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Development of energy monito for cerebral cortex using NADH fluorescence

Research Project

Project/Area Number 26293345
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Anesthesiology
Research InstitutionOkayama University

Principal Investigator

Takeda Yoshimasa  岡山大学, 大学病院, 准教授 (30294466)

Co-Investigator(Kenkyū-buntansha) 山根 延元  岡山大学, 自然科学研究科, 准教授 (80174762)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords脳虚血 / ミトコンドリア / モニター / NADH / エネルギー状態 / モニタ-
Outline of Final Research Achievements

To visualize the changes in NADH fluorescence, the signal intensities of NADH fluorescence were divided by those in a control image and were shown in 256-gradation gray scale. Therefore, any movements in the camera and the subjects strongly diminish the quality of the image. In the present study, we used image matching method. This method replaces the original image to the image showing a local feature and executes the pattern matching with use of statistical technique.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (4 results)

All 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results) (of which Invited: 3 results)

  • [Journal Article] NADH fluorescence imaging and the histological impact of cortical spreading depolarization during the acute phase of subarachnoid hemorrhage in rats.2017

    • Author(s)
      Shimizu T, Hishikawa T, Nishihiro S, Shinji Y, Takasugi Y, Haruma J, Hiramatsu M, Kawase H, Sato S, Mizoue R, Takeda Y, Sugiu K, Morimatsu H, Date I
    • Journal Title

      J Neurosurg

      Volume: 27 Pages: 1-7

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] 脳のエネルギー状態のイメージング装置2017

    • Author(s)
      武田吉正
    • Organizer
      中央西日本メディカル・イノベーション2017
    • Place of Presentation
      岡山
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 脳低温療法の現状と近未来2016

    • Author(s)
      武田吉正
    • Organizer
      日本蘇生学会
    • Place of Presentation
      久留米
    • Year and Date
      2016-11-11
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 蘇生中に施行する低体温療法2016

    • Author(s)
      武田吉正
    • Organizer
      日本臨床麻酔学会
    • Place of Presentation
      高知
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
    • Invited

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Published: 2014-04-04   Modified: 2018-03-22  

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