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Analysis of the mechanisms by which mast cell activation is regulated by paired receptors LMIR3 and LMIR7

Research Project

Project/Area Number 26293231
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Collagenous pathology/Allergology
Research InstitutionJuntendo University

Principal Investigator

Kitaura Jiro  順天堂大学, 医学(系)研究科(研究院), 准教授 (30282651)

Co-Investigator(Kenkyū-buntansha) 北村 俊雄  東京大学, 医科学研究所, 教授 (20282527)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2016: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Keywordsアレルギー / 炎症 / マスト細胞 / 抑制型受容体 / 活性化型受容体 / ペア型受容体 / アレルギー・ぜんそく / アレルギー・炎症
Outline of Final Research Achievements

LMIR3-deficient colonic mast cells were pivotal in the exacerbation of DSS-induced colitis in LMIR3-deficeint mice. Ceramide vesicles attenuated DSS-induced colitis by inhibiting ATP-mediated activation of colonic mast cells through ceraimide-LMIR3 binding. On the other hand, LMIR3-deficient mice were highly resistant to septic peritonitis induced by cecal ligation and puncture (CLP). Ceramide-LMIR3 binding inhibited the release of neutrophil chemoattractaaants from mast cells and neutrophils in response to E. coli, thereby suppressing neutrophil recruitment to sites of infection. Accordingly, disrupting ceramide-LMIR3 interactions prevents septic peritonitis by stimulating neutrophil recruitment.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(32 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 8 results,  Acknowledgement Compliant: 7 results) Presentation (21 results) (of which Int'l Joint Research: 3 results,  Invited: 6 results) Remarks (2 results)

  • [Int'l Joint Research] University Hospital Erlangen/Technische Universität Dresden(Germany)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Ceramide-CD300f Binding Inhibits Lipopolysaccharide-induced Skin Inflammation.2017

    • Author(s)
      Shiba E, Izawa K, Kaitani A, Isobe M, Maehara A, Uchida K, Maeda K, Nakano N, Ogawa H, Okumura K, Kitamura T, Shimizu T, Kitaura J
    • Journal Title

      The Journal of biological chemistry

      Volume: 292 Pages: 2924-2932

    • DOI

      10.1074/jbc.m116.768366

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Pharmacological inhibition of Notch signaling suppresses food antigen-induced mucosal mast cell hyperplasia.2017

    • Author(s)
      Honjo A, Nakano N, Yamazaki S, Hara M, Uchida K, Kitaura J, Nishiyama C, Yagita H, Ohtsuka Y, Ogawa H, Okumura K, Shimizu T
    • Journal Title

      J Allergy Clin Immunol

      Volume: 139 Pages: 987-996

    • DOI

      10.1016/j.jaci.2016.05.046

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ceramide-CD300f binding suppresses experimental colitis by inhibiting ATP-mediated mast cell activation.2016

    • Author(s)
      Matsukawa T, Izawa K, Isobe M, Takahashi M, Maehara A, Yamanishi Y, Kaitani A, Okumura K, Teshima T, Kitamura T, Kitaura J
    • Journal Title

      Gut.

      Volume: 印刷中 Pages: 1-11

    • DOI

      10.1136/gutjnl-2014-308900

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The phosphatidylserine and phosphatidylethanolamine receptor CD300a binds dengue virus and enhances infection.2015

    • Author(s)
      Carnec X, Meertens L, Dejarnac O, Perera-Lecoin M, Lamine Hafirassou M, Kitaura J, Ramdasi R, Schwartz O, Amara A
    • Journal Title

      J Virol.

      Volume: 90 Pages: 92-102

    • DOI

      10.1128/jvi.01849-15

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Transcription Factor Ehf Is Involved in TGF-β-Induced Suppression of FcεRI and c-Kit Expression and FcεRI-Mediated Activation in Mast Cells.2015

    • Author(s)
      Yamazaki S, Nakano N, Honjo A, Hara M, Maeda K, Nishiyama C, Kitaura J, Ohtsuka Y, Okumura K, Ogawa H, Shimizu T
    • Journal Title

      J Immunol.

