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Hologenome analysis for elucidation of the pathogenesis and identification of the therapeutic target of IgA nephropathy

Research Project

Project/Area Number 26293201
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionNiigata University

Principal Investigator

Narita Ichiei  新潟大学, 医歯学系, 教授 (20272817)

Co-Investigator(Kenkyū-buntansha) 後藤 眞  新潟大学, 医歯学系, 准教授 (00463969)
山本 卓  新潟大学, 医歯学総合病院, 准教授 (70444156)
金子 佳賢  新潟大学, 医歯学系, 講師 (80444157)
Co-Investigator(Renkei-kenkyūsha) YAMAMOTO Tadashi  新潟大学, 大学院医歯学総合研究科, 客員研究員 (30092737)
Research Collaborator YAMAGUCHI Hiroki  
WATANABE Hirohumi  
TUCHIDA Masahumi  
CHO Takamasa  
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
KeywordsIgA腎症 / ゲノム解析 / 家族性IgA腎症 / エクソーム解析 / メタゲノム解析 / プロテオミクス解析 / 糸球体腎炎 / エクソーム / メタゲノム / プロテオーム / エピゲノム / ゲノム / 口蓋扁桃 / マイクロバイオーム解析 / 扁桃 / 次世代シークエンサー
Outline of Final Research Achievements

To elucidate the etiology of IgA nephropathy, we tried to clarify the functional abnormality and disease process by analyzing simultaneously the host genomics, metagenomics of tonsils, and glomerular proteomics of samples from patients with IgAN. We observed the up-regulation of APRIL and production of galactose-deficient IgA1 (GdIgA1) in the tonsils, which was well correlated with the amount of deposition of GdIgA1 in the glomerulus. The possible involvement of periodontal anaerobic bacilli was suggested by IgA-Seq analysis of tonsils from the patients. The high activity of biosynthesis, TCA cycle, and carbon metabolism, whereas reduced activity of cytoskeleton structure of podocyte, were revealed by glomerular proteomics.
Genome analyses of both isolated and familial cases indicated that the abnormality in natural innate immunity and antigen presentation may be involved in the initiation of the IgA nephropathy.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (55 results)

All 2018 2017 2016 2015 2014

All Journal Article (19 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 19 results,  Open Access: 9 results,  Acknowledgement Compliant: 5 results) Presentation (22 results) (of which Int'l Joint Research: 11 results,  Invited: 5 results) Book (14 results)

  • [Journal Article] Attenuated Macrophage Infiltration in Glomeruli of Aged Mice Resulting in Ameliorated Kidney Injury in Nephrotoxic Serum Nephritis2018

    • Author(s)
      Kaneko Y, Cho T, Sato Y, Goto K, Yamamoto S, Goto S, Madaio MP, Narita I.
    • Journal Title

      J Gerontol A Biol Sci Med Sci

      Volume: in press Issue: 9 Pages: 1178-1186

    • DOI

      10.1093/gerona/gly019

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association of dipstick hematuria with all-cause mortality in the general population: results from the specific health check and guidance program in Japan2018

    • Author(s)
      Iseki K, Konta T, Asahi K, Yamagata K, Fujimoto S, Tsuruya K, Narita I, Kasahara M, Shibagaki Y, Moriyama T, Kondo M, Iseki C, Watanabe T
    • Journal Title

      Nephrol Dial Transplant

      Volume: 33 Issue: 5 Pages: 825-832

    • DOI

      10.1093/ndt/gfx213

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tubulointerstitial Nephritis with IgM-Positive Plasma Cells.2017

    • Author(s)
      Takahashi N, Kimura H et al
    • Journal Title

      J Am Soc Nephrol.

