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Nrf2 regulates innate immunity activated by periodontal disease bacteria and prevents onset and progression of obesity-related liver diseases.

Research Project

Project/Area Number 26293284
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field General surgery
Research InstitutionUniversity of Tsukuba

Principal Investigator

ONIZAWA Kojiro  筑波大学, 医学医療系, 教授 (60194578)

Co-Investigator(Kenkyū-buntansha) 柳川 徹  筑波大学, 医学医療系, 准教授 (10312852)
酒井 俊  筑波大学, 医学医療系, 講師 (30282362)
磯辺 智範  筑波大学, 医学医療系, 准教授 (70383643)
蕨 栄治  筑波大学, 医学医療系, 講師 (70396612)
正田 純一  筑波大学, 医学医療系, 教授 (90241827)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Keywords脂肪性肝炎 / 生活習慣病 / LPS / 歯周病菌 / 腸内細菌 / 非アルコール性脂肪性肝炎 / Kupffer細胞 / 歯周病 / 転写因子 / 酸化ストレス / 遺伝子改変マウス / 運動 / 口腔内環境 / 脂肪性肝疾患 / 運動療法
Outline of Final Research Achievements

It has been reported that the onset mechanism of NASH is associated with abnormal intestinal bacterial flora, infection of periodontal disease bacteria, and its related increase in LPS influx into the liver. p62:Nrf2 gene double knockout mice (DKO) spontaneously develop NASH. Therefore, DKO was studied in terms of the abnormalities of intestinal bacterial flora and intestinal barrier function. In vivo analysis, the serum and fecal LPS concentrations were increased in DKO. In the intestinal microflora, the number of gram-negative bacteria species was increased in DKO. The intestinal permeability was increased in DKO. In vitro analysis, the cellular membrane resistance value and tight junction protein expression levels were decreased in the Nrf2-deficient intestinal cells. It is likely that the onset mechanism of NASH is attributed to an increase in gram-negative bacteria species and a weakness of intestinal barrier function.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(95 results)

All 2017 2016 2015 2014

All Journal Article (24 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 23 results,  Open Access: 22 results,  Acknowledgement Compliant: 19 results) Presentation (62 results) (of which Int'l Joint Research: 2 results) Book (9 results)

  • [Journal Article] High-intensity aerobic exercise improves both hepatic fat content and stiffness in sedentary obese men with non-alcoholic fatty liver disease: A randomized controlled study.2017

    • Author(s)
      Oh S, So R, Shida T, Matsuo T, Kim B, Akiyama K, Isobe T, Okamoto Y, Tanaka K, Shoda J.
    • Journal Title

      Sci Rep.

      Volume: 7 Pages: 43029-43029

    • DOI

      10.1038/srep43029

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Wisteria floribunda Agglutinin-Sialylated Mucin Core Polypeptide 1 is a Sensitive Biomarker for Biliary Tract Carcinoma and Intrahepatic Cholangiocarcinoma: A Multicenter Study.2017

    • Author(s)
      Shoda J, Matsuda A, Shida T, Yamamoto M, Nagino M, Tsuyuguchi T, Yasaka T, Tazuma S, Uchiyama K, Unno M, Ohkohchi N, Nakanuma Y, Kuno A, Narimatsu H.
    • Journal Title

      Journal of Gastroenterology

      Volume: 52 Pages: 218-228

    • DOI

      10.1007/s00535-016-1230-0

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 閉塞性睡眠時無呼吸症候群に対する口腔内装置治療の有用性に関する検討2016

    • Author(s)
      内田 文彦, 鬼澤 浩司郎, 馬場 脩, 菅野 直美, 伊藤 寛之, 長谷川 正午, 山縣 憲司, 柳川 徹, 佐藤 誠, 武川 寛樹
    • Journal Title

      日本口腔外科学会雑誌

      Volume: 62 Pages: 395-403

    • NAID

      130005431512

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p62 modulates the intrinsic signaling of UVB-induced apoptosis.2016

    • Author(s)
      Ito S, Kimura S, Warabi E, Kawachi Y, Yamatoji M, Uchida F, Ishibashi-Kanno N, Yamagata K, Hasegawa S, Shoda J, Tabuchi K, Sakai S, Bukawa H, Sekido M, Yanagawa T.
    • Journal Title

      J Dermatol Sci.

