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The regulatory role of Nrf2 in pathogenesis and carcinogenesis of NASH using gene rescued mice

Research Project

Project/Area Number 26293297
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionUniversity of Tsukuba

Principal Investigator

ISHIGE Kazunori  筑波大学, 医学医療系, 講師 (20597918)

Co-Investigator(Kenkyū-buntansha) 柳川 徹  筑波大学, 医学医療系, 准教授 (10312852)
酒井 俊  筑波大学, 医学医療系, 講師 (30282362)
磯辺 智範  筑波大学, 医学医療系, 准教授 (70383643)
蕨 栄治  筑波大学, 医学医療系, 講師 (70396612)
正田 純一  筑波大学, 医学医療系, 教授 (90241827)
Co-Investigator(Renkei-kenkyūsha) YAMAMOTO Masayuki  東北大学, 医学系研究科, 教授 (50166823)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Keywords生活習慣病 / 脂肪性肝炎 / 肝癌 / 遺伝子改変マウス / 病態生理 / 肥満関連肝疾患 / 転写因子 / 遺伝子レスキューマウス / 肝発癌
Outline of Final Research Achievements

We generated Sqstm1 and Nrf2 double knockout (DKO) mice as the noble NASH animal model. We revealed the mechanism for the development of steatohepatitis in DKO mice as follows: (1) Deficiency of Nrf2 led to hypersensitivity to endotoxin of Kupffer cells and resulted in the inflammatory response in the DKO livers. (2) Acceleration of intestinal permeability which was caused by down-regulation of Zo-1 and Claudin1 in Nrf2 deficiency and increased endotoxin from intestinal microbiota by Sqstm1 deficiency led to an overload of serum endotoxin. (3) These hyper-endotoxemia drove inflammatory signaling in livers directly, and also led to inflammation of adipose tissue. (4) These enhanced inflammatory signaling could cause progression of steatohepatitis in DKO livers. We plan to compare DKO and Nrf2 gene rescued mice, and explore the detail of the mechanism for development of NASH and the carcinogenesis in contribution of each organ in the near future.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(83 results)

All 2017 2016 2015 2014

All Journal Article (22 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 20 results,  Open Access: 20 results,  Acknowledgement Compliant: 17 results) Presentation (52 results) (of which Int'l Joint Research: 2 results) Book (9 results)

  • [Journal Article] High-intensity aerobic exercise improves both hepatic fat content and stiffness in sedentary obese men with non-alcoholic fatty liver disease: A randomized controlled study.2017

    • Author(s)
      Oh S, So R, Shida T, Matsuo T, Kim B, Akiyama K, Isobe T, Okamoto Y, Tanaka K, Shoda J.
    • Journal Title

      Sci Rep.

      Volume: 7 Pages: 43029-43029

    • DOI

      10.1038/srep43029

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Wisteria floribunda Agglutinin-Sialylated Mucin Core Polypeptide 1 is a Sensitive Biomarker for Biliary Tract Carcinoma and Intrahepatic Cholangiocarcinoma: A Multicenter Study.2017

    • Author(s)
      Shoda J, Matsuda A, Shida T, Yamamoto M, Nagino M, Tsuyuguchi T, Yasaka T, Tazuma S, Uchiyama K, Unno M, Ohkohchi N, Nakanuma Y, Kuno A, Narimatsu H.
    • Journal Title

      Journal of Gastroenterology

      Volume: 52 Pages: 218-228

    • DOI

      10.1007/s00535-016-1230-0

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 陽子線による放射線性十二指腸炎からの出血に対してアルゴンプラズマ凝固法が有用であった1例2016

    • Author(s)
      高木 薫子, 長谷川 直之, 新里 悠輔, 山浦 正道, 小松 義希, 俣野 大介, 岩井 健太郎, 江南 ちあき, 石毛 和紀, 福田 邦明, 奈良坂 俊明, 金子 剛, 安部井 誠人, 兵頭 一之介, 溝上 裕士
    • Journal Title

      Progress of Digestive Endoscopy

      Volume: 89 Pages: 106-107

    • NAID

      130005303529

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 小細胞肺癌へ転化し、EGFR遺伝子変異検索が鑑別に有用であった肺腺癌の1例2016

