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Development of novel nucleic acid treatment through nano-micelles delivering tumor suppressive microRNA in bladder cancer

Research Project

Project/Area Number 26293354
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Urology
Research InstitutionKagoshima University

Principal Investigator

ENOKIDA Hideki  鹿児島大学, 医歯学域医学系, 准教授 (80347103)

Co-Investigator(Kenkyū-buntansha) 関 直彦  千葉大学, 大学院医学研究院, 准教授 (50345013)
中川 昌之  鹿児島大学, 医歯学域医学系, 教授 (90164144)
千代丸 剛  鹿児島大学, 医学部・歯学部附属病院, 助教 (60593796)
Co-Investigator(Renkei-kenkyūsha) KATAOKA Kazunori  東京大学, 疾患生命工学センター, 教授 (00130245)
MIYATA Kanjiro  東京大学, 疾患生命工学センター, 准教授 (50436523)
Research Collaborator INOGUCHI Satoru  鹿児島大学, 医歯学総合研究科, 大学院生
ISHIHARA Tomoaki  鹿児島大学, 医歯学総合研究科, 大学院生
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
KeywordsマイクロRNA / 膀胱癌 / ナノミセル / 癌抑制型マイクロRNA
Outline of Final Research Achievements

Based on the microRNAs expression profile by next generation sequencing in bladder cancer, we identified several tumor suppressive microRNAs including miR-23b/24/27b, miR-144-5p/3p, miR-26a/b-5, and miR-199 family and found their target tumor-associated genes. Next, we established nano-micelles carrier containing tumor suppressive miR-218 and administrated it intravenously to xenograft model mice. Finally, we confirmed that the red-pigmented carrier was successfully delivered to cancer tissues.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (16 results)

All 2017 2016 2015 2014 Other

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Open Access: 5 results,  Acknowledgement Compliant: 6 results) Presentation (8 results) (of which Int'l Joint Research: 5 results) Remarks (1 results)

  • [Journal Article] Regulation of ITGA3 by the dual-stranded microRNA-199 family as a potential prognostic marker in bladder cancer.2017

    • Author(s)
      Sakaguchi T, Yoshino H, Yonemori M, Miyamoto K, Sugita S, Matsushita R, Itesako T, Tatarano S, Nakagawa M, Enokida H.
    • Journal Title

      British Journal of Cancer

      Volume: 116 Issue: 8 Pages: 1077-1087

    • DOI

      10.1038/bjc.2017.43

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dual tumor-suppressors miR-139-5p and miR-139-3p targeting matrix metalloprotease 11 in bladder cancer.2016

    • Author(s)
      Yonemori M, Seki N, Yoshino H, Matsushita R, Miyamoto K, Nakagawa M, Enokida H.
    • Journal Title

      Cancer Science

      Volume: 107 Issue: 9 Pages: 1233-1242

    • DOI

      10.1111/cas.13002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Tumour-suppressive miRNA-26a-5p and miR-26b-5p inhibit cell aggressiveness by regulating PLOD2 in bladder cancer2016

    • Author(s)
      Miyamoto K, Seki N, Matsushita R, Yonemori M, Yoshino H, Nakagawa M, Enokida H.
    • Journal Title

      British Journal of Cancer

      Volume: 115 Issue: 3 Pages: 354-363

    • DOI

      10.1038/bjc.2016.179

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Regulation of UHRF1 by dual-strand tumor-suppressor microRNA-145 (miR-145-5p and miR 145-3p): Inhibition of bladder cancer cell aggressiveness2016

    • Author(s)
      Matsushita R, Yoshino H, Enokida H, Goto Y, Miyamoto K, Yonemori M, Inoguchi S, Nakagawa M, Seki N.
    • Journal Title

      Oncotarget

      Volume: 7 Issue: 19 Pages: 28460

    • DOI

      10.18632/oncotarget.8668

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Tumour-suppressive microRNA-144-5p directly targets CCNE1/2 as potential prognostic markers in bladder cancer2015