      Volume: 83 Pages: 9-17

    • DOI

      10.1016/j.jdermsci.2016.05.005

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Verification of WFA-Sialylated MUC1 as a Sensitive Biliary Biomarker for Human Biliary Tract Cancer.2016

    • Author(s)
      Yamaguchi T, Yokoyama Y, Ebata T, Matsuda A, Kuno A, Ikehara Y,Shoda J, Narimatsu H, Nagino M.
    • Journal Title

      Anal Sug Oncol

      Volume: 23(2) Pages: 671-677

    • DOI

      10.1245/s10434-015-4878-4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ビスフォスフォネート製剤関連顎骨壊死症例の臨床的検討 外科療法の効果について2015

    • Author(s)
      鬼澤 浩司郎, 伊藤 寛之
    • Journal Title

      日本農村医学会雑誌

      Volume: 64 Pages: 747-748

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Moderate to vigorous physical activity volume is an important factor for managing non-alcoholic fatty liver disease : A retrospec tive study2015

    • Author(s)
      Oh S, Shida T, Tanaka K, Y amagishi K, So R, Tsujimoto T, Shoda J:
    • Journal Title

      Hepatology

      Volume: 61(4) Pages: 1205-1215

    • DOI

      10.1002/hep.27544

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Viwatthanasittiphong C, Srivatanakul P, Miwa M, Shoda J, Narimatsu H. Lectin Microarray-Based Sero-Biomarker Verification Targeting Aberrant O-Linked Glycosylation on Mucin 1.2015

    • Author(s)
      Matsuda A, Kuno A, Nakagawa T, Ikehara Y, Irimura T, Yamamoto M, Nakanuma Y, Miyoshi E, Nakamori S, Nakanishi H.
    • Journal Title

      Analytical Chemistry

      Volume: 87(14) Pages: 7274-7281

    • DOI

      10.1021/acs.analchem.5b01329

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Moderate to vigorous physical activity is an important factor for managing non-alcoholic fatty liver disease: a retrospective study.2015

    • Author(s)
      Oh S, Tanaka K, Chiaki K, Tsujimoto T, So R, Shida T, Shoda J
    • Journal Title

      Hepatology

      Volume: 61 Pages: 1205-1215

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] FibroScan502の肝脂肪量測定による非アルコール性脂肪性肝疾患の非侵襲的診断法の有用性について.2015

    • Author(s)
      志田隆史,磯辺智範,呉 世昶,上牧 隆,岡本嘉一,安藤浩樹,正田純一
    • Journal Title

      日本超音波技師学会雑誌

      Volume: 40 Pages: 167-173

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Overexpression and Gene Amplification of HER1, HER2 and HER3 in Biliary Tract Carcinomas and the Possibility for Therapy with a HER2-Targeting Antibody Pertuzumab.2015

    • Author(s)
      Kawamoto T, Thomas M, Yamashita-Kashima Y, Shu S, Ishikura N, Ariizumi S, Yamamoto M, Kurosaki K, Shoda J.
    • Journal Title

      J Gastroenterrol

      Volume: 50 Pages: 467-479

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Expression of insulin-like growth factor receptor (IGFR) as a useful biomarker for predicting prognosis in biliary tract cancer patients.2015

    • Author(s)
      Suzuki H, Roa JC, Kawamoto T, Ishige K, Shoda J, Wistuba II, Li D, Thomas MB.
    • Journal Title

      Mol & Clin Oncol

      Volume: 3 Pages: 464-470

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Mandibular reconstruction using plates prebent to fit rapid prototyping 3-dimensional printing models ameliorates contour deformity2014

    • Author(s)
      Azuma, M, et al.
    • Journal Title

      Head Face Med.

      Volume: 10 Pages: 1186-1186

    • DOI

      10.1186/1746-160x-10-45

    • NAID

      120007136550

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Severe Pulmonary Suppuration with Infection-Induced Systemic Inflammatory Response Syndrome following Tongue Cancer Surgery in a Patient Undergoing Tocilizumab Therapy for Rheumatoid Arthritis.2014

    • Author(s)
      Yamagata K, Shimojo N, Ito H, Ijima J, Hasegawa S, Yanagawa T, Mizutani T, Bukawa H.
    • Journal Title

      Case Rep Dent.

      Volume: 10 Pages: 1155-1155

    • DOI

      10.1155/2014/649086

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Interleukin-4 receptor α-based hybrid peptide effectively induces antitumor activity in biliary tract cancer cells2014

    • Author(s)
      Seto K, Shoda J, Horibe T, Warabi E, Kohno M, Yanagawa T, Bukawa H, Nakanuma Y, Kawakami K
    • Journal Title

      Int J Hepatol.

