2015)
  • Author(s): Ono K, Horie T, Nishino T, Baba O, Kuwabara Y, Yokode M, Kita T, Kimura T.
  • Journal Title: Circulation Journal Volume: 79 Issue: 2 Pages: 278-284
  • DOI: 10.1253/circj.CJ-14-1252
  • NAID: 130004927073
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Impact of Left Ventricular Outflow Tract Obstruction in Takotsubo Cardiomyopathy (2015)
  • Author(s): Kawaji T, Shiomi H, Morimoto T, Tazaki J, Imai M, Saito N, Makiyama T, Shizuta S, Ono K, Kimura T.
  • Journal Title: Circulation Journal Volume: 79 Issue: 4 Pages: 839-846
  • DOI: 10.1253/circj.CJ-14-1148
  • NAID: 130005130261
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] MicroRNA-451 exacerbates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy in mice through suppression of the LKB1/AMPK pathway. (2015)
  • Author(s): Kuwabara Y, Horie T, Baba O, Watanabe S, Nishiga M, Usami S, Izuhara M, Nakao T, Nishino T, Otsu K, Kita T, Kimura T, Ono K.
  • Journal Title: Circulation Research Volume: 116 Issue: 2 Pages: 279-288
  • DOI: 10.1161/circresaha.116.304707
  • Peer Reviewed
• [Journal Article] Effect of Statin Therapy on Cardiovascular Outcomes after Coronary Revascularization in Patients over 80 Years of Age (2014)
  • Author(s): Natsuaki M, Morimoto T, Furukawa Y, Shiomi H, Ono K, Kimura T
  • Journal Title: Atherosclerosis Volume: 237 Issue: 2 Pages: 821-828
  • DOI: 10.1016/j.atherosclerosis.2014.10.108
  • Peer Reviewed / Open Access
• [Journal Article] Cardiac-Specific Inhibition of Kinase Activity in Calcium/Calmodulin-Dependent Protein Kinase Kinase-β Leads to Accelerated Left Ventricular Remodeling and Heart Failure after Transverse Aortic Constriction in Mice (2014)
  • Author(s): Shin Watanabe, Takahiro Horie, Kazuya Nagao, Yasuhide Kuwabara, Osamu Baba, Hitoo Nishi, Naoya Sowa, Michiko Narazaki, Tetsuya Matsuda, Genzou Takemura, Hiromichi Wada, Koji Hasegawa, Takeshi Kimura, Koh Ono
  • Journal Title: PLoS ONE Volume: 9 Issue: 9 Pages: e108201-e108201
  • DOI: 10.1371/journal.pone.0108201
  • NAID: 120005496630
  • Peer Reviewed / Open Access
• [Journal Article] Effect of Pre-infarction Angina Pectoris on Long-term Survival in Patients with ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention (2014)
  • Author(s): Taniguchi T, Shiomi H, Toyota T, Morimoto T, Akao M, Nakatsuma K, Ono K, Makiyama T, Shizuta S, Furukawa Y, Nakagawa Y, Ando K, Kadota K, Horie M, Kimura T.
  • Journal Title: Am J Cardiol Volume: 114 Issue: 8 Pages: 1179-1186
  • DOI: 10.1016/j.amjcard.2014.07.038
  • Peer Reviewed / Open Access
• [Journal Article] Incidence and Outcome of Surgical Procedures After Coronary Artery Bypass Grafting Compared With Those After Percutaneous Coronary Intervention: A Report From the Coronar Revascularization Demonstrating Outcome Study in Kyoto PCI/CABG Registry Cohort-2. (2014)
  • Author(s): Tokushige A, Shiomi H, Morimoto T, Ono K, et. al.
  • Journal Title: Circ Cardiovasc Interv. Volume: 7 Pages: 482-491
  • Peer Reviewed
• [Journal Article] Anticoagulant and Antiplatelet Therapy in Patients with Atrial Fibrillation Undergoing Percutaneous Coronary Intervention (2014)
  • Author(s): Goto K, Nakai K, Shizuta S, Morimoto T, Shiomi H, Natsuaki M, Tahata M, Ota C, Ono K, Makiyama T, Nakagawa Y, Furukawa Y, et al.
