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The genotype, the phenotype and the end-phenotype measured by MEG in autism spectrum disorder.

Research Project

Project/Area Number 26293262
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionKanazawa University

Principal Investigator

Kikuchi Mitsuru  金沢大学, 子どものこころの発達研究センター, 教授 (00377384)

Co-Investigator(Kenkyū-buntansha) 横山 茂  金沢大学, 子どものこころの発達研究センター, 教授 (00210633)
真田 茂  金沢大学, 保健学系, 教授 (50020029)
吉村 優子  金沢大学, 子どものこころの発達研究センター, 助教 (70597070)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Keywords自閉スペクトラム症 / 脳磁図 / 幼児 / 遺伝子多型 / MET遺伝子 / 社会性 / ワーキングメモリ / 言語発達 / 脳内ネットワーク / 遺伝子 / 自閉症 / 中間表現型 / 脳磁図計 / 自閉症スペクトラム
Outline of Final Research Achievements

The symptom of ASD was evaluated using the behavioral and neurophysiological methods. We researched the effect of the genotype (which was thought to be risk type for ASD) on phenotype measured by behavioral data and end-phenotype measured by MEG. Young children with ASD (N=71: including the repeated subjects) and typically developing children (N=102: including the repeated subjects) participated. At the present moment, single nucleotide polymorphism of rs1858830 in a MET gene have identified in 33 children with ASD and 30 TD children. We defined CC and a CG genotype (which include risk type genetic polymorphism C) as CC_CG group, and we compared some phenotype and end-phenotype between CC_CG and GG groups. As the result, in the ASD group including genetic polymorphism C, developmental delay was observed in working memory task. On the other hand, TD group was affected by the risk gene more about the latency of auditory evoked field measured by MEG.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(42 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (5 results) Journal Article (14 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 14 results,  Open Access: 8 results,  Acknowledgement Compliant: 4 results) Presentation (18 results) (of which Int'l Joint Research: 2 results,  Invited: 7 results) Remarks (5 results)

  • [Int'l Joint Research] University of Montreal(カナダ)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University of Washington(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Macquarie University(オーストラリア)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University of Montreal(カナダ)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] University of Washington(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Mu rhythm suppression reflects mother-child face-to-face interactions : a pilot study with simultaneous MEG recording2017

    • Author(s)
      Chiaki Hasegawa, Takashi Ikeda, Yuko Yoshimura, Hirotoshi Hiraishi, Tetsuya Takahashi, Naoki Furutani, Norio Hayashi, Yoshio Minabe, Masayuki Hirata, Minoru Asada, Mitsuru Kikuchi
    • Journal Title

      Scientific Reports

      Volume: 6 Pages: 34977-34977

    • DOI

      10.1038/srep34977

    • Description
      【掲載確定】 印刷中
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Characteristics of communication among Japanese children with autism spectrum disorder: A cluster analysis using the Children’s Communication Checklist-22017

    • Author(s)
      Tanaka,S., Oi,M., Fujino,H., et al
    • Journal Title

      Clinical Linguistics & Phonetics

      Volume: 31 Pages: 1-16

    • DOI

      10.1080/02699206.2016.1238509

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The contribution of increased gamma band connectivity to visual non-verbal reasoning in autistic children : A MEG study2016

    • Author(s)
      Natsumi Takesaki, Mitsuru Kikuchi, Yuko Yoshimura, Hirotoshi Hiraishi, Chiaki Hasegawa, Reizo Kaneda, Hideo Nakatani, Tetsuya Takahashi, Laurent Mottron, and Yoshio Minabe
    • Journal Title

      PLoS One

      Volume: 15 Issue: 9

    • DOI

      10.1371/journal.pone.0163133

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Synchrony of auditory brain responses predicts behavioral ability to keep still in children with autism spectrum disorder : Auditory-evoked response in children with autism spectrum disorder2016

