Roles of Pin1 and PAR 14 on the metabolic regulations

• Project/Area Number: 26293219
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Hiroshima University
• Principal Investigator: Asano Tomoichiro 広島大学, その他の研究科, 教授 (70242063)
• Co-Investigator(Kenkyū-buntansha): 中津 祐介 広島大学, 医歯薬保健学研究院(医), 助教 (20452584) ; 福嶋 俊明 広島大学, 医歯薬保健学研究院, 助教 (70543552)
• Co-Investigator(Renkei-kenkyūsha): SAKODA HIDEYUKI 東京大学, 附属病院, 助教 (50376464) ; FUJISHIRO MIDORI 東京大学, 附属病院, 助教 (50420211) ; HONDA HIROAKI 広島大学, 原爆放射線医科学研究所, 教授 (40245064)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000); Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
• Keywords: 代謝 / 糖尿病 / Pin1 / インスリン / プロリン異性化酵素 / メタボリックシンドローム / 肥満 / シグナル伝達 / 肝細胞 / LUBAC / TFG / メタボシックシンドローム / インスリン抵抗性 / インスリン分泌

Outline of Final Research Achievements

Prolyl isomerases are divided into three groups, the FKBP family, Cyclophilin and the Parvulin family (Pin1 and Par14). Pin1 is a unique prolyl isomerase binding to the motif including pSer/pThr-Pro that is phosphorylated by kinases. We have newly demonstrated Pin1 to be involved in regulating glucose and lipid metabolism. Interestingly, while Pin1 expression is markedly increased by high-fat diet feeding, Pin1 KO mice are resistant to diet-induced obesity, non-alcoholic steatohepatitis (NASH) and diabetic vascular dysfunction. These phenomena result from the binding of Pin1 to several key factors regulating metabolic functions, which include insulin receptor substrate-1, AMPK, Crtc2 and NF-kappaB p65.

Research Products

• [Journal Article] USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination (2017)
  • Author(s): Fukushima, T., Yoshihara, H., Furuta, H., Hakuno, F., Saeki, Y., Iemura, SI., Natsume, T., Nakatsu, Y., Kamata, H., Asano, T., Komada, M., Takahashi, SI.
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 484 Pages: 522-528
  • Peer Reviewed / Open Access
• [Journal Article] Reduced SHARPIN and LUBAC Formation May Contribute to CCl4- or Acetaminophen-Induced Liver Cirrhosis in Mice. (2017)
  • Author(s): Yamamotoya, T., Nakatsu, Y., Matsunaga, Y., Fukushima, T., Yamazaki, H., Kaneko, S., Fujishiro, M., Kikuchi, T., Kushiyama, A., Tokunaga, F., Asano, T., Sakoda, H.
  • Journal Title: Int. J. Mol. Sci. Volume: 18 Pages: 326
  • Peer Reviewed / Open Access
• [Journal Article] Role of uric acid metabolism-related inflammation in the pathogenesis of metabolic syndrome components such as atherosclerosis and non-alcoholic steatohepatitis (2016)
  • Author(s): Kushiyama, A., Nakatasu, Y., Matsunaga, Y., Yamamotoya, T., Mori, K., Ueda, K., Sakoda, H., Fujishiro, M., Ono, H., and Asano, T.
  • Journal Title: Mediators Inflamm. Volume: 2016 Pages: 8603164
  • Peer Reviewed / Open Access
• [Journal Article] Involvement of Resistin-like molecule beta in the development of methionine-choline deficient diet-induced non-alcoholic steatohepatitis in mice (2016)
  • Author(s): Okubo H., Kushiyama, A., Sakoda, H., Nakatsu, Y., Iizuka, M., Taki, N., Fujishiro, M., Fukushima, T., Kamata, H., Nagamachi, A., Inaba, T., Nishimura, F., Katagiri, H., Asahara, T., Yoshida, Y., Chonan, O., Encinas, J., and Asano, T.