  • Journal Title: Am J Cardiol Volume: 114 Issue: 1 Pages: 70-78
  • DOI: 10.1016/j.amjcard.2014.03.060
  • Peer Reviewed / Open Access
• [Journal Article] Long-Term Efficacy and SafetyOutcomes After Unrestricted Use of Drug-Eluting Stents in Patients With AcuteCoronary Syndrome. (2014)
  • Author(s): Kawaji T, Shiomi H, Morimoto T, Tamura T, Nishikawa R, Yano M, Tazaki J, Imai M, Saito N, Makiyama T, Shizuta S, Ono K, Kimura T.
  • Journal Title: Circ J. Volume: 78 Pages: 1628-1635
  • Peer Reviewed / Open Access
• [Journal Article] Evolution in practice patterns and long-term outcomes of coronary revascularization from bare-metal stent era to drug-eluting stent era in Japan. (2014)
  • Author(s): Shiomi H, Morimoto T, Makiyama T, Ono K, Furukawa Y, Nakagawa Y, Kadota K, Onodera T, Takatsu Y, Mitsudo K, Kita T, Sakata R, Okabayashi H, Hanyu M, Komiya T, Yamazaki F, Nishiwaki N, Kimura T; CREDO-Kyoto Investigators.
  • Journal Title: Am J Cardiol. Volume: 113 Issue: 10 Pages: 1652-9
  • DOI: 10.1016/j.amjcard.2014.02.037
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Molecular Links between Lipid Metabolism and Heart Failure (2017)
  • Author(s): Koh Ono
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県立音楽堂外（石川県金沢市）
  • Year and Date: 2017-03-17
  • Invited
• [Presentation] LincRNA Upregulated by Pressure-Overload Induces Hypertrophy in Neonatal Mouse Cardiac Myocytes by Binding with Multiple Partners. (2017)
  • Author(s): Kuwabara Y, Horie T, Baba O, Nishiga M, Nakao M, Nishino T, Nakazeki F, Koyama S, Kimura T, Ono K.
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県立音楽堂外（石川県金沢市）
  • Year and Date: 2017-03-17
• [Presentation] MicroRNA-33b promotes atherosclerotic plaque formation in Apoe-/- mice (2017)
  • Author(s): Nishino T, Horie T, Baba O, Kuwabara Y, Hakuno D, Nakashima Y, Nakao T, Nishiga M, Kimura T, Ono K.
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県立音楽堂外（石川県金沢市）
  • Year and Date: 2017-03-17
• [Presentation] MicroRNA-33は脂質ラフトの維持を介して代償性の心臓線維化を促進する (2016)
  • Author(s): 西賀雅隆、堀江貴裕、桑原康秀、長央和也、中尾哲史、西野共達、長谷川浩二、北徹、木村剛、尾野亘
  • Organizer: 第20回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 東京コンベンションホール（東京都）
  • Year and Date: 2016-12-16
• [Presentation] MicroRNA-33の抑制は複数の分子メカニズムを介して炎症を抑制し、大動脈瘤形成を抑制する (2016)
  • Author(s): 中尾哲史, 堀江貴裕, 馬場理, 西賀雅隆, 西野共達, 宇佐美俊輔, 桑原康秀, 出原正康, 中関典子, 井手裕也, 小山智史, 曽和尚也, 西仁勇, 大野聡子, 青木浩樹, 木村剛, 尾野亘
  • Organizer: 第３９回 日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-11-30
• [Presentation] MicroRNA-33は脂質ラフト維持を介して心臓線維化を促進する (2016)
  • Author(s): 西賀雅隆、堀江貴裕、桑原康秀、長央和也、中尾哲史、西野共達、中関典子、井手裕也、小山智史、北徹、木村剛、尾野亘
  • Organizer: 第３９回 日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-11-30
• [Presentation] Reverse Cholesterol Transport regulated by micro RNA-33 (2016)
  • Author(s): 花田律子、西野共達、堀江貴裕、桑原康秀、西仁勇、中尾哲史、西賀雅隆、中関典子、井手裕也、小山智史、木村昌弘、Randolph Ruiz Rodriguez、曽和尚也、木村剛、尾野亘
  • Organizer: 第３９回 日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-11-30
• [Presentation] Genetic Ablation of miR-33 Attenuates Inflammation and Reduces Abdominal Aortic Aneurysm Formation (2016)
  • Author(s): Tetsushi Nakao, Takahiro Horie, Osamu Baba, Masataka Nishiga, Tomohiro Nishino, Hitoo Nishi, Masayasu Izuhara, Shunsuke Usami, Noriko Nakaseki, Satoshi Koyama, Yuya Ide, Takeshi Kimura, Koh Ono
  • Organizer: American Heart Association Annual Scientific Sessions
  • Place of Presentation: New Orleans, Louisiana（アメリカ合衆国）
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] MicroRNA-33 Maintains Cellular Cholesterol Content in Fibroblasts and Fibrotic Response in Heart (2016)
  • Author(s): Masataka Nishiga, Takahiro Horie, Yasuhide Kuwabara, Osamu Baba, Tetsushi Nakao, Tomohiro Nishino, Daihiko Hakuno, Yasuhiro Nakashima, Kazuya Nagao, Koji Hasegawa, Toru Kita, Takeshi Kimura and Koh Ono.
