| Project/Area Number |
26293354
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kagoshima University |
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Principal Investigator |
ENOKIDA Hideki 鹿児島大学, 医歯学域医学系, 准教授 (80347103)
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| Co-Investigator(Kenkyū-buntansha) |
関 直彦 千葉大学, 大学院医学研究院, 准教授 (50345013)
中川 昌之 鹿児島大学, 医歯学域医学系, 教授 (90164144)
千代丸 剛 鹿児島大学, 医学部・歯学部附属病院, 助教 (60593796)
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| Co-Investigator(Renkei-kenkyūsha) |
KATAOKA Kazunori 東京大学, 疾患生命工学センター, 教授 (00130245)
MIYATA Kanjiro 東京大学, 疾患生命工学センター, 准教授 (50436523)
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| Research Collaborator |
INOGUCHI Satoru 鹿児島大学, 医歯学総合研究科, 大学院生
ISHIHARA Tomoaki 鹿児島大学, 医歯学総合研究科, 大学院生
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | マイクロRNA / 膀胱癌 / ナノミセル / 癌抑制型マイクロRNA |
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| Outline of Final Research Achievements |
Based on the microRNAs expression profile by next generation sequencing in bladder cancer, we identified several tumor suppressive microRNAs including miR-23b/24/27b, miR-144-5p/3p, miR-26a/b-5, and miR-199 family and found their target tumor-associated genes. Next, we established nano-micelles carrier containing tumor suppressive miR-218 and administrated it intravenously to xenograft model mice. Finally, we confirmed that the red-pigmented carrier was successfully delivered to cancer tissues.
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