      Volume: 28 Issue: 12 Pages: 3688-3698

    • DOI

      10.1681/asn.2016101074

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Megalin Blockade with Cilastatin Suppresses Drug-Induced Nephrotoxicity2017

    • Author(s)
      Hori Y, Aoki N, Kuwahara S, Hosojima M, Kaseda R, Goto S, Iida T, De S, Kabasawa H, Kaneko R, Aoki H, Tanabe Y, Kagamu H, Narita I, Kikuchi T, Saito A.
    • Journal Title

      J Am Soc Nephrol

      Volume: in press Issue: 6 Pages: 1783-1791

    • DOI

      10.1681/asn.2016060606

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exocytosis-Mediated Urinary Full-Length Megalin Excretion is Linked with the Pathogenesis of Diabetic Nephropathy2017

    • Author(s)
      De S, Kuwahara S, Hosojima M, Ishikawa T, Kaseda R, Sarkar P, Yoshioka Y, Kabasawa H, Iida T, Goto S, Toba K, Higuchi Y, Suzuki Y, Hara M, Kurosawa H, Narita I, Hirayama Y, Ochiya T, Saito A
    • Journal Title

      Diabetes

      Volume: in press Issue: 5 Pages: 1391-1404

    • DOI

      10.2337/db16-1031

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prolactin up-regulates female-predominant Cyp gene expressions and down-regulates male-predominant gene expressions in mice liver2017

    • Author(s)
      Sato Y, Kaneko Y, Cho T, Goto K, Otsuka T, Yamamoto S, Goto S, Maruyama H, Narita I.
    • Journal Title

      Drug Metab Dispos

      Volume: in press Issue: 6 Pages: 586-592

    • DOI

      10.1124/dmd.116.074658

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Oral pharmacological chaperone migalastat compared with enzyme replacement therapy in Fabry disease: 18-month results from the randomised phase III ATTRACT study2017

    • Author(s)
      Hughes DA, Nicholls K, Shankar SP, Ohashi T, Olivotto I, Sakai N, Eyskens F, Germain DP, Goker-Alpan O, Hachulla E, Jovanovic A, Lourenco CM, Narita I, Thomas M,
    • Journal Title

      J Med Genet

      Volume: 54 Issue: 4 Pages: 288-296

    • DOI

      10.1136/jmedgenet-2016-104178

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comprehensive microbiome analysis of tonsillar crypts in IgA nephropathy2017

    • Author(s)
      Watanabe H, Goto S, Mori H, Higashi K, Hosomichi K, Aizawa N, Takahashi N, Tsuchida M, Suzuki Y, Yamada T, Horii A, Inoue I, Kurokawa K, Narita I.
    • Journal Title

      Nephrol Dial Transplant

      Volume: in press Pages: 2072-2079

    • DOI

      10.1093/ndt/gfw343

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Comparison of methods of steroid administration combined with tonsillectomy for IgA nephropathy patients2016

    • Author(s)
      Watanabe H, Goto S, Kondo D, Takata T, Yamazaki H, Hosojima M, Yamamoto S, Kaneko Y, Aoyagi R, Narita I.
    • Journal Title

      Clin Exp Nephrol

      Volume: in press Issue: 2 Pages: 257-265

    • DOI

      10.1007/s10157-016-1282-8

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Megalin-Mediated Tubuloglomerular Alterations in High-Fat Diet-Induced Kidney Disease2016

    • Author(s)
      Kuwahara S, Hosojima M, Kaneko R, Aoki H, Nakano D, Sasagawa T, Kabasawa H, Kaseda R, Yasukawa R, Ishikawa T, Suzuki A, Sato H, Kageyama S, Tanaka T, Kitamura N, Narita I, Komatsu M, Nishiyama A, Saito A
    • Journal Title

      J Am Soc Nephro

      Volume: in press Issue: 7 Pages: 1996-2008

    • DOI

      10.1681/asn.2015020190

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Extracapillary proliferation and arteriolar hyalinosis are associated with long-term kidney survival in IgA nephropathy2016

    • Author(s)
      Kaneko Y, Yoshita K, Kono E, Ito Y, Imai N, Yamamoto S, Goto S, Narita I.
    • Journal Title

      Clin Exp Nephrol

      Volume: in press Issue: 4 Pages: 569-577

    • DOI

      10.1007/s10157-015-1185-0

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High rates of death and hospitalization follow bone fracture among hemodialysis patients2015