  • Organizer: American Heart Association Annual Scientific Sessions
  • Place of Presentation: New Orleans, Louisiana（アメリカ合衆国）
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] MicroRNA-33 Promotes Cardiac Fibrosis Through Maintaining Cellular Lpid Contents. (2016)
  • Author(s): Nishiga M, Horie T, Kuwabara Y, Nakao K, Kimura T, Ono K.
  • Organizer: 第20回 日本心不全学会学術集会
  • Place of Presentation: ロイトン札幌外（北海道札幌市）
  • Year and Date: 2016-10-07
• [Presentation] Overexpression of the LincRNA Regulated by Pressure-Overload Leads to Cardiomyocyte Hypertrophy. (2016)
  • Author(s): Kuwabara Y, Horie T, Baba O, Nishiga M, Nakao M, Nishino T, Nakazeki F, Koyama S, Kimura T, Ono K.
  • Organizer: 第20回 日本心不全学会学術集会
  • Place of Presentation: ロイトン札幌外（北海道札幌市）
  • Year and Date: 2016-10-07
• [Presentation] Relationship between Systemic Remodeling of Extracellular Matrix (ECM) and Clinical Course of the Disease in Heart Failure. (2016)
  • Author(s): Nagao K, Yukawa H, Shimamura K, Nishiga M, Horie T, Ono K, Sato Y, Inada T, Makita T, Tanaka M.
  • Organizer: 第20回 日本心不全学会学術集会
  • Place of Presentation: ロイトン札幌外（北海道札幌市）
  • Year and Date: 2016-10-07
• [Presentation] Changes and Physiological Meanings of Serum microRNA during Therapeutic Course of Acute Heart Failure. (2016)
  • Author(s): Koyama S, Kuragaichi T, Sato Y, Kuwabara Y, Horie T, Baba O, Kimura T, Ono K.
  • Organizer: 第20回 日本心不全学会学術集会
  • Place of Presentation: ロイトン札幌外（北海道札幌市）
  • Year and Date: 2016-10-07
• [Presentation] MicroRNA-33 promotes cardiac fibrosis by maintaining cellular lipid homeostasis. (2016)
  • Author(s): Masataka Nishiga, Takahiro Horie, Yasuhide Kuwabara, Osamu Baba, Tetsushi Nakao, Tomohiro Nishino, Daihiko Hakuno, Yasuhiro Nakashima, Noriko Nakazeki, Yuya Ide, Satoshi Koyama, Koji Hasegawa, Toru Kita, Takeshi Kimura, Koh Ono.
