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Roles of Pin1 and PAR 14 on the metabolic regulations

Research Project

Project/Area Number 26293219
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Metabolomics
Research InstitutionHiroshima University

Principal Investigator

Asano Tomoichiro  広島大学, その他の研究科, 教授 (70242063)

Co-Investigator(Kenkyū-buntansha) 中津 祐介  広島大学, 医歯薬保健学研究院(医), 助教 (20452584)
福嶋 俊明  広島大学, 医歯薬保健学研究院, 助教 (70543552)
Co-Investigator(Renkei-kenkyūsha) SAKODA HIDEYUKI  東京大学, 附属病院, 助教 (50376464)
FUJISHIRO MIDORI  東京大学, 附属病院, 助教 (50420211)
HONDA HIROAKI  広島大学, 原爆放射線医科学研究所, 教授 (40245064)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Keywords代謝 / 糖尿病 / Pin1 / インスリン / プロリン異性化酵素 / メタボリックシンドローム / 肥満 / シグナル伝達 / 肝細胞 / LUBAC / TFG / メタボシックシンドローム / インスリン抵抗性 / インスリン分泌
Outline of Final Research Achievements

Prolyl isomerases are divided into three groups, the FKBP family, Cyclophilin and the Parvulin family (Pin1 and Par14). Pin1 is a unique prolyl isomerase binding to the motif including pSer/pThr-Pro that is phosphorylated by kinases. We have newly demonstrated Pin1 to be involved in regulating glucose and lipid metabolism. Interestingly, while Pin1 expression is markedly increased by high-fat diet feeding, Pin1 KO mice are resistant to diet-induced obesity, non-alcoholic steatohepatitis (NASH) and diabetic vascular dysfunction. These phenomena result from the binding of Pin1 to several key factors regulating metabolic functions, which include insulin receptor substrate-1, AMPK, Crtc2 and NF-kappaB p65.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (48 results)

All 2017 2016 2015 2014

All Journal Article (23 results) (of which Peer Reviewed: 23 results,  Open Access: 18 results,  Acknowledgement Compliant: 1 results) Presentation (23 results) (of which Invited: 1 results) Book (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination2017

    • Author(s)
      Fukushima, T., Yoshihara, H., Furuta, H., Hakuno, F., Saeki, Y., Iemura, SI., Natsume, T., Nakatsu, Y., Kamata, H., Asano, T., Komada, M., Takahashi, SI.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 484 Pages: 522-528

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reduced SHARPIN and LUBAC Formation May Contribute to CCl4- or Acetaminophen-Induced Liver Cirrhosis in Mice.2017

    • Author(s)
      Yamamotoya, T., Nakatsu, Y., Matsunaga, Y., Fukushima, T., Yamazaki, H., Kaneko, S., Fujishiro, M., Kikuchi, T., Kushiyama, A., Tokunaga, F., Asano, T., Sakoda, H.
    • Journal Title

      Int. J. Mol. Sci.

      Volume: 18 Pages: 326-326

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of uric acid metabolism-related inflammation in the pathogenesis of metabolic syndrome components such as atherosclerosis and non-alcoholic steatohepatitis2016

    • Author(s)
      Kushiyama, A., Nakatasu, Y., Matsunaga, Y., Yamamotoya, T., Mori, K., Ueda, K., Sakoda, H., Fujishiro, M., Ono, H., and Asano, T.
    • Journal Title

      Mediators Inflamm.

      Volume: 2016 Pages: 8603164-8603164

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of Resistin-like molecule beta in the development of methionine-choline deficient diet-induced non-alcoholic steatohepatitis in mice2016

    • Author(s)
      Okubo H., Kushiyama, A., Sakoda, H., Nakatsu, Y., Iizuka, M., Taki, N., Fujishiro, M., Fukushima, T., Kamata, H., Nagamachi, A., Inaba, T., Nishimura, F., Katagiri, H., Asahara, T., Yoshida, Y., Chonan, O., Encinas, J., and Asano, T.
    • Journal Title

      Scientific Reports

      Volume: 6 Pages: 20157-20157

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Physiological and Pathogenic Roles of Prolyl Isomerase Pin1 in Metabolic Regulations via Multiple Signal Transduction Pathway Modulations.2016

    • Author(s)
      Nakatsu, Y., Matsunaga, Y., Yamamotoya, T., Ueda, K., Inoue, Y., Mori, K., Sakoda, H., Fujishiro, M., Ono, H., Kushiyama, A., and Asano, T.
    • Journal Title

      Int. J. Mol. Sci.