    • Author(s)
      Wakasugi M, Kazama JJ, Narita I.
    • Journal Title

      Kidney Int 2014; 86: 649

      Volume: 86 Issue: 3 Pages: 649-649

    • DOI

      10.1038/ki.2014.156

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atherosclerosis following renal injury is ameliorated by pioglitazone and losartan via macrophage phenotype.2015

    • Author(s)
      Yamamoto S, Zhong J, Yancey PG, Zuo Y, Linton MF, Fazio S, Yang H, Narita I, Kon V.
    • Journal Title

      Atherosclerosis

      Volume: 242 Issue: 1 Pages: 56-64

    • DOI

      10.1016/j.atherosclerosis.2015.06.055

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Continuous Reduction of Protein-Bound Uraemic Toxins with Improved Oxidative Stress by Using the Oral Charcoal Adsorbent AST-120 in Haemodialysis Patients.2015

    • Author(s)
      Yamamoto S, Kazama JJ, Omori K, Matsuo K, Takahashi Y, Kawamura K, Matsuto T, Watanabe H, Maruyama T, Narita I.
    • Journal Title

      Sci Rep.

      Volume: N/A Issue: 1 Pages: 14381-14381

    • DOI

      10.1038/srep14381

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Specific overexpression of TNFAIP9 in CD14 CD16 monocytes in patients with rheumatoid arthritis:Comparative analysis with TNFAIP32015

    • Author(s)
      Takai C, Matsumoto I, Inoue A, Umeda N, Tanaka Y, Kurashima Y, Wada Y, Narita I, Sumida T
    • Journal Title

      Clin Exp Immuno

      Volume: 印刷中 Issue: 3 Pages: 458-466

    • DOI

      10.1111/cei.12606

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of the p.E66Q variant of GLA in the progression of chronic kidney disease2014

    • Author(s)
      Watanabe H, Goto S, Miyashita A, Maruyama H, Wakasugi M, Yokoseki A, Kuwano R, Narita I
    • Journal Title

      Clin Exp Nephrol

      Volume: Epub ahead of print Issue: 2 Pages: 225-230

    • DOI

      10.1007/s10157-014-0969-y

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens.2014

    • Author(s)
      Kiryluk K, , Suzuki H, Wyatt RJ, Novak J, Julian BA, Feehally J, Lifton RP, Gharavi AG, et al.
    • Journal Title

      Nat Genet

      Volume: 46 Issue: 11 Pages: 1187-1196

    • DOI

      10.1038/ng.3118

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A hip fracture in a dialysis patient with Abeta2M amyloidosis2014

    • Author(s)
      Kazama JJ, Yamamoto S, Wakasugi M, Narita I
    • Journal Title

      Kidney International

      Volume: 85 Issue: 1 Pages: 214-215

    • DOI

      10.1038/ki.2013.412

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of prolactin receptor in proximal tubular cells was induced in cardiac dysfunction model mice.2014

    • Author(s)
      Tsuchida Y, Kaneko Y, Otsuka T, Goto K, Saito A, Yamamoto K, Yamamoto T, Narita I
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 18 Issue: 1 Pages: 65-74

    • DOI

      10.1007/s10157-013-0820-x

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] Renin-angiotensin system inhibition ameliorates bone fragility due to altered material properties in uremic rats with secondary hyperparathyroidism2017

    • Author(s)
      Yamamoto S, Wakamatsu T, Iwasaki Y, Ito A, Narita I, Fukagawa M, Kazama J
    • Organizer
      American Society for Bone and Mineral Research
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Are RAASi Underused in Moderate to Advanced CKD? Early Findings from CKDopps2017

    • Author(s)
      Filho RP, Tu R, Zee J, Zepel L, Bieber B, Wong MM, Port KF, Combe C, Fliser D, Sesso R, Narita I, Robinson BM, Massy Z.
    • Organizer
      American Society of Nephrology Kidney Week 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Proteomics of Glomeruli with IgA Nephropathy Reveals the Concomitant Abnormalities of Cytoskeleton in the Podocytes2017

