Analysis of pathophysiology of brain radiation necrosis and establishment of novel treatment strategy
| Project/Area Number |
26293327
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中村 浩之 東京工業大学, 資源化学研究所, 教授 (30274434)
藤田 貢 近畿大学, 医学部, 准教授 (40609997)
野々口 直助 大阪医科大学, 医学部, 助教 (70388263)
近藤 夏子 京都大学, 原子炉実験所, 助教 (00582131)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | 脳放射線壊死 / 血管内皮増殖因子 / ホウ素中性子捕捉療法 / ベバシズマブ / HIF-1 alpha / BNCT / bevacizumab / HIF-1阻害剤 / 再発悪性神経膠腫 / 放射線脳壊死 / 脳神経疾患 / ベﾊﾞｼｽﾞﾏﾌﾞ |
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| Outline of Final Research Achievements |
1)Establishment of model rat and mouse of radiation necrosis in the brain：Wister rats were irradiated with 65 Gy X-ray. Five to 6 months after X-ray irradiation brain radiation necrosis was confirmed almost all rats by MRI and autopsy specimen.To establish smaller sized model, mice were irradiated with 70MeV proton with 60Gy-equivalent. The irradiated mice were treated with 2 different kinds of HIF-1 inhibitors (YC-1 and GN44028). Now these mice were observed with periodic MRI. Another couple of months will be mandatory to elucidate some conclusions.
2)Seven recurrent malignant glioma patients were treated with boron neutron capture therapy with the simultaneous use of bevacizumab to prevent the occurrence of symptomatic radiation necrosis. All cases showed favorable prolongation of overall survival without radiation necrosis.
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Report
(4 results)
Research Products
(65 results)
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[Journal Article] A prospective multicenter single-arm clinical trial of bevacizumab for patients with surgically untreatable symptomatic brain radiation necrosis2016
Author(s)
Furuse M, Nonoguchi N, Kuroiwa T, Miyamoto S, Arakawa Y, Shinoda J, Miwa K, Iuchi T, K, Houkin K, Terasaka S, Tabei Y, Nakamura H, Nagane M, Sugiyama K, Terasaki M, Abe T, Narita Y, Saito N, Mukasa A, Ogasawara K, Beppu T, Kumabe T, Nariai T, Tsuyuguchi N, Nakatani E, Kurisu S, Naakagawa Y, Miyatake S.
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Journal Title
Neurooncol Pract.
Volume: 0
Pages: 272-280
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] DNA damage induced by boron neutron capture therapy is partially repaired by DNA ligase IV.2016
Author(s)
Kondo N, Sakurai Y, Hirota Y, Tanaka H, Watanabe T, Nakagawa Y, Narabayashi M, Kinashi Y, Miyatake S, Hasegawa M, Suzuki M, Masunaga S, Ohnishi T, Ono K.
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Journal Title
Radiat. Environ. Biophys.
Volume: 55(1)
Pages: 89-94
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The Anti-Proliferative Effect of Boron Neutron Capture Therapy in a Prostate Cancer Xenograft Model2015
Author(s)
Takahara K, Inamoto T, Minami K, Yoshikawa Y, Takai T, Ibuki N, Hirano H, Nomi H, Kawabata S, Kiyama S, Miyatake S, Kuroiwa T, Suzuki M, Kirihata M, Azuma H.
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Journal Title
PLOS ONE
Volume: 10
Pages: 1-11
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Localized radiation necrosis model in mouse brain using proton ion beams2015
Author(s)
Kondo N, Sakurai Y, Takata T, Takai N, Nakagawa Y, Tanaka H, Watanabe T, Kume K, Toho T, Miyatake S, Suzuki M, Masunaga S, Ono K.
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Journal Title
Appl Radiat Isot.
Volume: 106
Pages: 242-246
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Inflammation as well as angiogenesis may participate in the pathophysiology of brain radiation necrosis2014
Author(s)
Yoritsune E, Furuse M, Kuwabara H, Miyata T, Nonoguchi N, Kawabata S, Hana Hayasaki H, Kuroiwa T, Ono K, Shibayama Y, and Miyatake S
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Journal Title
J Radiate Res
Volume: 55(4)
Pages: 803-11
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 放射線壊死の機序と対策2015
Author(s)
宮武伸一
Organizer
第17回放射線腫瘍学夏季セミナー
Place of Presentation
金沢都ホテル（石川県金沢市）
Year and Date
2015-08-29
Related Report
Invited
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