Cell therapy and electrical stimulation for diseases in the central nervous system
Project/Area Number |
26293323
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Neurosurgery
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Research Institution | Okayama University |
Principal Investigator |
Date Isao 岡山大学, 医歯(薬)学総合研究科, 教授 (70236785)
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Co-Investigator(Kenkyū-buntansha) |
黒住 和彦 岡山大学, 大学病院, 講師 (20509608)
道上 宏之 岡山大学, 医歯(薬)学総合研究科, 助教 (20572499)
近藤 聡彦 独立行政法人国立病院機構(静岡・てんかん神経医療センター臨床研究部), その他部局等, 脳神経外科医師 (20721137)
安原 隆雄 岡山大学, 医歯(薬)学総合研究科, 講師 (50457214)
亀田 雅博 岡山大学, 医歯(薬)学総合研究科, 助教 (50586427)
上利 崇 岡山大学, 大学病院, 助教 (60423290)
菱川 朋人 岡山大学, 大学病院, 助教 (60509610)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
|
Keywords | 細胞移植 / 電気刺激 / 脳梗塞 / パーキンソン病 |
Outline of Final Research Achievements |
We revealed the following. 1. Neuroprotective effects of spinal cord stimulation for Parkinson’s disease model of rats 2. Strong therapeutic effects of transplantation of mesenchymal stem cells at 24 hours after onset for stroke model of rats 3. Enhanced migratory effects of transplanted mesenchymal stem cells by electrical stimulation for stroke model of rats
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Report
(4 results)
Research Products
(225 results)
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[Journal Article] A case of very long longitudinally extensive transverse myelitis (LETM) with necrotizing Vasculitis2017
Author(s)
Sato K , Tsunoda K , Yamashita T, Takemoto M , Hishikawa N, Ohta Y , Takahashi T , Nakashima I , Yasuhara T , Date I , Abe K
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Journal Title
Journal of the Neurological Sciences
Volume: 373
Pages: 152-154
DOI
Related Report
Peer Reviewed
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[Journal Article] Perioperative Management Center (PERIO) for Neurosurgical Patients2016
Author(s)
Yasuhara T, Hishikawa T, Agari T, Kurozumi K, Ichikawa T, Kameda M, Shinko A, Ishida J, Hiramatsu M, Kobayashi M, Matsuoka Y, Sasaki T, Soga Y, Yamanaka R, Ashiwa T, Arioka A, Hashimoto Y, Misaki A, Ishihara Y, Sato M, Morimatsu H, Date I
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Journal Title
Neurologia medico-chirurgica
Volume: 56
Issue: 9
Pages: 574-579
DOI
NAID
ISSN
0470-8105, 1349-8029
Related Report
Peer Reviewed / Open Access
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[Journal Article] Anti-high mobility group box 1 antibody exerts neuroprotection in a rat model of Parkinson's disease.2016
Author(s)
Sasaki, T., Liu, K., Agari, T., Yasuhara, T., Morimoto, J., Okazaki, M., Takeuchi, H., Toyoshima, A., Sasada, S., Shinko, A., Kondo, A., Kameda, M., Miyazaki, I., Asanuma, M., Borlongan, C.V., Nishibori, M. and Date, I.
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Journal Title
Exp. Neurol.
Volume: 275
Pages: 220-231
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Annexin A2 regulates angiogenesis and invasion phenotypes of malignant glioma2015
Author(s)
Onishi M , Ichikawa T , Kurozumi K , Inoue S , Maruo T , Otani Y , Fujii K , Ishida J , Shimazu Y , Yoshida K , Michiue H , Chiocca EA , Date I
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Journal Title
Brain Tumor Patholog
Volume: -
Issue: 3
Pages: 184-194
DOI
Related Report
Peer Reviewed
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[Journal Article] Intra-arterial transplantation of allogeneic mesenchymal stem cells mounts neuroprotective effects in a transient ischemic stroke model in rats: Analyses of therapeutic time window and its mechanisms2015
Author(s)
Toyoshima A , Yasuhara T , Kameda M , Morimoto J , Takeuchi H , Wang F , Sasaki T , Sasada S , Shinko A , Wakamori T , Okazaki M , Kondo A , Agari T , Borlongan CV, Date I
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Journal Title
PLOS ONE
Volume: -
Issue: 6
Pages: e0127302-e0127302
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] For U.J., Investigators U.I. Risk of rupture of unruptured cerebral aneurysms in elderly patients.2015
Author(s)
Hishikawa T., Date I., Tokunaga K., Tominari S., Nozaki K., Shiokawa Y., Houkin K., Murayama Y., Ishibashi T., Takao H., Kimura T., Nakayama T., Morita A.
