Analysis of pathophysiology of brain radiation necrosis and establishment of novel treatment strategy

• Project/Area Number: 26293327
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Osaka Medical College
• Principal Investigator: Miyatake Shin-Ichi 大阪医科大学, 医学部, 教授 (90209916)
• Co-Investigator(Kenkyū-buntansha): 中村 浩之 東京工業大学, 資源化学研究所, 教授 (30274434) ; 藤田 貢 近畿大学, 医学部, 准教授 (40609997) ; 野々口 直助 大阪医科大学, 医学部, 助教 (70388263) ; 近藤 夏子 京都大学, 原子炉実験所, 助教 (00582131)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000); Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2014: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
• Keywords: 脳放射線壊死 / 血管内皮増殖因子 / ホウ素中性子捕捉療法 / ベバシズマブ / HIF-1 alpha / BNCT / bevacizumab / HIF-1阻害剤 / 再発悪性神経膠腫 / 放射線脳壊死 / 脳神経疾患 / ベﾊﾞｼｽﾞﾏﾌﾞ

Outline of Final Research Achievements

1)Establishment of model rat and mouse of radiation necrosis in the brain：Wister rats were irradiated with 65 Gy X-ray. Five to 6 months after X-ray irradiation brain radiation necrosis was confirmed almost all rats by MRI and autopsy specimen.To establish smaller sized model, mice were irradiated with 70MeV proton with 60Gy-equivalent. The irradiated mice were treated with 2 different kinds of HIF-1 inhibitors (YC-1 and GN44028). Now these mice were observed with periodic MRI. Another couple of months will be mandatory to elucidate some conclusions.
2)Seven recurrent malignant glioma patients were treated with boron neutron capture therapy with the simultaneous use of bevacizumab to prevent the occurrence of symptomatic radiation necrosis. All cases showed favorable prolongation of overall survival without radiation necrosis.

Research Products

• [Journal Article] Boron Neutron Capture Therapy for Malignant Brain Tumors (2017)
  • Author(s): Shin-Ichi Miyatake, Shinji Kawabata, Ryo Hiramatsu, Toshihiko Kuroiwa, Minoru Suzuki, Natsuko Kondo,Hiroki Tanaka, Koji Ono
  • Journal Title: WFNOS Magazine Volume: 2(1) Pages: 2-11
  • NAID: 120006335649
  • Peer Reviewed / Open Access
• [Journal Article] A prospective, multicentre, single-arm clinical trial of bevacizumab for patients with surgically untreatable, symptomatic brain radiation necrosis (2016)
  • Author(s): Furuse M, Nonoguchi N, Kuroiwa T, Miyamoto S, Arakawa Y, Shinoda J, Miwa K, Iuchi T, K, Houkin K, Terasaka S, Tabei Y, Nakamura H, Nagane M, Sugiyama K, Terasaki M, Abe T, Narita Y, Saito N, Mukasa A, Ogasawara K, Beppu T, Kumabe T, Nariai T, Tsuyuguchi N, Nakatani E, Kurisu S, Naakagawa Y, Miyatake S.
  • Journal Title: Neuro-Oncology Practice Volume: 0 Issue: 4 Pages: 1-9
  • DOI: 10.1093/nop/npv064
  • Peer Reviewed / Open Access
• [Journal Article] DNA damage induced by boron neutron capture therapy is partially repaired by DNA ligase IV (2016)
  • Author(s): Kondo N, Sakurai Y, Hirota Y, Tanaka H, Watanabe T, Nakagawa Y, Narabayashi M, Kinashi Y, Miyatake S, Hasegawa M, Suzuki M, Masunaga S, Ohnishi T, Ono K.