    • Author(s)
      Yuko Yoshimura, Mitsuru Kikuchi, Hirotoshi Hiraishi, Chiaki Hasegawa, Tetsuya Takahashi, Gerard B. Remijn, Manabu Oi, Toshio Munesue, Haruhiro Higashida, and Yoshio Minabe
    • Journal Title

      NeuroImage : Clinical

      Volume: 12 Pages: 300-305

    • DOI

      10.1016/j.nicl.2016.07.009

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Atypical Bilateral Brain Synchronization in the Early Stage of Human Voice Auditory Processing in Young Children with Autism.2016

    • Author(s)
      Kurita T, Kikuchi M, Yoshimura Y, Hiraishi H, Hasegawa C, Takahashi T, Hirosawa T, Furutani N, Higashida H, Ikeda T, Mutou K, Asada M, Minabe Y.
    • Journal Title

      PLoS One.

      Volume: 13 Pages: 0153077-0153077

    • DOI

      10.1371/journal.pone.0153077

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enhanced Brain Signal Variability in Children with Autism Spectrum Disorder during Early Childhood2016

    • Author(s)
      Tetsuya Takahashi, Yuko Yoshimura, Hirotoshi Hiraishi, Chiaki Hasegawa, Toshio Munesue, Haruhiro Higashida, Yoshio Minabe, and Mitsuru Kikuchi
    • Journal Title

      Human Brain Mapping

      Volume: 37(3) Issue: 3 Pages: 1038-1050

    • DOI

      10.1002/hbm.23089

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Magnetoencephalography in the study of children with autism spectrum disorder2016

    • Author(s)
      Mitsuru Kikuchi, Yuko Yoshimura, Kouhei Mutou, and Yoshio Minabe
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 70 Pages: 74-88

    • DOI

      10.1111/pcn.12338

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 幼児用MEG(magnetoencephalography):自閉症スペクトラム症幼児への応用2016

    • Author(s)
      菊知 充
    • Journal Title

      児童青年精神医学とその近接領域

      Volume: 56 Pages: 781-789

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in autistic trait indicators in parents and their children with ASD : A preliminary longitudinal study2015

    • Author(s)
      Chiaki Hasegawa, Mitsuru Kikuchi, Yuko Yoshimura, Hirotoshi Hiraishi, Toshio Munesue, Natsumi Takesaki, Haruhiro Higashida, Manabu Oi, Yoshio Minabe, and Minoru Asada
    • Journal Title

      Psychiatry Research

      Volume: 228 Issue: 3 Pages: 956-957

    • DOI

      10.1016/j.psychres.2015.05.048

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Reduced long-range functional connectivity in young children with autism spectrum disorder.2015

    • Author(s)
      Kikuchi M, Yoshimura Y, Hiraishi H, Munesue T, Hashimoto T, Tsubokawa T, Takahashi T, Suzuki M, Higashida H, Minabe Y.
    • Journal Title

      Soc Cogn Affect Neurosci

      Volume: 10 Issue: 2 Pages: 248-254

    • DOI

      10.1093/scan/nsu049

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Broader autism phenotype in mothers predicts social responsiveness in young children with autism spectrum disorders.2015

    • Author(s)
      Hasegawa C, Kikuchi M, Yoshimura Y, Hiraishi H, Munesue T, Nakatani H, Higashida H, Asada M, Oi M, Minabe Y.
    • Journal Title

      Psychiatry Clin Neurosci.

      Volume: 69 Issue: 3 Pages: 136-144

    • DOI

      10.1111/pcn.12210

    • NAID

      130007819705

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unusual developmental pattern of brain lateralization in young boys with autism spectrum disorder: Power analysis with child-sized magnetoencephalography.2015

    • Author(s)
      Hiraishi H, Kikuchi M, Yoshimura Y, Kitagawa S, Hasegawa C, Munesue T, Takesaki N, Ono Y, Takahashi T, Suzuki M, Higashida H, Asada M, Minabe Y.
    • Journal Title

      Psychiatry Clin Neurosci.