      Volume: 未定 Pages: 1155-1155

    • DOI

      10.1155/2014/584650

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 茨城県における肝細胞癌疫学調査.2014

    • Author(s)
      佐野直樹,田村孝史,福永 潔,高野恵輔,山岸良匡,正田純一,相川達也,大河内信弘
    • Journal Title

      肝臓

      Volume: 55 Pages: 771-773

    • NAID

      130004897340

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Changes in diffusion tensor imaging (DTI) eigenvalues of skeletal muscle due to hybrid exercise training Magnetic Resonance Imaging.2014

    • Author(s)
      Okamoto Y, Kemp GJ, Isobe T, Sato E, Hirano Y, Shoda J, Minami M.
    • Journal Title

      Magnetic Resonance Imaging

      Volume: 32 Pages: 1297-1300

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Abdominal obesity: causal factor or simply a symptom of obesity-related healyh risk.2014

    • Author(s)
      Oh S, Tanaka K, Noh J, So R, Tsujimoto T, Sasai H, Kim M, Shoda J.
    • Journal Title

      Diabetes, Metab Syn & Obesity

      Volume: 7 Pages: 289-296

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Acceleration training for management of non-alcoholic fatty liver disease: a pilot study.2014

    • Author(s)
      Oh S, Shida T, Onozuka T, Maruyama T, Eguchi K, Isobe T, Okamoto Y, Someya N, Tanaka K, Tozawa A, Arai E, Shoda J.
    • Journal Title

      Ther Clin Risk Manag

      Volume: 10 Pages: 925-936

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Interaction of Muc4 and ErbB2 in a transgenic mouse model of gallbladder carcinoma: potential pathobiological implications.2014

    • Author(s)
      Miyahara N, Ishida H, Ueda T, Kawamoto T, Akimoto Y, Kawakami H, DiGiovanni J, Kiguchi K, Irimura T, Shoda J.
    • Journal Title

      Oncol Rep

      Volume: 32 Pages: 1796-1802

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Regular Exercise Coupled to Diet Regimen Accelerates Reduction of Hepatic Steatosis and Associated Pathological Conditions in Non-Alcoholic Fatty Liver Disease.2014

    • Author(s)
      Oh S, Tanaka K, Tsujimoto T, So R, Eto M, Shoda J.
    • Journal Title

      Metabolic Syndrome & Related Disorders

      Volume: 12 Pages: 290-298

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Therapeutic effect of hybrid training of voluntary and electrical muscle contractions on middle-aged obese women with NAFLD: a pilot study.2014

    • Author(s)
      Oh S, Shida T, Ikeda A, Maruyama T, Eguchi K, Isobe T, Okamoto Y, Arai E, Shiba N, Shoda J.
    • Journal Title

      Ther Clin Risk Manag

      Volume: 11 Pages: 371-380

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Peroxidoxin I plays a ptotective role against UVA irradiation through reduction of oxidative stress.2014

    • Author(s)
      Ito T, Kimura S, Seto K, Warabi E, Kawauchi Y, Shoda J, Tabuchi K, Yamagata K, Hasegawa S, Bukawa H, Ishii T, Yanagawa T.
    • Journal Title

      J Dermatol Sci

      Volume: 74 Pages: 9-17

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Expression of N-acetylglucosaminyltransferase V in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder.2014

    • Author(s)
      Onuki K, Sugiyama H, Ishige K, Kawamoto T, Ota T, Ariizumi S, Yamato M, Kadota S, Takeuchi K, Ishikawa A, Onodera M, Onizawa K, Yamamoto M, Miyoshi E, Shoda J.
    • Journal Title

      J Gastroenterol

      Volume: 49 Pages: 702-714

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] p62:Nrf2遺伝子二重欠損マウスの肝蔵,内臓脂肪,腸内環境の解析よりみた NASH発症機序の解明.2016

    • Author(s)
      秋山健太郎,蕨栄治,正田純一.
    • Organizer
      第41回日本肝臓学会東部会
    • Place of Presentation
      京王プラザホテル(東京都・新宿区)
    • Year and Date
      2016-12-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝炎(NASH)自然発症マウスにおける Kupffer 細胞の表現形質 の変化と発症機序との関連性.2016

    • Author(s)
      秋山健太郎,蕨栄治,正田純一.
    • Organizer
      第102回日本消化器病学会総会
    • Place of Presentation
      京王プラザホテル(東京都・新宿区)
    • Year and Date
      2016-04-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] p62:Nrf2 double knockout mice develop steatohepatitis through the serum endotoxin overload.2016

    • Author(s)
      Kentaro Akiyama, Eiji Warabi, Kosuke Okada, Syunnichi Ariizumi, Masakazu Yamamoto, Junnichi Shoda.
    • Organizer
      25th Conference of the Asian Pacific Association for the Study of the Liver
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2016-02-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effect of female hormones on NAFLD in p62 knockout mice.2016