  • Organizer: BCVS 2016 Scientific Sessions
  • Place of Presentation: Phoenix, AZ（アメリカ合衆国）
  • Year and Date: 2016-07-18
  • Int'l Joint Research
• [Presentation] マイクロRNAによるHDL代謝制御 (2016)
  • Author(s): 堀江貴裕
  • Organizer: 第48回 日本動脈硬化学会総会・学術集会
  • Place of Presentation: 京王プラザホテル（東京都）
  • Year and Date: 2016-07-14
• [Presentation] MicroRNA-33bは動脈硬化形成を促進させる (2016)
  • Author(s): 西野 共達、堀江 貴裕、馬場 理、桑原 康秀、中尾 哲史、西賀 雅隆、宇佐美 俊輔、出原 正康、中関 典子、井手 裕也、小山 智史、尾野 亘
  • Organizer: 第48回 日本動脈硬化学会総会・学術集会
  • Place of Presentation: 京王プラザホテル（東京都）
  • Year and Date: 2016-07-14
• [Presentation] miR-33ノックアウトマウスにおける大動脈瘤についての検討 (2016)
  • Author(s): 中尾哲史, 堀江貴裕, 馬場理, 西賀雅隆, 西野共達, 宇佐美俊輔, 桑原康秀, 出原正康, 中関典子, 井手裕也, 小山智史, 曽和尚也, 大野聡子, 青木浩樹, 尾野亘
  • Organizer: 第二回J-ISCP学術集会
  • Place of Presentation: 阿波観光ホテル（徳島県徳島市）
  • Year and Date: 2016-06-25
• [Presentation] MicroRNA-33は細胞内コレステロール維持を通して心臓線維化を促進する (2016)
  • Author(s): 西賀雅隆、堀江貴裕、桑原康秀、馬場理、伯野大彦、中島康弘、中尾哲史、西野共達、長谷川浩二、北徹、木村剛、尾野亘.
  • Organizer: 第二回J-ISCP学術集会
  • Place of Presentation: 阿波観光ホテル（徳島県徳島市）
  • Year and Date: 2016-06-25
• [Presentation] AHA-JCS Joint Symposium “Functional Importance of Immune Cells in the Heart” MicroRNA-451 Exacerbates Lipotoxicity in Cardiomyocytes and High-Fat Diet-Induced Cardiac Hypertrophy in Mice through Suppression of the LKB1/AMPK Pathway (2016)
  • Author(s): 尾野 亘
  • Organizer: 第80回日本循環器学会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18
• [Presentation] High-density Lipoprotein Cholesterol Levels and Cardiovascular Outcomes in Japanese Patients after Percutaneous Coronary Intervention from the CREDO-Kyoto Registry Cohort-2 (2016)
  • Author(s): Masayasu Izuhara, Koh Ono, Hiroki Shiomi, Takeshi Morimoto, Yutaka Furukawa, Yoshihisa Nakagawa, Satoshi Shizuta, Tomohisa Tada, Junichi Tazaki, Takahiro Horie, Yasuhide Kuwabara, Osamu Baba, Tomohiro Nishino, Toru Kita, Takeshi Kimura
  • Organizer: 第80回日本循環器学会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18
• [Presentation] LincRNAs Regulated by Pressure-overload Induce Hypertrophy in Neonatal Mouse Cardiac Myocytes (2016)
  • Author(s): Yasuhide Kuwabara, Koh Ono, Takahiro Horie, Shin Watanabe, Daihiko Hakuno, Yasuhiro Nakashima, Osamu Baba, Masayasu Izuhara, Masataka Nishiga, Shunsuke Usami, Tetsushi Nakao, Tomohiro Nishino, Yuya Ide, Fumiko Nakazeki, Satoshi Koyama, Toru Kita, Takeshi Kimura
  • Organizer: 第80回日本循環器学会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18
• [Presentation] Expression Patterns of miRNA-423-5p in the Serum and Pericardial Fluid in Patients Undergoing Cardiac Surgery. (2016)
  • Author(s): Shunsuke Usami, Shoichi Miyamoto, Yasuhide Kuwabara, Takahiro Horie, Osamu Baba, Daihiko Hakuno, Yasuhiro Nakashima, Masataka Nishiga, Masayasu Izuhara, Tetsushi Nakao, Tomohiro Nishino, Yuya Ide, Fumiko Nakazeki, Koji Ueyama, Takeshi Kimura, Koh Ono
  • Organizer: 第80回日本循環器学会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18
• [Presentation] MicroRNAs as a New Mechanism Regulating Obesity and Its Complications (2016)
  • Author(s): Ono K.
  • Organizer: International conference of obesity and metabolic syndrome
  • Place of Presentation: Seoul（大韓民国）
  • Int'l Joint Research / Invited
• [Presentation] miR-33a/bの生体における働きの解明と臨床応用への取り組み (2016)
  • Author(s): 尾野 亘
  • Organizer: 第53回日本臨床分子医学会
  • Place of Presentation: 東京国際フォーラム（東京都）
  • Invited
• [Presentation] マイクロRNA-33は細胞内の脂質恒常性を維持することで心臓線維化を促進する (2016)
  • Author(s): 西賀雅隆、堀江貴裕、桑原康秀、馬場理、伯野大彦、中島康弘、中尾哲史、西野共達、長谷川浩二、北徹、木村剛、尾野亘.
