Induction of aoutoantibodies to BP230 and analysis of new function of BP230 using gene-engineered mouse
Project/Area Number |
26293254
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Dermatology
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Research Institution | Hirosaki University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
松崎 康司 弘前大学, 医学部附属病院, 講師 (50322946)
中野 創 弘前大学, 医学研究科, 准教授 (90281922)
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
|
Keywords | 遺伝子 / 自己免疫 / 皮膚 / 水疱 / マウス |
Outline of Final Research Achievements |
Bullous pemphigoid is a skin disease which shows generalized blisters and occurs mostly in the elderly. This disease is characterized by autoantibodies to basement membrane zone and considered as autoimmune blistering disease. In this study, we generated knockout mouse of BP230 and also conditional knockout mouse without epidermal BP230 expression. The results demonstrated that BP230 plays an important role in muscle function. Furthermore, BP230 has great contributions to stability of biding between the epidermis and the dermis.
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Report
(5 results)
Research Products
(40 results)
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[Journal Article] Prevalence of skin infections caused by Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus ?in?Japan, particularly in Ishigaki, Okinawa2017
Author(s)
Takadama S, Nakaminami H, Aoki S, Akashi M, Wajima T, Ikeda M, Mochida A, Shimoe F, Kimura K, Matsuzaki Y, Sawamura D, Inaba Y, Oishi T, Nemoto O, Baba N, Noguchi N
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Journal Title
J Infect Chemother.
Volume: 23
Issue: 11
Pages: 800-803
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Mycosis fungoides bullosa associated with bullous pemphigoid.2015
Author(s)
Korekawa A, Kaneko T, Nakajima K, Rokunohe D, Akasaka E, Nakano H, Sawamura D, Fukui T, Takiyoshi N, Kitamura H, Harada K
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Journal Title
Int J Dermatol
Volume: 54
Issue: 9
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 表皮水疱症の最近の話題2016
Author(s)
澤村大輔
Organizer
皮膚病態学アフェレシスフォーラム
Place of Presentation
ホテルグランヴィア大阪(大阪府・大阪市)
Year and Date
2016-08-04
Related Report
Invited
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[Presentation] 表皮水疱症の最近の話題2015
Author(s)
澤村大輔
Organizer
第4回東京水疱症研究会
Place of Presentation
フォーシーズンズ丸ノ内(東京都千代田区)
Year and Date
2015-12-03
Related Report
Invited
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