  • Journal Title: Scientific Reports Volume: 6 Pages: 20157
  • Peer Reviewed / Open Access
• [Journal Article] Physiological and Pathogenic Roles of Prolyl Isomerase Pin1 in Metabolic Regulations via Multiple Signal Transduction Pathway Modulations. (2016)
  • Author(s): Nakatsu, Y., Matsunaga, Y., Yamamotoya, T., Ueda, K., Inoue, Y., Mori, K., Sakoda, H., Fujishiro, M., Ono, H., Kushiyama, A., and Asano, T.
  • Journal Title: Int. J. Mol. Sci. Volume: 17 Pages: E1495
  • Peer Reviewed / Open Access
• [Journal Article] IL-17A synergistically enhances TNFα-induced IL-6 and CCL20 production in 3T3-L1 adipocytes. (2016)
  • Author(s): Shinjo, T., Iwashita, M., Yamashita, A., Sano, T., Tsuruta, M., Matsunaga, H., Sanui, T., Asano, T., and Nishimura, F.
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 477 Pages: 241-6
  • Peer Reviewed / Open Access
• [Journal Article] Treatment with the SGLT2 inhibitor luseogliflozin improves nonalcoholic steatohepatitis in a rodent model with diabetes mellitus. (2015)
  • Author(s): Qiang, S., Nakatsu, Y., Seno, Y., Fujishiro, M., Sakoda, H., Kushiyama, A., Mori, K., Matsunaga, Y., Yamamotoya, T., Kamata, H., and Asano, T.
  • Journal Title: Diabetol. Metab. Syndr. Volume: 7 Pages: 104
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Prolyl Isomerase Pin1 Negatively Regulates AMPK by Associating with the CBS Domain in the γ-subunit. (2015)
  • Author(s): Nakatsu, Y., Iwashita, M., Sakoda, H., Ono, H., Nagata, K., Matsunaga, Y., Fukushima, T., Fujishiro, M., Kushiyama, A., Kamata, H., Takahashi, S., Katagiri, H., Honda, H., Kiyonari, H., Uchida, T., and Asano, T.
  • Journal Title: J. Biol. Chem. Volume: 290 Pages: 24255-24266
  • Peer Reviewed / Open Access
• [Journal Article] A hepatic amino acid/mTOR/S6K-dependent signalling pathway modulates systemic lipid metabolism via neuronal signals. (2015)
  • Author(s): Uno, K., Yamada, T., Ishigaki, Y., Imai, J., Hasegawa, Y., Sawada, S., Kaneko, K., Ono, H., Asano, T., Oka, Y., and Katagiri, H.
  • Journal Title: Nat. Commun. Volume: 6 Pages: 7940
  • Peer Reviewed / Open Access
• [Journal Article] Distinct Time Course of the Decrease in Hepatic AMP-Activated Protein Kinase and Akt Phosphorylation in Mice Fed a High Fat Diet. (2015)
  • Author(s): Shiwa, M., Yoneda, M., Okubo, H., Ohno, H., Kobuke, K., Monzen, Y., Kishimoto, R., Nakatasu, Y., Asano, T., and Kohno, N.
  • Journal Title: PLoS One Volume: 10 Pages: e0135554
  • Peer Reviewed / Open Access
• [Journal Article] LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis. (2015)
  • Author(s): Matsunaga, Y., Nakatsu, Y., Fukushima, T., Okubo, H., Iwashita, M., Sakoda, H., Fujishiro, M., Yamamotoya, T., Kushiyama, A., Takahashi, S., Tsuchiya, Y., Kamata, H., Tokunaga, F., Iwai, K., and Asano, T.
  • Journal Title: Mediators Inflamm. Volume: 12 Pages: 125380
  • Peer Reviewed / Open Access
• [Journal Article] High-fat diet feeding significantly attenuates anagliptin-induced regeneration of islets of Langerhans in streptozotocin-induced diabetic mice. (2015)
  • Author(s): Shinjo, T., Nakatsu, Y., Iwashita, M., Sano, T., Sakoda, H., Ishihara, H., Kushiyama, A., Fujishiro, M., Nishimura, F., and Asano, T.
