Nrf2 regulates innate immunity activated by periodontal disease bacteria and prevents onset and progression of obesity-related liver diseases.
Project/Area Number |
26293284
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
General surgery
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Research Institution | University of Tsukuba |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
柳川 徹 筑波大学, 医学医療系, 准教授 (10312852)
酒井 俊 筑波大学, 医学医療系, 講師 (30282362)
磯辺 智範 筑波大学, 医学医療系, 准教授 (70383643)
蕨 栄治 筑波大学, 医学医療系, 講師 (70396612)
正田 純一 筑波大学, 医学医療系, 教授 (90241827)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
|
Keywords | 脂肪性肝炎 / 生活習慣病 / LPS / 歯周病菌 / 腸内細菌 / 非アルコール性脂肪性肝炎 / Kupffer細胞 / 歯周病 / 転写因子 / 酸化ストレス / 遺伝子改変マウス / 運動 / 口腔内環境 / 脂肪性肝疾患 / 運動療法 |
Outline of Final Research Achievements |
It has been reported that the onset mechanism of NASH is associated with abnormal intestinal bacterial flora, infection of periodontal disease bacteria, and its related increase in LPS influx into the liver. p62:Nrf2 gene double knockout mice (DKO) spontaneously develop NASH. Therefore, DKO was studied in terms of the abnormalities of intestinal bacterial flora and intestinal barrier function. In vivo analysis, the serum and fecal LPS concentrations were increased in DKO. In the intestinal microflora, the number of gram-negative bacteria species was increased in DKO. The intestinal permeability was increased in DKO. In vitro analysis, the cellular membrane resistance value and tight junction protein expression levels were decreased in the Nrf2-deficient intestinal cells. It is likely that the onset mechanism of NASH is attributed to an increase in gram-negative bacteria species and a weakness of intestinal barrier function.
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Report
(4 results)
Research Products
(95 results)
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[Journal Article] p62 modulates the intrinsic signaling of UVB-induced apoptosis.2016
Author(s)
Ito S, Kimura S, Warabi E, Kawachi Y, Yamatoji M, Uchida F, Ishibashi-Kanno N, Yamagata K, Hasegawa S, Shoda J, Tabuchi K, Sakai S, Bukawa H, Sekido M, Yanagawa T.
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Journal Title
Journal of Dermatological Science
Volume: 83
Issue: 3
Pages: 226-233
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Wisteria floribunda Agglutinin-Sialylated Mucin Core Polypeptide 1 is a Sensitive Biomarker for Biliary Tract Carcinoma and Intrahepatic Cholangiocarcinoma: A Multicenter Study.2016
Author(s)
Shoda J, Matsuda A, Shida T, Yamamoto M, Nagino M, Tsuyuguchi T, Yasaka T, Tazuma S, Uchiyama K, Unno M, Ohkohchi N, Nakanuma Y, Kuno A, Narimatsu H.
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Journal Title
J Gastroenterol
Volume: 52
Issue: 2
Pages: 218-228
DOI
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Peer Reviewed / Open Access
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[Journal Article] Viwatthanasittiphong C, Srivatanakul P, Miwa M, Shoda J, Narimatsu H. Lectin Microarray-Based Sero-Biomarker Verification Targeting Aberrant O-Linked Glycosylation on Mucin 1.2015
Author(s)
Matsuda A, Kuno A, Nakagawa T, Ikehara Y, Irimura T, Yamamoto M, Nakanuma Y, Miyoshi E, Nakamori S, Nakanishi H.
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Journal Title
Anal Chem.
Volume: 87(14)
Issue: 14
Pages: 7274-7281
DOI
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Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Acceleration training for management of non-alcoholic fatty liver disease: a pilot study.2014
Author(s)
Oh S, Shida T, Onozuka T, Maruyama T, Eguchi K, Isobe T, Okamoto Y, Someya N, Tanaka K, Tozawa A, Arai E, Shoda J.
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Journal Title
Ther Clin Risk Manag
Volume: 10
Pages: 925-936
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Peroxidoxin I plays a ptotective role against UVA irradiation through reduction of oxidative stress.2014
Author(s)
Ito T, Kimura S, Seto K, Warabi E, Kawauchi Y, Shoda J, Tabuchi K, Yamagata K, Hasegawa S, Bukawa H, Ishii T, Yanagawa T.
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Journal Title
J Dermatol Sci
Volume: 74
Pages: 9-17
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Expression of N-acetylglucosaminyltransferase V in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder.2014
Author(s)
Onuki K, Sugiyama H, Ishige K, Kawamoto T, Ota T, Ariizumi S, Yamato M, Kadota S, Takeuchi K, Ishikawa A, Onodera M, Onizawa K, Yamamoto M, Miyoshi E, Shoda J.
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Journal Title
J Gastroenterol
Volume: 49
Pages: 702-714
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 上顎転移を来した肺腺癌の1例2016
Author(s)
岡内 愼一郎, 伊藤 寛之, 鬼澤 浩司郎, 高屋敷 典生, 大原 元, 籠橋 克紀, 佐藤 浩昭
Organizer
日本内科学会関東地方会 623回
Place of Presentation
日内会館(東京都・文京区)
Related Report
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[Presentation] 運動習慣が口腔内環境に及ぼす影響についての検討2015
Author(s)
大森 翔英, 内田 文彦, 長谷川 正午, 馬場 脩, 大和地 正信, 山縣 憲司, 柳川 徹, 志田 隆史, 蘇 リナ, 正田 純一, 田中 喜代次, 武川 寛樹
Organizer
第69回日本口腔科学会
Place of Presentation
大阪, 大阪国際会議場
Year and Date
2015-05-15
Related Report
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[Presentation] ARONJに続発した脳膿瘍の1例.2014
Author(s)
長井宏樹, 山縣憲司, 鈴木亮広, 肥田智香子, 内田文彦, 大和地正信, 菅野直美, 長谷川正午, 柳川 徹, 武川寛樹
Organizer
第198回公益社団法人日本口腔外科学会関東支部学術集会
Place of Presentation
栃木
Year and Date
2014-12-06
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[Presentation] ルビエールリンパ節転移を伴った再発口腔癌に対しホウ素中性子捕捉療法を施行した1例.2014
Author(s)
内田文彦, 長谷川正午, 菅野直美, 大和地正信, 山縣憲司, 柳川 徹, 武川寛樹, 大西かよ子, 粟飯原輝人, 石川 仁, 櫻井英幸
Organizer
平成26年度京都大学原子炉実験所専門研究会
Place of Presentation
大阪
Year and Date
2014-09-30
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[Presentation] Clinical benefits of acceleration training for management of obese subjects with non-alcoholic fatty liver disease.2014
Author(s)
Oh S, Shida T, Sawai A, Eguchi K, Maruyama T, So T, Komine S, Horie M, Akiyama K, Tanaka K, Shoda J
Organizer
INCHEON ASIAN GAMES INTERNATIONAL SPORT SCIENCE CONGRESS
Place of Presentation
Korea
Year and Date
2014-08-20 – 2014-08-22
Related Report
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