    • Author(s)
      Miho Ikeuchi, Eiji Warabi, Tsugumi Nagaoka, Syunichi Ariizumi, Masakazu Yamamoto, Junichi Shoda.
    • Organizer
      25th Conference of the Asian Pacific Association for the Study of the Liver
    • Place of Presentation
      Tokyo
    • Year and Date
      2016-02-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 上顎転移を来した肺腺癌の1例2016

    • Author(s)
      岡内 愼一郎, 伊藤 寛之, 鬼澤 浩司郎, 高屋敷 典生, 大原 元, 籠橋 克紀, 佐藤 浩昭
    • Organizer
      日本内科学会関東地方会 623回
    • Place of Presentation
      日内会館(東京都・文京区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] NAFLDに随伴する中高度肥満と糖尿病がKupffer細胞機能に及ぼす影響と運動療法の効果.2016

    • Author(s)
      志田隆史,秋山健太郎,内田文彦,蘇 リナ,呉 世昶,田中弘教,飯島尋子,正田純一.
    • Organizer
      第102回日本消化器病学会総会
    • Place of Presentation
      京王プラザホテル(東京都・新宿区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] NASH自然発症モデルマウスの腸内環境よりみた疾病病態の解析と発症機序の解明2015

    • Author(s)
      秋山健太郎、池内美穂、蕨栄治、正田純一
    • Organizer
      第19回日本肝臓学会大会
    • Place of Presentation
      東京,東京フォーラム
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] 身体活動が歯周病へ及ぼす影響についての検討2015

    • Author(s)
      大森翔英,内田文彦,蘇 リナ,辻本健彦,正田純一,田中喜代次,武川寛樹
    • Organizer
      第70回日本体力医学会大会
    • Place of Presentation
      和歌山,和歌山県民会館
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 運動習慣が口腔内環境に及ぼす影響についての検討2015

    • Author(s)
      大森 翔英, 内田 文彦, 長谷川 正午, 馬場 脩, 大和地 正信, 山縣 憲司, 柳川 徹, 志田 隆史, 蘇 リナ, 正田 純一, 田中 喜代次, 武川 寛樹
    • Organizer
      第69回日本口腔科学会
    • Place of Presentation
      大阪, 大阪国際会議場
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] 筋萎縮予防法ハイブリッド訓練の女性NAFLD患者に対する有用性の検討2015

    • Author(s)
      丸山 剛,呉 世昶,志田隆史,新井恵美,志波直人,正田純一
    • Organizer
      第163回日本体力医学会関東地方会
    • Place of Presentation
      東京
    • Year and Date
      2015-02-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肥満者におけるirisinの分泌動態と身体活動量の関連性2015

    • Author(s)
      蘇 リナ,呉 世昶,志田隆史,辻本健彦,田中喜代次,正田純一
    • Organizer
      第163回日本体力医学会関東地方会
    • Place of Presentation
      東京
    • Year and Date
      2015-02-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝疾患に対する3次元加速度トレーニングの効果2014

    • Author(s)
      丸山 剛,呉 世昶,佐治朱美,染谷典子,志田隆史,新井恵美,磯辺智範,岡本嘉一,正田純一
    • Organizer
      第162回日本体力医学会関東地方会
    • Place of Presentation
      東京
    • Year and Date
      2014-12-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] ARONJに続発した脳膿瘍の1例.2014

    • Author(s)
      長井宏樹, 山縣憲司, 鈴木亮広, 肥田智香子, 内田文彦, 大和地正信, 菅野直美, 長谷川正午, 柳川 徹, 武川寛樹
    • Organizer
      第198回公益社団法人日本口腔外科学会関東支部学術集会
    • Place of Presentation
      栃木
    • Year and Date
      2014-12-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝疾患における新規筋由来生理活性物質Irisinの分泌動態と病態因子との関連性2014

    • Author(s)
      蘇 リナ,志田隆史,正田純一
    • Organizer
      第40回日本肝臓学会東部会
    • Place of Presentation
      東京
    • Year and Date
      2014-11-27 – 2014-11-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 顎関節強直症に対し側頭筋膜弁を用いた顎関節受動術の1例.2014

    • Author(s)
      肥田智香子, 山縣憲司, 寺邊健人, 長井宏樹, 大和地正信, 菅野直美, 長谷川正午, 柳川 徹, 武川寛樹
    • Organizer
      第1257回千葉医学会(第35回歯科口腔外科例会)
    • Place of Presentation
      千葉
    • Year and Date
      2014-11-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 唇顎口蓋裂における上顎劣成長に対しRigid External Distraction System (REDシステム)を応用した1例.2014