    • Author(s)
      田地 広明, 會田 有香, 大澤 翔, 北沢 晴奈, 中嶋 真之, 渡辺 裕子, 塩澤 利博, 中澤 健介, 増子 裕典, 小川 良子, 際本 拓未, 松野 洋輔, 川口 未央, 森島 祐子, 坂本 透, 家城 隆次, 檜澤 伸之, 石毛 和紀, 坂下 信悟, 野口 雅之, 後藤 行延, 佐藤 幸夫, 関根 郁夫
    • Journal Title

      肺癌

      Volume: 56 Pages: 321-322

    • Related Report
      2016 Annual Research Report
  • [Journal Article] p62 modulates the intrinsic signaling of UVB-induced apoptosis.2016

    • Author(s)
      Ito S, Kimura S, Warabi E, Kawachi Y, Yamatoji M, Uchida F, Ishibashi-Kanno N, Yamagata K, Hasegawa S, Shoda J, Tabuchi K, Sakai S, Bukawa H, Sekido M, Yanagawa T.
    • Journal Title

      J Dermatol Sci.

      Volume: 83 Pages: 9-17

    • DOI

      10.1016/j.jdermsci.2016.05.005

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Verification of WFA-Sialylated MUC1 as a Sensitive Biliary Biomarker for Human Biliary Tract Cancer.2016

    • Author(s)
      Yamaguchi T, Yokoyama Y, Ebata T, Matsuda A, Kuno A, Ikehara Y,Shoda J, Narimatsu H, Nagino M.
    • Journal Title

      Anal Sug Oncol

      Volume: 23(2) Pages: 671-677

    • DOI

      10.1245/s10434-015-4878-4

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cytoprotective Role of Nrf2 in Electrical Pulse Stimulated C2C12 Myotube.2015

    • Author(s)
      Horie M, Warabi E, Komine S, Oh S, Shoda J.
    • Journal Title

      PLOS ONE

      Volume: 10 Pages: 12-12

    • DOI

      10.1371/journal.pone.0144835

    • NAID

      120007127849

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Moderate to vigorous physical activity volume is an important factor for managing non-alcoholic fatty liver disease : A retrospec tive study2015

    • Author(s)
      Oh S, Shida T, Tanaka K, Y amagishi K, So R, Tsujimoto T, Shoda J:
    • Journal Title

      Hepatology

      Volume: 61(4) Pages: 1205-1215

    • DOI

      10.1002/hep.27544

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Moderate to vigorous physical activity is an important factor for managing non-alcoholic fatty liver disease2015

    • Author(s)
      Oh S, Tanaka K, Chiaki K, Tsujimoto T, So R, Shida T, Shoda J
    • Journal Title

      Hepatology

      Volume: 61 Pages: 1205-2015

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] FibroScan502の肝脂肪量測定による非アルコール性脂肪性肝疾患の非侵襲的診断法の有用性について2015

    • Author(s)
      志田隆史,磯辺智範,呉 世昶,上牧 隆,岡本嘉一,安藤浩樹,正田純一
    • Journal Title

      日本超音波技師学会雑誌

      Volume: 40 Pages: 167-173

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Overexpression and Gene Amplification of HER1, HER2 and HER3 in Biliary Tract Carcinomas and the Possibility for Therapy with a HER2-Targeting Antibody Pertuzumab.2015

    • Author(s)
      Kawamoto T, Thomas M, Yamashita-Kashima Y, Shu S, Ishikura N, Ariizumi S, Yamamoto M, Kurosaki K, Shoda J
    • Journal Title

      J Gastroenterrol

      Volume: 50 Pages: 467-479

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Therapeutic effect of hybrid training of voluntary and electrical muscle contractions on middle-aged obese women with NAFLD: a pilot study.2015

    • Author(s)
      Oh S, Shida T, Ikeda A, Maruyama T, Eguchi K, Isobe T, Okamoto Y, Arai E, Shiba N, Shoda J.
    • Journal Title