      Volume: 69 Issue: 3 Pages: 153-160

    • DOI

      10.1111/pcn.12261

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Attentional control and interpretation of facial expression after oxytocin administration to typically developed male adults.2015

    • Author(s)
      Hirosawa T, Kikuchi M, Okumura E, Yoshimura Y, Hiraishi H, Munesue T, Takesaki N, Furutani N, Ono Y, Higashida H, Minabe Y
    • Journal Title

      PlosOne

      Volume: 6

    • DOI

      10.1371/journal.pone.0116918

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A longitudinal study of auditory evoked field and language development in young children2014

    • Author(s)
      Yoshimura Yuko, Kikuchi Mitsuru, Ueno Sanae, Shitamichi Kiyomi, Remijn Gerard, Hiraishi Hirotoshi, Hasegawa Chiaki, Furutani Naoki, Oi Manabu, Munesue Toshio, Tsubokawa Tunehisa, Higashida Haruhiro, Minabe Yoshio
    • Journal Title

      Neuroimage

      Volume: 1;101 Pages: 440-447

    • DOI

      10.1016/j.neuroimage.2014.07.034

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 自閉症幼児期のMEG研究2016

    • Author(s)
      菊知 充 三邉義雄
    • Organizer
      第31回日本生体磁気学会大会
    • Place of Presentation
      金沢市文化ホール(金沢市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Atypical development of the auditory system in children with autism: custom child-sized MEG studies2016

    • Author(s)
      菊知 充
    • Organizer
      第55回日本生体医工学会大会
    • Place of Presentation
      富山国際会議場(富山市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Atypical development of the auditory system in children with autism spectrum disorder2016

    • Author(s)
      Mitsuru Kikuchi,Yoshio Minabe
    • Organizer
      The 20th International Conference on Biomagnetism (BIOMAG2016)
    • Place of Presentation
      Seoul (Korea)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Atypical brain activity in children with autism spectrum disorder2016

    • Author(s)
      Mitsuru Kikuchi
    • Organizer
      The 3rd International Symposium on Cognitive Neuroscience Robotics: Toward Constructive Developmental Science
    • Place of Presentation
      Osaka (Japan)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Atypical bilateral brain synchronization in the early stage of human voice auditory processing in young children with autism2016

    • Author(s)
      Toshiharu Kurita, Mitsuru Kikuchi,Yuko Yoshimura, Hirotoshi Hiraishi, Chiaki Hasegawa, Tetsuya Takahashi, Tetsu Hirosawa, Naoki Furutani, Haruhiro Higashida, Takashi Ikeda, Kouhei Mutou, Minoru Asada, and Yoshio Minabe
    • Organizer
      第31回日本生体磁気学会大会
    • Place of Presentation
      金沢市文化ホール(金沢市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Influence of oxytocin administration on SEF by median nerve stimulation:ahealthy volunteer study2016

    • Author(s)
      Yasuki Ono, Mitsuru Kikuchi, Tetsu Hirosawa, Chiaki Hasegawa, Yuko Yoshimura, and Yoshio Minabe
    • Organizer
      第31回日本生体磁気学会大会
    • Place of Presentation
      金沢市文化ホール(金沢市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Contribution of bottom-up functional connectivity2016

    • Author(s)
      Natsumi Takesaki, Mitsuru Kikuchi, Yuko Yoshimura, Hirotoshi Hiraishi, Chiaki Hasegawa, Tetsuya Takahashi, Haruhiro Higashida,Laurent Mottron, and Yoshio Minabe
    • Organizer
      第31回日本生体磁気学会大会
    • Place of Presentation
      金沢市文化ホール(金沢市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Enhanced functional network in autism spectrum disorder during early childhood2016

    • Author(s)
      Yoshiaki Miyagishi, Tetsuya Takahashi, Teruya Yamanishi, Shinya Kasakawa, Yuko Yoshimura, Hirotoshi Hiraishi, Chiaki Hasegawa, Tetsu Hirosawa, Toshio Munesue, Haruhiro Higashida, Yoshio Minabe, and Mitsuru Kikuchi
    • Organizer
      第31回日本生体磁気学会大会
    • Place of Presentation
      金沢市文化ホール(金沢市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Multilateral Analysis of Brain Activities2016

