Identification of molecular mechanisms of inter-organ neuronal network in body weight regulation
Project/Area Number |
26293215
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Metabolomics
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Research Institution | Tohoku University |
Principal Investigator |
Yamada Tetsuya 東北大学, 医学系研究科, 准教授 (90400374)
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2017: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
|
Keywords | エネルギー代謝 / 神経 / エネルギー代謝調節 / 臓器間相互作用 / 体重調節 / 自律神経 |
Outline of Final Research Achievements |
We previously demonstrated that afferent neuronal signals are transmitted to the brain according to alterations in fat accumulation in the liver thereby enhancing energy expenditure in brown adipose tissue (BAT). On the other hand, we recently identified a novel positive-feedback system for promoting weight gain by suppressing energy expenditure in BAT when there are sign of energy abundance in the liver. The aim of this study was to detect particular molecule that is responsible for initiating afferent neuronal signal at the liver. A comprehensive screening with mass spectrometry revealed two peptides and one metabolite that could be such candidates, but after further experiments, we found out that neither of them was actually involved in the neuronal network connecting the liver and systemic energy metabolism. These results suggest that substance (s) other than peptides or metabolites might initiate the neural network at the liver.
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Report
(5 results)
Research Products
(38 results)
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[Journal Article] Olfactory receptors are expressed in pancreatic beta-cells and promote glucose-stimulated insulin secretion.2018
Author(s)
Munakata Y, Yamada T, Imai J, Takahashi K, Tsukita S, Shirai Y, Kodama S, Asai Y, Sugisawa T, Chiba Y, Kaneko K, Uno K, Sawada S, Hatakeyama H, Kanzaki M, Miyazaki JI, Oka Y, Katagiri H
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Journal Title
Scientific Reports
Volume: 8
Issue: 1
Pages: 1499-1499
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Neuronal signals regulate obesity induced beta-cell proliferation by FoxM1 dependent mechanism.2017
Author(s)
Yamamoto J, Imai J, Izumi T, Takahashi H, Kawana Y, Takahashi K, Kodama S, Kaneko K, Gao J, Uno K, Sawada S, Asano T, Kalinichenko VV, Susaki EA, Kanzaki M, Ueda HR, Ishigaki Y, Yamada T, Katagiri H
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Journal Title
Nature Communications
Volume: 8
Issue: 1
Pages: 1930-1930
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Effects of the activations of three major hepatic Akt substrates on glucose metabolism in male mice.2017
Author(s)
Sakai G, Inoue I, Suzuki T, Sumita T, Inukai K, Katayama S, Awata T, Yamada T, Asano T, Katagiri H, Noda M, Shimada A, Ono H.
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Journal Title
Endocrinology.
Volume: 158
Issue: 8
Pages: 2659-2671
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Metformin Directly Binds the Alarmin HMGB1 and Inhibits its Proinflammatory Activity.2017
Author(s)
Horiuchi T, Sakata N, Narumi Y, Kimura T, Hayashi T, Nagano K, Liu K, Nishibori M, Tsukita S, Yamada T, Katagiri H, Shirakawa R, Horiuchi H.
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Journal Title
J Biol Chem.