      Ther Clin Risk Manag

      Volume: 11 Pages: 371-380

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Expression of insulin-like growth factor receptor (IGFR) as a useful biomarker for predicting prognosis in biliary tract cancer patients.2015

    • Author(s)
      Suzuki H, Roa JC, Kawamoto T, Ishige K, Shoda J, Wistuba II, Li D, Thomas MB.
    • Journal Title

      Mol & Clin Oncol

      Volume: 3 Pages: 464-470

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 茨城県における肝細胞癌疫学調査.2014

    • Author(s)
      佐野直樹,田村孝史,福永 潔,高野恵輔,山岸良匡,正田純一,相川達也,大河内信弘
    • Journal Title

      肝臓

      Volume: 55 Pages: 771-773

    • NAID

      130004897340

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Changes in diffusion tensor imaging (DTI) eigenvalues of skeletal muscle due to hybrid exercise training Magnetic Resonance Imaging.2014

    • Author(s)
      Okamoto Y, Kemp GJ, Isobe T, Sato E, Hirano Y, Shoda J, Minami M.
    • Journal Title

      Magnetic Resonance Imaging

      Volume: 32 Pages: 1297-1300

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Abdominal obesity: causal factor or simply a symptom of obesity-related healyh risk.2014

    • Author(s)
      Oh S, Tanaka K, Noh J, So R, Tsujimoto T, Sasai H, Kim M, Shoda J.
    • Journal Title

      Diabetes, Metab Syn & Obesity

      Volume: 7 Pages: 289-296

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Acceleration training for management of non-alcoholic fatty liver disease: a pilot study.2014

    • Author(s)
      Oh S, Shida T, Onozuka T, Maruyama T, Eguchi K, Isobe T, Okamoto Y, Someya N, Tanaka K, Tozawa A, Arai E, Shoda J.
    • Journal Title

      Ther Clin Risk Manag

      Volume: 10 Pages: 925-936

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Interaction of Muc4 and ErbB2 in a transgenic mouse model of gallbladder carcinoma: potential pathobiological implications.2014

    • Author(s)
      Miyahara N, Ishida H, Ueda T, Kawamoto T, Akimoto Y, Kawakami H, DiGiovanni J, Kiguchi K, Irimura T, Shoda J.
    • Journal Title

      Oncol Rep

      Volume: 32 Pages: 1796-1802

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Regular Exercise Coupled to Diet Regimen Accelerates Reduction of Hepatic Steatosis and Associated Pathological Conditions in Non-Alcoholic Fatty Liver Disease.2014

    • Author(s)
      Oh S, Tanaka K, Tsujimoto T, So R, Eto M, Shoda J.
    • Journal Title

      Metabolic Syndrome & Related Disorders

      Volume: 12 Pages: 290-298

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Interleukin-4 receptor α-based hybrid peptide effectively induces antitumor activity in biliary tract cancer cells.2014

    • Author(s)
      Seto K, Shoda J, Horibe T, Warabi E, Kohno M, Yanagawa T, Bukawa H, Nakanuma Y, Kawakami Y.
    • Journal Title

      Int J Hepatol

      Volume: 10 Pages: 1155-1161

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Peroxidoxin I plays a ptotective role against UVA irradiation through reduction of oxidative stress.2014

    • Author(s)
      Ito T, Kimura S, Seto K, Warabi E, Kawauchi Y, Shoda J, Tabuchi K, Yamagata K, Hasegawa S, Bukawa H, Ishii T, Yanagawa T.
    • Journal Title

      J Dermatol Sci

      Volume: 74 Pages: 9-17

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Expression of N-acetylglucosaminyltransferase V in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder.2014

    • Author(s)
      Onuki K, Sugiyama H, Ishige K, Kawamoto T, Ota T, Ariizumi S, Yamato M, Kadota S, Takeuchi K, Ishikawa A, Onodera M, Onizawa K, Yamamoto M, Miyoshi E, Shoda J.
    • Journal Title

      J Gastroenterol

      Volume: 49 Pages: 702-714

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 内視鏡的経胃ドレナージ・経乳頭ドレナージ、経皮的ドレナージを組み合わせた治療が有用であった慢性膵炎後膵仮性嚢胞の一例2016