  • Journal Title: Diabetol. Metab. Syndr. Volume: 7 Pages: 50
  • Peer Reviewed / Open Access
• [Journal Article] Protection from diet-induced obesity and insulin resistance in mice lacking CCL19-CCR7 signaling. (2015)
  • Author(s): Sano, T., Iwashita, M., Nagayasu, S., Yamashita, A., Shinjo, T., Hashikata, A., Asano, T., Kushiyama, A., Ishimaru, N., Takahama, Y., and Nishimura, F.
  • Journal Title: Obesity Volume: 23 Pages: 1460-1471
  • Peer Reviewed / Open Access
• [Journal Article] Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines. (2015)
  • Author(s): Kanaoka, R., Kushiyama, A., Seno, Y., Nakatsu, Y., Matsunaga, Y., Fukushima, T., Tsuchiya, Y., Sakoda, H., Fujishiro, M., Yamamotoya, T., Kamata, H., Matsubara, A., and Asano, T.
  • Journal Title: PLoS One. Volume: 10 Pages: e0127467
  • Peer Reviewed / Open Access
• [Journal Article] DPP-IV inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation. (2015)
  • Author(s): Shinjo, T., Nakatsu, Y., Iwashita, M., Sano, T., Sakoda, H., Ishihara, H., Kushiyama, A., Fujishiro, M., Fukushima, T., Tsuchiya, Y., Kamata, H., Nishimutra, F., and Asano, T.
  • Journal Title: Am. J. Physiol. Endocrinol Metab. Volume: 309 Pages: E214-23
  • Peer Reviewed / Open Access
• [Journal Article] The xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic steatohepatitis in a rodent model. (2015)
  • Author(s): Nakatsu, Y., Seno, Y., Kushiyama, A., Sakoda, H., Fujishiro, M., Katasako, A., Mori, K., Matsunaga, Y., Fukushima, T., Kanaoka, R., Yamamotoya, T., Kamata, H., and Asano, T.
  • Journal Title: Am. J. Physiol. Gastrointest Liver Physiol. Volume: 309 Pages: G42-51
  • Peer Reviewed / Open Access
• [Journal Article] Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity (2015)
  • Author(s): Fukushima, T., Yoshihara, H., furuta, H., Kamei, H., Hakuno, F., Luan, J., Duan, C., Saeki, Y., Tanaka, K., Iemura, S., Natsume, T., Chida, K., Nakatsu, Y., Kamata, H., Asano, T., and Takahashi, S.
  • Journal Title: Nat. Commun. Volume: 6 Pages: 6780
  • Peer Reviewed / Open Access
• [Journal Article] Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model. (2015)
  • Author(s): Okubo, H., Nakatsu, Y., Sakoda, H., Kushiyama, A., Fujishiro, M., Fukushima, T., Matsunaga, Y., Ohno, H., Yoneda, M., Kamata, H., Shinjo, T., Iwashita, M., Nishimura, F., and Asano, T.
  • Journal Title: Am. J. Physiol. Gastrointest Liver Physiol. Volume: 308 Pages: G151-8
  • Peer Reviewed / Open Access
• [Journal Article] Insulin receptor substrate-4 binds to Slingshot-1 phosphatase and promotes cofilin dephosphorylation. (2014)
  • Author(s): Homma, Y., Kanno, S., Sasaki, K., Nishita, M., Yasui, A., Asano, T., Ohashi, K., and Mizuno, K.
  • Journal Title: J. Biol. Chem. Volume: 289 Pages: 26302-13
  • Peer Reviewed
• [Journal Article] A high-throughput screen for inhibitors of the prolyl isomerase, Pin1, identifies a seaweed polyphenol that reduces adipose cell differentiation. (2014)
  • Author(s): Mori, T., Hidaka, M., Ikuji, H., Yoshizawa, I., Toyohara, H., Okuda, T., Uvhida, C., Asano, T., Yotsu-Yamashita, M., and Uchida, T..