    • Author(s)
      高岡昇平, 山縣憲司, 内田文彦, 菅野直美, 大和地正信, 長谷川正午, 柳川 徹, 武川寛樹,若松進治
    • Organizer
      第1257回千葉医学会(第35回歯科口腔外科例会)
    • Place of Presentation
      千葉
    • Year and Date
      2014-11-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肥満者の肝臓,筋肉,インスリン抵抗性:運動の効果2014

    • Author(s)
      正田純一
    • Organizer
      Metabolic Syndrome と肝疾患研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-11-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] NAFLDを有する肥満者に対する加速度トレーニングの臨床的有用性2014

    • Author(s)
      澤井朱美,呉 世昶,白木 仁,田中喜代次,正田純一
    • Organizer
      第25回臨床スポーツ医学会
    • Place of Presentation
      東京
    • Year and Date
      2014-11-08 – 2014-11-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Moderate-Vigorous Physical Activity (MVPA) Volume in a Week is an Important Factor for Management of Non-Alcoholic Fatty Liver Disease: A Retrospective Study.2014

    • Author(s)
      Oh S, Shida T, So R, Tsujimoto T, Tanaka K, Shoda J
    • Organizer
      The 65th Annual Meeting of the American Association for the Study of Liver Disesaes
    • Place of Presentation
      Boston
    • Year and Date
      2014-11-07 – 2014-11-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Deletion of both p62 and Nrf2 spontaneously leads to development of steatohepatitis in mice.2014

    • Author(s)
      Akiyama K, Warabi E, Okada K, Ikeuchi M, Kose K, Shoda J
    • Organizer
      The 65th Annual Meeting of the American Association for the Study of Liver Disesaes
    • Place of Presentation
      Boston
    • Year and Date
      2014-11-07 – 2014-11-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Irisin is associated with physical activity and hepatic steatosis in non-alcoholic fatty disease patients.2014

    • Author(s)
      So R, Oh S, Shida T, Tanaka K, Shoda J
    • Organizer
      The 65th Annual Meeting of the American Association for the Study of Liver Disesaes
    • Place of Presentation
      Boston
    • Year and Date
      2014-11-07 – 2014-11-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肥満者の肝臓,筋肉,インスリン抵抗性:運動の効果2014

    • Author(s)
      正田純一
    • Organizer
      第10回愛媛軽症糖尿病懇話会
    • Place of Presentation
      愛媛
    • Year and Date
      2014-10-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝疾患を有する肥満者における新しいレジスタンス運動の臨床的有用性2014

    • Author(s)
      呉 世昶,田中喜代次,正田純一
    • Organizer
      第18回日本肝臓学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2014-10-23 – 2014-10-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝炎(NASH)自然発症モデルマウスにおける腸肝相関からみた病態評価と機序の解明2014

    • Author(s)
      秋山健太郎,蕨 栄治,正田純一
    • Organizer
      第18回日本肝臓学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2014-10-23 – 2014-10-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] NAFLD肥満者における中高強度身体活動量の増加が血中脂肪酸組成に及ぼす影響について2014

    • Author(s)
      呉 世昶,田中喜代次,蘇 リナ,加藤千晶,澤井朱美,正田純一
    • Organizer
      第18回日本肝臓学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2014-10-23 – 2014-10-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] HER3陽性の胆道癌に対する分子標的治療pertuzumabの効果2014

    • Author(s)
      川本 徹,山本雅一,正田純一
    • Organizer
      第56回日本消化器病学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2014-10-23 – 2014-10-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 口腔癌の頸部リンパ節転移におけるmiR-205 とInterferon Regulatory Factor 1 の関係.2014

    • Author(s)
      長谷川正午, 内田文彦, 馬場 脩, 長井宏樹, 伊藤孝明, 大和地正信, 菅野直美, 山縣憲司, 柳川 徹, 武川寛樹
    • Organizer
      第59回公益社団法人日本口腔外科学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2014-10-17 – 2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 口腔癌の頸部リンパ節転移におけるmiR-155-5p とzinc finger protein 703 の関係.2014

    • Author(s)
      内田文彦, 長谷川正午, 馬場 脩, 寺邊健人, 伊藤孝明, 大和地正信, 菅野直美, 山縣憲司, 柳川 徹, 武川寛樹
    • Organizer
      第59回公益社団法人日本口腔外科学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2014-10-17 – 2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 口腔がんにおけるmiR-203 の機能解析と臨床応用.2014

    • Author(s)
      馬場 脩, 伊藤孝明, 内田文彦, 大和地正信, 菅野直美, 山縣憲司, 長谷川正午, 柳川 徹, 鬼澤浩司郎, 武川寛樹
    • Organizer
      第59回公益社団法人日本口腔外科学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2014-10-17 – 2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 口底部の小唾液腺に生じた嚢胞腺癌の1 例.2014