    • Author(s)
      内田 優一, 長谷川 直之, 石毛 和紀, 福田 邦明, 奈良坂 俊明, 金子 剛, 安部井 誠人, 溝上 裕士, 兵頭 一之介
    • Organizer
      第103回日本消化器内視鏡学会関東支部会
    • Place of Presentation
      シェーンバッハ・サボー(東京都・千代田区)
    • Year and Date
      2016-12-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] ダビガトランによる剥離性食道炎を伴った食道表在癌の1例2016

    • Author(s)
      野中 遥奈, 田島 大樹, 廣瀬 優, 山浦 正道, 菅沼 大輔, 佐藤 雅志, 内田 優一, 山田 武史, 山本 祥之, 長谷川 直之, 石毛 和紀, 金子 剛, 鈴木 英雄, 奈良坂 俊明, 福田 邦明, 安部井 誠人, 兵頭 一之介, 溝上 裕士
    • Organizer
      第103回日本消化器内視鏡学会関東支部会
    • Place of Presentation
      シェーンバッハ・サボー(東京都・千代田区)
    • Year and Date
      2016-12-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 陽子線による放射線性十二指腸炎からの出血に対してアルゴンプラズマ凝固法(APC)が有用であった一例2016

    • Author(s)
      高木 薫子, 長谷川 直之, 新里 悠輔, 山浦 正道, 小松 義希, 俣野 大介, 岩井 健太郎, 江南 ちあき, 石毛 和紀, 福田 邦明, 奈良坂 俊明, 金子 剛, 安部井 誠人, 溝上 裕士, 兵頭 一之介
    • Organizer
      第102回日本消化器内視鏡学会関東支部会
    • Place of Presentation
      シェーンバッハ・サボー(東京都・千代田区)
    • Year and Date
      2016-12-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 肝癌ラジオ波焼灼術におけるSPIO-MRIの有用性2016

    • Author(s)
      福田 邦明, 森 健作, 長谷川 直之, 石毛 和紀, 那須 克宏, 安部井 誠人, 南 学, 兵頭 一之介
    • Organizer
      第58回日本消化器病学会大会
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 抗凝固薬による薬剤性食道炎の検討2016

    • Author(s)
      奈良坂 俊明, 溝上 裕士, 俣野 大介, 岩井 健太郎, 江南 ちあき, 寺崎 正彦, 圷 大輔, 長谷川 直之, 石毛 和紀, 金子 剛, 鈴木 英雄, 福田 邦明, 松井 裕史, 兵頭 一之介
    • Organizer
      第92回日本消化器内視鏡学会総会
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 胆道癌に関連した後天性血友病の2例2016

    • Author(s)
      佐藤 雅志, 長谷川 直之, 松田 健二, 橋本 真治, 石毛 和紀, 福田 邦明, 西 雅明, 川西 宣裕, 松木 康彦, 安部井 誠人, 溝上 裕士, 兵頭 一之介
    • Organizer
      胆道
    • Place of Presentation
      横浜プリンスホテル(神奈川県・横浜市)
    • Year and Date
      2016-09-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] 安全で確実な内視鏡診療のためのリスクマネージメント 当院における内視鏡リスクマネージメント2016

    • Author(s)
      奈良坂 俊明, 石毛 和紀, 長谷川 直之, 圷 大輔, 溝上 裕士
    • Organizer
      第102回日本消化器内視鏡学会関東支部会
    • Place of Presentation
      シェーンバッハ・サボー(東京都・千代田区)
    • Year and Date
      2016-06-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] 超音波を用いた非アルコール性脂肪性肝疾患における骨格筋異常の解析.2016

    • Author(s)
      志田隆史,丸山 剛,呉 世昶,秋山健太郎,澤井朱美,福元喜啓,磯辺智範,平野雄二,岡本嘉一,正田純一.
    • Organizer
      日本超音波医学会第89回学術集会
    • Place of Presentation
      京都国際会館(京都府・京都市)
    • Year and Date
      2016-05-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝疾患に効果的な運動プログラムの検討ー前向きランダム化比較試験よりー2016

