Development of Quantitative Cerebral Blood Flow and Oxygen Metabolism using O-17 Water and Oxygen Molecules

• Project/Area Number: 26293269
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: Kudo Kohsuke 北海道大学, 大学病院, 准教授 (10374232)
• Co-Investigator(Kenkyū-buntansha): 真鍋 治 北海道大学, 医学(系)研究科(研究院), 助教 (40443957) ; 真鍋 徳子 北海道大学, 大学病院, 講師 (70463742) ; 佐々木 真理 岩手医科大学, 医学部, 教授 (80205864) ; 加藤 扶美 北海道大学, 大学病院, 助教 (80399865) ; 藤間 憲幸 北海道大学, 大学病院, 助教 (80431360) ; 宮本 憲幸 北海道大学, 大学病院, 特任助教 (10707110) ; 阿保 大介 北海道大学, 大学病院, 助教 (30399844)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000); Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
• Keywords: 酸素代謝 / 脳血流 / MRI / O-17 / 各磁気共鳴画像（MRI） / 脳血流酸素代謝 / 放射線科学 / 核磁気共鳴画像（MRI） / 脳血流代謝 / 核磁気共鳴画像

Outline of Final Research Achievements

Signal simulations for the various tissue were conducted using theoretical equations of MRI signals. Good correlations were noted between signal simulation and O-17 phantom signal, and conversion method from MRI signal to O-17 concentration was determined. Based on the MRI scans of normal volunteers, scan method with FSE sequence was established, and development of algorithm for quantitative analysis of cerebral blood flow.
Manufacturing of O-17 oxygen was established, and inhalation apparatus of O-17 was designed. Smaller O-17 phantom was created, and MRI scans with animal MRI were performed. Good image contrast was obtained for marmosets with the administration of O-17 water.