  • Journal Title: Radiat Environ Biophys Volume: 55(1) Issue: 1 Pages: 89-94
  • DOI: 10.1007/s00411-015-0625-2
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 後頭蓋窩脳腫瘍によるえまい症状に早期リハビリテーションが有効であった1症例 (2016)
  • Author(s): 草場 正彦、黒田 健司、太田 善行、大野 博司、佐浦 隆一、宮武 伸一
  • Journal Title: 総合リハビリテーション Volume: 44(2) Pages: 141-145
  • Peer Reviewed
• [Journal Article] Boron Neutron Capture Therapy for Malignant Brain Tumors (2016)
  • Author(s): Shin-Ichi MIYATAKE, Shinji KAWABATA, Ryo HIRAMATSU, Toshihiko KUROIWA, Minoru SUZUKI, Natsuko KONDO, Koji ONO
  • Journal Title: Neurologia medico-chirurgica Volume: 56 Issue: 7 Pages: 361-371
  • DOI: 10.2176/nmc.ra.2015-0297
  • NAID: 130005165070
  • ISSN: 0470-8105, 1349-8029
  • Peer Reviewed / Open Access
• [Journal Article] Early clinical experience utilizing scintillator with optical fiber (SOF) detector in clinical boron neutron capture therapy: its issues and solutions (2016)
  • Author(s): M. Ishikawa, T. Yamamoto, A. Matsumura, J. Hiratsuka, S. Miyatake, I. Kato, Y. Sakurai, H. Kumada, S.J.Shrestha, K.Ono
  • Journal Title: Radiation Oncology Volume: 11 (105) Issue: 1 Pages: 1-10
  • DOI: 10.1186/s13014-016-0680-0
  • NAID: 120007129420
  • Peer Reviewed / Open Access
• [Journal Article] ホウ素中性子捕捉療法（BNCT)と他の粒子線治療との違い (2016)
  • Author(s): 宮武 伸一、川端 信司、不破 信和
  • Journal Title: 日本臨牀 増刊号7 Volume: 74 Pages: 615-621
• [Journal Article] 夢の細胞選択的粒子線治療BNCT (2016)
  • Author(s): 宮武 伸一
  • Journal Title: 大阪医科大学雑誌 Volume: 75 1・2 Pages: 12-15
  • NAID: 40020982064
• [Journal Article] 放射線脳壊死の治療 (2016)
  • Author(s): 宮武 伸一
  • Journal Title: JASTRO NEWSLETTER Volume: 4(122) Pages: 23-24
• [Journal Article] Effect of boron neutron capture therapy for recurrent anaplastic meningioma: an autopsy case report. (2015)
  • Author(s): Kawaji H, Miyatake SI, Shinmura K, Kawabata S, Tokuyama T, Namba H
  • Journal Title: Brain Tumor Pathol Volume: 32 Issue: 1 Pages: 61-65
  • DOI: 10.1007/s10014-014-0189-x
  • Peer Reviewed
• [Journal Article] Pathophysiology, Diagnosis, and Treatment of Radiation Necrosis in the Brain (2015)
  • Author(s): Shin-Ichi Miyatake, Noasuke Nonoguchi, Motomasa Furuse, Erina Yoritsune, Tomo Miyata, Shinji Kawabata, and Toshihiko Kuroiwa
  • Journal Title: Neurologia medico-chirurgica Volume: 55 Issue: 1 Pages: 50-59
  • DOI: 10.2176/nmc.ra.2014-0188
  • NAID: 130004922267
  • ISSN: 0470-8105, 1349-8029
  • Peer Reviewed / Open Access
• [Journal Article] Long-term survival after treatment of glioblastoma multiforme with hyperfractionated concomitant boost proton beam therapy. (2015)
  • Author(s): Mizumoto M, Yamamoto T, Takano S, Ishikawa E, Matsumura A, Ishikawa H, Okumura T, Sakurai H, Miyatake S, Tsuboi K.
  • Journal Title: Pract Radiat Oncol. Volume: 5 Issue: 1 Pages: e9-e16
  • DOI: 10.1016/j.prro.2014.03.012
  • Peer Reviewed / Open Access
• [Journal Article] 症候性脳放射線壊死の核医学的診断とベバシズマブによる治療（先進医療Bからの薬事承認に向けて） (2015)
  • Author(s): 宮武伸一、古瀬元雅、野々口直助、川端信司、黒岩敏彦
  • Journal Title: 脳神経外科ジャーナル Volume: 24(6) Pages: 399-406
  • NAID: 130005083634
  • Peer Reviewed
• [Journal Article] Intratumoral and peritumoral post-irradiation changes, but not viable tumor. (2015)
  • Author(s): Furuse M, Nonoguchi N, Kawabata S, Miyata T, Toho T, Kuroiwa T, Miyatake S.
