| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Outline of Final Research Achievements |
We examined molecules that relate to microglial activation and investigated a linkage between neurogenesis and neuroinflammation using AD-like animal models (SAMP8 mice and naturally-developed demented macaque confirmed by [11C]PIB for amyloid pathology) by developing methods with which we were able to quantify the amount of neurogenesis and determine the types of microglial activation: protective or inflammatory.
With the SAMP8 mice, a combination of Nestin promoter LAT4 system and [18F]dFMT enabled to illustrate the neurogenesis but the signal was small and ex vivo postmortem brain imaging was found to be necessary. Using a CB2R ligand permitted to depict microglial activation, but we found a more sensitive probe and method system necessary for examining these two phenomena in vivo in a living single animal.
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