Investigation of regulatory mechanism of secretary protein kinase and its application for treatment of rheumatoid arthritis

• Project/Area Number: 26293233
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Collagenous pathology/Allergology
• Research Institution: Keio University
• Principal Investigator: Takeuchi Tsutomu 慶應義塾大学, 医学部, 教授 (50179610)
• Co-Investigator(Kenkyū-buntansha): 中川 種昭 慶應義塾大学, 医学部, 教授 (00227745) ; 仲 哲治 国立研究開発法人医薬基盤・健康・栄養研究所, その他部局等, その他 (30303936) ; 鈴木 勝也 慶應義塾大学, 医学部, 講師 (70306695)
• Research Collaborator: TAKESHITA Masaru 慶應義塾大学, 医学部リウマチ内科, 特任助教 (10571135)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000); Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2014: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
• Keywords: 関節リウマチ / FAM20A / キナーゼ / 分泌型キナーゼ / 膠原病・アレルギー内科学 / リウマチ内科学

Outline of Final Research Achievements

We have identified FAM20A which regulates post-transcriptional protein modification as a molecule associated with pathophysiology of rheumatoid arthritis in the previous research using peripheral blood. In this research, we generated anti-FAM20A antibody and deeply analyzed association between FAM20A and affected sites. Our investigation successfully revealed the expression affected site and its induction by inflammatory cytokines. These findings suggested that post-transcriptional protein modification involved in pathophysiology of rheumatoid arthritis.

Research Products

• [Journal Article] Identification of baseline gene expression signatures predicting therapeutic responses to three biologic agents in rheumatoid arthritis: a retrospective observational study (2016)
  • Author(s): Nakamura S, Suzuki K, Iijima H, Hata Y, Lim CR, Ishizawa Y, Kameda H, Amano K, Matsubara K, Matoba R, Takeuchi T
  • Journal Title: Arthritis Research & Therapy Volume: 18 Pages: 159-159
  • DOI: 10.1186/s13075-016-1052-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] DNAマイクロアレイ解析を用いた生物学的製剤のテーラーメイド医療へのアプローチ (2014)
  • Author(s): 鈴木勝也、竹内 勤
  • Organizer: 第29回日本臨床リウマチ学会
  • Place of Presentation: 福岡国際会議場３F メインホール
  • Year and Date: 2014-11-30