      Volume: 17

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] IL-17A synergistically enhances TNFα-induced IL-6 and CCL20 production in 3T3-L1 adipocytes.2016

    • Author(s)
      Shinjo, T., Iwashita, M., Yamashita, A., Sano, T., Tsuruta, M., Matsunaga, H., Sanui, T., Asano, T., and Nishimura, F.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 477 Pages: 241-6

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Treatment with the SGLT2 inhibitor luseogliflozin improves nonalcoholic steatohepatitis in a rodent model with diabetes mellitus.2015

    • Author(s)
      Qiang, S., Nakatsu, Y., Seno, Y., Fujishiro, M., Sakoda, H., Kushiyama, A., Mori, K., Matsunaga, Y., Yamamotoya, T., Kamata, H., and Asano, T.
    • Journal Title

      Diabetol. Metab. Syndr.

      Volume: 7 Pages: 104-104

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prolyl Isomerase Pin1 Negatively Regulates AMPK by Associating with the CBS Domain in the γ-subunit.2015

    • Author(s)
      Nakatsu, Y., Iwashita, M., Sakoda, H., Ono, H., Nagata, K., Matsunaga, Y., Fukushima, T., Fujishiro, M., Kushiyama, A., Kamata, H., Takahashi, S., Katagiri, H., Honda, H., Kiyonari, H., Uchida, T., and Asano, T.
    • Journal Title

      J. Biol. Chem.

      Volume: 290 Pages: 24255-24266

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A hepatic amino acid/mTOR/S6K-dependent signalling pathway modulates systemic lipid metabolism via neuronal signals.2015

    • Author(s)
      Uno, K., Yamada, T., Ishigaki, Y., Imai, J., Hasegawa, Y., Sawada, S., Kaneko, K., Ono, H., Asano, T., Oka, Y., and Katagiri, H.
    • Journal Title

      Nat. Commun.

      Volume: 6 Pages: 7940-7940

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distinct Time Course of the Decrease in Hepatic AMP-Activated Protein Kinase and Akt Phosphorylation in Mice Fed a High Fat Diet.2015

    • Author(s)
      Shiwa, M., Yoneda, M., Okubo, H., Ohno, H., Kobuke, K., Monzen, Y., Kishimoto, R., Nakatasu, Y., Asano, T., and Kohno, N.
    • Journal Title

      PLoS One

      Volume: 10

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis.2015

    • Author(s)
      Matsunaga, Y., Nakatsu, Y., Fukushima, T., Okubo, H., Iwashita, M., Sakoda, H., Fujishiro, M., Yamamotoya, T., Kushiyama, A., Takahashi, S., Tsuchiya, Y., Kamata, H., Tokunaga, F., Iwai, K., and Asano, T.
    • Journal Title

      Mediators Inflamm.

      Volume: 12 Pages: 125380-125380

    • NAID

      120005745641

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High-fat diet feeding significantly attenuates anagliptin-induced regeneration of islets of Langerhans in streptozotocin-induced diabetic mice.2015

    • Author(s)
      Shinjo, T., Nakatsu, Y., Iwashita, M., Sano, T., Sakoda, H., Ishihara, H., Kushiyama, A., Fujishiro, M., Nishimura, F., and Asano, T.
    • Journal Title

      Diabetol. Metab. Syndr.

