The genotype, the phenotype and the end-phenotype measured by MEG in autism spectrum disorder.

• Project/Area Number: 26293262
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kanazawa University
• Principal Investigator: Kikuchi Mitsuru 金沢大学, 子どものこころの発達研究センター, 教授 (00377384)
• Co-Investigator(Kenkyū-buntansha): 横山 茂 金沢大学, 子どものこころの発達研究センター, 教授 (00210633) ; 真田 茂 金沢大学, 保健学系, 教授 (50020029) ; 吉村 優子 金沢大学, 子どものこころの発達研究センター, 助教 (70597070)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000); Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
• Keywords: 自閉スペクトラム症 / 脳磁図 / 幼児 / 遺伝子多型 / MET遺伝子 / 社会性 / ワーキングメモリ / 言語発達 / 脳内ネットワーク / 遺伝子 / 自閉症 / 中間表現型 / 脳磁図計 / 自閉症スペクトラム

Outline of Final Research Achievements

The symptom of ASD was evaluated using the behavioral and neurophysiological methods. We researched the effect of the genotype (which was thought to be risk type for ASD) on phenotype measured by behavioral data and end-phenotype measured by MEG. Young children with ASD (N=71: including the repeated subjects) and typically developing children (N=102: including the repeated subjects) participated. At the present moment, single nucleotide polymorphism of rs1858830 in a MET gene have identified in 33 children with ASD and 30 TD children. We defined CC and a CG genotype (which include risk type genetic polymorphism C) as CC_CG group, and we compared some phenotype and end-phenotype between CC_CG and GG groups. As the result, in the ASD group including genetic polymorphism C, developmental delay was observed in working memory task. On the other hand, TD group was affected by the risk gene more about the latency of auditory evoked field measured by MEG.

Research Products

• [Int'l Joint Research] University of Montreal(カナダ)
• [Int'l Joint Research] University of Washington(米国)
• [Int'l Joint Research] Macquarie University(オーストラリア)
• [Int'l Joint Research] University of Montreal(カナダ)
• [Int'l Joint Research] University of Washington(米国)
• [Journal Article] Mu rhythm suppression reflects mother-child face-to-face interactions : a pilot study with simultaneous MEG recording (2017)
  • Author(s): Chiaki Hasegawa, Takashi Ikeda, Yuko Yoshimura, Hirotoshi Hiraishi, Tetsuya Takahashi, Naoki Furutani, Norio Hayashi, Yoshio Minabe, Masayuki Hirata, Minoru Asada, Mitsuru Kikuchi
  • Journal Title: Scientific Reports Volume: 6 Pages: 34977-34977
  • DOI: 10.1038/srep34977
  • Description: 【掲載確定】 印刷中
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Characteristics of communication among Japanese children with autism spectrum disorder: A cluster analysis using the Children’s Communication Checklist-2 (2017)
  • Author(s): Tanaka,S., Oi,M., Fujino,H., et al
  • Journal Title: Clinical Linguistics & Phonetics Volume: 31 Pages: 1-16
  • DOI: 10.1080/02699206.2016.1238509
  • Peer Reviewed
• [Journal Article] The contribution of increased gamma band connectivity to visual non-verbal reasoning in autistic children : A MEG study (2016)
  • Author(s): Natsumi Takesaki, Mitsuru Kikuchi, Yuko Yoshimura, Hirotoshi Hiraishi, Chiaki Hasegawa, Reizo Kaneda, Hideo Nakatani, Tetsuya Takahashi, Laurent Mottron, and Yoshio Minabe
  • Journal Title: PLoS One Volume: 15 Issue: 9
  • DOI: 10.1371/journal.pone.0163133
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Synchrony of auditory brain responses predicts behavioral ability to keep still in children with autism spectrum disorder : Auditory-evoked response in children with autism spectrum disorder (2016)
  • Author(s): Yuko Yoshimura, Mitsuru Kikuchi, Hirotoshi Hiraishi, Chiaki Hasegawa, Tetsuya Takahashi, Gerard B. Remijn, Manabu Oi, Toshio Munesue, Haruhiro Higashida, and Yoshio Minabe
  • Journal Title: NeuroImage : Clinical Volume: 12 Pages: 300-305
  • DOI: 10.1016/j.nicl.2016.07.009
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Atypical Bilateral Brain Synchronization in the Early Stage of Human Voice Auditory Processing in Young Children with Autism. (2016)
  • Author(s): Kurita T, Kikuchi M, Yoshimura Y, Hiraishi H, Hasegawa C, Takahashi T, Hirosawa T, Furutani N, Higashida H, Ikeda T, Mutou K, Asada M, Minabe Y.