  • Organizer: 第53回日本臨床分子医学会
  • Place of Presentation: 東京国際フォーラム（東京都）
• [Presentation] 急性心不全の治療経過中のマイクロRNA122-5pの変動は肝機能障害を反映する (2016)
  • Author(s): 小山智史、蔵垣内敬、佐藤幸人、木村剛、尾野亘
  • Organizer: 第64回日本心臓病学会学術集会
  • Place of Presentation: 東京国際フォーラム（東京都）
• [Presentation] Serum HDL cholesterol decreases in microRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor1 (Srebf1) (2015)
  • Author(s): Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Nakazeki F, Ide Y, Koyama S, Sowa N, Nakashima Y, Hakuno D, Kimura T, Ono K
  • Organizer: American Heart Association Annual Scientific Sessions 2015
  • Place of Presentation: Orlando, Florida
  • Year and Date: 2015-11-07
  • Int'l Joint Research
• [Presentation] High-density lipoprotein cholesterol levels and cardiovascular outcomes in Japanese patients after percutaneous coronary intervention: A report from the CREDO-Kyoto registry cohort-2. (2015)
  • Author(s): Izuhara M, Ono K, Shiomi H, Morimoto T, Furukawa Y, Nakagawa Y, Shizuta S, Tada T, Tazaki J, Horie T, Kuwabara Y, Baba O, Nishino T, Kita T, Kimura T; CREDO-Kyoto PCI/CABG Registry Cohort-2Investigators.
  • Organizer: American Heart Association Annual Scientific Sessions 2015
  • Place of Presentation: Orlando, Florida
  • Year and Date: 2015-11-07
  • Int'l Joint Research
• [Presentation] マウス大動脈縮窄モデルにより増加するlincRNAはマウス心筋細胞において心肥大を誘導する (2015)
  • Author(s): 桑原康秀、堀江貴裕、馬場理、出原正康、宇佐美俊輔、西賀雅隆、西野共達、北徹、木村剛、尾野亘
  • Organizer: 第19回 日本心不全学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-10-22
• [Presentation] microRNA-33a/bの脂質代謝における働き (2015)
  • Author(s): 尾野 亘
  • Organizer: 動脈硬化Update 2015
  • Place of Presentation: 東京
  • Year and Date: 2015-09-05
  • Invited
• [Presentation] Organ memory achieved by the interaction of miR-33a/b and SREBP2/1 (2015)
  • Author(s): 尾野 亘
  • Organizer: “臓器の記憶”国際シンポジウム2015
  • Place of Presentation: 東京
  • Year and Date: 2015-08-23
  • Int'l Joint Research
• [Presentation] MicroRNA-451 Aggravates Lipotoxic Cardiomyopathy through Suppression of the LKB1/AMPK Pathway. (2015)
  • Author(s): Yasuhide Kuwabara, Takahiro Horie, Osamu Baba, Toru Kita, Takeshi Kimura, Koh Ono
  • Organizer: Basic Cardiovascular Sciences 2015
  • Place of Presentation: New Orleans, Louisiana, USA
  • Year and Date: 2015-07-13
  • Int'l Joint Research
• [Presentation] 医学・薬学ジョイントシンポジウム 心血管疾患の創薬分子標的と再生・発生 (2015)
  • Author(s): 尾野 亘
  • Organizer: 第1回J-ISCP学術集会
  • Place of Presentation: 京都
  • Year and Date: 2015-06-21
  • Invited
• [Presentation] 脂質代謝を起点としたmicroRNA-33a/bの作用の解明 (2015)
  • Author(s): 尾野 亘、堀江貴裕、桑原康秀、馬場 理、西野共達、中尾哲史、西賀雅隆、木村 剛
  • Organizer: 生命素子による転写環境とエネルギー代謝のクロストーク制御｢転写代謝システム｣ 平成27年度 領域班会議
  • Place of Presentation: 熊本
  • Year and Date: 2015-06-14
• [Presentation] microRNA-33a/bによる細胞・臓器レベルの脂質代謝制御機構 (2015)
  • Author(s): 尾野 亘
  • Organizer: 第58回日本糖尿病学会年次学術集会
  • Place of Presentation: 下関
  • Year and Date: 2015-05-23
  • Invited