    • Author(s)
      Naoki Furutani, Eiichi Okumura, and Mitsuru Kikuchi
    • Organizer
      第31回日本生体磁気学会大会
    • Place of Presentation
      金沢市文化ホール(金沢市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Atypical brain auditory processing in young children with autism spectrum disorder.2015

    • Author(s)
      菊知 充  三邉 義雄
    • Organizer
      第58回 神経化学会
    • Place of Presentation
      大宮ソニックシティ(さいたま市)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 幼児の長所を見える化し、弱点克服をモニターする2015

    • Author(s)
      菊知 充
    • Organizer
      第5回CiNetシンポジウム
    • Place of Presentation
      東京国際フォーラムホール(東京)
    • Year and Date
      2015-06-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 自閉症スペクトラム障害児のMEG研究2015

    • Author(s)
      菊知 充
    • Organizer
      第57回日本小児神経学会学術集会
    • Place of Presentation
      帝国ホテル大阪(大阪)
    • Year and Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Brain connectivity during a high-level visual perceptual task in young ASD children: a MEG investigation2015

    • Author(s)
      Mitsuru Kikuchi, Laurent Mottron, Natsumi Takesaki, Tetsuya Takahashi, Tetsu Hirosawa, Yuko Yoshimura, Naoki Furutani, Hirotoshi Hiraishi, Chiaki Hasegawa, Sachiko Kitagawa, Yoshio Minabe
    • Organizer
      The International Meeting for Autism Research.
    • Place of Presentation
      Salt Lake City, Utah, USA.
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Mental rotation: a high-level perceptual strength of young ASD children.2015

    • Author(s)
      Yuko Yoshimura, Laurent Mottron, Natsumi Takesaki,Tetsuya Takahashi, Tetsu Hirosawa, Naoki Furutani,Hirotoshi Hiraishi, Chiaki Hasegawa, Sachiko Kitagawa, Yoshio Minabe, Mitsuru Kikuchi
    • Organizer
      The International Meeting for Autism Research.
    • Place of Presentation
      Salt Lake City, Utah, USA.
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 幼児脳の個性の「見える化」への取り組み2014

    • Author(s)
      菊知 充
    • Organizer
      第3回金沢大学子どものこころサミット
    • Place of Presentation
      赤羽ホール(金沢)
    • Year and Date
      2014-11-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 自閉症スペクトラム障害の認知特性と脳機能の特徴2014

    • Author(s)
      菊知 充
    • Organizer
      第14回、「精神疾患と認知機能研究会」
    • Place of Presentation
      海運クラブ(東京)
    • Year and Date
      2014-11-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Neuroimaging for brain development in young children2014

    • Author(s)
      菊知 充
    • Organizer
      第4回 賀戸久先生記念研究会
    • Place of Presentation
      TOKYU REIT 虎ノ門ビル(東京)
    • Year and Date
      2014-11-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 広汎性発達障害の早期診断のための診断システム開発2014

    • Author(s)
      菊知 充
    • Organizer
      第45回公益財団法人アステラス病態代謝研究会
    • Place of Presentation
      日本工業倶楽部(東京)
    • Year and Date
      2014-10-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Remarks] バンビプラン - 金沢大学

    • URL

      http://bambiplan.w3.kanazawa-u.ac.jp/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 金沢大学子どものこころの発達研究センター

    • URL

      https://kodomokokoro.w3.kanazawa-u.ac.jp/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 金沢大学子どものこころの発達研究センター

    • URL

      http://kodomokokoro.w3.kanazawa-u.ac.jp/

    • Related Report
      2015 Annual Research Report
  • [Remarks] バンビプラン

    • URL

      http://bambiplan.w3.kanazawa-u.ac.jp/

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
  • [Remarks] 連合小児発達学研究科金沢校

    • URL

      http://rengou.w3.kanazawa-u.ac.jp/

    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2022-02-16  

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