  • Journal Title: PLoS One. Volume: 13 Pages: 0153077-0153077
  • DOI: 10.1371/journal.pone.0153077
  • Peer Reviewed / Open Access
• [Journal Article] Enhanced Brain Signal Variability in Children with Autism Spectrum Disorder during Early Childhood (2016)
  • Author(s): Tetsuya Takahashi, Yuko Yoshimura, Hirotoshi Hiraishi, Chiaki Hasegawa, Toshio Munesue, Haruhiro Higashida, Yoshio Minabe, and Mitsuru Kikuchi
  • Journal Title: Human Brain Mapping Volume: 37（3） Issue: 3 Pages: 1038-1050
  • DOI: 10.1002/hbm.23089
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Magnetoencephalography in the study of children with autism spectrum disorder (2016)
  • Author(s): Mitsuru Kikuchi, Yuko Yoshimura, Kouhei Mutou, and Yoshio Minabe
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 70 Pages: 74-88
  • DOI: 10.1111/pcn.12338
  • Peer Reviewed
• [Journal Article] 幼児用MEG（magnetoencephalography）:自閉症スペクトラム症幼児への応用 (2016)
  • Author(s): 菊知 充
  • Journal Title: 児童青年精神医学とその近接領域 Volume: 56 Pages: 781-789
  • Peer Reviewed
• [Journal Article] Changes in autistic trait indicators in parents and their children with ASD : A preliminary longitudinal study (2015)
  • Author(s): Chiaki Hasegawa, Mitsuru Kikuchi, Yuko Yoshimura, Hirotoshi Hiraishi, Toshio Munesue, Natsumi Takesaki, Haruhiro Higashida, Manabu Oi, Yoshio Minabe, and Minoru Asada
  • Journal Title: Psychiatry Research Volume: 228 Issue: 3 Pages: 956-957
  • DOI: 10.1016/j.psychres.2015.05.048
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Reduced long-range functional connectivity in young children with autism spectrum disorder. (2015)
  • Author(s): Kikuchi M, Yoshimura Y, Hiraishi H, Munesue T, Hashimoto T, Tsubokawa T, Takahashi T, Suzuki M, Higashida H, Minabe Y.
  • Journal Title: Soc Cogn Affect Neurosci Volume: 10 Issue: 2 Pages: 248-254
  • DOI: 10.1093/scan/nsu049
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Broader autism phenotype in mothers predicts social responsiveness in young children with autism spectrum disorders. (2015)
  • Author(s): Hasegawa C, Kikuchi M, Yoshimura Y, Hiraishi H, Munesue T, Nakatani H, Higashida H, Asada M, Oi M, Minabe Y.
  • Journal Title: Psychiatry Clin Neurosci. Volume: 69 Issue: 3 Pages: 136-144
  • DOI: 10.1111/pcn.12210
  • NAID: 130007819705
  • Peer Reviewed
• [Journal Article] Unusual developmental pattern of brain lateralization in young boys with autism spectrum disorder: Power analysis with child-sized magnetoencephalography. (2015)
  • Author(s): Hiraishi H, Kikuchi M, Yoshimura Y, Kitagawa S, Hasegawa C, Munesue T, Takesaki N, Ono Y, Takahashi T, Suzuki M, Higashida H, Asada M, Minabe Y.