      Volume: 195(7) Pages: 3427-3425

    • DOI

      10.4049/jimmunol.1402856

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A C-terminal mutant of CCAAT-enhancer-binding protein α (C/EBPα-C(m)) downregulates Csf1r, a potent accelerator in the progression of acute myeloid leukemia with C/EBPα-C(m).2015

    • Author(s)
      Togami K, Kitaura J, Uchida T, Inoue D, Nishimura K, Kawabata KC, Nagase R, Horikawa S, Izawa K, Fukuyama T, Nakahara F, Oki T, Harada Y, Harada H, Aburatani H, Kitamura T.
    • Journal Title

      Experimental hematology

      Volume: 43(4) Pages: 300-308

    • DOI

      10.1016/j.exphem.2014.11.011

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] SETBP1 mutations drive leukemic transformation in ASXL1-mutated MDS.2015

    • Author(s)
      Inoue D, Kitaura J, Matsui H, Hou HA, Chou WC, Nagamachi A, Kawabata KC, Togami K, Nagase R, Horikawa S, Saika M, Micol JB, Hayashi Y, Harada Y, Harada H, Inaba T, Tien HF, Abdel-Wahab O, Kitamura T.
    • Journal Title

      Leukemia

      Volume: 29(4) Pages: 847-57

    • DOI

      10.1038/leu.2014.301

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells.2014

    • Author(s)
      Nakahara F, Kitaura J, Uchida T, Nishida C, Togami K, Inoue D, Matsukawa T, Kagiyama Y, Enomoto Y, Kawabata KC, Chen-Yi L, Komeno Y, Izawa K, Oki T, Nagae G, Harada Y, Harada H, Otsu M, Aburatani H, Heissig B, Hattori K, Kitamura T.
    • Journal Title

      blood

      Volume: 123(25) Pages: 3932-3942

    • DOI

      10.1182/blood-2013-01-476747

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Leukocyte mono-immunoglobulin-like receptor 6 (LMIR6) is an activating receptor expressed in patrolling monocytes.2016

    • Author(s)
      Isobe Masamichi, Takamori Ayako, Izawa Kumi, Maehara Akie, Kaitani Ayako, Uchida Shino, Nakano Nobuhiro, Maeda Keiko, Ando Tomoaki, Okumura Ko, Kitamura Toshio, Kitaura Jiro
    • Organizer
      第45回日本免疫学会
    • Place of Presentation
      Okinawa Convention Center・Laguna Garden Hotel、沖縄
    • Year and Date
      2016-12-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Ceramide-CD300f interaction inhibits Mrgprb2-mediated pseudo-allergic drug reactions in mice.2016

    • Author(s)
      Hatayama Tomoki, Takamori Ayako, Izawa Kumi, Maehara Akie, Isobe Masamichi, Kaitani Ayako, Uchida Shino, Nakano Nobuhiro, Maeda Keiko, Ando Tomoaki, Okumura Ko, Kitamura Toshio, Kitaura Jiro
    • Organizer
      第45回日本免疫学会
    • Place of Presentation
      Okinawa Convention Center・Laguna Garden Hotel、沖縄
    • Year and Date
      2016-12-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] A critical role of ceramide-CD300f interaction in septic peritonitis.2016

    • Author(s)
      Izawa Kumi, Maehara Akie, Isobe Masamichi, Kaitani Ayako, Nakano Nobuhiro, Maeda Keiko, Takamori Ayako, Okumura Ko, Kitamura Toshio, Kitaura Jiro
    • Organizer
      第45回日本免疫学会
    • Place of Presentation
      Okinawa Convention Center・Laguna Garden Hotel、沖縄
    • Year and Date
      2016-12-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] CD300f suppresses LPS-induced skin inflammation.2016

    • Author(s)
      Watanabe Daiki, Izawa Kumi, Kaitani Ayako, Maehara Akie, Isobe Masamichi, Takamori Ayako, Uchida Shino, Nakano Nobuhiro, Maeda Keiko, Ando Tomoaki, Okumura Ko, Kitamura Toshio, Kitaura Jiro
    • Organizer
      第45回日本免疫学会
    • Place of Presentation
      Okinawa Convention Center・Laguna Garden Hotel、沖縄
    • Year and Date
      2016-12-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] The role of leukocyte mono-immunoglobulin-like receptor 8 (LMIR8)/CLM-6 in plasmacytoid dendritic cell (pDC)2016

    • Author(s)
      Kaitani Ayako, Izawa Kumi, Maehara Akie, Isobe Masamichi, Takamori Ayako, Uchida Shino, Nakano Nobuhiro, Maeda Keiko, Ando Tomoaki, Okumura Ko, Kitamura Toshio, Kitaura Jiro
    • Organizer
      第45回日本免疫学会
    • Place of Presentation
      Okinawa Convention Center・Laguna Garden Hotel、沖縄
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] 敗血症性腹膜炎におけるセラミド-CD300fシグナルの役割2016

    • Author(s)
      伊沢久未、奥村康、北浦次郎
    • Organizer
      第9回セラミド研究会学術集会
    • Place of Presentation
      東京ユビキタス協創広場CANVAS、東京
    • Year and Date
      2016-10-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] Inhibition of allergic responses by ceramide-CD300f axis.2016