  • Journal Title: Biosci. Biotechnol. Biochem. Volume: 78 Pages: 832-8
  • Peer Reviewed
• [Journal Article] Mediobasal hypothalamic PTEN modulates hepatic insulin resistance independently of food intake in rats. (2014)
  • Author(s): Sumita, T., Ono, H., Suzuki, T., Inukai, K., Katagiri, H., Asano, T., Katayama, S., and Awata, T.
  • Journal Title: Am. J. Physiol. Endocrinol Metab. Volume: 307 Pages: E47-60
  • Peer Reviewed
• [Journal Article] Insulin receptor substrate-1 associates with small nucleolar RNA which contributes to ribosome biogenesis. (2014)
  • Author(s): Ozoe, A., Sone, M., Fukushima, T., Kataoka, N., Chida, K., Asano, T., Hakuno, F., and Takahashi, S.
  • Journal Title: Front Endocrinol. Volume: 5 Pages: 1-12
  • Peer Reviewed
• [Journal Article] The inflammation-lipocalin 2 axis may contribute to the development of chronic kidney disease. (2014)
  • Author(s): Hashikata, A., Yamashita, A., Suzuki, S., Nagayasu, S., Shinjo, T., Taniguchi, A., Fukushima, M., Nakai, Y., Nin, K., Watanabe, N., Asano, T., Abiko, Y., Kushiyama, A., Nagasaka, S.,and Nishimura, F.
  • Journal Title: Nephrol. Dial. Transplant. Volume: 29 Pages: 611-8
  • Peer Reviewed
• [Presentation] Pin1を介した熱産生調節機構及び肥満との関係解明 (2016)
  • Author(s): 松永 泰花、中津 祐介、櫛山 暁史、菊池 貴子、山本屋 武、鎌田 英明、浅野 知一郎
  • Organizer: 第59回日本糖尿病学会学術集会
  • Place of Presentation: 国立京都国際会議場
  • Year and Date: 2016-05-20 – 2016-05-21
• [Presentation] Trk-fused gene（TFG）の膵β細胞における役割の解明 (2016)
  • Author(s): 山本屋 武、中津 祐介、迫田 秀之、藤城 緑、山崎 広貴、菊池 貴子、浅野 知一郎、櫛山 暁史
  • Organizer: 第59回日本糖尿病学会学術集会
  • Place of Presentation: 国立京都国際会議場
  • Year and Date: 2016-05-20 – 2016-05-21
• [Presentation] 性ホルモン結合グロブリン（SHBG）による脂肪量減少効果と抗炎症効果 (2016)
  • Author(s): 山崎 広貴、櫛山 暁史、迫田 秀之、藤城 緑、山本屋 武、菊池 貴子、金子 直、浅野 知一郎
  • Organizer: 第59回日本糖尿病学会学術集会
  • Place of Presentation: 国立京都国際会議場
  • Year and Date: 2016-05-20 – 2016-05-21
• [Presentation] プロリン異性化酵素Pin1を介した膵β細胞調節機構の解明 (2016)
  • Author(s): 中津 祐介、森 馨一、松永 泰花、山本屋 武、藤城 緑、石原 寿光、浅野 知一郎
  • Organizer: 第59回日本糖尿病学会学術集会
  • Place of Presentation: 国立京都国際会議場
  • Year and Date: 2016-05-20 – 2016-05-21
• [Presentation] 肝外キサンチンオキシダーゼのインスリン抵抗性への関与 (2016)
  • Author(s): 櫛山 暁史、菊池 貴子、山崎 広貴、迫田 秀之、藤城 緑、浅野 知一郎、岩本 安彦
  • Organizer: 第59回日本糖尿病学会学術集会