  • Journal Title: Psychiatry Clin Neurosci. Volume: 69 Issue: 3 Pages: 153-160
  • DOI: 10.1111/pcn.12261
  • Peer Reviewed
• [Journal Article] Attentional control and interpretation of facial expression after oxytocin administration to typically developed male adults. (2015)
  • Author(s): Hirosawa T, Kikuchi M, Okumura E, Yoshimura Y, Hiraishi H, Munesue T, Takesaki N, Furutani N, Ono Y, Higashida H, Minabe Y
  • Journal Title: PlosOne Volume: 6
  • DOI: 10.1371/journal.pone.0116918
  • Peer Reviewed / Open Access
• [Journal Article] A longitudinal study of auditory evoked field and language development in young children (2014)
  • Author(s): Yoshimura Yuko, Kikuchi Mitsuru, Ueno Sanae, Shitamichi Kiyomi, Remijn Gerard, Hiraishi Hirotoshi, Hasegawa Chiaki, Furutani Naoki, Oi Manabu, Munesue Toshio, Tsubokawa Tunehisa, Higashida Haruhiro, Minabe Yoshio
  • Journal Title: Neuroimage Volume: 1;101 Pages: 440-447
  • DOI: 10.1016/j.neuroimage.2014.07.034
  • Peer Reviewed / Open Access
• [Presentation] 自閉症幼児期のMEG研究 (2016)
  • Author(s): 菊知 充 三邉義雄
  • Organizer: 第31回日本生体磁気学会大会
  • Place of Presentation: 金沢市文化ホール（金沢市）
  • Invited
• [Presentation] Atypical development of the auditory system in children with autism: custom child-sized MEG studies (2016)
  • Author(s): 菊知 充
  • Organizer: 第55回日本生体医工学会大会
  • Place of Presentation: 富山国際会議場（富山市）
  • Invited
• [Presentation] Atypical development of the auditory system in children with autism spectrum disorder (2016)
  • Author(s): Mitsuru Kikuchi，Yoshio Minabe
  • Organizer: The 20th International Conference on Biomagnetism (BIOMAG2016)
  • Place of Presentation: Seoul (Korea)
  • Int'l Joint Research
• [Presentation] Atypical brain activity in children with autism spectrum disorder (2016)
  • Author(s): Mitsuru Kikuchi
  • Organizer: The 3rd International Symposium on Cognitive Neuroscience Robotics: Toward Constructive Developmental Science
  • Place of Presentation: Osaka (Japan)
  • Int'l Joint Research
• [Presentation] Atypical bilateral brain synchronization in the early stage of human voice auditory processing in young children with autism (2016)
  • Author(s): Toshiharu Kurita, Mitsuru Kikuchi,Yuko Yoshimura, Hirotoshi Hiraishi, Chiaki Hasegawa, Tetsuya Takahashi, Tetsu Hirosawa, Naoki Furutani, Haruhiro Higashida, Takashi Ikeda, Kouhei Mutou, Minoru Asada, and Yoshio Minabe
  • Organizer: 第31回日本生体磁気学会大会
  • Place of Presentation: 金沢市文化ホール（金沢市）
• [Presentation] Influence of oxytocin administration on SEF by median nerve stimulation:ahealthy volunteer study (2016)
  • Author(s): Yasuki Ono, Mitsuru Kikuchi, Tetsu Hirosawa, Chiaki Hasegawa, Yuko Yoshimura, and Yoshio Minabe
  • Organizer: 第31回日本生体磁気学会大会
  • Place of Presentation: 金沢市文化ホール（金沢市）
• [Presentation] Contribution of bottom-up functional connectivity (2016)
  • Author(s): Natsumi Takesaki, Mitsuru Kikuchi, Yuko Yoshimura, Hirotoshi Hiraishi, Chiaki Hasegawa, Tetsuya Takahashi, Haruhiro Higashida,Laurent Mottron, and Yoshio Minabe
  • Organizer: 第31回日本生体磁気学会大会
  • Place of Presentation: 金沢市文化ホール（金沢市）
• [Presentation] Enhanced functional network in autism spectrum disorder during early childhood (2016)