• [Presentation] ①プレナリーセッション: Future Perspective in Atherosclerosis Research: Seeking for Novel Therapeutic Targets against Cardiovascular Diseases ‘miR-33a/b as novel therapeutic targets for the treatment of cardiovascular diseases’ (2015)
  • Author(s): 尾野 亘
  • Organizer: 第79回日本循環器学会
  • Place of Presentation: 大阪国際会議場 大阪
  • Year and Date: 2015-04-24
• [Presentation] MicroRNA-451 is Involved in Diabetic Cardiomyopathy through LKB1/AMPK Pathway (2015)
  • Author(s): Kuwabara Y, Ono K, Horie T, Baba O, Nishiga M, Usami S, Izuhara M, Nakao T, Nishino T, Ide Y, Nakazeki F, Koyama S, Kita T, Kimura T
  • Organizer: 第79回日本循環器学会
  • Place of Presentation: 大阪国際会議場 大阪
  • Year and Date: 2015-04-24
• [Presentation] SREBP-2,-1のイントロン性microRNA-33,-33bの脂質代謝における制御機構の包括的解明 (2015)
  • Author(s): 堀江貴裕
  • Organizer: 第11回榊原記念研究助成 研究成果発表会
  • Place of Presentation: 東京
  • Year and Date: 2015-04-18
• [Presentation] microRNA-451はLKB1-AMPK経路を抑制することで、ラット心筋細胞において細胞障害を、生体においては高脂肪食誘導性心肥大を誘導する (2015)
  • Author(s): 桑原康秀、堀江貴裕、馬場理、出原正康、宇佐美俊輔、中尾哲史、西賀雅隆、西野共達、北徹、木村剛、尾野亘
  • Organizer: 第52回 日本臨床分子医学会学術集会
  • Place of Presentation: みやこめっせ 京都
  • Year and Date: 2015-04-10
• [Presentation] miR-33a/bによる細胞・臓器レベルの脂質代謝制御機構 (2015)
  • Author(s): 尾野 亘
  • Organizer: 第44回日本心脈管作動物質学会
  • Place of Presentation: 高松
  • Year and Date: 2015-02-07
  • Invited
• [Presentation] Srebf1のイントロンにmicroRNA-33bをノックインしたマウスはHDLコレステロールの減少を示す (2015)
  • Author(s): 堀江貴裕、西野共達、馬場 理、桑原康秀、中尾哲史、西賀雅隆、宇佐美俊輔、出原正康、中関典子、井手裕也、小山智史、曽和尚也、矢作直也、島野 仁、横出正之、北 徹、木村 剛、尾野 亘
  • Organizer: 学術領域研究 転写代謝システム 新学術領域若手ワークショップ
  • Place of Presentation: 伊香保
  • Year and Date: 2015-02-06 – 2015-02-07
• [Presentation] 心肥大・心不全におけるlincRNAの機能解析 (2015)
  • Author(s): 桑原康秀、堀江貴裕、中島康弘、伯野大彦、馬場 理、出原正康、宇佐美俊輔、西賀雅隆、西野共達、中尾哲史、井手裕也、中関典子、小山智史、北 徹、木村 剛、尾野 亘
  • Organizer: 学術領域研究 転写代謝システム 新学術領域若手ワークショップ
  • Place of Presentation: 伊香保
  • Year and Date: 2015-02-06 – 2015-02-07
• [Presentation] miR-33ノックアウトマウスにおける大動脈瘤についての検討 (2015)
  • Author(s): 中尾哲史、堀江貴裕、馬場 理、西賀雅隆、西野共達、宇佐美俊輔、桑原康秀、出原正康、中関典子、井手裕也、小山智史、曽和尚也、大野聡子、青木浩樹、木村 剛、尾野 亘
  • Organizer: 学術領域研究 転写代謝システム 新学術領域若手ワークショップ
  • Place of Presentation: 伊香保
  • Year and Date: 2015-02-06 – 2015-02-07
• [Presentation] microRNA-33b promotes atherosclerotic plaque formation in vivo (2015)
  • Author(s): 西野共達、堀江貴裕、馬場 理、桑原康秀、尾野 亘
  • Organizer: 学術領域研究 転写代謝システム 新学術領域若手ワークショップ
  • Place of Presentation: 伊香保
  • Year and Date: 2015-02-06 – 2015-02-07
• [Presentation] マイクロRNA-33の骨髄機能および慢性炎症における役割 (2015)
  • Author(s): 馬場理、堀江貴裕、伯野大彦、中島康弘、桑原康秀、中尾哲史、出原正康、宇佐美俊輔、西賀雅隆、西野共達、井手裕也、中関典子、小山智史、木村 剛、尾野 亘
  • Organizer: 学術領域研究 転写代謝システム 新学術領域若手ワークショップ
  • Place of Presentation: 伊香保
  • Year and Date: 2015-02-06 – 2015-02-07
• [Presentation] Microrna-33, Located Within Srebf2 Intron, Regulate Fatty Acid Synthesis via Targeting SREBP-1 in vivo (2014)
  • Author(s): Nishino T, Horie T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Ide Y, Nakazeki F, Koyama S, Yokode M, Kita T, Kimura T, Ono K.