  • Place of Presentation: 国立京都国際会議場
  • Year and Date: 2016-05-20 – 2016-05-21
• [Presentation] DPP-4阻害薬による抗炎症効果 (2015)
  • Author(s): 浅野知一郎
  • Organizer: 第53回日本糖尿病学会九州地方会
  • Place of Presentation: 福岡
  • Year and Date: 2015-11-27 – 2015-11-27
  • Invited
• [Presentation] マクロファージにおける糖代謝による活性酸素産生とインスリン抵抗性 (2015)
  • Author(s): 櫛山暁史、菊池貴子、迫田秀之、藤城緑、山本屋武、山崎広貴、中津祐介、浅野知一郎、河津捷二
  • Organizer: 第５８回日本糖尿病学会年次学術集会
  • Place of Presentation: 下関
  • Year and Date: 2015-05-21 – 2015-05-24
• [Presentation] 高脂肪食負荷による近位筋優位遺伝性運動感覚ニューロパチー原因遺伝子TFGの発現低下とその病的意義 (2015)
  • Author(s): 浅野知一郎、松永泰花、迫田秀之、櫛山暁史、藤城緑、山本屋武、鎌田英明、小野啓、中津祐介
  • Organizer: 第５８回日本糖尿病学会年次学術集会
  • Place of Presentation: 下関
  • Year and Date: 2015-05-21 – 2015-05-24
• [Presentation] 性ホルモン結合グルブリン(SHBG)の代謝への影響の検討 (2015)
  • Author(s): 山崎広貴、櫛山暁史、迫田秀之、藤城緑、山本屋武、菊池貴子、金子直、浅野知一郎
  • Organizer: 第５８回日本糖尿病学会年次学術集会
  • Place of Presentation: 下関
  • Year and Date: 2015-05-21 – 2015-05-24
• [Presentation] DPP4阻害薬anagliptineはLPS投与マウスの肝臓・脂肪組織における炎症反応を抑制する (2015)
  • Author(s): 新城尊徳、岩下未咲、中津祐介、鎌田英明、迫田秀之、藤城緑、櫛山暁史、浅野知一郎、西村英紀
  • Organizer: 第５８回日本糖尿病学会年次学術集会
  • Place of Presentation: 下関
  • Year and Date: 2015-05-21 – 2015-05-24
• [Presentation] 膵β細胞機能におけるプロリン異性化酵素Pin1の役割 (2015)
  • Author(s): 中津祐介、森馨一、松永泰花、山本屋武、迫田秀之、藤城緑、櫛山暁史、石原寿光、浅野知一郎
  • Organizer: 第５８回日本糖尿病学会年次学術集会
  • Place of Presentation: 下関
  • Year and Date: 2015-05-21 – 2015-05-24
• [Presentation] 肝臓におけるLUBAC(linear ubiquitin assembly complex)活性低下はAkt-mTOR経路の亢進および肝での炎症を惹起する (2015)
  • Author(s): 山本屋武、迫田秀之、藤城緑、山崎広貴、金子直、菊池貴子、櫛山暁史、浅野知一郎
  • Organizer: 第５８回日本糖尿病学会年次学術集会
  • Place of Presentation: 下関
  • Year and Date: 2015-05-21 – 2015-05-24
• [Presentation] SGLT2阻害薬ルセオグリフロジンによる非アルコール性脂肪性肝炎の改善作用 (2015)
  • Author(s): 藤城緑、中津祐介、迫田秀之、櫛山暁史、松永泰花、山本屋武、鎌田英明、浅野知一郎
  • Organizer: 第５８回日本糖尿病学会年次学術集会
  • Place of Presentation: 下関
  • Year and Date: 2015-05-21 – 2015-05-24
• [Presentation] キサンチンオキシダーゼ阻害剤FebuxostatによるNASH改善作用の検討 (2015)
  • Author(s): 松永泰花、中津祐介、迫田秀之、櫛山暁史、藤城緑、山本屋武、鎌田英明、新城尊徳、岩下未咲、西村英紀、小野啓、浅野知一郎
  • Organizer: 第５８回日本糖尿病学会年次学術集会
  • Place of Presentation: 下関
  • Year and Date: 2015-05-21 – 2015-05-24
• [Presentation] 膵β細胞からのインスリン分泌におけるプロリン異性化酵素Pin1の役割 (2014)
  • Author(s): 浅野知一郎、松永泰花、福嶋俊明、山崎広貴、山本屋武、櫛山暁史、中津祐介
