Analysis for the role of cell competition in the tumorigenesis and treatment strategy of nasopharyngeal carcinoma
Project/Area Number |
26293367
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Otorhinolaryngology
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Research Institution | Kanazawa University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
脇坂 尚宏 金沢大学, 医学系, 准教授 (70377414)
近藤 悟 金沢大学, 大学病院, 講師 (70436822)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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Keywords | 上咽頭癌 / EBウイルス / LMP1 / エクソソーム / 腫瘍微小環境 / 代償性増殖 / EBV / 細胞競合 / エクソゾーム / Epstein-Barr ウイルス |
Outline of Final Research Achievements |
Compensative growth is a concept that neighboring cell competes each other, and the winner cells in cell competition, without invasive property, take place of the looser cells. We analysed the role of cell competition in the pathogenesis of nasopharyngeal carcinoma (NPC). SPARC is anti-apoptotic factor that is usually expressed in the cell competition looser cells. In NPC tumor tissue, SPARC expression is observed in the tumor surrounding cells. LMP1 is a primary oncogene encoded by Epstein-Barr virus, a causative agent of NPC. We find LMP1 increase the exosome-mediated delivery of HIF1α. Modulation of microenvironment via exosome may play some role in the regulation of cell competition, especially at the initial carcinogenic stage of NPC, and thus, upregulate invasion and metastatic potential of NPC in the early stage.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] APOBEC3A Associates with Human Papillomavirus Genome Integration in Oropharyngeal Cancers2017
Author(s)
Satoru Kondo, Kousho Wakae, Naohiro Wakisaka, Yosuke Nakanishi, Kazuya Ishikawa, Takeshi Komori, Makiko Moriyama-Kita, Kazuhira Endo, Shigeyuki Murono, Zhe Wang,, Kouichi Kitamura, Tomoaki Nishiyama, Katsushi Yamaguchi, Shuji Shigenobu, Masamichi Muramatsu, and Tomokazu Yoshizaki
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Journal Title
Oncogene.
Volume: 36
Issue: 12
Pages: 1687-1697
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] EBV infection is prevalent in the adenoid and palatine tonsils in adults2017
Author(s)
Seishima N, Kondo S, Wakisaka N, Kobayashi E, Imoto T, Moriyama-Kita M, Nakanishi Y, Endo K, Murono S, Sugimoto H, Hatano M, Ueno T, Yoshizaki T.
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Journal Title
J Med Virol
Volume: 89
Issue: 6
Pages: 1088-1095
DOI
Related Report
Peer Reviewed
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[Journal Article] T-status and an oral fluoropyrimidine, S-1, adjuvant chemotherapy are prognostic factors in reduced-RADPLAT for resectable hypopharyngeal cancer2016
Author(s)
Wakisaka N, Hirai N, Kondo S, Aga M, Nakanishi Y, Tsuji A, Endo K, Murono S, Yoshizaki T
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Journal Title
Acta Otolaryngol
Volume: 136
Issue: 8
Pages: 834-840
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Potential Interest in Circulating miR-BART17-5p As a Post-Treatment Biomarker for Prediction of Recurrence in Epstein-Barr Virus-Related Nasopharyngeal Carcinoma2016
Author(s)
Hirai N, Wakisaka N, Kondo S, Aga M, Moriyama-Kita M, Ueno T, Nakanishi Y, Endo K, Sugimoto H, Murono S, Sato H, Yoshizaki T.
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Journal Title
PLOS ONE
Volume: 11
Issue: 9
Pages: e0163609-e0163609
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] T-status and an oral fluoropyrimidine, S-1, adjuvant chemotherapy are prognostic factors in reduced-RADPLAT for resectable hypopharyngeal cancer2016
Author(s)
Wakisaka N, Hirai N, Kondo S, Aga M, Nakanishi Y, Tsuji A, Endo K, Murono S, Yoshizaki T
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Journal Title
Acta Otolaryngol
Volume: 137
Pages: 1-7
NAID
Related Report
Peer Reviewed
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[Journal Article] Progress and controversy for the role of chemotherapy in nasopharyngeal carcinoma2015
Author(s)
Yoshizaki T, Kondo S, Murono S, Endo K, Tsuji A, Nakanishi Y, Nakanishi S, Sugimoto H, Hatano M, Ueno T, Wakisaka N
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Journal Title
Jpn J Clin Oncol
Volume: 45
Issue: 3
Pages: 244-247
DOI
Related Report
Peer Reviewed
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[Journal Article] HPV Status Determines the Efficacy of Adjuvant Chemotherapy With S-1, an Oral Fluorouracil Prodrug, in Oropharyngeal Cancer2015
Author(s)
Wakisaka N, Yoshida S, Kondo S, Kita M, Endo K, Tsuji A, Murono S, Muramatsu M, Yoshizaki T
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Journal Title
Ann Otol Rhinol Laryngol
Volume: 124
Issue: 5
Pages: 400-6
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Progress and controversy for the role of chemotherapy in nasopharyngeal carcinoma.2015
Author(s)
Yoshizaki T, Kondo S, Murono S, Endo K, Tsuji A, Nakanishi Y, Nakanishi S, Sugimoto H, Hatano M, Ueno T, Wakisaka N.
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Journal Title
Jpn J Clin Oncol.
Volume: 45
Pages: 244-7
Related Report
Peer Reviewed
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[Journal Article] Immunoglobulin class switching to IgG4 in Warthin tumor and analysis of serum IgG4 levels and IgG4-positive plasma cells in the tumor.2014
Author(s)
Aga M, Kondo S, Yamada K, Wakisaka N, Yagi-Nakanishi S, Tsuji A, Endo K, Murono S, Ito M, Muramatsu M, Kawano M, Yoshizaki T.
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Journal Title
Hum Pathol.
Volume: 45
Pages: 793-801
Related Report
Peer Reviewed
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[Journal Article] Assessment of antitumor activity and acute peripheral neuropathy of 1,2-diaminocyclohexane platinum (II)-incorporating micelles (NC-4016).2014
Author(s)
Ueno T, Endo K, Hori K, Ozaki N, Tsuji A, Kondo S, Wakisaka N, Murono S, Kataoka K, Kato Y, Yoshizaki T.
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Journal Title
Int J Nanomedicine.
Volume: 19
Pages: 3005-12
Related Report
Peer Reviewed
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[Presentation] ウイルスが病気を起こすメカニズム2014
Author(s)
吉崎智一
Organizer
第115回日本耳鼻咽喉科学会総会・学術講演会
Place of Presentation
ヒルトン福岡シーホーク(福岡県、福岡市)
Year and Date
2014-05-14 – 2014-05-17
Related Report
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