      Volume: 7 Pages: 50-50

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protection from diet-induced obesity and insulin resistance in mice lacking CCL19-CCR7 signaling.2015

    • Author(s)
      Sano, T., Iwashita, M., Nagayasu, S., Yamashita, A., Shinjo, T., Hashikata, A., Asano, T., Kushiyama, A., Ishimaru, N., Takahama, Y., and Nishimura, F.
    • Journal Title

      Obesity

      Volume: 23 Pages: 1460-1471

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines.2015

    • Author(s)
      Kanaoka, R., Kushiyama, A., Seno, Y., Nakatsu, Y., Matsunaga, Y., Fukushima, T., Tsuchiya, Y., Sakoda, H., Fujishiro, M., Yamamotoya, T., Kamata, H., Matsubara, A., and Asano, T.
    • Journal Title

      PLoS One.

      Volume: 10

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] DPP-IV inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation.2015

    • Author(s)
      Shinjo, T., Nakatsu, Y., Iwashita, M., Sano, T., Sakoda, H., Ishihara, H., Kushiyama, A., Fujishiro, M., Fukushima, T., Tsuchiya, Y., Kamata, H., Nishimutra, F., and Asano, T.
    • Journal Title

      Am. J. Physiol. Endocrinol Metab.

      Volume: 309

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic steatohepatitis in a rodent model.2015

    • Author(s)
      Nakatsu, Y., Seno, Y., Kushiyama, A., Sakoda, H., Fujishiro, M., Katasako, A., Mori, K., Matsunaga, Y., Fukushima, T., Kanaoka, R., Yamamotoya, T., Kamata, H., and Asano, T.
    • Journal Title

      Am. J. Physiol. Gastrointest Liver Physiol.

      Volume: 309

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity2015

    • Author(s)
      Fukushima, T., Yoshihara, H., furuta, H., Kamei, H., Hakuno, F., Luan, J., Duan, C., Saeki, Y., Tanaka, K., Iemura, S., Natsume, T., Chida, K., Nakatsu, Y., Kamata, H., Asano, T., and Takahashi, S.
    • Journal Title

      Nat. Commun.

      Volume: 6 Pages: 6780-6780

    • NAID

      120006348510

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model.2015

    • Author(s)
      Okubo, H., Nakatsu, Y., Sakoda, H., Kushiyama, A., Fujishiro, M., Fukushima, T., Matsunaga, Y., Ohno, H., Yoneda, M., Kamata, H., Shinjo, T., Iwashita, M., Nishimura, F., and Asano, T.
    • Journal Title

      Am. J. Physiol. Gastrointest Liver Physiol.

      Volume: 308

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Insulin receptor substrate-4 binds to Slingshot-1 phosphatase and promotes cofilin dephosphorylation.2014

    • Author(s)
      Homma, Y., Kanno, S., Sasaki, K., Nishita, M., Yasui, A., Asano, T., Ohashi, K., and Mizuno, K.
    • Journal Title

      J. Biol. Chem.

      Volume: 289 Pages: 26302-13

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A high-throughput screen for inhibitors of the prolyl isomerase, Pin1, identifies a seaweed polyphenol that reduces adipose cell differentiation.2014

    • Author(s)
      Mori, T., Hidaka, M., Ikuji, H., Yoshizawa, I., Toyohara, H., Okuda, T., Uvhida, C., Asano, T., Yotsu-Yamashita, M., and Uchida, T..
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 78 Pages: 832-8

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mediobasal hypothalamic PTEN modulates hepatic insulin resistance independently of food intake in rats.2014

    • Author(s)
      Sumita, T., Ono, H., Suzuki, T., Inukai, K., Katagiri, H., Asano, T., Katayama, S., and Awata, T.
    • Journal Title

      Am. J. Physiol. Endocrinol Metab.

      Volume: 307

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Insulin receptor substrate-1 associates with small nucleolar RNA which contributes to ribosome biogenesis.2014

    • Author(s)
      Ozoe, A., Sone, M., Fukushima, T., Kataoka, N., Chida, K., Asano, T., Hakuno, F., and Takahashi, S.
    • Journal Title

      Front Endocrinol.