Volume: 印刷中
Issue: 20
Pages: 8436-8446
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Activation of Hypoxia Inducible Factor 1α Subunit Pathway in Steatotic Liver Contributes to Formation of Cholestrol Gallstones.2017
Author(s)
Asai Y, Yamada T, Tsukita S, Takahashi K, Maekawa M, Honma M, Ikeda M, Murakami K, Munakata Y, Shirai Y, Kodama S, Sugisawa T, Chiba Y, Kondo Y, Kaneko K, Uno K, Sawada S, Imai J, Nakamura Y, Yamaguchi H, Tanaka K, Sasano H, Mano N, Ueno Y, Shimosegawa T, Katagiri H
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Journal Title
Gastroenterology
Volume: 印刷中
Issue: 6
Pages: 30012-4
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] ES Stress Protein CHOP Mediates Insulin Resistanse by Modulating Adipose Tissue Macrophage Polarity.2017
Author(s)
Suzuki T, Gao J, Ishigaki Y, Kondo K, Sawada S, Izumi T, Uno K, Kaneko K, Tsukita S, Takahashi K, Asao A, Ishii N, Imai J, Yamada T, Oyadomarai S, Katagiri H
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Journal Title
Cell Rep
Volume: 18
Issue: 8
Pages: 2045-2057
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] MicroRNAs 106b and 222 Improve Hyperglycemia in a Mouse Model of Insulin-Deficient Diabetes via Pancreatic beta-Cell Proliferation.2016
Author(s)
Tsukita S, Yamada T, Takahashi K, Munakata Y, Hosaka S, Takahashi H, Gao J, Shirai Y, Kodama S, Asai Y, Sugisawa T, Chiba Y, Kaneko K, Uno K, Sawada S, Imai J, Katagiri H
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Journal Title
EBioMedicine
Volume: 15
Pages: 163-172
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Dapagliflozin, a sodium-glucose co-transporter 2 inhibitor, acutely reduces energy expenditure in BAT via neural signals in mice.2016
Author(s)
Yumiko Chiba, Tetsuya Yamada, Sohei Tsukita, Kei Takahashi, Yuichiro Munakata, Yuta Shirai, Shinjiro Kodama, Yoichiro Asai, Takashi Sugisawa, Kenji Uno, Shojiro Sawada, Junta Imai, Kazuhiro Nakamura, Hideki Katagiri
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Journal Title
PLOS ONE
Volume: 11
Issue: 3
Pages: e0150756-e0150756
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Maternal dietary imbalance between omega-6 and omega-3 polyunsaturated fatty acids impairs neocortical development via epoxy metabolites.2016
Author(s)
Sakayori N, Kikkawa T, Tokuda H, Kiryu E, Yoshizaki K, Kawashima H, Yamada T, Arai H, Kang JX, Katagiri H, Shibata H, Innis SM, Arita M, Osumi N.
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Journal Title
Stem Cells.
Volume: 34(2)
Issue: 2
Pages: 470-482
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Impacts of the Great East Japan Earthquake on diabetic patients.2015
Author(s)
anaka M, Imai J, Satoh M, Hashimoto T, Izumi T, Sawada S, Uno K, Hasegawa Y, Kaneko K, Yamada T, Ishigaki Y, Imai Y and Katagiri H.
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Journal Title
J Diabetes Invest.
Volume: 印刷中
Issue: 5
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A hepatic amino acid/mTOR/S6K-dependent signalling pathway modulates systemic lipid metabolism via neuronal signals2015
Author(s)
Uno K, Yamada T, Ishigaki Y, Imai J, Hasegawa Y, Sawada S, Kaneko K, Ono H, Asano T, Oka Y, Katagiri H
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Journal Title
Nat Commun
Volume: 6
Issue: 1
Pages: 7940-7940
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Rho-Kinase Inhibition Ameliorates Metabolic Disorders through Activation of AMPK Pathway in Mice2014
Author(s)
Noda K, Nakajima S, Godo S, Saito H, Ikeda S, Shimizu T, Enkhjargal B, Fukumoto Y, Tsukita S, Yamada T, Katagiri H, Shimokawa H.
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Journal Title
PLoS One
Volume: 9(11)
Issue: 11
Pages: e110446-e110446
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Glycemic control in diabetic patients with impaired endogenous insulin secretory capacity is vulnerable after a natural disaster: study of Great East Japan Earthquake2014
Author(s)
Tanaka M, Imai J, Satoh M, Hashimoto T, Izumi T, Sawada S, Uno K, Hasegawa Y, Kaneko K, Yamada T, Ishigaki Y, Imai Y, Katagiri H
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Journal Title
Diabetes Care
Volume: 37(10)
Issue: 10
Pages: e212-e213
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Simultaneous copy number losses within multiple subtelomeric regions in early-onset type 2 diabetes mellitus2014
Author(s)
Kodama S, Yamada T, Imai J, Sawada S, Takahashi K, Tsukita S, Kaneko K, Uno K, Ishigaki Y, Oka Y, Katagiri H
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Journal Title
PLoS One
Volume: 9(4)
Issue: 4
Pages: e88602-e88602
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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