Development of biomarkers and novel therapeutic targets for malignant bone and soft tissue tumors using the methods of global expression analysis
Project/Area Number |
26293342
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | National Cancer Center Japan |
Principal Investigator |
KAWAI AKIRA 国立研究開発法人国立がん研究センター, 骨軟部腫瘍・リハビリテーション科, 科長 (90252965)
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Co-Investigator(Kenkyū-buntansha) |
近藤 格 国立研究開発法人国立がん研究センター, 研究所, 分野長 (30284061)
落谷 孝広 国立研究開発法人国立がん研究センター, 研究所, 主任分野長 (60192530)
市川 仁 国立研究開発法人国立がん研究センター, 先端医療開発センター, ユニット長 (30201924)
吉田 朗彦 国立研究開発法人国立がん研究センター, 中央病院, 医員 (80574780)
細野 亜古 国立研究開発法人国立がん研究センター, 東病院, 医長 (00602947)
小倉 浩一 国立研究開発法人国立がん研究センター, 中央病院, 特任研究員 (20583115)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
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Keywords | 骨軟部腫瘍 / 肉腫 / 骨肉腫 / 粘液線維肉腫 / 粘液型脂肪肉腫 / 遺伝子 / microRNA / タンパク質 / ゲノム解析 / エピゲノム解析 / プロテオーム解析 / PDXモデル / 医療・福祉 / 癌 / バイオマーカー / 軟骨肉腫 / ゼノグラフト / 全エクソン解析 / 全トランスクリプトーム解析 / 悪性骨軟部腫瘍 / 胞巣状軟部肉腫 / 全ゲノム解析 |
Outline of Final Research Achievements |
In the current study, we performed whole exome and transcriptome sequences of chondrosarcoma, myxofibrosarcoma and giant cell tumor of bone. Myxofibrosarcoma was divided into 3 groups depending on the epigenome characteristics. Invasiveness and potential of pulmonary metastasis were regulated by microRNA133a in osteosarcoma and by microRNA135b in myxoid liposarcoma. Immunohistochemistries for TFE3, FGF23 and H3K27me3, and FISH for WT1 and USP6 were useful for pathological diagnosis of bone and soft tissue sarcomas.
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Report
(4 results)
Research Products
(110 results)
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[Journal Article] Cross-cultural adaptation and validation of the Japanese version of the Toronto Extremity Salvage Score (TESS) for patients with malignant musculoskeletal tumors in the upper extremities.2017
Author(s)
Akiyama T, Uehara K, Ogura K, Shinoda Y, Iwata S, Saita K, Tanzawa Y, Nakatani F, Yonemoto T, Kawano H, Davis AM, Kawai A.
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Journal Title
J Orthop Sci.
Volume: 22(1)
Issue: 1
Pages: 127-132
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Phase 2 study of eribulin in patients with previously treated advanced or metastatic soft tissue sarcoma.2017
Author(s)
Kawai A, Araki N, Naito Y, Ozaki T, Sugiura H, Yazawa Y, Morioka H, Matsumine A, Saito K, Asami S, Isu K.
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Journal Title
Jpn J Clin Oncol.
Volume: 47(2)
Issue: 2
Pages: 137-144
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] requent amplification of receptor tyrosine kinase genes in well-differentiated/dedifferentiated liposarcoma.2017
Author(s)
Asano N, Yoshida A, Mitani S, Kobayashi E, Shiotani B, Komiyama M, Fujimoto H, Chuman H, Morioka H, Matsumoto M, Nakamura M, Kubo T, Kato M, Kohno T, Kawai A, Kondo T, Ichikawa H.
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Journal Title
Oncotarget.
Volume: 8
Issue: 8
Pages: 12941-12952
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Highly recurrent H3F3A mutations with additional epigenetic regulator alterations in giant cell tumor of bone.2017
Author(s)
Ogura K, Hosoda F, Nakamura H, Hama N, Totoki Y, Yoshida A, Ohashi S, Rokutan H, Takai E, Yachida S, Kawai A, Tanaka S, Shibata T.
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Journal Title
Genes Chromosomes Cancer.
Volume: 印刷中
Related Report
Peer Reviewed / Open Access
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[Journal Article] Reduced argininosuccinate synthetase expression in refractory sarcomas.2016
Author(s)
Kim Y, Kobayashi E, Kubota D, Suehara Y, Mukaihara K, Akaike K, Ito A, Kaneko K, Chuman H, Kawai A, Kitano S.