    • Author(s)
      蘇リナ,田中 喜代次,正田 純一.
    • Organizer
      第52回日本肝臓学会総会
    • Place of Presentation
      ホテルニューオータニ幕張(千葉県・千葉市)
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 骨格筋が非アルコール性脂肪性肝疾患(NAFLD)における代謝病態因子に及ぼす影響2016

    • Author(s)
      呉世昶,石原瑞穂,志田隆史,正田純一,
    • Organizer
      第52回日本肝臓学会総会
    • Place of Presentation
      ホテルニューオータニ幕張(千葉県・千葉市)
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝炎(NASH)自然発症マウスにおける Kupffer 細胞の表現形質 の変化と発症機序との関連性.2016

    • Author(s)
      秋山健太郎,蕨栄治,正田純一.
    • Organizer
      第102回日本消化器病学会総会
    • Place of Presentation
      京王プラザホテル(東京都・新宿区)
    • Year and Date
      2016-04-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] NAFLDに随伴する中高度肥満と糖尿病がKupffer細胞機能に及ぼす影響と運動療法の効果.2016

    • Author(s)
      志田隆史,秋山健太郎,内田文彦,蘇 リナ,呉 世昶,田中弘教,飯島尋子,正田純一.
    • Organizer
      第102回日本消化器病学会総会
    • Place of Presentation
      京王プラザホテル(東京都・新宿区)
    • Year and Date
      2016-04-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] p62:Nrf2 double knockout mice develop steatohepatitis through the serum endotoxin overload.2016

    • Author(s)
      Kentaro Akiyama, Eiji Warabi, Kosuke Okada, Syunnichi Ariizumi, Masakazu Yamamoto, Junnichi Shoda.
    • Organizer
      25th Conference of the Asian Pacific Association for the Study of the Liver
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2016-02-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effect of female hormones on NAFLD in p62 knockout mice.2016

    • Author(s)
      Miho Ikeuchi, Eiji Warabi, Tsugumi Nagaoka, Syunichi Ariizumi, Masakazu Yamamoto, Junichi Shoda.
    • Organizer
      25th Conference of the Asian Pacific Association for the Study of the Liver
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2016-02-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] p62: Nrf2遺伝子二重欠損マウスは血清中エンドトキシンが増加し,脂肪性肝炎を発症する.2015

    • Author(s)
      秋山健太郎、蕨栄治、岡田浩介、正田純一.
    • Organizer
      第88回日本生化学会大会
    • Place of Presentation
      神戸,ポートピアホテル
    • Year and Date
      2015-12-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] 筋萎縮予防法ハイブリッド訓練の女性NAFLD患者に対する有用性の検討2015

    • Author(s)
      丸山 剛,呉 世昶,志田隆史,新井恵美,志波直人,正田純一
    • Organizer
      第163回日本体力医学会関東地方会
    • Place of Presentation
      東京
    • Year and Date
      2015-02-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肥満者におけるirisinの分泌動態と身体活動量の関連性2015

    • Author(s)
      蘇 リナ,呉 世昶,志田隆史,辻本健彦,田中喜代次,正田純一
    • Organizer
      第163回日本体力医学会関東地方会
    • Place of Presentation
      東京
    • Year and Date
      2015-02-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝疾患に対する3次元加速度トレーニングの効果2014

    • Author(s)
      丸山 剛,呉 世昶,佐治朱美,染谷典子,志田隆史,新井恵美,磯辺智範,岡本嘉一,正田純一
    • Organizer
      第162回日本体力医学会関東地方会
    • Place of Presentation
      東京
    • Year and Date
      2014-12-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝疾患における新規筋由来生理活性物質Irisinの分泌動態と病態因子との関連性2014

    • Author(s)
      蘇 リナ,志田隆史,正田純一
    • Organizer
      第40回日本肝臓学会東部会
    • Place of Presentation
      東京
    • Year and Date
      2014-11-27 – 2014-11-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肥満者の肝臓,筋肉,インスリン抵抗性:運動の効果2014

