Comprehensive analysis of autophagy in the pathogenesis of diabetes and its complications
| Project/Area Number |
26293217
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KUME Shinji 滋賀医科大学, 内科, 講師 (00452235)
MAEDA Shiro 琉球大学, 医学(系)研究科, 教授 (50314159)
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| Research Collaborator |
YAMAHARA Mako
TAGAWA Atsuko
YOSHIBAYASHI Mamoru
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2017: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Keywords | 糖尿病 / 肥満 / 糖尿病性腎症 / 腎臓 / オートファジー / 内科 / 脳・神経 / 飢餓 / ケトン体 / ケトン産生 |
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| Outline of Final Research Achievements |
Autophagy is an intracellular catabolic process that can maintain cellular homeostasis during several stress conditions such as starvation and mitochondrial oxidative stress. Growing evidences have shown that altered autophagy activity is associated with the pathogenesis of a variety of diseases. The present study revealed that mammalian autophagy is essential for maintaining energy homeostasis via enhancing ketogenesis during starvation, and that diabetes-related dysregulation of autophagy is involved in the pathogenesis of diabetic vascular complications, such as diabetic nephropathy. These observation suggest that autophagy activation should shed a light on therapy for diabetic complications and contribute to health promotion in diabetic patients.
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Report
(5 results)
Research Products
(25 results)
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[Journal Article] Mammalian autophagy is essential for hepatic and renal ketogenesis during starvation.2016
Author(s)
Takagi A, Kume S, Kondo M, Nakazawa J, Chin-Kanasaki M, Araki H, Araki S, Koya D, Haneda M, Chano T, Matsusaka T, Nagao K, Adachi Y, Chan L, Maegawa H, Uzu T.
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Journal Title
Scientific Reports
Volume: 6
Pages: 18944-18944
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Impaired Podocyte Autophagy Exacerbates Proteinuria in Diabetic Nephropathy.2016
Author(s)
Tagawa A, Yasuda M, Kume S, Ymahara K, Nakazawa J, Chin-Kanasaki M, Araki H, Araki SI, Koya D, Asanuma K, Kim EH, Haneda M, Kajiwara N, Hayashi K, Ohashi H, Ugi S, Maegawa H, Uzu T
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Journal Title
Diabetes
Volume: -
Pages: 755-767
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Lamp-2 deficiency prevents high-fat diet-induced obese diabetes via enhancing energy expenditure.2015
Author(s)
Yasuda-Yamahara M, Kume S, Yamahara K, Nakazawa J, Chin-Kanasaki M, Araki H, Araki S, Koya D, Haneda M, Ugi S, Maegawa H, Uzu T.
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Journal Title
Biochem Biophys Res Commun
Volume: 18
Pages: 249-255
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] 糸球体上皮細胞におけるオートファジー不全は糖尿病性腎症における蛋白尿を増悪させる.2015
Author(s)
田川 安都子, 安田 真子, 久米 真司, 中澤 純, 金崎 雅美, 荒木 久澄,荒木 信一, 古家 大祐, 羽田 勝計, 宇津 貴, 前川 聡.
Organizer
第58回日本腎臓学会学術総会
Place of Presentation
愛知県名古屋市
Year and Date
2015-06-05
Related Report
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[Presentation] Podocyte Autophagy is Associated with the Progression of Proteinuria in Diabetic Nephropathy2014
Author(s)
Mako Yasuda, Atsuko Tagawa, Shinji Kume, Yuki Tanaka, Kosuke Yamahara, Hisazumi Araki, Keiji Isshiki, Shin-ichi Araki, Daisuke Koya, Masakazu Haneda, Takashi Uzu, Hiroshi Maegawa
Organizer
American Diabetes Association (ADA) 74th Scientific Sessions
Place of Presentation
サンフランシスコ, アメリカ合衆国
Year and Date
2014-06-13 – 2014-06-17
Related Report
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[Presentation] 糸球体上皮細胞オートファジー不全は糖尿病性腎症における蛋白尿を増悪させる2014
Author(s)
安田 真子, 田川 安都子, 久米 真司, 田中 敬, 金崎 雅美, 荒木 久澄, 一色 啓二, 荒木 信一, 古家 大祐, 羽田 勝計, 柏木 厚典, 宇津 貴, 前川 聡
Organizer
第57回日本糖尿病学会年次学術集会
Place of Presentation
大阪
Year and Date
2014-05-22 – 2014-05-24
Related Report
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