    • Author(s)
      Ryosuke Matsushita
    • Journal Title

      British Journal of Cancer

      Volume: 113 Issue: 2 Pages: 282

    • DOI

      10.1038/bjc.2015.195

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dual regulation of receptor tyrosine kinase genes EGFR and c-Met by the tumor-suppressive microRNA-23b/27b cluster in bladder cancer2015

    • Author(s)
      Chiyomaru T, Seki N, Inoguchi S, Ishihara T, Mataki H, Matsushita R, Goto Y, Nishikawa R, Tatarano S, Itesako T, Nakagawa M, Enokida H.
    • Journal Title

      International Journal of Oncology

      Volume: 46 Issue: 2 Pages: 487

    • DOI

      10.3892/ijo.2014.2752

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Tumour-suppressive microRNA-24-1 inhibits cancer cell proliferation through targeting FOXM1 in bladder cancer2014

    • Author(s)
      Inoguchi S, Seki N, Chiyomaru T, Ishihara T, Matsushita R, Mataki H, Itesako T, Tatarano S, Yoshino H, Goto Y, Nishikawa R, Nakagawa M, Enokida H.
    • Journal Title

      FEBS letter

      Volume: 588 Issue: 17 Pages: 3170

    • DOI

      10.1016/j.febslet.2014.06.058

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Tumor-suppressive microRNA-26a-5p/-26b-5p inhibit cancer cell migration and invasion through targeting PLOD2 that is a potential prognostic maker in bladder cancer.2017

    • Author(s)
      Miyamoto K, Seki N, Matsushita R, Yonemori M, Yoshino H, Sakaguchi T, Sugita S, Enokida H, Nakagawa M.
    • Organizer
      American Urological Association (AUA) annual meeting
    • Place of Presentation
      Boston (USA)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dual tumor-suppressors (miR-145-5p/miR-145-3p) inducing cancer cell apoptosis via direct targeting UHRF1 in bladder cancer2016

    • Author(s)
      Ryosuke Matsushita
    • Organizer
      American Urological Association Annual Meeting
    • Place of Presentation
      San Diego ( USA )
    • Year and Date
      2016-05-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dual tumor-suppressors (miR-145-5p/miR-145-3p) inducing cancer cell apoptosis via direct targeting UHRF1 in bladder cancer2016

    • Author(s)
      Matsushita R, Seki N, Yoshino H, Miyamoto K, Yonemori M, Kurozumi A, Goto Y, Enokida H, Nakagawa M.
    • Organizer
      American Urological Association (AUA) annual meeting
    • Place of Presentation
      San Diego (USA)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dual tumor-suppressors miR-139-5p/-3p derived from pre-miR-139 via targeting matrix metalloprotease 11 (MMP11) in bladder cancer2016

    • Author(s)
      Yonemori M, Seki N, Matsushita R, Miyamoto K, Yoshino H, Goto Y, Kato M, Kurozumi A, Nakagawa M, Enokida H
    • Organizer
      American Urological Association (AUA) annual meeting
    • Place of Presentation
      San Diego (USA)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pre-microRNA-145 (miR-145-5p/miR-145-3p) function2015

    • Author(s)
      松下 良介
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] MicroRNA-144-5p functions as tumor suppressor through targeting cyclin E1/E2 that are potential prognostic markers in bladder cancer2015

    • Author(s)
      Ryosuke Matsushita
    • Organizer
      American Urological Association Annual Meeting
    • Place of Presentation
      New Orleans ( USA )
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Tumor suppressive microRNA-24 inhibits bladder cancer through regulation of FOXM12014

    • Author(s)
      井口 智生
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜市・パシフィコ横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Tumor suppressive microRNA-24 inhibits bladder cancer via targeting transcription factor FOXM12014

    • Author(s)
      Satoru Inoguchi
    • Organizer
      2014 AUA annual meeting
    • Place of Presentation
      Orland, USA
    • Year and Date
      2014-05-16 – 2014-05-21
    • Related Report
      2014 Annual Research Report
  • [Remarks] 千葉大学大学院医学研究院 先端医学応用講座 機能ゲノム学

    • URL

      http://genomejet.jp/research/

    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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