  • Journal Title: Radiat Oncol. Volume: 10 Issue: 1 Pages: 156-156
  • DOI: 10.1186/s13014-015-0446-0
  • Peer Reviewed / Open Access
• [Journal Article] The Anti-Proliferative Effect of Boron Neutron Capture Therapy in Prostate Cancer Xenograft Model (2015)
  • Author(s): Takahara K, Inamoto T, Minami K, Yoshikawa Y, Takai T, Ibuki N, Hirano H, Nomi H, Kawabata S, Kiyama S, Miyatake S, Kuroiwa T, Suzuki M, Kirihata M, Azuma H.
  • Journal Title: PLoS One Volume: 10 Issue: 9 Pages: 136981-2
  • DOI: 10.1371/journal.pone.0136981
  • NAID: 120005763435
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Delayed brain radiation necrosis: pathological review and new molecular targets for treatment (2015)
  • Author(s): Furuse M., Nonoguchi N., Kawabata S., Miyatake S., Kuroiwa T
  • Journal Title: Med Mol Morphol Volume: 48(4) Issue: 4 Pages: 183-190
  • DOI: 10.1007/s00795-015-0123-2
  • Peer Reviewed
• [Journal Article] Localized radiation necrosis model in mouse brain using proton ion beams. (2015)
  • Author(s): Kondo N, Sakurai Y, Takata T, Takai N, Nakagawa Y, Tanaka H, Watanabe T, Kume K, Toho T, Miyatake S, Suzuki M, Masunaga S, Ono K.
  • Journal Title: Applied Radiation and Isotopes Volume: 106 Pages: 242-246
  • DOI: 10.1016/j.apradiso.2015.07.032
  • Peer Reviewed / Open Access
• [Journal Article] 脳放射線壊死とミクログリア (2015)
  • Author(s): 野々口 直助、古瀬 元雅、宮武 伸一
  • Journal Title: Clinical Neuroscience 月刊 臨床神経科学 Volume: VOL.33,12 Pages: 1377-1381
• [Journal Article] Tetrakis(p-Carboranylthio-Tetrafluorophenyl)Chlorin (TPFC):Application for Photodynamic Therapy and Boron Neutron Capture Therapy (2014)
  • Author(s): Hiramatsu R, Kawabata S, Tanaka H, Sakurai Y, Suzuki M, Ono K, Miyatake SI, Kuroiwa T, Hao E, Vicente MG
  • Journal Title: Journal of Pharmaceutical Volume: Dec 26 Issue: 3 Pages: 0-0
  • DOI: 10.1002/jps.24317
  • Peer Reviewed
• [Journal Article] Inflammation as well as angiogenesis may participate in the pathophysiology of brain radiation necrosis. (2014)
  • Author(s): Yoritsune E, Furuse M, Kuwabara H, Miyata T, Nonoguchi N, Kawabata S, Hana Hayasaki H, Kuroiwa T, Ono K, Shibayama Y, and Miyatake S
  • Journal Title: J Radiat Res Volume: 55(4) Issue: 4 Pages: 803-11
  • DOI: 10.1093/jrr/rru017
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A case of radiation-induced osteosarcoma treated effectively by boron neutron capture therapy. (2014)
  • Author(s): Gen Futamura, Shinji Kawabata, Hiroyuki Siba, Toshihiko Kuroiwa, Minoru Suzuki, Natsuko Kondo, Yoshinori Sakurai, Koji Ono, Minoru Tanaka, Tomoki Todo and Shin-Ichi Miyatake
  • Journal Title: Radiat Oncol. Volume: 4;9(1) Issue: 1 Pages: 237-237
  • DOI: 10.1186/s13014-014-0237-z
  • Peer Reviewed / Open Access
• [Presentation] 腫瘍選択的粒子線治療BNCTの現状と展望 (2017)
  • Author(s): 宮武伸一
  • Organizer: サイバーナイフ研究会 第11回学術研究会
  • Place of Presentation: ベルサール八重洲(東京都中央区）
  • Year and Date: 2017-03-11
  • Invited
• [Presentation] 再発膠芽腫に対する加速器BNCTによる第二相臨床試験（治験）の紹介 (2016)
  • Author(s): 宮武伸一
  • Organizer: 第34回日本脳腫瘍学会学術集会
  • Place of Presentation: 甲府富士屋ホテル(山梨県甲府市）
  • Year and Date: 2016-12-05
• [Presentation] Boron, neutron capture therapy for malignant brain tumors, from reactor to accelerator (2016)
  • Author(s): Miyatake S-I
  • Organizer: 21ST ANNUAL SCIENTIFIC MEETING AND EDUCATION DAY OF THE SOCIETY FOR NEURO-ONCOLOGY
  • Place of Presentation: Scottsdale(U.S.A.)