  • Organizer: American Heart Association Annual Scientific Sessions 2014
  • Place of Presentation: Chicago
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] MicroRNA-33b Knock-in Mice for an Intron of Sterol Regulatory Element-Binding Factor 1 (Srebf1) Exhibit Reduced HDL-C in vivo (2014)
  • Author(s): Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Ide Y, Nakazeki F, Koyama S, Yokode M, Kita T, Kimura T, Ono K.
  • Organizer: American Heart Association Annual Scientific Sessions 2014
  • Place of Presentation: Chicago
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Self-rating Depression Scale Score as an Inverse and Independent Predictor of Successful Smoking Cessation with a Pharmacological Treatment for Nicotine Addiction (2014)
  • Author(s): Wada H, Satoh-Asahara N, Akao M, Abe M, Ono K, Morimoto M, Shimatsu A, Takahashi Y, Hasegawa K.
  • Organizer: American Heart Association Annual Scientific Sessions 2014
  • Place of Presentation: Chicago
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] MicroRNA-451 is involved in diabetic cardiomyopathy through suppression of the LKB1/AMPK pathway. (2014)
  • Author(s): Kuwabara Y, Horie T, Baba O, Nishiga M, Usami S, Izuhara M, Nakao T, Nishino T, Kita T, Kimura T, Ono K.
  • Organizer: 9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress
  • Place of Presentation: Kyoto
  • Year and Date: 2014-09-12 – 2014-09-14
• [Presentation] Serum HDL-C decreases in microRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1). (2014)
  • Author(s): Horie T, Nishino T, Baba O, Kuwabara Y, Nakano T, Nishiga M, Usami S, Izuhara M, Kimura T, Ono K.
  • Organizer: 9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress
  • Place of Presentation: Kyoto
  • Year and Date: 2014-09-12 – 2014-09-14
• [Presentation] MicroRNA-33 deficiency reduces atherosclerotic plaque progression in apoE knockout mice. (2014)
  • Author(s): Baba O, Horie T, Ono K, Kuwabara Y, Sowa N, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T.
  • Organizer: 9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress
  • Place of Presentation: Kyoto
  • Year and Date: 2014-09-12 – 2014-09-14
• [Presentation] MicroRNA-33, embedded in Srebf2 intron, regulate fatty acid synthesis through targeting SREBP-1 in vivo. (2014)
  • Author(s): Nishino T, Horie T, Baba O, Kuwabara Y, YOkode M, Kita T, Kimura T, Ono K. MicroRNA-33, embedded in Srebf2 intron, regulate fatty acid synthesis through targeting SREBP-1 in vivo.
  • Organizer: 9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress
  • Place of Presentation: Kyoto
  • Year and Date: 2014-09-12 – 2014-09-14
• [Presentation] MicroRNA-33 deficiency leads to high fat diet- induced obesity and insulin resistance in vivo. (2014)
  • Author(s): Horie T, Nishino T, Baba O, Kuwabara Y, Nakano T, Nishiga M, Usami S, Izuhara M, Kimura T, Ono K.
  • Organizer: European Society of Cardiology Congress 2014
  • Place of Presentation: Barcerona
  • Year and Date: 2014-08-30 – 2014-09-04
• [Presentation] MicroRNA-33, embedded in Srebf2 intron, regulate fatty acid synthesis through targeting SREBP-1 in vivo. (2014)
  • Author(s): Nishino T, Horie T, Baba O, Kuwabara Y, YOkode M, Kita T, Kimura T, Ono K.