    • Author(s)
      菅野直美, 秋月弘道, 川崎陽子, 柳川 徹, 武川寛樹
    • Organizer
      第59回公益社団法人日本口腔外科学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2014-10-17 – 2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] トシリズマブ(アクテムラ)投与患者の舌がん術後に発生した重症肺化膿症の1 例.2014

    • Author(s)
      飯島淳也, 山縣憲司, 内田文彦, 大和地正信, 菅野直美, 生井友農, 廣畠広実, 長谷川正午,柳川 徹, 武川寛樹
    • Organizer
      第59回公益社団法人日本口腔外科学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2014-10-17 – 2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 口腔悪性腫瘍における3D モデルを用いたプレートによる下顎骨再建の審美性の改善.2014

    • Author(s)
      我妻将喜, 柳川 徹, 菅野直美, 山縣憲司, 長谷川正午, 内田文彦, 足立孝二, 武川寛樹
    • Organizer
      第59回公益社団法人日本口腔外科学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2014-10-17 – 2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] ルビエールリンパ節転移を伴った再発口腔癌に対しホウ素中性子捕捉療法を施行した1例.2014

    • Author(s)
      内田文彦, 長谷川正午, 菅野直美, 大和地正信, 山縣憲司, 柳川 徹, 武川寛樹, 大西かよ子, 粟飯原輝人, 石川 仁, 櫻井英幸
    • Organizer
      平成26年度京都大学原子炉実験所専門研究会
    • Place of Presentation
      大阪
    • Year and Date
      2014-09-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 胆道癌における高感度診断システムの開発:新しい腫瘍マーカーとしてのWFA-sialyl MUC1の意義2014

    • Author(s)
      樋口亮太,正田純一,山本雅一
    • Organizer
      第50回日本胆道学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-09-26 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肥満者の肝臓,筋肉,インスリン抵抗性:運動の効果 シンポジウム「メデイカルフィットネス:過去,現在,未来」2014

    • Author(s)
      正田純一
    • Organizer
      第69回日本体力医学会大会
    • Place of Presentation
      長崎
    • Year and Date
      2014-09-19 – 2014-09-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 減量による血中Irisin濃度の変動が肥満病態の改善に及ぼす影響2014

    • Author(s)
      蘇 リナ,辻本健彦,呉 世昶,金 甫建,蕨 栄治,田中喜代次,正田 純一
    • Organizer
      第69回日本体力医学会大会
    • Place of Presentation
      長崎
    • Year and Date
      2014-09-19 – 2014-09-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肥満予防を目的とした全身振動刺激の有用性の基礎的検討2014

    • Author(s)
      堀江正樹,小峰昇一,蘇 リナ,蕨 栄治,正田純一
    • Organizer
      第69回日本体力医学会大会
    • Place of Presentation
      長崎
    • Year and Date
      2014-09-19 – 2014-09-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 運動による肝・骨格筋におけるNrf2活性化の解析2014

    • Author(s)
      小峰昇一,蕨栄治,呉 世昶,堀江正樹,岩脇隆夫,正田純一
    • Organizer
      第69回日本体力医学会大会
    • Place of Presentation
      長崎
    • Year and Date
      2014-09-19 – 2014-09-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] miR-205-5p Targets Interferon Regulatory Factor 1 and Suppresses Metastasis in Oral Cancer Cells.2014

    • Author(s)
      Shogo Hasegawa, Fumihiko Uchida, Osamu Baba, Takaaki Ito, Masanobu Yamatoji, Naomi I. Kanno, Kenji Yamagata, Toru Yanagawa, Hiroki Bukawa.
    • Organizer
      AAOMS Annual Meeting - American Association of Oral and Maxillofacial Surgeons
    • Place of Presentation
      Honolulu
    • Year and Date
      2014-09-08 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] miRNA-155-5p Targets ZNF703 and Suppresses Metastasis in Oral Cancer Cells.2014

    • Author(s)
      Fumihiko Uchida, Shogo Hasegawa, Osamu Baba, Takaaki Ito, Masanobu Yamatoji, Naomi I. Kanno, Kenji Yamagata, Toru Yanagawa, Hiroki Bukawa.
    • Organizer
      AAOMS Annual Meeting - American Association of Oral and Maxillofacial Surgeons
    • Place of Presentation
      Honolulu
    • Year and Date
      2014-09-08 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Utility of Saliva in the Evaluation of Microrna Functions as a Tumor Suppressor in Oral Squamous Cell Carcinoma.2014

