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Development of nuclear medical imaging probes targeting cerebral amyloid antipathy

Research Project

Project/Area Number 26293274
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Radiation science
Research InstitutionKyoto University

Principal Investigator

Ono Masahiro  京都大学, 薬学研究科(研究院), 准教授 (80336180)

Co-Investigator(Renkei-kenkyūsha) TEMMA Takashi  京都大学, 大学院薬学研究科, 助教 (90378787)
KIMURA Hiroyuki  京都大学, 放射性同位元素総合センター, 助教 (50437240)
SANO Kohei  京都大学, 大学院医学研究科, 助教 (00546476)
WATANABE Hiroyuki  京都大学, 大学院薬学研究科, 研究員 (40710786)
IHARA Masafumi  国立循環器病研究センター, 脳血管内科, 医長 (00372590)
Research Collaborator MATSUMURA Kenji  京都大学, 大学院薬学研究科, 大学院生
YOSHIMURA Masashi  京都大学, 大学院薬学研究科, 大学院生
IIKUNI Shimpei  京都大学, 大学院薬学研究科, 大学院生
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Keywords脳アミロイドアンギオパチー / イメージング / 金属錯体 / 診断 / βアミロイド
Outline of Final Research Achievements

Cerebral amyloid angiopathy (CAA) is characterized by the deposition of amyloid aggregates in the walls of cerebral vasculature, and constitutes a major factor in intracerebral hemorrhage and vascular cognitive impairment. In this study, we carried out the development of nuclear medical imaging probes targeting CAA. As a result, we successfully developed a novel 99mTc complex that showed selective binding to CAA while it did not show marked radioactivity accumulation in senile plaques in the cortex.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(8 results)

All 2016 2015 2014

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 3 results) Presentation (5 results) (of which Invited: 1 results)

  • [Journal Article] Novel Bivalent 99mTc-Complex with N-Methyl-Substituted Hydroxamamide as Probe for Imaging of Cerebral Amyloid Angiopathy2016

    • Author(s)
      Shimpei Iikuni, Masahiro Ono, Hiroyuki Watanabe, Masashi Yoshimura, Hatsue Ishibashi-Ueda, Masafumi Ihara, Hideo Saji.
    • Journal Title

      PLoS ONE

      Volume: 11(9)

    • DOI

      10.1371/journal.pone.0163969

    • NAID

      120005997741

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Imaging of Cerebral Amyloid Angiopathy with Bivalent 99mTc-Hydroxamamide Complexes2016

    • Author(s)
      Shimpei Iikuni, Masahiro Ono, Hiroyuki Watanabe, Kenji Matsumura, Masashi Yoshimura, Hiroyuki Kimura, Hatsue Ishibashi-Ueda, Yoko Okamoto, Masafumi Ihara, Hideo Saji.
    • Journal Title

      Scientific Reports

      Volume: 6 Pages: 25990-25990

    • DOI

      10.1038/srep25990

    • NAID

      120005767022

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Enhancement of Binding Affinity for Amyloid Aggregates by Multivalent Interactions of 99mTc-Hydroxamamide Complexes2014

    • Author(s)
      Iikuni S, Ono M, Watanabe H, Matsumura K, Yoshimura M, Harada N, Kimura H, Nakayama M, Saji H.
    • Journal Title

      Mol Pharm

      Volume: 11 Pages: 1132-1139

    • DOI

      10.1021/mp400499y

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 多価99mTc錯体を用いる脳アミロイドアンギオパチーの核医学イメージング2016

    • Author(s)
      小野正博
    • Organizer
      日本核医学会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 脳アミロイドアンギオパチーイメージングを目的とした新規2価99mTc錯体の合成と評価2015

    • Author(s)
      飯國 慎平, 小野 正博, 渡邊 裕之, 木村 寛之, 佐治 英郎
    • Organizer
      第55回日本核医学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 脳アミロイドアンギオパチーの核医学分子イメージングを目的とした99mTc 標識ベンゾチアゾール誘導体の開発2015

    • Author(s)
      飯國 慎平, 小野 正博, 渡邊 裕之, 木村 寛之, 佐治 英郎
    • Organizer
      日本薬学会 第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脳アミロイドアンギオパチーの核医学イメージングを目的とした2価99mTc錯体の開発2014

    • Author(s)
      飯國慎平、小野正博、渡邊裕之、木村寛之、佐治英郎
    • Organizer
      第54回日本核医学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2014-11-06 – 2014-11-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] 2 価 99mTc 錯体を用いた脳アミロイドアンギオパチーの生体イメージング2014

    • Author(s)
      飯國慎平、小野正博、渡邊裕之、木村寛之、佐治英郎
    • Organizer
      第12回次世代を担う若手のためのフィジカル・ファーマフォーラム
    • Place of Presentation
      箱根
    • Year and Date
      2014-07-14 – 2014-07-15
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2021-03-11  

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