    • Author(s)
      Yamaguchi H, Goto S, Hirao Y, Xu B, Yamamoto K, Yamamoto S, Kaneko Y, Yamamoto T, Narita I
    • Organizer
      American Society of Nephrology Kidney Week 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 新規糖尿病治療薬による腎保護効果2017

    • Author(s)
      細島 康宏、 蒲澤 秀門、 鈴木 芳樹、 成田 一衛
    • Organizer
      第47回日本腎臓学会東部学術大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 難治性腎疾患に関する調査研究班の現況と課題2017

    • Author(s)
      成田 一衛、丸山 彰一、和田 隆志、岡田 浩一、柏原 直樹
    • Organizer
      第6 0 回日本腎臓学会学術総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 家族性IgA腎症候補遺伝子を対象としたレアバリアント関連解析2017

    • Author(s)
      後藤 眞、塚口 裕康、渡辺 博文、土田 雅史、福田 顕弘、藤元 昭一、成田 一衛
    • Organizer
      第6 0 回日本腎臓学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Quantitative Urine Proteomics by SWATH-MS Reflects Intricate Metabolic Processing in Cirrhosis Patients2017

    • Author(s)
      Xu B, Hirao Y, Yamamoto K, Narita I, Yamamoto T
    • Organizer
      American Society of Nephrology Kidney Week 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Two Forms of Urinary Megalin Excretion Are Novel Predictors of the Progression of Early-Stage Diabetic Nephropathy in Type 2 Diabetes Mellitus2016

    • Author(s)
      Iida T, Hosojima M, Kabasawa K, Nakamura K, Kuwahara S, Ishikawa T, Kaseda R, Suzuki Y, Narita I, Saito A.
    • Organizer
      American Society of Nephrology 2016,
    • Place of Presentation
      Convention Center, Chicago, IL, USA
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Protein-Bound Uremic Toxin Adsorption by Hexadecyl-Immobilized Cellulose Beads in Hemodialysis.2016

    • Author(s)
      Yamamoto S, Sato M, Wakamatsu T, Takahashi Y, Iguchi A, Omori K, Suzuki Y, Ei I, Kazama J, Gejyo F, Narita I
    • Organizer
      American Society of Nephrology 2016,
    • Place of Presentation
      Convention Center, Chicago, IL, USA
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Differential Effects of Angiotensin II Receptor Blocker (ARB) versus ACE Inhibitor (ACEI) on HDL Functionality in Patients on Maintenance Hemodialysis (MHD).2016

    • Author(s)
      Kaseda R, Tsuchida Y, Zhong J, Narita I, Ikizler T, Kon V
    • Organizer
      American Society of Nephrology 2016,
    • Place of Presentation
      Convention Center, Chicago, IL, USA
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Renin-Angiotensin System Inhibition Ameliorates Bone Fragility Through Blocking Both Osteocytic and Osteoblastic Actions in Uremic Rats.2016

    • Author(s)
      Wakamatsu T, Iwasaki Y, Yamamoto S, Ito A, Takahashi Y, Gejyo F, Kazaa J, Fukagawa M, Narita I
    • Organizer
      American Society of Nephrology 2016,
    • Place of Presentation
      Convention Center, Chicago, IL, USA
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] シンポジウム)IgA腎症の口蓋扁桃陰窩のマイクロバイオーム解析2016

    • Author(s)
      後藤 眞、渡辺博文、土田雅史、井ノ上逸朗、黒川 顕、成田一衛
    • Organizer
      第59回日本腎臓学会学術総会,
    • Place of Presentation
      パシフィコ横浜、神奈川県、横浜市
    • Year and Date
      2016-06-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Comprehensive Microbiome Analysis of Tonsillar Crypts in IgA Nephropathy2015