  • Organizer: European Society of Cardiology Congress 2014
  • Place of Presentation: Barcerona
  • Year and Date: 2014-08-30 – 2014-09-04
• [Presentation] microRNA-33の動脈硬化・脂質制御における役割 (2014)
  • Author(s): 尾野 亘
  • Organizer: 第46回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-07-10
  • Invited
• [Presentation] High impact of microRNA-33 on atherosclerosis and lipid metabolism (2014)
  • Author(s): 尾野 亘
  • Organizer: 第46回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-07-10
  • Invited
• [Presentation] MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein-2 (Srebp2) regulates Srebp1 in vivo (2014)
  • Author(s): Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Sowa N, Yahagi N, Shimano H, Hasegawa K, Kume N Yokode M, Kita T, Kimura T, Ono K.
  • Organizer: The 18th International Vascular Biology Meeting
  • Place of Presentation: Kyoto
  • Year and Date: 2014-04-14
• [Presentation] MicroRNA-33 deficiency reduces atherosclerotic plaque progression in apoE knockout mice. (2014)
  • Author(s): Baba O, Horie T, Kuwabara Y, Chujo Y, Watanabe S, Kinoshita M, Horiguchi M, Nakamura T, Chonabayashi K, Hishizawa M, Hasegawa K, Kume N Yokode M, Kita T, Kimura T, Ono K.
  • Organizer: The 18th International Vascular Biology Meeting
  • Place of Presentation: Kyoto
  • Year and Date: 2014-04-14
• [Presentation] SREBP-2のイントロンに存在するマイクロRNA-33はSREBP-1の発現を制御する (2014)
  • Author(s): 堀江貴裕
  • Organizer: 第51回日本臨床分子医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-11
• [Presentation] microRNA-451はLKB1-AMPK経路を抑制することで、ラット心筋細胞において細胞障害を、生体においては高脂肪食誘導性心肥大を誘導する (2014)
  • Author(s): 桑原康秀
  • Organizer: 第51回日本臨床分子医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-11
• [Presentation] アポE欠損マウスにおいてマイクロRNA-33欠損は動脈硬化進展を抑制する (2014)
  • Author(s): 馬場 理
  • Organizer: 第51回日本臨床分子医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-11
• [Book] microRNAと生活習慣病 (2016)
  • Author(s): 尾野 亘
  • Publisher: 科学評論社
• [Book] 循環器領域におけるマイクロRNAの重要性 (2016)
  • Author(s): 尾野 亘
  • Publisher: メディカルレビュー社
• [Book] miRs（miR-33a, 185）から見えるsterol regulationの新たな視点 (2016)
  • Author(s): 尾野 亘
  • Publisher: 北隆館
• [Book] ｢生活習慣病とmiRNA｣ 実験医学 ノンコーディングRNAテキストブック (2015)
  • Author(s): 尾野 亘
  • Total Pages: 251
  • Publisher: 羊土社
• [Remarks] 心血管疾患分子機構解明グループ
  • URL: http://kyoto-u-cardio.jp/kisokenkyu/metabolic/
• [Remarks] 京都大学循環器内科
  • URL: http://kyoto-u-cardio.jp/
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  • URL: http://kyoto-u-cardio.jp/kisokenkyu/metabolic/
• [Patent(Industrial Property Rights)] miR-33bノックインマウスによる非アルコール性脂肪肝炎モデル (2017)
  • Inventor(s): 尾野 亘、堀江貴裕、西野共達
  • Industrial Property Rights Holder: 尾野 亘、堀江貴裕、西野共達
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2017-059580
  • Filing Date: 2017-03-24
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  • Inventor(s): 尾野 亘、斉藤成達、出原正康、木村 剛
  • Industrial Property Rights Holder: 尾野 亘、斉藤成達、出原正康、木村 剛
  • Industrial Property Rights Type: 特許
  • Filing Date: 2016-09-05
• [Patent(Industrial Property Rights)] マイクロＲＮＡ溶出型ステント及びそれを用いた管腔治療 (2015)
  • Inventor(s): 尾野 亘、齋藤成達、出原正康、木村 剛
  • Industrial Property Rights Holder: 尾野 亘、齋藤成達、出原正康、木村 剛
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-03-06
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