    • Author(s)
      Osamu Baba, Takaaki Ito, Fumihiko Uchida, Masanobu Yamatoji, Naomi I. Kanno, Kenji Yamagata, Shogo Hasegawa, Toru Yanagawa, Hiroki Bukawa.
    • Organizer
      AAOMS Annual Meeting - American Association of Oral and Maxillofacial Surgeons
    • Place of Presentation
      Honolulu
    • Year and Date
      2014-09-08 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] NAFLD肥満成人男性の肝および代謝異常の改善を目指した適切な身体活動量の検討2014

    • Author(s)
      呉 世昶,田中喜代次,正田純一
    • Organizer
      第33回日本臨床運動療法学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-09-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肥満・生活習慣病と胆道疾患(胆石・胆道がん)シンポジウム「生活習慣が消化器がんの発生に与える影響:最近の知見」2014

    • Author(s)
      正田純一
    • Organizer
      第52回日本癌治療学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-08-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Clinical benefits of acceleration training for management of obese subjects with non-alcoholic fatty liver disease.2014

    • Author(s)
      Oh S, Shida T, Sawai A, Eguchi K, Maruyama T, So T, Komine S, Horie M, Akiyama K, Tanaka K, Shoda J
    • Organizer
      INCHEON ASIAN GAMES INTERNATIONAL SPORT SCIENCE CONGRESS
    • Place of Presentation
      Korea
    • Year and Date
      2014-08-20 – 2014-08-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 胆管がん患者血清中MUC1 の比較糖鎖プロファイリング2014

    • Author(s)
      松田厚志,久野 敦,中川知美,池原 譲,入村達郎,正田純一,成松 久
    • Organizer
      第12回日本プロテオーム学会
    • Place of Presentation
      つくば
    • Year and Date
      2014-07-17 – 2014-07-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 座談会「NASH の最近の知見 基礎と臨床」2014

    • Author(s)
      正田純一,竹井謙之,橋本悦子
    • Organizer
      最新医学社 座談会
    • Place of Presentation
      東京
    • Year and Date
      2014-06-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肥満・生活習慣病と肝疾患 ― その対策2014

    • Author(s)
      正田純一
    • Organizer
      消化器と生活習慣病フォーラム
    • Place of Presentation
      つくば
    • Year and Date
      2014-06-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肥満と肝臓病 - 加速度トレーニングの臨床的有用性2014

    • Author(s)
      正田純一
    • Organizer
      プロテイアジャパン主催情報交換会
    • Place of Presentation
      東京
    • Year and Date
      2014-06-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 上顎に発生した類腱型エナメル上脾腫に対し上顎部分切除術を施行した1例.2014

    • Author(s)
      長井宏樹, 大和地正信, 柳川 徹, 馬場 脩, 内田文彦, 菅野直美, 山崎善純, 長谷川正午, 山縣憲司, 武川寛樹
    • Organizer
      第197回公益社団法人日本口腔外科学会関東支部学術集会
    • Place of Presentation
      栃木
    • Year and Date
      2014-06-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝疾患(NAFLD)における効果的な運動療法のための適切な身体活動量の検討2014

    • Author(s)
      呉世昶,山岸良匡,田中喜代次,正田純一
    • Organizer
      第22回肝病態生理研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝疾患(NAFLD)における中高度肥満と糖尿病が肝病態に及す影響2014

    • Author(s)
      志田隆史,小野塚太郎,呉 世昶,磯辺智範,岡本嘉一,矢藤 繁,島野 仁,正田純一
    • Organizer
      第22回肝病態生理研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] NASH自然発症モデルマウスにおける腸肝相関よりみたNASH発症とその進展機序の解析2014

    • Author(s)
      秋山健太郎,蕨 栄治,池内美穂,後藤直弘,拝師智之,巨瀬勝美,正田純一
    • Organizer
      第22回肝病態生理研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] p62およびNrf2遺伝子の二重欠損マウスにおけるNASH発症機序の解明―肝と腸管の臓器連関の観点より2014

    • Author(s)
      秋山健太郎,蕨 栄治,池内美穂,後藤直弘,拝師智之,巨瀬勝美,正田純一
    • Organizer
      第50回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-29 – 2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝疾患(NAFLD)における中高度肥満と糖尿病が肝病態に及す影響と病態関連因子の解析2014

    • Author(s)
      志田隆史,小野塚太郎,呉 世昶,磯辺智範,岡本嘉一,矢藤 繁,島野 仁,正田純一
    • Organizer
      第50回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-29 – 2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] NAFLD肥満者に効果的な運動療法を実践するための中高強度身体活動量の検討2014

    • Author(s)
      呉世昶, 田中喜代次, 正田純一
    • Organizer
      第50回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-29 – 2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脂肪肝合併2型糖尿病患者における血中脂肪酸組成と肝弾性度・脂肪量の関係についての検討2014