      Volume: 5 Pages: 1-12

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The inflammation-lipocalin 2 axis may contribute to the development of chronic kidney disease.2014

    • Author(s)
      Hashikata, A., Yamashita, A., Suzuki, S., Nagayasu, S., Shinjo, T., Taniguchi, A., Fukushima, M., Nakai, Y., Nin, K., Watanabe, N., Asano, T., Abiko, Y., Kushiyama, A., Nagasaka, S.,and Nishimura, F.
    • Journal Title

      Nephrol. Dial. Transplant.

      Volume: 29 Pages: 611-8

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] Pin1を介した熱産生調節機構及び肥満との関係解明2016

    • Author(s)
      松永 泰花、中津 祐介、櫛山 暁史、菊池 貴子、山本屋 武、鎌田 英明、浅野 知一郎
    • Organizer
      第59回日本糖尿病学会学術集会
    • Place of Presentation
      国立京都国際会議場
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Trk-fused gene(TFG)の膵β細胞における役割の解明2016

    • Author(s)
      山本屋 武、中津 祐介、迫田 秀之、藤城 緑、山崎 広貴、菊池 貴子、浅野 知一郎、櫛山 暁史
    • Organizer
      第59回日本糖尿病学会学術集会
    • Place of Presentation
      国立京都国際会議場
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] 性ホルモン結合グロブリン(SHBG)による脂肪量減少効果と抗炎症効果2016

    • Author(s)
      山崎 広貴、櫛山 暁史、迫田 秀之、藤城 緑、山本屋 武、菊池 貴子、金子 直、浅野 知一郎
    • Organizer
      第59回日本糖尿病学会学術集会
    • Place of Presentation
      国立京都国際会議場
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] プロリン異性化酵素Pin1を介した膵β細胞調節機構の解明2016

    • Author(s)
      中津 祐介、森 馨一、松永 泰花、山本屋 武、藤城 緑、石原 寿光、浅野 知一郎
    • Organizer
      第59回日本糖尿病学会学術集会
    • Place of Presentation
      国立京都国際会議場
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] 肝外キサンチンオキシダーゼのインスリン抵抗性への関与2016

    • Author(s)
      櫛山 暁史、菊池 貴子、山崎 広貴、迫田 秀之、藤城 緑、浅野 知一郎、岩本 安彦
    • Organizer
      第59回日本糖尿病学会学術集会
    • Place of Presentation
      国立京都国際会議場
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] DPP-4阻害薬による抗炎症効果2015

    • Author(s)
      浅野知一郎
    • Organizer
      第53回日本糖尿病学会九州地方会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] マクロファージにおける糖代謝による活性酸素産生とインスリン抵抗性2015

    • Author(s)
      櫛山暁史、菊池貴子、迫田秀之、藤城緑、山本屋武、山崎広貴、中津祐介、浅野知一郎、河津捷二
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      下関
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 高脂肪食負荷による近位筋優位遺伝性運動感覚ニューロパチー原因遺伝子TFGの発現低下とその病的意義2015

    • Author(s)
      浅野知一郎、松永泰花、迫田秀之、櫛山暁史、藤城緑、山本屋武、鎌田英明、小野啓、中津祐介
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      下関
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 性ホルモン結合グルブリン(SHBG)の代謝への影響の検討2015

    • Author(s)
      山崎広貴、櫛山暁史、迫田秀之、藤城緑、山本屋武、菊池貴子、金子直、浅野知一郎
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      下関
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] DPP4阻害薬anagliptineはLPS投与マウスの肝臓・脂肪組織における炎症反応を抑制する2015

    • Author(s)
      新城尊徳、岩下未咲、中津祐介、鎌田英明、迫田秀之、藤城緑、櫛山暁史、浅野知一郎、西村英紀
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      下関
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 膵β細胞機能におけるプロリン異性化酵素Pin1の役割2015

    • Author(s)
      中津祐介、森馨一、松永泰花、山本屋武、迫田秀之、藤城緑、櫛山暁史、石原寿光、浅野知一郎
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      下関
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肝臓におけるLUBAC(linear ubiquitin assembly complex)活性低下はAkt-mTOR経路の亢進および肝での炎症を惹起する2015