  • Year and Date: 2016-11-18
  • Int'l Joint Research / Invited
• [Presentation] Gene expression landscape including miRNAs in delayed radiation necrosis of brain (2016)
  • Author(s): Miyatake S-I, Toho T, Fujita M, Furuse M,Kawabata S, Kuroiwa T, Nonoguchi N
  • Organizer: 21ST ANNUAL SCIENTIFIC MEETING AND EDUCATION DAY OF THE SOCIETY FOR NEURO-ONCOLOGY
  • Place of Presentation: Scottsdale(U.S.A.)
  • Year and Date: 2016-11-18
  • Int'l Joint Research
• [Presentation] 腫瘍選択的粒子線治療 ホウ素中性子捕捉療法 (2016)
  • Author(s): 宮武伸一
  • Organizer: 大阪医科大との医工連携に関する講演会
  • Place of Presentation: 関西大学 千里山キャンパス(大阪府吹田市）
  • Year and Date: 2016-11-11
• [Presentation] Clinical Study for GBM in Japan (2016)
  • Author(s): 宮武伸一
  • Organizer: IAEA-Southern TOHOKU Hospital Group Joint Workshop on BNCT
  • Place of Presentation: 総合南東北病院(福島県郡山市）
  • Year and Date: 2016-10-28
  • Invited
• [Presentation] 悪性脳腫瘍を中心とする難治性がんへのホウ素中性子捕捉療法BNCTの適用 (2016)
  • Author(s): 宮武伸一
  • Organizer: 岡山県医用工学研究会・メディカルテクノおかやま・共催 平成28年度第2回シンポジウム
  • Place of Presentation: 岡山大学 鹿田キャンパス(岡山県岡山市）
  • Year and Date: 2016-10-27
• [Presentation] A prospective multicenter single-arm clinical trial of bevacizumab for patients with surgically untreatable symptomatic brain radiation necrosis (2016)
  • Author(s): Miyatake S-I
  • Organizer: The European Association of Neuro-Oncology (EANO)
  • Place of Presentation: Mannheim(Germany)
  • Year and Date: 2016-10-15
  • Int'l Joint Research
• [Presentation] Clinical results of reactor-based BNCT using BPA for the patients with recurrent malignant glioma (2016)
  • Author(s): Miyatake S-I、Takeuchi K, Shiba H
  • Organizer: the 17th International Congress on Neutron Capture Therapy
  • Place of Presentation: Columbia(U.S.A.)
  • Year and Date: 2016-10-06
  • Int'l Joint Research
• [Presentation] BNCT for Malignant Brain Tumors, from Reactor to Accelerator (2016)
  • Author(s): Miyatake S-I
  • Organizer: the 17th International Congress on Neutron Capture Therapy
  • Place of Presentation: Columbia(U.S.A.)