    • Author(s)
      Jiro Kitaura
    • Organizer
      Federation of American Societies for Experimental Biology (FASEB): IgE and Allergy: 50 Years and Onward
    • Place of Presentation
      West Palm Beach, Florida (USA)
    • Year and Date
      2016-07-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] マスト細胞に発現する活性化型受容体LMIR7のアレルギー反応にける役割2016

    • Author(s)
      伊沢久未、奥村康、北村俊雄、北浦次郎
    • Organizer
      第65回日本アレルギー学会学術大会
    • Place of Presentation
      東京国際フォーラム、東京
    • Year and Date
      2016-06-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] The regulatory role of a novel activating receptor in mast cell- and IgE-dependent anaphylaxis2016

    • Author(s)
      Jiro Kitaura
    • Organizer
      31st Symposium of the Collegium Internationale Allergologicum
    • Place of Presentation
      Charleston, South Carolina(USA)
    • Year and Date
      2016-04-07
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The novel role of LMIR7/CLM-3 in mast cell- and IgE-dependent anaphylaxis2015

    • Author(s)
      Isobe Masamichi, Izawa Kumi, Maehara Akie, Matsukawa Toshihiro, Kaitani Akie, Okumura Ko, Kitamura Toshio, Kitaura Jiro
    • Organizer
      第44回日本免疫学会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Disrupting ceramide-LMIR3 interaction prevents bacterial sepsis by stimulating neutrophil recruitment2015

    • Author(s)
      伊沢久未、磯部優理、奥村康、北村俊雄、北浦次郎
    • Organizer
      第43回日本臨床免疫学会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2015-10-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] セラミドによるアレルギー性炎症の制御2015

    • Author(s)
      北浦次郎
    • Organizer
      第64 回日本アレルギー学会学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪 (東京)
    • Year and Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] マウスおよびヒトLMIR3のリガンド同定と機能解析2015

    • Author(s)
      伊沢久未、奥村康、北村俊雄、北浦次郎
    • Organizer
      第64回日本アレルギー学会学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京)
    • Year and Date
      2015-05-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Ceramide-CD300f binding suppresses experimental colitis by inhibiting ATP-mediated mast cell activation.2015

    • Author(s)
      Matsukawa Toshihiro, Izawa Kumi, Okumura Ko, Teshima Takanori, Kitamura Toshio, Kitaura Jiro
    • Organizer
      THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS IMMUNOLOGY 2015
    • Place of Presentation
      NEW ORLEANS (AMERICA)
    • Year and Date
      2015-05-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ペア型受容体LMIR/CD300による敗血症の制御機構2015

    • Author(s)
      北浦次郎
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-03-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 抑制型受容体LMIR3/CD300fによるアレルギー・炎症性疾患の制御メカニズム2015

    • Author(s)
      北浦次郎
    • Organizer
      第143回御茶ノ水木曜会
    • Place of Presentation
      順天堂大学
    • Year and Date
      2015-03-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] セラミドを認識する抑制型受容体LMIR3/CD300fによるアレルギー・炎症の制御機構2015

    • Author(s)
      北浦次郎
    • Organizer
      第10回順天堂眼アレルギー研究会
    • Place of Presentation
      ホテル東京ガーデンパレス
    • Year and Date
      2015-03-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Disrupting ceramide-LMIR3 interaction prevents bacterial sepsis by stimulating neutrophil recruitment2014

    • Author(s)
      Izawa Kumi, Isobe Masamichi, Matsukawa Toshihiro, Maehara Akie, Takahashi Mariko, Kaitani Ayako, Okumura Ko, Kitamura Toshio, Kitaura Jiro
    • Organizer
      第43回日本免疫学会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] LMIR3/CD300f deficiency aggravates DSS-induced colitis2014

    • Author(s)
      Matsukawa Toshihiro, Izawa Kumi, Isobe Masamichi, Takahashi Mariko, Maehara Akie, Kaitani Ayako, Okumura Ko, Kitamura Toshio, Kitaura Jiro
    • Organizer
      第43回日本免疫学会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2014-12-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 抑制型レセプターLMIR3/CD300fの欠損はDSS腸炎を悪化させる2014

    • Author(s)
      松川敏大、伊沢久未、北村俊雄、北浦次郎
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] ペア型受容体LMIR/CD300ファミリーとアレルギー・炎症2014

    • Author(s)
      北浦次郎
    • Organizer
      御茶ノ水がん学アカデミア第106回集会
    • Place of Presentation
      順天堂大学
    • Year and Date
      2014-10-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Remarks] 炎症性腸疾患の発症・進展を抑制する仕組みを解明

    • URL

      https://www.juntendo.ac.jp/graduate/pdf/news16.pdf

    • Related Report
      2015 Annual Research Report
  • [Remarks] 炎症性腸疾患の発症・進展を抑制する仕組みを解明

    • URL

      http://www.juntendo.ac.jp/graduate/pdf/news16.pdf

    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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