    • Author(s)
      正田純一
    • Organizer
      Metabolic Syndrome と肝疾患研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-11-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] NAFLDを有する肥満者に対する加速度トレーニングの臨床的有用性2014

    • Author(s)
      澤井朱美,呉 世昶,白木 仁,田中喜代次,正田純一
    • Organizer
      第25回臨床スポーツ医学会
    • Place of Presentation
      東京
    • Year and Date
      2014-11-08 – 2014-11-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Moderate-Vigorous Physical Activity (MVPA) Volume in a Week is an Important Factor for Management of Non-Alcoholic Fatty Liver Disease: A Retrospective Study.2014

    • Author(s)
      Oh S, Shida T, So R, Tsujimoto T, Tanaka K, Shoda J
    • Organizer
      The 65th Annual Meeting of the American Association for the Study of Liver Disesaes
    • Place of Presentation
      Boston
    • Year and Date
      2014-11-07 – 2014-11-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Deletion of both p62 and Nrf2 spontaneously leads to development of steatohepatitis in mice.2014

    • Author(s)
      Akiyama K, Warabi E, Okada K, Ikeuchi M, Kose K, Shoda J
    • Organizer
      The 65th Annual Meeting of the American Association for the Study of Liver Disesaes
    • Place of Presentation
      Boston
    • Year and Date
      2014-11-07 – 2014-11-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Irisin is associated with physical activity and hepatic steatosis in non-alcoholic fatty disease patients.2014

    • Author(s)
      So R, Oh S, Shida T, Tanaka K, Shoda J
    • Organizer
      The 65th Annual Meeting of the American Association for the Study of Liver Disesaes
    • Place of Presentation
      Boston
    • Year and Date
      2014-11-07 – 2014-11-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肥満者の肝臓,筋肉,インスリン抵抗性:運動の効果2014

    • Author(s)
      正田純一
    • Organizer
      第10回愛媛軽症糖尿病懇話会
    • Place of Presentation
      愛媛
    • Year and Date
      2014-10-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝疾患を有する肥満者における新しいレジスタンス運動の臨床的有用性2014

    • Author(s)
      呉 世昶,田中喜代次,正田純一
    • Organizer
      第18回日本肝臓学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2014-10-23 – 2014-10-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝炎(NASH)自然発症モデルマウスにおける腸肝相関からみた病態評価と機序の解明2014

    • Author(s)
      秋山健太郎,蕨 栄治,正田純一
    • Organizer
      第18回日本肝臓学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2014-10-23 – 2014-10-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] NAFLD肥満者における中高強度身体活動量の増加が血中脂肪酸組成に及ぼす影響について2014

    • Author(s)
      呉 世昶,田中喜代次,蘇 リナ,加藤千晶,澤井朱美,正田純一
    • Organizer
      第18回日本肝臓学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2014-10-23 – 2014-10-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] HER3陽性の胆道癌に対する分子標的治療pertuzumabの効果2014

    • Author(s)
      川本 徹,山本雅一,正田純一
    • Organizer
      第56回日本消化器病学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2014-10-23 – 2014-10-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 胆道癌における高感度診断システムの開発:新しい腫瘍マーカーとしてのWFA-sialyl MUC1の意義2014

    • Author(s)
      樋口亮太,正田純一,山本雅一
    • Organizer
      第50回日本胆道学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-09-26 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肥満者の肝臓,筋肉,インスリン抵抗性:運動の効果 シンポジウム「メデイカルフィットネス:過去,現在,未来」2014

    • Author(s)
      正田純一
    • Organizer
      第69回日本体力医学会大会
    • Place of Presentation
      長崎
    • Year and Date
      2014-09-19 – 2014-09-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 減量による血中Irisin濃度の変動が肥満病態の改善に及ぼす影響2014

    • Author(s)
      蘇 リナ,辻本健彦,呉 世昶,金 甫建,蕨 栄治,田中喜代次,正田 純一
    • Organizer
      第69回日本体力医学会大会
    • Place of Presentation
      長崎
    • Year and Date
      2014-09-19 – 2014-09-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肥満予防を目的とした全身振動刺激の有用性の基礎的検討2014