    • Author(s)
      Hirofumi Watanabe, Shin Goto, Masafumi Tsuchida, Ichiei Narita
    • Organizer
      American Society of Nephrology Kidney Week 2015
    • Place of Presentation
      Convention Center, San Diego, USA
    • Year and Date
      2015-11-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mechanism of Increased Urinary Full-Length Megalin Excretion in Type 2 Diabetes Mellitus Patients with Nephropathy2015

    • Author(s)
      Shankhajit De, Shoji Kuwahara, Michihiro Hosojima, Tomomi Ishikawa, Ryohei Kaseda, Yusuke Yoshioka, Yoshiki Suzuki, Ichiei Narita, Takahiro Ochiya, Akihiko Saito
    • Organizer
      American Society of Nephrology Kidney Week 2015
    • Place of Presentation
      Convention Center, San Diego, USA
    • Year and Date
      2015-11-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ワークショップ 尿毒素物質の除去と患者予後2015

    • Author(s)
      山本  卓、風間 順一郎、成田 一衛
    • Organizer
      60回日本透析医学会学術集会・総会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2015-06-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 総会長主導企画 IgA腎症の責任遺伝子探索―候補遺伝子解析から疾患感受性は予測可能か―2015

    • Author(s)
      成田 一衛、後藤  眞
    • Organizer
      第58回日本腎臓学会学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県、名古屋市)
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 家族性非典型溶血性尿毒症症候群のエクソーム解析2015

    • Author(s)
      渡辺 博文、後藤 眞、山崎 肇、土田 雅史 、日高 義彦 、渡部 登志雄 、山本 格、成田 一衛
    • Organizer
      第58回日本腎臓学会学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県、名古屋市)
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] Exome Sequencing Identified Novel Mutations of FKRP in Familial Atypical Hemolytic Uremic Syndrome2014

    • Author(s)
      Watanabe H, Goto S, Yamazaki H, Narita I
    • Organizer
      American Society of Nephrology Kidney Week 2014
    • Place of Presentation
      Pennsylvania Convention Center, Philadelphia, PA, USA
    • Year and Date
      2014-11-11 – 2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Leptin Deficiency Inhibits IL-23/Th-17axis and Monocyte Chemoattractant Protein-1 Production in a Murine Model of Nephrotoxic Serum Nephritis2014

    • Author(s)
      Goto K, Kaneko Y, Goto S, Narita I
    • Organizer
      American Society of Nephrology Kidney Week 2014
    • Place of Presentation
      Pennsylvania Convention Center, Philadelphia, PA, USA
    • Year and Date
      2014-11-11 – 2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Pathological Prognosticators and Therapeutic Impact of Tonsillectomy in IgA Nephropathy2014

    • Author(s)
      Kaneko Y, Goto S, Narita I
    • Organizer
      American Society of Nephrology Kidney Week 2014
    • Place of Presentation
      Pennsylvania Convention Center, Philadelphia, PA, USA
    • Year and Date
      2014-11-11 – 2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Continuous Reduction of Protein-bound Uremic Toxins with Improved Oxidative Stress by Oral Charcoal Adsorbent in Maintenance Hemodialysis Patients; an Additional Blood Purification Therapy2014

    • Author(s)
      amamoto S, Omori K, Kawamura K, Maruyama H, Watanabe H, Maruyama T, Kazama J, Narita I
    • Organizer
      American Society of Nephrology Kidney Week 2014
    • Place of Presentation
      Pennsylvania Convention Center, Philadelphia, PA, USA
    • Year and Date
      2014-11-11 – 2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] 公開セッション 薬剤等による腎障害の早期診断法と治療法の開発.2014

    • Author(s)
      成田 一衛
    • Organizer
      第57回日本腎臓学会学術総会
    • Place of Presentation
      パシフィコ横浜、横浜市、神奈川県
    • Year and Date
      2014-07-04 – 2014-07-06
    • Related Report
      2014 Annual Research Report
  • [Book] IgA 腎症の発症因子(遺伝要因) (山縣 邦弘、 南学 正臣 編) 腎疾患・透析最新の治療2017-20192017