  • Year and Date: 2016-10-05
  • Int'l Joint Research / Invited
• [Presentation] 悪性脳腫瘍に対するホウ素中性子捕捉療法の進歩（原子炉から加速器へ） (2016)
  • Author(s): 宮武伸一
  • Organizer: 日本脳神経外科学会第75回学術総会
  • Place of Presentation: 福岡国際会議場(福岡県福岡市）
  • Year and Date: 2016-10-01
• [Presentation] A prospective multicenter single-arm clinical trial of bevacizumab for patients with surgically untreatable symptomatic brain radiation necrosis (2016)
  • Author(s): Miyatake S-I
  • Organizer: the ASNO-COGNO 2016 Meeting
  • Place of Presentation: Sydney(Australia)
  • Year and Date: 2016-09-12
  • Int'l Joint Research
• [Presentation] 再発悪性神経膠腫に対するBNCT 原子炉から加速器へ (2016)
  • Author(s): 宮武伸一
  • Organizer: 第21回日本脳腫瘍の外科学会
  • Place of Presentation: 虎ノ門ヒルズフォーラム(東京都港区）
  • Year and Date: 2016-09-09
• [Presentation] 再発悪性神経膠腫に対する加速器BNCTの第2相臨床試験の概要 (2016)
  • Author(s): 宮武伸一
  • Organizer: 第13回日本中性子捕捉療法学会学術大会
  • Place of Presentation: 東京大学伊藤国際学術研究センター(東京都文京区）
  • Year and Date: 2016-08-06
• [Presentation] 悪性脳腫瘍に対するBNCT 大阪医科大学での１５年の歩み (2016)
  • Author(s): 宮武伸一
  • Organizer: 第45回放射線による制癌シンポジウム 第54回日本放射線腫瘍学会生物部会学術大会
  • Place of Presentation: I-siteなんば(大阪府大阪市）
  • Year and Date: 2016-07-15
• [Presentation] 悪性脳腫瘍に対する放射線化学療法の進歩～腫瘍選択的粒子線治療ＢＮＣＴと抗血管新生薬による症候性脳放射線壊死の治療～ (2016)
  • Author(s): 宮武伸一
  • Organizer: 第21回新潟脳腫瘍研究会
  • Place of Presentation: ホテル日航新潟(新潟県新潟市）
  • Year and Date: 2016-06-10
  • Invited
• [Presentation] 悪性神経膠腫の治療におけるベバシズマブの功罪 (2016)
  • Author(s): 宮武伸一
  • Organizer: 第25回日本定位放射線治療学会
  • Place of Presentation: ハイアットリージェンシー京都(京都府京都市）
  • Year and Date: 2016-05-27
• [Presentation] 臨床研究について（利用者から） (2016)
  • Author(s): 宮武伸一
  • Organizer: 平成28年度京都大学原子炉実験所専門研究会
  • Place of Presentation: 京都大学原子炉実験所(大阪府泉南郡）
  • Year and Date: 2016-05-13
• [Presentation] A Prospective Multicenter Single-Arm Clinical Trial of Bevacizumab for Patients with Surgically Untreatable Symptomatic Brain Radiation Necrosis (2016)
  • Author(s): Miyatake S-I
  • Organizer: Ｔｈｅ 21st International Conference on Brain Tumor Research and Therapy
  • Place of Presentation: 万国津梁館(沖縄県名護市）
  • Year and Date: 2016-04-13
  • Int'l Joint Research
• [Presentation] BNCT for the Treatment of Malignant Brain Tumors in Comparison with Other Particle Radiation (2016)
  • Author(s): Miyatake S-I
  • Organizer: Ｔｈｅ 21st International Conference on Brain Tumor Research and Therapy
  • Place of Presentation: 万国津梁館(沖縄県名護市）
  • Year and Date: 2016-04-13
  • Int'l Joint Research / Invited
• [Presentation] 悪性神経膠腫の治療におけるベバシズマブの功罪 (2015)
  • Author(s): 宮武伸一
  • Organizer: 第33回日本脳腫瘍学会学術集会
  • Place of Presentation: グランドプリンスホテル京都（京都府京都市）
  • Year and Date: 2015-12-07
• [Presentation] Advantage and Disadvantage of Bevacizumab in BNCT (2015)
  • Author(s): Miyatake S-I