    • Author(s)
      堀江正樹,小峰昇一,蘇 リナ,蕨 栄治,正田純一
    • Organizer
      第69回日本体力医学会大会
    • Place of Presentation
      長崎
    • Year and Date
      2014-09-19 – 2014-09-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 運動による肝・骨格筋におけるNrf2活性化の解析2014

    • Author(s)
      小峰昇一,蕨栄治,呉 世昶,堀江正樹,岩脇隆夫,正田純一
    • Organizer
      第69回日本体力医学会大会
    • Place of Presentation
      長崎
    • Year and Date
      2014-09-19 – 2014-09-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] NAFLD肥満成人男性の肝および代謝異常の改善を目指した適切な身体活動量の検討2014

    • Author(s)
      呉 世昶,田中喜代次,正田純一
    • Organizer
      第33回日本臨床運動療法学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-09-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肥満・生活習慣病と胆道疾患(胆石・胆道がん)シンポジウム「生活習慣が消化器がんの発生に与える影響:最近の知見」2014

    • Author(s)
      正田純一
    • Organizer
      第52回日本癌治療学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-08-28 – 2014-08-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Clinical benefits of acceleration training for management of obese subjects with non-alcoholic fatty liver disease.2014

    • Author(s)
      Oh S, Shida T, Sawai A, Eguchi K, Maruyama T, So T, Komine S, Horie M, Akiyama K, Tanaka K, Shoda J
    • Organizer
      INCHEON ASIAN GAMES INTERNATIONAL SPORT SCIENCE CONGRESS (Korea)
    • Place of Presentation
      Korea
    • Year and Date
      2014-08-20 – 2014-08-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 胆管がん患者血清中MUC1 の比較糖鎖プロファイリング2014

    • Author(s)
      松田厚志,久野 敦,中川知美,池原 譲,入村達郎,正田純一,成松 久
    • Organizer
      第12回日本プロテオーム学会
    • Place of Presentation
      つくば
    • Year and Date
      2014-07-17 – 2014-07-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 座談会「NASH の最近の知見 基礎と臨床」2014

    • Author(s)
      正田純一,竹井謙之,橋本悦子
    • Organizer
      最新医学社 座談会
    • Place of Presentation
      東京
    • Year and Date
      2014-06-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肥満・生活習慣病と肝疾患2014

    • Author(s)
      正田純一
    • Organizer
      その対策 消化器と生活習慣病フォーラム
    • Place of Presentation
      つくば
    • Year and Date
      2014-06-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肥満と肝臓病 - 加速度トレーニングの臨床的有用性2014

    • Author(s)
      正田純一
    • Organizer
      プロテイアジャパン主催情報交換会
    • Place of Presentation
      東京
    • Year and Date
      2014-06-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝疾患(NAFLD)における効果的な運動療法のための適切な身体活動量の検討2014

    • Author(s)
      呉世昶,山岸良匡,田中喜代次,正田純一
    • Organizer
      第22回肝病態生理研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝疾患(NAFLD)における中高度肥満と糖尿病が肝病態に及す影響2014

    • Author(s)
      志田隆史,小野塚太郎,呉 世昶,磯辺智範,岡本嘉一,矢藤 繁,島野 仁,正田純一
    • Organizer
      第22回肝病態生理研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] NASH自然発症モデルマウスにおける腸肝相関よりみたNASH発症とその進展機序の解析2014

    • Author(s)
      秋山健太郎,蕨 栄治,池内美穂,後藤直弘,拝師智之,巨瀬勝美,正田純一
    • Organizer
      第22回肝病態生理研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] p62およびNrf2遺伝子の二重欠損マウスにおけるNASH発症機序の解明―肝と腸管の臓器連関の観点より2014

    • Author(s)
      秋山健太郎,蕨 栄治,池内美穂,後藤直弘,拝師智之,巨瀬勝美,正田純一
    • Organizer
      第50回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-29 – 2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝疾患(NAFLD)における中高度肥満と糖尿病が肝病態に及す影響と病態関連因子の解析2014