    • Author(s)
      山本屋武、迫田秀之、藤城緑、山崎広貴、金子直、菊池貴子、櫛山暁史、浅野知一郎
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      下関
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] SGLT2阻害薬ルセオグリフロジンによる非アルコール性脂肪性肝炎の改善作用2015

    • Author(s)
      藤城緑、中津祐介、迫田秀之、櫛山暁史、松永泰花、山本屋武、鎌田英明、浅野知一郎
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      下関
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] キサンチンオキシダーゼ阻害剤FebuxostatによるNASH改善作用の検討2015

    • Author(s)
      松永泰花、中津祐介、迫田秀之、櫛山暁史、藤城緑、山本屋武、鎌田英明、新城尊徳、岩下未咲、西村英紀、小野啓、浅野知一郎
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      下関
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 膵β細胞からのインスリン分泌におけるプロリン異性化酵素Pin1の役割2014

    • Author(s)
      浅野知一郎、松永泰花、福嶋俊明、山崎広貴、山本屋武、櫛山暁史、中津祐介
    • Organizer
      第57回日本糖尿病学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-22 – 2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] キサンチンオキシダーゼ阻害剤FebuxostatによるNASH改善作用の検討2014

    • Author(s)
      藤城緑、中津祐介、福嶋俊明、松永泰花、迫田秀之、櫛山暁史、山本屋武、西村英紀、浅野知一郎
    • Organizer
      第57回日本糖尿病学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-22 – 2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] LUBAC (linear ubiquitin chain assembly complex)のインスリンシグナル伝達系における役割の検討2014

    • Author(s)
      山本屋武、迫田秀之、藤城緑、山崎広貴、菊池貴子、櫛山暁史、浅野知一郎
    • Organizer
      第57回日本糖尿病学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-22 – 2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] マクロファージresistin like molecule βによるインスリン抵抗性・動脈硬化発症の機序2014

    • Author(s)
      櫛山暁史、菊池貴子、迫田秀之、藤城緑、山崎広貴、山本屋武、大久保博史、中津祐介、河津捷二、浅野知一郎
    • Organizer
      第57回日本糖尿病学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-22 – 2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] CC7経路が肥満およびインスリン抵抗性に及ぼす影響に関する検討2014

    • Author(s)
      岩下未咲、佐野朋美、新城尊徳、箸方厚之、浅野知一郎、西村英紀
    • Organizer
      第57回日本糖尿病学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-22 – 2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] DPP4阻害薬anagliptinは、活性化マクロファージおよびマクロファージ共培養下脂肪細胞の炎症反応を抑制する2014

    • Author(s)
      新城尊徳、岩下未咲、中津祐介、迫田秀之、藤城緑、櫛山暁史、鎌田英明、西村英紀、浅野知一郎
    • Organizer
      第57回日本糖尿病学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-22 – 2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Pin1阻害薬Jugloneを用いたNASH治療効果の検討2014

    • Author(s)
      山崎広貴、中津祐介、鎌田英明、西村英紀、菊池貴子、藤城緑、迫田秀之、浅野知一郎
    • Organizer
      第57回日本糖尿病学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-22 – 2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] プロリン異性化酵素Pin1はAMPKγ subunitに結合し、活性を抑制する2014

    • Author(s)
      中津祐介、岩下未咲、福嶋俊明、菊池貴子、櫛山暁史、迫田秀之、浅野知一郎
    • Organizer
      第57回日本糖尿病学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-22 – 2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝炎発症におけるLUBAC形成障害の役割2014

    • Author(s)
      松永泰花、中津祐介、鎌田英明、福嶋俊明、岩下未咲、新城尊徳、菊池貴子、藤城緑、浅野知一郎
    • Organizer
      第57回日本糖尿病学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-22 – 2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Book] SGLT2阻害薬のすべて2014

    • Author(s)
      浅野 知一郎、中津 祐介
    • Total Pages
      200
    • Publisher
      先端医学社
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] Pin1 阻害薬を用いた炎症性腸疾患の治療または予防方法2014

    • Inventor(s)
      浅野知一郎、中津祐介
    • Industrial Property Rights Holder
      浅野知一郎、中津祐介
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-10-29
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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