    • Author(s)
      後藤 眞、 成田 一衛
    • Total Pages
      392
    • Publisher
      南江堂
    • ISBN
      9784524254217
    • Related Report
      2017 Annual Research Report
  • [Book] IgA腎症と紫斑病性腎炎 (矢﨑義雄) 内科学 第11版2017

    • Author(s)
      成田 一衛
    • Total Pages
      1855
    • Publisher
      朝倉書店
    • ISBN
      9784254322705
    • Related Report
      2017 Annual Research Report
  • [Book] 難治性腎疾患に閏する調査研究班) エビデンスに基づくIgA腎症診療ガイドライン20172017

    • Author(s)
      丸山 彰一、成田 一衛、岡田 浩一 他
    • Total Pages
      130
    • Publisher
      東京医学社
    • ISBN
      9784885632815
    • Related Report
      2017 Annual Research Report
  • [Book] 薬剤性腎障害(DKI)診療Q&A DKI診療ガイドラインを実践するために2017

    • Author(s)
      成田一衛
    • Total Pages
      321
    • Publisher
      診断と治療社
    • ISBN
      9784787822505
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Book] 膜性増殖性糸球体腎炎 (鈴木 洋道) 1336専門家による 私の治療 2017-18年度版2017

    • Author(s)
      佐藤 勇也、成田 一衛
    • Total Pages
      1734
    • Publisher
      日本医事新報社
    • ISBN
      9784784946501
    • Related Report
      2017 Annual Research Report
  • [Book] IgA 腎症の発症因子(遺伝要因): 腎疾患・透析最新の治療2017-20192017

    • Author(s)
      後藤 眞、 成田 一衛
    • Total Pages
      392
    • Publisher
      南江堂
    • Related Report
      2016 Annual Research Report
  • [Book] 薬剤性腎障害に関する最近の話題: Annual Review腎臓 20162016

    • Author(s)
      酒巻 裕一、成田 一衛
    • Total Pages
      205
    • Publisher
      中外医学社・東京
    • Related Report
      2016 Annual Research Report
  • [Book] 透析関連アミロイドーシスの治療 update: 腎と骨~ CKD-MBDの概念から新たな展開へ~2016

    • Author(s)
      山本  卓、成田 一衛
    • Total Pages
      231
    • Publisher
      医薬ジャーナル社・大阪
    • Related Report
      2016 Annual Research Report
  • [Book] Is IgAN a familial or sporadic disease? in Pathogenesis and Treatment in IgA Nephropathy, Tomino Y, ed.2016

    • Author(s)
      Narita I, Kaneko Y, Itho Y, Sakamaki Y, Iguchi S, Yamamoto S, Wakasugi M, Kazama JJ, Goto S.
    • Publisher
      Springer, Tokyo, Japan
    • Related Report
      2015 Annual Research Report
  • [Book] 薬剤性腎障害に関する最近の話題2016

    • Author(s)
      酒巻裕一、成田一衛
    • Total Pages
      205
    • Publisher
      中外医学社
    • Related Report
      2015 Annual Research Report
  • [Book] 腎臓病学におけるゲノミクス 腎臓内科・泌尿器科2015

    • Author(s)
      土田雅史、後藤眞、成田一衛
    • Total Pages
      310
    • Publisher
      科学評論社
    • Related Report
      2015 Annual Research Report
  • [Book] 腎移植後再発性腎炎とそのメカニズム2015

    • Author(s)
      酒巻裕一、成田一衛
    • Total Pages
      194
    • Publisher
      科学評論社
    • Related Report
      2015 Annual Research Report
  • [Book] マイクロバイオーム研究の展望. Annual Review腎臓20142014

    • Author(s)
      渡部博文、後藤眞、成田一衛
    • Total Pages
      230
    • Publisher
      中外医学社
    • Related Report
      2014 Annual Research Report
  • [Book] 腎臓病・高血圧と薬剤 実践Q&A2014

    • Author(s)
      26.河野恵美子、成田一衛
    • Total Pages
      246
    • Publisher
      中外医学社
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2019-03-29  

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