  • Organizer: The 1st Academic Meeting of Taiwan’s Society of Neutron Capture Therapy (TSNCT)Jointly with The 8th Trilateral BNCT Meeting
  • Place of Presentation: 大板根森林温泉リゾート村（台湾）
  • Year and Date: 2015-12-05
  • Int'l Joint Research / Invited
• [Presentation] A prospective multicenter single-arm clinical trial of bevacizumab for patients with surgically untreatable symptomatic brain radiation necrosis (2015)
  • Author(s): Motomasa Furuse, Naosuke Nonoguchi, Toshihiko Kuroiwa, Eiji Nakatani, Shoko Kurisu, Yoko Nakagawa, Shin-Ichi Miyatake
  • Organizer: 20th Annual Scientific Meeting and Education Day of the Society for Neuro-Oncology
  • Place of Presentation: San Antonio Marriott Rivercenter, Texas（U..S.A)
  • Year and Date: 2015-11-21
  • Int'l Joint Research
• [Presentation] 悪性脳腫瘍に対する放射線化学療法の進歩 腫瘍選択的粒子線治療BNCTと抗血管新生薬による症候性脳放射線壊死の治療 (2015)
  • Author(s): 宮武伸一
  • Organizer: 第9回信州脳腫瘍研究会
  • Place of Presentation: ホテルブエナビスタ（長野県松本市）
  • Year and Date: 2015-11-06
  • Invited
• [Presentation] 腫瘍選択的粒子線治療BNCTと症候性脳放射線壊死の核医学的診断と抗血管新生薬による治療 (2015)
  • Author(s): 宮武伸一
  • Organizer: 第20回東海腫瘍核医学研究会
  • Place of Presentation: ウインクあいち
  • Year and Date: 2015-10-17
  • Invited
• [Presentation] 症候性脳放射線壊死の診断とベバシズマブの静脈内投与による治療（先進医療Bの結果） (2015)
  • Author(s): 宮武伸一
  • Organizer: 日本脳神経外科学会第74回学術総会
  • Place of Presentation: さっぽろ芸術文化の館（北海道札幌市）
  • Year and Date: 2015-10-16
• [Presentation] 重粒子（陽子線）とBNCTの違い、merit,demerit、日本、世界でのBNCT用の加速器の動向 (2015)
  • Author(s): 宮武伸一
  • Organizer: 公益財団法人佐賀国際重粒子線がん治療財団
  • Place of Presentation: 九州国際重粒子線がん治療センター （サガハイマット）（佐賀県鳥栖市）
  • Year and Date: 2015-09-25
  • Invited
• [Presentation] Advantage and Disadvantage of Bevacizumab in BNCT (2015)
  • Author(s): Miyatake S-I
  • Organizer: 8th Young Researchers BNCT Meeting
  • Place of Presentation: Almo Collegio Borromeo Pavia（Italia)
  • Year and Date: 2015-09-16
  • Int'l Joint Research
• [Presentation] Advantage and Disadvantage of Bevacizumab in BNCT (2015)
  • Author(s): 宮武伸一
  • Organizer: 第12回日本中性子捕捉療法学会学術大会
  • Place of Presentation: 神戸学院大学ポートアイランドキャンパス（兵庫県神戸市）
  • Year and Date: 2015-09-04
• [Presentation] 放射線壊死の機序と対策 (2015)
  • Author(s): 宮武伸一
  • Organizer: 第17回放射線腫瘍学夏季セミナー
  • Place of Presentation: 金沢都ホテル（石川県金沢市）
  • Year and Date: 2015-08-29
  • Invited
• [Presentation] ＢＮＣＴ（中性子捕捉療法）の現状と未来 (2015)
  • Author(s): 宮武伸一
  • Organizer: JUN.2015 放射線診療学術講演会
  • Place of Presentation: AP大阪駅前梅田1丁目会議室 APホール（大阪府大阪市）
  • Year and Date: 2015-06-26
  • Invited
• [Presentation] 悪性脳腫瘍に対するホウ素中性子捕捉療法と放射線壊死に対するアバスチンによる治療 (2015)
  • Author(s): 宮武伸一
  • Organizer: 第5回北河内神経カンファレンス
  • Place of Presentation: ホテルモントレ ラ・スール大阪（大阪府大阪市）
  • Year and Date: 2015-06-13
  • Invited
• [Presentation] Role of VEGF in the Pathophysiology of Brain Radiation Necrosis, from Diagnosis to Treatment (2015)
  • Author(s): Miyatake S-I