    • Author(s)
      志田隆史,小野塚太郎,呉 世昶,磯辺智範,岡本嘉一,矢藤 繁,島野 仁,正田純一
    • Organizer
      第50回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-29 – 2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] NAFLD肥満者に効果的な運動療法を実践するための中高強度身体活動量の検討2014

    • Author(s)
      呉世昶, 田中喜代次, 正田純一
    • Organizer
      第50回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-29 – 2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脂肪肝合併2型糖尿病患者における血中脂肪酸組成と肝弾性度・脂肪量の関係についての検討2014

    • Author(s)
      矢藤 繁,志田隆史,正田純一,松坂 賢,岩崎 仁,小林和人,鈴木浩明,島野 仁
    • Organizer
      糖尿病学会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-22 – 2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Non-invasive assessment of ectopic fat in non-alcoholic fatty liver disease using 1H-MRS2014

    • Author(s)
      Isobe T, Okamoto Y, Sihda T, Hirano Y, Sato E, Shoda J
    • Organizer
      The 23rd Annual Meeting of the Section of Magnetic Resonance Technologists.
    • Place of Presentation
      Italy
    • Year and Date
      2014-05-10 – 2014-05-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肥満と糖尿病が肝脂肪化と線維化に及す影響と病態関連因子の解析2014

    • Author(s)
      志田隆史,小野塚太郎,呉 世昶,磯辺智範,岡本嘉一,矢藤 繁,島野 仁,正田純一
    • Organizer
      第87回日本超音波医学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-05-09 – 2014-05-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝疾患(NAFLD)における最適な運動療法の検討2014

    • Author(s)
      呉世昶,田中喜代次,正田純一
    • Organizer
      第100回日本消化器病学会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-23 – 2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] p62およびNrf2遺伝子の二重欠損マウスにおける腸管相関よりみたNASH発症機序の解明2014

    • Author(s)
      蕨 栄治,秋山健太郎,正田純一
    • Organizer
      第100回日本消化器病学会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-23 – 2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Book] New Horizon of Herbal Medicines2016

    • Author(s)
      Shoda J, Warabi E, Okada K, Yamamoto M
    • Total Pages
      264
    • Publisher
      Springer
    • Related Report
      2016 Annual Research Report
  • [Book] 今日の治療指針20172016

    • Author(s)
      正田純一
    • Total Pages
      1999
    • Publisher
      医学書院
    • Related Report
      2016 Annual Research Report
  • [Book] 肥満と消化器疾患 市民向けガイド2016

    • Author(s)
      正田純一
    • Total Pages
      18
    • Publisher
      金原出版
    • Related Report
      2016 Annual Research Report
  • [Book] 結石症の診断と治療2016

    • Author(s)
      正田純一
    • Total Pages
      1592
    • Publisher
      医学と薬学
    • Related Report
      2016 Annual Research Report
  • [Book] 肝胆膵 HER family:肝内胆管癌のpotential drug targets2016

    • Author(s)
      川本 徹,山本雅一,正田純一
    • Total Pages
      176
    • Publisher
      メディカルビュー社
    • Related Report
      2016 Annual Research Report
  • [Book] 胆汁酸とその分画 新・検査値のみかた2015

    • Author(s)
      正田純一
    • Total Pages
      2
    • Publisher
      中外医学社
    • Related Report
      2014 Annual Research Report
  • [Book] Epidemiology and Pathogenesis of Hepatocellular Carcinoma. In: Hepatocellular Carcinoma.2014

    • Author(s)
      Shoda, J., Ohokohchi, N.
    • Total Pages
      23
    • Publisher
      NOVA Science Publishers
    • Related Report
      2014 Annual Research Report
  • [Book] 肝内胆管癌の新規バイオマーカー2014

    • Author(s)
      正田純一,松田厚志,久野 敦,池原 譲,成松 久,大河内信弘,山本雅一,中沼安二
    • Total Pages
      3
    • Publisher
      Hepatology Practice 文光堂
    • Related Report
      2014 Annual Research Report
  • [Book] 生活習慣と胆道癌-胆管癌集団発症への対策も含めて Annual Review 消化器 20142014

    • Author(s)
      正田純一
    • Total Pages
      5
    • Publisher
      中外医学社
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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