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Journal Title
Oncotarget.
Volume: 7(43)
Issue: 43
Pages: 70832-70844
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Results of sub-analysis of a phase 2 study on trabectedin treatment for extraskeletal myxoid chondrosarcoma and mesenchymal chondrosarcoma.2016
Author(s)
Morioka H, Takahashi S, Araki N, Sugiura H, Ueda T, Takahashi M, Yonemoto T, Hiraga H, Hiruma T, Kunisada T, Matsumine A, Susa M, Nakayama R, Nishimoto K, Kikuta K, Horiuchi K, Kawai A
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Journal Title
BMC Cancer
Volume: 16
Issue: 1
Pages: 479-479
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The clinical outcome of pazopanib treatment in Japanese patients with relapsed soft tissue sarcoma: A Japanese Musculoskeletal Oncology Group (JMOG) study.2016
Author(s)
Nakamura T, Matsumine A, Kawai A, Araki N, Goto T, Yonemoto T, Sugiura H, Nishida Y, Hiraga H, Honoki K, Yasuda T, Boku S, Sudo A, Ueda T.
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Journal Title
Cancer
Volume: 122(9)
Issue: 9
Pages: 1408-1416
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A randomized, double-blind, placebo-controlled, Phase III study of pazopanib in patients with soft tissue sarcoma: results from the Japanese subgroup.2016
Author(s)
Kawai A, Araki N, Hiraga H, Sugiura H, Matsumine A, Ozaki T, Ueda T, Ishii T, Esaki T, Machida M, Fukasawa N.
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Journal Title
Jpn J Clin Oncol.
Volume: 46(3)
Issue: 3
Pages: 248-253
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Retrospective inter- and intra-patient evaluation of trabectedin after best supportive care for patients with advanced translocation-related sarcoma after failure of standard chemotherapy.2016
Author(s)
Araki N, Takahashi S, Sugiura H, Ueda T, Yonemoto T, Takahashi M, Morioka H, Hiraga H, Hiruma T, Kunisada T, Matsumine A, Kawai A.
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Journal Title
Eur J Cancer.
Volume: 56
Pages: 122-130
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A novel p53 target gene FUCA1 encodes a fucosidase and regulates growth and survival of cancer cells.2016
Author(s)
Ezawa I, Sawai Y, Kawase T, Okabe A, Tsutsumi S, Ichikawa H, Kobayashi Y, Tashiro F, Namiki H, Kondo T, Semba K, Aburatani H, Taya Y, Nakagama H, Ohki R.
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Journal Title
Cancer Sci.
Volume: 印刷中
Issue: 6
Pages: 734-745
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] PAI-1, a target gene of miR-143, regulates invasion and metastasis by upregulating MMP-13 expression of human osteosarcoma.2016
Author(s)
Hirahata M, Osaki M, Kanda Y, Sugimoto Y, Yoshioka Y, Kosaka N, Takeshita F, Fujiwara T, Kawai A, Ito H, Ochiya T, Okada F.
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Journal Title
Cancer Med
Volume: -
Issue: 5
Pages: 892-902
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] miR-135b, a key regulator of malignancy, is linked to poor prognosis in human myxoid liposarcoma.2016
Author(s)
Nezu Y, Hagiwara K, Yamamoto Y, Fujiwara T, Matsuo K, Yoshida A, Kawai A, Saito T, Ochiya T.
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Journal Title
Oncogene.
Volume: 35
Issue: 48
Pages: 6177-6188
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] CIC-rearranged Sarcomas: A Study of 20 Cases and Comparisons With Ewing Sarcomas.2016
Author(s)
Yoshida A, Goto K, Kodaira M, Kobayashi E, Kawamoto H, Mori T, Yoshimoto S, Endo O, Kodama N, Kushima R, Hiraoka N, Motoi T, Kawai A.
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Journal Title
Am J Surg Pathol.
Volume: 40(3)
Pages: 313-23
Related Report
Peer Reviewed / Open Access
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[Journal Article] Myoepithelioma-like Tumors of the Vulvar Region: A Distinctive Group of SMARCB1-deficient Neoplasms.2015
Author(s)
Yoshida A, Yoshida H, Yoshida M, Mori T, Kobayashi E, Tanzawa Y, Yasugi T, Kawana K, Ishikawa M, Sugiura H, Maeda D, Fukayama M, Kawai A, Hiraoka N, Motoi T.