  • Organizer: 第５７回日本糖尿病学会
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-22 – 2014-05-24
• [Presentation] キサンチンオキシダーゼ阻害剤FebuxostatによるNASH改善作用の検討 (2014)
  • Author(s): 藤城緑、中津祐介、福嶋俊明、松永泰花、迫田秀之、櫛山暁史、山本屋武、西村英紀、浅野知一郎
  • Organizer: 第５７回日本糖尿病学会
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-22 – 2014-05-24
• [Presentation] LUBAC (linear ubiquitin chain assembly complex)のインスリンシグナル伝達系における役割の検討 (2014)
  • Author(s): 山本屋武、迫田秀之、藤城緑、山崎広貴、菊池貴子、櫛山暁史、浅野知一郎
  • Organizer: 第５７回日本糖尿病学会
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-22 – 2014-05-24
• [Presentation] マクロファージresistin like molecule βによるインスリン抵抗性・動脈硬化発症の機序 (2014)
  • Author(s): 櫛山暁史、菊池貴子、迫田秀之、藤城緑、山崎広貴、山本屋武、大久保博史、中津祐介、河津捷二、浅野知一郎
  • Organizer: 第５７回日本糖尿病学会
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-22 – 2014-05-24
• [Presentation] CC7経路が肥満およびインスリン抵抗性に及ぼす影響に関する検討 (2014)
  • Author(s): 岩下未咲、佐野朋美、新城尊徳、箸方厚之、浅野知一郎、西村英紀
  • Organizer: 第５７回日本糖尿病学会
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-22 – 2014-05-24
• [Presentation] DPP4阻害薬anagliptinは、活性化マクロファージおよびマクロファージ共培養下脂肪細胞の炎症反応を抑制する (2014)
  • Author(s): 新城尊徳、岩下未咲、中津祐介、迫田秀之、藤城緑、櫛山暁史、鎌田英明、西村英紀、浅野知一郎
  • Organizer: 第５７回日本糖尿病学会
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-22 – 2014-05-24
• [Presentation] Pin1阻害薬Jugloneを用いたNASH治療効果の検討 (2014)
  • Author(s): 山崎広貴、中津祐介、鎌田英明、西村英紀、菊池貴子、藤城緑、迫田秀之、浅野知一郎
  • Organizer: 第５７回日本糖尿病学会
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-22 – 2014-05-24
• [Presentation] プロリン異性化酵素Pin1はAMPKγ subunitに結合し、活性を抑制する (2014)
  • Author(s): 中津祐介、岩下未咲、福嶋俊明、菊池貴子、櫛山暁史、迫田秀之、浅野知一郎
  • Organizer: 第５７回日本糖尿病学会
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-22 – 2014-05-24
• [Presentation] 非アルコール性脂肪性肝炎発症におけるLUBAC形成障害の役割 (2014)
  • Author(s): 松永泰花、中津祐介、鎌田英明、福嶋俊明、岩下未咲、新城尊徳、菊池貴子、藤城緑、浅野知一郎
  • Organizer: 第５７回日本糖尿病学会
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-22 – 2014-05-24
• [Book] SGLT2阻害薬のすべて (2014)
  • Author(s): 浅野 知一郎、中津 祐介
  • Total Pages: 200
  • Publisher: 先端医学社
• [Patent(Industrial Property Rights)] Pin1 阻害薬を用いた炎症性腸疾患の治療または予防方法 (2014)
  • Inventor(s): 浅野知一郎、中津祐介
  • Industrial Property Rights Holder: 浅野知一郎、中津祐介
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2014-220655
  • Filing Date: 2014-10-29