  • Author(s): Yoshiaki Miyagishi, Tetsuya Takahashi, Teruya Yamanishi, Shinya Kasakawa, Yuko Yoshimura, Hirotoshi Hiraishi, Chiaki Hasegawa, Tetsu Hirosawa, Toshio Munesue, Haruhiro Higashida, Yoshio Minabe, and Mitsuru Kikuchi
  • Organizer: 第31回日本生体磁気学会大会
  • Place of Presentation: 金沢市文化ホール（金沢市）
• [Presentation] Multilateral Analysis of Brain Activities (2016)
  • Author(s): Naoki Furutani, Eiichi Okumura, and Mitsuru Kikuchi
  • Organizer: 第31回日本生体磁気学会大会
  • Place of Presentation: 金沢市文化ホール（金沢市）
• [Presentation] Atypical brain auditory processing in young children with autism spectrum disorder. (2015)
  • Author(s): 菊知 充 三邉 義雄
  • Organizer: 第58回 神経化学会
  • Place of Presentation: 大宮ソニックシティ（さいたま市）
  • Year and Date: 2015-09-12
• [Presentation] 幼児の長所を見える化し、弱点克服をモニターする (2015)
  • Author(s): 菊知 充
  • Organizer: 第5回CiNetシンポジウム
  • Place of Presentation: 東京国際フォーラムホール（東京）
  • Year and Date: 2015-06-17
• [Presentation] 自閉症スペクトラム障害児のMEG研究 (2015)
  • Author(s): 菊知 充
  • Organizer: 第57回日本小児神経学会学術集会
  • Place of Presentation: 帝国ホテル大阪（大阪）
  • Year and Date: 2015-05-29
• [Presentation] Brain connectivity during a high-level visual perceptual task in young ASD children: a MEG investigation (2015)
  • Author(s): Mitsuru Kikuchi, Laurent Mottron, Natsumi Takesaki, Tetsuya Takahashi, Tetsu Hirosawa, Yuko Yoshimura, Naoki Furutani, Hirotoshi Hiraishi, Chiaki Hasegawa, Sachiko Kitagawa, Yoshio Minabe
  • Organizer: The International Meeting for Autism Research.
  • Place of Presentation: Salt Lake City, Utah, USA.
  • Year and Date: 2015-05-16
  • Invited
• [Presentation] Mental rotation: a high-level perceptual strength of young ASD children. (2015)
  • Author(s): Yuko Yoshimura, Laurent Mottron, Natsumi Takesaki,Tetsuya Takahashi, Tetsu Hirosawa, Naoki Furutani,Hirotoshi Hiraishi, Chiaki Hasegawa, Sachiko Kitagawa, Yoshio Minabe, Mitsuru Kikuchi
  • Organizer: The International Meeting for Autism Research.
  • Place of Presentation: Salt Lake City, Utah, USA.
  • Year and Date: 2015-05-16
  • Invited
• [Presentation] 幼児脳の個性の「見える化」への取り組み (2014)
  • Author(s): 菊知 充
  • Organizer: 第3回金沢大学子どものこころサミット
  • Place of Presentation: 赤羽ホール（金沢）
  • Year and Date: 2014-11-29
• [Presentation] 自閉症スペクトラム障害の認知特性と脳機能の特徴 (2014)
  • Author(s): 菊知 充
  • Organizer: 第14回、「精神疾患と認知機能研究会」
  • Place of Presentation: 海運クラブ（東京）
  • Year and Date: 2014-11-08
  • Invited
• [Presentation] Neuroimaging for brain development in young children (2014)
  • Author(s): 菊知 充
  • Organizer: 第4回 賀戸久先生記念研究会
  • Place of Presentation: TOKYU REIT 虎ノ門ビル（東京）
  • Year and Date: 2014-11-07
  • Invited
• [Presentation] 広汎性発達障害の早期診断のための診断システム開発 (2014)
  • Author(s): 菊知 充
  • Organizer: 第45回公益財団法人アステラス病態代謝研究会
  • Place of Presentation: 日本工業倶楽部（東京）
  • Year and Date: 2014-10-18
  • Invited
• [Remarks] バンビプラン - 金沢大学
  • URL: http://bambiplan.w3.kanazawa-u.ac.jp/
• [Remarks] 金沢大学子どものこころの発達研究センター
  • URL: https://kodomokokoro.w3.kanazawa-u.ac.jp/
• [Remarks] 金沢大学子どものこころの発達研究センター
  • URL: http://kodomokokoro.w3.kanazawa-u.ac.jp/
• [Remarks] バンビプラン
  • URL: http://bambiplan.w3.kanazawa-u.ac.jp/
• [Remarks] 連合小児発達学研究科金沢校
  • URL: http://rengou.w3.kanazawa-u.ac.jp/