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Journal Title
Am J Surg Pathol.
Volume: 39(8)
Pages: 1102-13
Related Report
Peer Reviewed / Open Access
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[Journal Article] Trabectedin monotherapy after standard chemotherapy versus best supportive care in patients with advanced, translocation-related sarcoma: a randomised, open-label, phase 2 study.2015
Author(s)
Kawai A, Araki N, Sugiura H, Ueda T, Yonemoto T, Takahashi M, Morioka H, Hiraga H, Hiruma T, Kunisada T, Matsumine A, Tanase T, Hasegawa T, Takahashi S.
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Journal Title
Lancet Oncol.
Volume: 16
Issue: 4
Pages: 406-16
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Prognostic significance of PML expression in gastrointestinal stromal tumor; integrated proteomic and transcriptomic analysis2015
Author(s)
Ichikawa H, Yoshida A, Kanda T, Kosugi S, Ishikawa T, Hanyu T, Taguchi T, Sakumoto M, Katai H, Kawai A, Wakai T, Kondo T.
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Journal Title
Cancer Science
Volume: 106
Issue: 1
Pages: 115-24
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinical relevance and therapeutic significance of microRNA-133a expression profiles and functions in malignant osteosarcoma-initiating cells.2014
Author(s)
Fujiwara T, Katsuda T, Hagiwara K, Kosaka N, Yoshioka Y, Takahashi RU, Takeshita F, Kubota D, Kondo T, Ichikawa H, Yoshida A, Kobayashi E, Kawai A, Ozaki T, Ochiya T.
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Journal Title
Stem Cells.
Volume: 32
Issue: 4
Pages: 959-973
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Chronic expanding hematoma with a significantly high fluorodeoxyglucose uptake on 18F-fluorodeoxyglucose positron emission tomography, mimicking a malignant soft tissue tumor: a case report.2014
Author(s)
Nishida Y, Kobayashi E, Kubota D, Setsu N, Ogura K, Tanzawa Y, Nakatani F, Kato Y, Chuman H, Kawai A
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Journal Title
J Med Case Rep
Volume: 8
Issue: 1
Pages: 349-349
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Global PROTOMAP Profiling to Search for Biomarkers of Early-Recurrent Hepatocellular Carcinoma2014
Author(s)
Taoka, Masato; Morofuji, Noriaki; Yamauchi, Yoshio; Ojima, Hidenori; Kubota, Daisuke; Terukina, Goro; Nobe, Yuko; Nakayama, Hiroshi; Takahashi, Nobuhiro; Kosuge, Tomoo; Isobe, Toshiaki; Kondo, Tadashi
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Journal Title
J. Proteome Res.
Volume: 13
Issue: 11
Pages: 4847-4858
DOI
Related Report
Peer Reviewed
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[Presentation] 肉腫のプロテオーム解析2016
Author(s)
近藤格
Organizer
第89回日本整形外科学会学術総会
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Year and Date
2016-05-12
Related Report
Invited
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[Presentation] AYA世代骨軟部肉腫の外科治療2015
Author(s)
川井 章
Organizer
第57回 日本小児血液・がん学会学術集会
Place of Presentation
甲府富士屋ホテル(山梨県)
Year and Date
2015-11-27
Related Report
Int'l Joint Research
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[Presentation] 日本発新規microRNA阻害核酸製剤Synthetic Tough Decoyを用いた骨肉腫に対する前臨床的検討.2015
Author(s)
藤原智洋, 根津 悠, 吉田 晶, 魚谷弘二, 武田 健, 国定俊之, 伊庭英夫, 伊藤 博, 尾﨑敏文, 落谷孝広, 川井 章.
Organizer
第88回日本整形外科学会学術集会
Place of Presentation
神戸国際会議場(兵庫県)
Year and Date
2015-05-21
Related Report
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[Presentation] 肉腫(サルコーマ)2014
Author(s)
川井 章
Organizer
AKIBA Cancer Forum 2014
Place of Presentation
東京, 秋葉原
Year and Date
2014-08-09
Related Report
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