Research Products

• [Journal Article] Comparison of Different Post-Processing Algorithms for Dynamic Susceptibility Contrast Perfusion Imaging of Cerebral Gliomas (2017)
  • Author(s): Kudo K, Uwano I, Hirai T, Murakami R, Nakamura H, Fujima N, Yamashita F, Goodwin J, Higuchi S, Sasaki M
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 16 Issue: 2 Pages: 129-136
  • DOI: 10.2463/mrms.mp.2016-0036
  • NAID: 130005589294
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Tmax Determined Using a Bayesian Estimation Deconvolution Algorithm Applied to Bolus Tracking Perfusion Imaging: A Digital Phantom Validation Study (2017)
  • Author(s): Uwano I, Sasaki M, Kudo K, Boutelier T, Kameda H, Mori F, Yamashita F
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 16 Issue: 1 Pages: 32-37
  • DOI: 10.2463/mrms.mp.2015-0167
  • NAID: 130005286865
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed / Open Access
• [Journal Article] Fast nonlinear regression method for CT brain perfusion analysis (2016)
  • Author(s): Bennink E, Oosterbroek J, Kudo K, Viergever MA, Velthuis BK, de Jong HW
  • Journal Title: J Med Imaging Volume: － Issue: 2 Pages: 026003-026003
  • DOI: 10.1117/1.jmi.3.2.026003
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Oxygen Extraction Fraction Measurement using Quantitative Susceptibility Mapping: Comparison with Positron Emission Tomography (2016)
  • Author(s): Kudo K, Liu T, Murakami T, Goodwin J, Uwano I, Yamashita F, Higuchi S, Wang Y, Ogasawara K, Ogawa A, Sasaki M
  • Journal Title: JCBFM Volume: 36 Issue: 8 Pages: 1424-33
  • DOI: 10.1177/0271678x15606713
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Transcatheter arterial embolization with ethanol injection in symptomatic patients with enlarged polycystic kidneys. (2015)
  • Author(s): Sakuhara Y, Nishio S, Morita K, Abo D, Hasegawa Y, Yuasa N, Mochizuki T, Soyama T, Oba K, Shirato H, Kudo K
  • Journal Title: Radiology Volume: 277(1) Issue: 1 Pages: 277-285
  • DOI: 10.1148/radiol.2015141637
  • Peer Reviewed
• [Journal Article] Oxygen Extraction Fraction Measurement using Quantitative Susceptibility Mapping: Comparison with Positron Emission Tomography (2015)
  • Author(s): Kudo K, Liu T, Murakami T, Goodwin J, Uwano I, Yamashita F, Higuchi S, Wang Y, Ogasawara K, Ogawa A, Sasaki M
  • Journal Title: Journal of Cerebral Blood Flow and Metabolism Volume: -
  • Peer Reviewed
• [Journal Article] Evaluation of cerebral blood flow using multi-phase pseudo continuous arterial spin labeling at 3-tesla (2015)
  • Author(s): Sugimori H, Fujima N, Suzuki Y, Hamaguchi H, Sakata M, Kudo K
  • Journal Title: Magnetic Resonance Imaging Volume: 33 Issue: 10 Pages: 1338-1344
  • DOI: 10.1016/j.mri.2015.07.016
  • Peer Reviewed
• [Journal Article] Differences in morphological features and minimum apparent diffusion coefficient values among breast cancer subtypes using 3-tesla MRI (2015)
  • Author(s): Kato F, Kudo K, Yamashita H, Wang J; Hosoda M, Hatanaka K, Mimura R, Oyama-Manabe N, Shirato H
  • Journal Title: European Journal of Radiology Volume: 85 Pages: 96-102
  • NAID: 120005905605
  • Peer Reviewed
• [Journal Article] Measurement of tumor blood flow in head and neck squamous cell carcinoma by pseudo-continuous arterial spin labeling: Comparison with dynamic contrast-enhanced MRI. (2015)
  • Author(s): Fujima N, Kudo K, Tsukahara A, Yoshida D, Sakashita T, Homma A, Tha KK, Shirato H
  • Journal Title: J Magn Reson Imaging Volume: 41(4) Issue: 4 Pages: 983-991
  • DOI: 10.1002/jmri.24637
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Evaluating Middle Cerebral Artery Atherosclerotic Lesions in Acute Ischemic Stroke Using Magnetic Resonance T1-Weighted 3-Dimensional Vessel Wall Imaging (2014)
  • Author(s): Natori T, Sasaki M, Miyoshi M, Ohba H, Katsura N, Yamaguchi M, Narumi S, Kabasawa H, Kudo K, Ito K, Terayama Y
  • Journal Title: J Stroke Cerebrovasc Dis Volume: 23 Issue: 4 Pages: 706-711
  • DOI: 10.1016/j.jstrokecerebrovasdis.2013.06.025
  • Peer Reviewed
• [Journal Article] Standardized uptake value in high uptake area on positron emission tomography with 18F-FRP170 as a hypoxic cell tracer correlates with intratumoral oxygen pressure in glioblastoma (2014)
  • Author(s): Beppu T, Terasaki K, Sasaki T, Fujiwara S, Matsuura H, Ogasawara K, Sera K, Yamada N, Uesugi N, Sugai T, Kudo K, Sasaki M, Ehara S, Iwata R, Takai Y
  • Journal Title: Mol Imaging Biol Volume: 16 Issue: 1 Pages: 127-135
