Analysis of the dysregulation of the brain reward system induced by chronic pain
Project/Area Number |
26293346
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Anesthesiology
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Research Institution | Hoshi University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
|
Keywords | 中脳辺縁ドパミン神経 / 疼痛制御 / モルヒネ / エピジェネティクス / オプトジェネティクス / DREADD / 中脳ドパミン神経 / 側坐核 / 神経科学 / 疼痛 |
Outline of Final Research Achievements |
In this research, we first clarified that the intrinsic neuronal excitability of ventral tegmental area (VTA) dopaminergic neurons projecting to the nucleus accumbens (N.Acc.) was significantly reduced in neuropathic pain- and cancer pain-model mice using patch clamp electrophysiology. Under these conditions, we found that phasic activation of mesolimbic dopaminergic neurons produced a significant but transient anti-allodynic effect in these mice using optogenetics or designer receptors exclusively activated by designer drugs (DREADD) technology. On the other hand, we revealed that the expression of Dnmt3a was significantly increased along with the downregulation of miR-200b/429 expression in the N.Acc. under the neuropathic pain condition. Furthermore, we found that a significant decrease in Pde10a expression in the N.Acc. was caused by an increase in the level of DNA methylation at the Pde10a promoter.
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Report
(5 results)
Research Products
(45 results)
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[Journal Article] Extracellular N-acetylaspartylglutamate released in the nucleus accumbens modulates the pain sensation: Analysis using a microdialysis/mass spectrometry integrated system2018
Author(s)
Watanabe M, Sugiura Y, Sugiyama E, Narita M, Navratilova E, Kondo T, Uchiyama N, Yamanaka A, Kuzumaki N, Porreca F, Narita M
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Journal Title
Molecular Pain
Volume: 14
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Involvement of mesolimbic dopaminergic network in neuropathic pain relief by treadmill exercise: A study for specific neural control with gi-dreadd in mice.2016
Author(s)
Wakaizumi K, Kondo T, Hamada Y, Narita M, Kawabe R, Narita H, Watanabe M, Kato S, Senba E, Kobayashi K, Kuzumaki N, Yamanaka A, Morisaki H, *Narita M
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Journal Title
Mol Pain
Volume: 12
Pages: 1-11
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Changes in the expression of IL-6-mediated microRNAs in the dorsal root ganglion under neuropathic pain in mice.2015
Author(s)
Hori N, Narita M, Yamashita A, Horiuchi H, Hamada Y, Kondo T, Watanabe M, Igarashi K, Kawata M, Shibasaki M, Yamazaki M, Kuzumaki N, Inada E, Ochiya T, Iseki M, Mori T, Narita M.
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Journal Title
Synapse
Volume: なし
Issue: 8
Pages: 21902-21902
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Reduced Adult Hippocampal Neurogenesis and Cognitive Impairments following Prenatal Treatment of the Antiepileptic Drug Valproic Acid2015
Author(s)
Juliandi B, Tanemura K, Igarashi K, Tominaga T, Furukawa Y, Otsuka M, Moriyama N, Ikegami D, Abematsu M, Sanosaka T, Tsujimura K, Narita M, Kanno J, Nakashima K
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Journal Title
Stem Cell Rep
Volume: 5
Issue: 6
Pages: 996-1009
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Peripheral opioid antagonist enhances the effect of anti-tumor drug by blocking a cell growth-suppressive pathway in vivo2015
Author(s)
Masami Suzuki, Fumiko Chiwaki, Yumi Sawada, Maho Ashikawa, Kazuhiko Aoyagi, Takeshi Fujita, Kazuyoshi Yanagihara, Masayuki Komatsu, Minoru Narita, Tsutomu Suzuki, Hiroshi Nagase, Ryoji Kushima, Hiromi Sakamoto, Takeo Fukagawa, Hitoshi Katai, Hitoshi Nakagama, Teruhiko Yoshida, Yasuhito Uezono, Hiroki Sasaki
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Journal Title
PLOS ONE
Volume: 10(4)
Issue: 4
Pages: 1-18
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Peripheral opioid antabonist enhances the effect of anti-tumor drug by blocking a cell growth-suppressive pathway in vivo.2015
Author(s)
Suzuki M, Chiwaki F, Sawada Y, Ashikawa M, Aoyagi K, Fujita T, Yanagihara K, Komatsu M, Narita M, Suzuki T, Nagase H, Kushima R, Sakamoto H, Fukagawa T, Katai H, Nakagama H, Yoshida T, Uezono Y, Sasaki H
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Journal Title
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Possible involvement of activated locus coeruleus-noradrenergic neurons in pain-related sleep disorders.2015
Author(s)
Koh K, Hamada A, Hamada Y, Yanase M, Sakaki M, Someya K, Narita M, Kuzumaki N, Ikegami D, Sakai H, Iseki M, Inada E, Narita M
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Journal Title
Neurosci lett
Volume: 589
Pages: 200-6
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Orally active opioid μ/δ dual agonist MGM-16, a derivative of the indole alkaloid mitragynine, exhibits potent antiallodynic effect on neuropathic pain in mice.2014
Author(s)
Matsumoto K, Narita M, Muramatsu N, Nakayama T, Misawa K, Kitajima M, Tashima K, Devi LA, Suzuki T, Takayama H, Horie S.
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Journal Title
J Pharmacol Exp Ther.
Volume: 348
Issue: 3
Pages: 383-392
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Changes in circadian rhythm for mRNA expression of melatonin 1A and 1B receptors in the hypothalamus under a neuropathic pain-like state.2014
Author(s)
Odo M, Koh K, Takada T, Yamashita A, Narita M, Kuzumaki N, Ikegami D, Sakai H, Iseki M, Inada E, Narita M.
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Journal Title
Synapse
Volume: 68
Issue: 4
Pages: 153-158
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Mechanisms of cisplatin-induced muscle atrophy.2014
Author(s)
Sakai H, Sagara A, Arakawa K, Sugiyama R, Hirosaki A, Takase K, Jo A, Sato K, Chiba Y, Yamazaki M, Matoba M, Narita M
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Journal Title
Toxicol Appl Pharmacol
Volume: 278
Issue: 2
Pages: 190-199
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Neutrophil recruitment is critical for 5-fluorouracil-induced diarrhea and the decrease in aquaporins in the colon.2014
Author(s)
Sakai H, Sagara A, Matsumoto K, Jo A, Hirosaki A, Takase K, Sugiyama R, Sato K, Ikegami D, Horie S, Matoba M, Narita M.
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Journal Title
Pharmacol Res.
Volume: 87
Pages: 71-9
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Kappa-Opioids inhibit tumor angiogenesis by suppressing VEGF signaling.2013
Author(s)
Yamamizu K, Furuta S, Hamada Y, Yamashita A, Kuzumaki N, Narita M, Doi K, Katayama S, Nagase H, Yamashita JK, Narita M.
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Journal Title
Scientific Reports
Volume: 3
Issue: 1
Pages: 3213-3213
DOI
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Peer Reviewed / Open Access
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[Presentation] パシフィコ横浜2016
Author(s)
葛巻 直子、成田 年
Organizer
日本薬学会第136回年会
Place of Presentation
パシフィコ横浜
Year and Date
2016-03-29
Related Report
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[Presentation] 慢性疼痛と細胞記憶2015
Author(s)
成田 年
Organizer
第29回日本ニューロモデュレーション学会
Place of Presentation
都市センターホテル(東京)
Year and Date
2015-04-25
Related Report
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