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Journal Title
Neurology
Volume: 85
Issue: 21
Pages: 1879-1885
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Integrin antagonist augments the therapeutic effect of adenovirus-mediated REIC/Dkk-3 gene therapy for malignant glioma.2014
Author(s)
Shimazu Y, Kurozumi K, Ichikawa T, Fujii K, Onishi M, Ishida J, Oka T, Watanabe M, Nasu Y, Kumon H, Date I.
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Journal Title
Gene Ther
Volume: 22
Issue: 2
Pages: 146-154
DOI
Related Report
Peer Reviewed
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[Journal Article] Infectious Spondylitis: Characteristics of Geriatric Patients and Significance of Surgery Infectious Spondylitis: Characteristics of Geriatric Patients and Significance of Surgery2014
Author(s)
Takao Yasuhara, Yuichi Takahashi, Yasukazu Hijikata,Tetsuya So, Shinji Kumamoto, Masayuki Nakahara, Takashi Tanoue, Akira Kusumegi, Takafumi Inoue, Koichi Ogawa,Hiroaki Manabe, Yasuyuki Miyoshi, Isao Date1and Kenki Nishida
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Journal Title
J Spine Neurosurg
Volume: 3
Pages: 2-2
Related Report
Peer Reviewed
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[Journal Article] Therapeutic outcomes of transplantation of amniotic fluid-derived stem cells in experimental ischemic stroke2014
Author(s)
Tajiri N , Acosta SA, Gonzales-Portillo GS, Aguirre D, Reyes S, Lozano , Pabon MM, Dela Pena I, Ji X, Yasuhara T , Date I , Solomita MA, Antonucci I, Stuppia L, Kaneko Y, Borlongan CV
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Journal Title
Frontiers in Cellular Neuroscience
Volume: 8
Pages: 227-227
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Spinal cord stimulation exerts neuroprotective effects against experimental Parkinson's disease2014
Author(s)
Shinko A, Agari T, Kameda M, Yasuhara T, Kondo A, Tayra JT, Sato K, Sasaki T, Sasada S, Takeuchi H, Wakamori T, Borlongan CV, Date I
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Journal Title
PLoS One
Volume: 9
Issue: 7
Pages: e101468-e101468
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Reduced neurotoxicity with combined treatment of high-dose methotrexate, cyclophosphamide, doxorubicin, vincristine and prednisolone (M-CHOP) and deferred radiotherapy for primary central nervous system lymphoma.2014
Author(s)
Ichikawa T, Kurozumi K, Michiue H, Ishida J, Maeda Y, Kondo E, Kawasaki A, Date I.
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Journal Title
Clin Neurol Neurosurg
Volume: 127
Pages: 106-11
DOI
Related Report
Peer Reviewed
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[Journal Article] Glycyrrhizin inhibits traumatic brain injury by reducing HMGB1-RAGE interaction.2014
Author(s)
OkumaY, Liu K, Wake H, Liu R, Nishimura Y, Zhong H, Teshigawara K, Haruma J, Yamamoto Y, Yamamoto H, Date I, Takahashi HK, Mori S, Nishibori M.
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Journal Title
Neuropharmacology
Volume: 85
Pages: 18-26
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Reoperation for posterior fossa lesion2016
Author(s)
Yasuhara T, Ichikawa T, Kurozumi K, Kameda M, Ishida J, Shinko A, Agari T, Hishikawa T, Date I
Organizer
28th Annual Meeting of Japanese Society for Skull Base Surgery・7th International Congress of the World Federation of Skull Base Societies
Place of Presentation
大阪国際会議場(大阪市北区)
Year and Date
2016-06-16
Related Report
Int'l Joint Research
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[Presentation] Electrical stimulation for the CNS diseases: from the aspect of regenerative medicine2016
Author(s)
Yasuhara T, Kameda M, Agari T, Takeuchi H, Morimoto J, Okazaki M, Kin K, Shinko A, Baba T, Morimoto T, Tajiri N, Date I
Organizer
2016 American Society for Neural Therapy and Repair
Place of Presentation
Tampa, U.S.A
Year and Date
2016-04-30
Related Report
Int'l Joint Research
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[Presentation] Encapsulated cell transplantation for central nervous system disorders2014
Author(s)
Yasuhara T, Kameda M, Agari T, Toyoshima A, Takeuchi H, Morimoto J, Kondo A, Shinko A, Sasada S, Sasaki T, Wakamori M, Okazaki M, Date I
Organizer
44th Neuroscience 2014
Place of Presentation
Washington, D.C ,U.S.A
Year and Date
2014-11-19
Related Report
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