  • Organizer: 12th International Stereotactic Radiosurgery Society (ISRS) congress
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-06-09
  • Int'l Joint Research / Invited
• [Presentation] Clinical Trial Using Anti-VEGF Antibody with Chemoradiation for Malignant Gliomas and the Role of VEGF in Radiation Necrosis (2015)
  • Author(s): Miyatake S-I
  • Organizer: The 15th International Congress of Radiation Research (ICRR 2015)
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2015-05-26
  • Int'l Joint Research / Invited
• [Presentation] 症候性脳放射線壊死の核医学的診断とベバシズマブの静脈内投与による治療 (2015)
  • Author(s): 宮武伸一
  • Organizer: 第24回日本定位放射線治療学会
  • Place of Presentation: 長崎ブリックホール（長崎県長崎市）
  • Year and Date: 2015-05-15
• [Presentation] 症候性脳放射線壊死の診断とベバシズマブの静脈内投与による治療 (2014)
  • Author(s): 宮武伸一
  • Organizer: 第2７ 回日本放射線腫瘍学会 プレジデンシャルシンポジウム
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-12-12
  • Invited
• [Presentation] 再発悪性神経膠腫に対するBNCTとbevacizumabの同時併用療法は新規治療法になりうるか？ (2014)
  • Author(s): 宮武伸一、川端信司、平松 亮、古瀬元雅、野々口直助、黒岩敏彦、鈴木 実、近藤夏子、櫻井良憲、小野公二
  • Organizer: 第32回日本脳腫瘍学会
  • Place of Presentation: シェラトングランデトーキョーベイホテル（千葉県浦安市）
  • Year and Date: 2014-12-01
• [Presentation] Tumor-selective particle radiation, boron neutron capture therapy (BNCT) (2014)
  • Author(s): Miyatake-S
  • Organizer: 第13回アジア核医学会教育講演
  • Place of Presentation: グランキューブ大阪（大阪府大阪市）
  • Year and Date: 2014-11-06
  • Invited
• [Presentation] 再発悪性神経膠腫に対するBNCTとbevacizumabの同時併用療法は新規治療法になりうるか？ (2014)
  • Author(s): 宮武伸一、川端信司、平松 亮、古瀬元雅、野々口直助、黒岩敏彦、鈴木 実、近藤夏子、櫻井良憲、小野公二
  • Organizer: 日本脳神経外科学会 第７3回学術総会 シンポジウム
  • Place of Presentation: グランドプリンスホテル新高輪（東京都港区）
  • Year and Date: 2014-10-10
• [Presentation] 悪性脳腫瘍に対する放射線化学療法の進歩 腫瘍選択的粒子線治療BNCTとアバスチンによる症候性脳放射線壊死とPsPDの治療 (2014)
  • Author(s): 宮武伸一
  • Organizer: 神戸大学がんプロセミナー
  • Place of Presentation: 神戸大学（兵庫県神戸市）
  • Year and Date: 2014-09-09
  • Invited
• [Presentation] 膠芽腫のベバシズマブ併用放射線治療と症候性脳放射線壊死の治療 (2014)
  • Author(s): 宮武伸一
  • Organizer: 日本放射線腫瘍学会 第43回制癌シンポジウム
  • Place of Presentation: メルパルク京都（京都府京都市）
  • Year and Date: 2014-07-11
  • Invited
• [Presentation] Development of BNCT in 12 years at Osaka Medical College (2014)
  • Author(s): Miyatake S-I
  • Organizer: 16th International congress of Neutron Capture Therapy
  • Place of Presentation: Helsinki (Finland)
  • Year and Date: 2014-06-15
  • Invited
• [Presentation] 症候性脳放射線壊死の核医学的診断とベバシズマブによる治療（先進医療Bからの薬事承認に向けて） (2014)
  • Author(s): 宮武伸一
  • Organizer: 第34回日本脳神経外科コングレス総会
  • Place of Presentation: グランキューブ大阪（大阪府大阪市）
  • Year and Date: 2014-05-17
  • Invited
• [Presentation] 悪性脳腫瘍に対する放射線化学療法の進歩 腫瘍選択的粒子線治療BNCTとアバスチンによる症候性脳放射線壊死とPsPDの治療 (2014)
  • Author(s): 宮武伸一
  • Organizer: 第67回日本脳神経外科学会近畿支部学術集会 教育セミナー
  • Place of Presentation: 千里ライフサイエンスセンター（大阪府豊中市）
  • Year and Date: 2014-04-05
  • Invited