    • Author(s)
      矢藤 繁,志田隆史,正田純一,松坂 賢,岩崎 仁,小林和人,鈴木浩明,島野 仁
    • Organizer
      糖尿病学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-22 – 2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Non-invasive assessment of ectopic fat in non-alcoholic fatty liver disease using 1H-MRS2014

    • Author(s)
      Isobe T, Okamoto Y, Shida T, Hirano Y, Sato E, Shoda J
    • Organizer
      The 23rd Annual Meeting of the Section of Magnetic Resonance Technologists.
    • Place of Presentation
      Italy
    • Year and Date
      2014-05-10 – 2014-05-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肥満と糖尿病が肝脂肪化と線維化に及す影響と病態関連因子の解析2014

    • Author(s)
      志田隆史,小野塚太郎,呉 世昶,磯辺智範,岡本嘉一,矢藤 繁,島野 仁,正田純一
    • Organizer
      第87回日本超音波医学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-05-09 – 2014-05-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 口腔がんの予後予測マーカーとしてのp62/SQSTM1の有用性.2014

    • Author(s)
      3.内田文彦, 瀬戸佳穂里, 大和地正信, 馬場 脩, 伊藤孝明, 伊藤寛之, 長谷川正午, 山縣憲司, 柳川 徹, 武川寛樹
    • Organizer
      第68回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-07 – 2014-05-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] 当科における異時性多発口腔がんに関する臨床的検討.2014

    • Author(s)
      山縣憲司, 伊藤寛之, 内田文彦, 大和地正信, 菅野直美, 長谷川正午, 柳川 徹, 鬼澤浩司郎, 武川寛樹
    • Organizer
      第68回NPO法人日口腔腔科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-07 – 2014-05-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝疾患(NAFLD)における最適な運動療法の検討2014

    • Author(s)
      呉世昶,田中喜代次,正田純一
    • Organizer
      第100回日本消化器病学会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-23 – 2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] p62およびNrf2遺伝子の二重欠損マウスにおける腸管相関よりみたNASH発症機序の解明2014

    • Author(s)
      蕨 栄治,秋山健太郎,正田純一
    • Organizer
      第100回日本消化器病学会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-23 – 2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Book] New Horizon of Herbal Medicines2016

    • Author(s)
      Shoda J, Warabi E, Okada K, Yamamoto M
    • Total Pages
      264
    • Publisher
      Springer
    • Related Report
      2016 Annual Research Report
  • [Book] 今日の治療指針20172016

    • Author(s)
      正田純一
    • Total Pages
      1999
    • Publisher
      医学書院
    • Related Report
      2016 Annual Research Report
  • [Book] 運動療法 肥満と消化器疾患 市民向けガイド2016

    • Author(s)
      正田純一
    • Total Pages
      18
    • Publisher
      金原出版
    • Related Report
      2016 Annual Research Report
  • [Book] 結石症の診断と治療2016

    • Author(s)
      正田純一
    • Total Pages
      1592
    • Publisher
      医学と薬学
    • Related Report
      2016 Annual Research Report
  • [Book] 胆汁酸とその分画 新・検査値のみかた2015

    • Author(s)
      正田純一
    • Total Pages
      2
    • Publisher
      中外医学社
    • Related Report
      2014 Annual Research Report
  • [Book] A clinical study of metachronous multiple cancers within the oral cavity.2014

    • Author(s)
      Yamagata K, Ito H, Uchida F, Kanno N, Yamatoji M, Hasegawa S, Yanagawa T, Onizawa K, Bukawa H
    • Total Pages
      2
    • Publisher
      Oral Science in Japan
    • Related Report
      2014 Annual Research Report
  • [Book] Epidemiology and Pathogenesis of Hepatocellular Carcinoma. In: Hepatocellular Carcinoma.2014

    • Author(s)
      Shoda, J., Ohokohchi, N.
    • Total Pages
      23
    • Publisher
      NOVA Science Publishers
    • Related Report
      2014 Annual Research Report
  • [Book] 肝内胆管癌の新規バイオマーカー2014

    • Author(s)
      正田純一,松田厚志,久野 敦,池原 譲,成松 久,大河内信弘,山本雅一,中沼安二
    • Total Pages
      5
    • Publisher
      Hepatology Practice 文光堂
    • Related Report
      2014 Annual Research Report
  • [Book] 生活習慣と胆道癌-胆管癌集団発症への対策も含めて Annual Review 消化器 20142014

    • Author(s)
      正田純一
    • Total Pages
      5
    • Publisher
      中外医学社
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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