| Co-Investigator(Kenkyū-buntansha) |
阿部 悠 福島県立医科大学, 医学部, 助教 (00722472)
葛西 宏介 弘前大学, 保健学研究科, 講師 (50400148)
吉田 光明 弘前大学, 被ばく医療総合研究所, 教授 (60182789)
坂井 晃 福島県立医科大学, 医学部, 教授 (70284221)
中田 章史 北海道薬科大学, 薬学部, 講師 (70415420)
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| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Outline of Final Research Achievements |
In this study, we investigated the clinical laboratory index on chromosome aberration and examined the usefulness of cell cycle progression index (CPI) as a radiosensitivity evaluation tool. Ankle brachial pressure index (ABI), one of the indexes related to atherosclerosis, was correlated with the frequency of dicentric chromosomes induced by 3 Gy X-ray irradiation and CPI . In addition, a positive correlation was found between CPI and blood glucose level.
It is suggested that radiation induced chromosomal abnormalities increase in patients with arteriosclerosis and that CPI may be useful as a method for evaluating radiation individual susceptibility.
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