  • DOI: 10.1007/s11307-013-0670-7
  • Peer Reviewed
• [Journal Article] Bayesian analysis of perfusion-weighted imaging to predict infarct volume: comparison with singular value decomposition (2014)
  • Author(s): Kudo K, Boutelier T, Pautot F, Honjo K, Hu JQ, Wang HB, Shintaku K, Uwano I, Sasaki M
  • Journal Title: Magn Reson Med Sci Volume: 13 Pages: 45-50
  • NAID: 130003392992
  • Peer Reviewed
• [Journal Article] Susceptibility-Weighted Phase Imaging and Oxygen Extraction Fraction Measurement during Sedation and Sedation Recovery using 7T MRI (2014)
  • Author(s): Jonathan A. Goodwin, Kohsuke Kudo, Yutaka Shinohe, Satomi Higuchi, Ikuko Uwano, Fumio Yamashita and Makoto Sasaki
  • Journal Title: Journal of Neuroimaging Volume: 00 Issue: 4 Pages: 1-7
  • DOI: 10.1111/jon.12192
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Noninvasive evaluation of collateral blood flow through circle of willis in cervical carotid stenosis using selective Magnetic Resonance Angiography (2013)
  • Author(s): Ito K, Sasaki M, Kobayashi M, Ogasawara K, Nishihara T, Takahashi T, Natori T, Uwano I, Yamashita F, Kudo K
  • Journal Title: J Stroke Cerebrovasc Dis. 2013 Oct 5. pii: S1052-3057(13)00347-9. Volume: 13 Issue: 5 Pages: 347-9
  • DOI: 10.1016/j.jstrokecerebrovasdis.2013.08.018
  • Peer Reviewed / Open Access
• [Presentation] Radiomics is Radio-MIX, Mix everything! (2017)
  • Author(s): Kudo K
  • Organizer: 22ndKSMRM
  • Place of Presentation: Seoul（Korea）
  • Year and Date: 2017-03-23
  • Int'l Joint Research / Invited
• [Presentation] MRIによる酸素代謝イメージング (2016)
  • Author(s): 工藤與亮
  • Organizer: 第72回秋田脳神経画像研究会
  • Place of Presentation: パーティーギャラリー イヤタカ（秋田県秋田市）
  • Invited
• [Presentation] 定量的磁化率マッピング（QSM）で脳の構造と酸素代謝をみる (2016)
  • Author(s): 工藤與亮
  • Organizer: 第75回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Invited
• [Presentation] Contrast Enhanced MRI for Brain Tumors (2015)
  • Author(s): Kudo K
  • Organizer: AOCNR 2015
  • Place of Presentation: Hilton Fukuoka Sea Hawk (福岡県, 福岡市)
  • Year and Date: 2015-11-05
  • Int'l Joint Research / Invited
• [Presentation] Diagnostic Performance of Dynamic Susceptibility Contrast Perfusion in Glioma Grading: Comparison of Cerebral Blood Volume among Different Analysis Software (2015)
  • Author(s): Kudo K, Uwano I, Hirai T, Nakamura H, Fujima N, Yamashita F, Goodwin J, Higuchi S, Sasaki M
  • Organizer: ISMRM 23rd annual meeting
  • Place of Presentation: Metro Tronto Convention Center (Tronto, Canada)
  • Year and Date: 2015-06-01
  • Int'l Joint Research
• [Presentation] Perfusion MRI for the Diagnosis of Brain Tumors (2015)
  • Author(s): Kudo K
  • Organizer: Advanced Neuroimaging Workshop 2015
  • Place of Presentation: Bellesalle Tokyo (東京都, 中央区)
  • Year and Date: 2015-05-23
  • Invited
• [Presentation] Perfusion MRI for the Diagnosis of Brain Tumors (2015)
  • Author(s): Kudo K
  • Organizer: KSMRM 2015
  • Place of Presentation: Grand HIlton Seoul (Seoul, Korea)
  • Year and Date: 2015-03-27
  • Invited
• [Presentation] Oxygen Extraction Fraction (OEF) Measurement using Quantitative Susceptibility Mapping (QSM) (2014)
  • Author(s): Kudo K
  • Organizer: AOCR 2014
  • Place of Presentation: 神戸コンベンションセンター (神戸市)
  • Year and Date: 2014-09-24
  • Invited
• [Presentation] Quantitative Susceptibility Mapping (2014)
  • Author(s): 工藤與亮
  • Organizer: 第42回 日本磁気共鳴医学会大会
  • Place of Presentation: ホテルグランヴィア京都 (京都市)
  • Year and Date: 2014-09-18
  • Invited
• [Presentation] Oxygen Extraction Fraction (OEF) using Quantitative Susceptibility Mapping (QSM) (2014)
  • Author(s): 工藤與亮
  • Organizer: 第33回 Mt. Fuji Workshop on CVD
  • Place of Presentation: ホテルメトロポリタン盛岡 (盛岡市)
  • Year and Date: 2014-08-30
  • Invited
• [Presentation] Oxygen Metabolism Imaging by Quantitative Susceptibility Mapping (QSM) (2014)
  • Author(s): 工藤與亮
  • Organizer: Parallel Imaging Synposim in Hokkaido
  • Place of Presentation: 札幌医科大学記念ホール (札幌市)
  • Year and Date: 2014-08-02
  • Invited
• [Presentation] Oxygen Extraction Fraction Measurement using Quantitative Susceptibility Mapping in Patients with Chronic Cerebral Ischemia: Comparison with Positron Emission Tomography (2014)
  • Author(s): Kudo K, Liu T, Goodwin J, Uwano I, Yamashita F, Higuchi S, Fujima N, Wang Y, Ogasawara K, Ogawa A, Sasaki M
  • Organizer: ISMRM 2014
  • Place of Presentation: Mico-Milano Congressi (Milano, Italy)
  • Year and Date: 2014-05-12 – 2014-05-15