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Investigation of regulatory mechanism of secretary protein kinase and its application for treatment of rheumatoid arthritis

Research Project

Project/Area Number 26293233
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Collagenous pathology/Allergology
Research InstitutionKeio University

Principal Investigator

Takeuchi Tsutomu  慶應義塾大学, 医学部, 教授 (50179610)

Co-Investigator(Kenkyū-buntansha) 中川 種昭  慶應義塾大学, 医学部, 教授 (00227745)
仲 哲治  国立研究開発法人医薬基盤・健康・栄養研究所, その他部局等, その他 (30303936)
鈴木 勝也  慶應義塾大学, 医学部, 講師 (70306695)
Research Collaborator TAKESHITA Masaru  慶應義塾大学, 医学部リウマチ内科, 特任助教 (10571135)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Keywords関節リウマチ / FAM20A / キナーゼ / 分泌型キナーゼ / 膠原病・アレルギー内科学 / リウマチ内科学
Outline of Final Research Achievements

We have identified FAM20A which regulates post-transcriptional protein modification as a molecule associated with pathophysiology of rheumatoid arthritis in the previous research using peripheral blood. In this research, we generated anti-FAM20A antibody and deeply analyzed association between FAM20A and affected sites. Our investigation successfully revealed the expression affected site and its induction by inflammatory cytokines. These findings suggested that post-transcriptional protein modification involved in pathophysiology of rheumatoid arthritis.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(2 results)

All 2016 2014

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results)

  • [Journal Article] Identification of baseline gene expression signatures predicting therapeutic responses to three biologic agents in rheumatoid arthritis: a retrospective observational study2016

    • Author(s)
      Nakamura S, Suzuki K, Iijima H, Hata Y, Lim CR, Ishizawa Y, Kameda H, Amano K, Matsubara K, Matoba R, Takeuchi T
    • Journal Title

      Arthritis Research & Therapy

      Volume: 18 Pages: 159-159

    • DOI

      10.1186/s13075-016-1052-8

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] DNAマイクロアレイ解析を用いた生物学的製剤のテーラーメイド医療へのアプローチ2014

    • Author(s)
      鈴木勝也、竹内 勤
    • Organizer
      第29回日本臨床リウマチ学会
    • Place of Presentation
      福岡国際会議場3F メインホール
    • Year and Date
      2014-11-30
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2018-12-17  

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