• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Degranulation from mast cell in the onset of allergic rhinitis

Research Project

Project/Area Number 26293368
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionUniversity of Fukui

Principal Investigator

Fujieda Shigeharu  福井大学, 学術研究院医学系部門, 教授 (30238539)

Co-Investigator(Kenkyū-buntansha) 徳永 貴広  福井大学, 医学部附属病院, 特命助教 (10464075)
野口 恵美子  筑波大学, 医学医療系, 教授 (40344882)
高林 哲司  福井大学, 医学部附属病院, 講師 (70397272)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2014: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Keywordsスギ花粉症 / HLA-DR / Apolipoprotein A4 / Dectin-1 / TSLP / IL-33 / C3a / C5a / HLA-DPB / Apolipoprotein A-IV / ヒスタミン / CpG-DNA / Hexaponda / アレルギー / 遺伝子 / 細胞・組織 / 発現制御 / 免疫学 / IgE / IL-17A / アレルギー性鼻炎 / Dectin 1 / ヒスタミン遊離
Outline of Final Research Achievements

HLA-DPB1*02:01 and HLA-DPB1*02:02 had a protective tendency and DPB1*05:01 had a susceptible tendency for sensitization of Japanese cedar pollen. Apo A4, which is induced by sublingual immunotherapy, inhibited sneezing, nasal itching and nasal obstruction. Dectin-1 is a critical factor in the tyrosine phosphorylation in mast cells. TSLP and IL-33 are important factors in production of IgE, but not release histamine from mast cells. Serum levels of C3a, C5a and IL-A were associated with symptom scores and increased by sublingual immunotherapy.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(33 results)

All 2018 2017 2016 2015 2014

All Journal Article (23 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 23 results,  Acknowledgement Compliant: 20 results,  Open Access: 14 results) Presentation (10 results) (of which Int'l Joint Research: 4 results,  Invited: 6 results)

  • [Journal Article] Association of Japanese cedar pollinosis and sensitization with <i>HLA-DPB1</i> in the Japanese adolescent2018

    • Author(s)
      Morii W, Sakai A, Ninomiya T, Kidoguchi M, Sumazaki R, Fujieda S, Noguchi E
    • Journal Title

      Allergol. Int.

      Volume: in press Issue: 1 Pages: 61-66

    • DOI

      10.1016/j.alit.2017.04.004

    • NAID

      130006322040

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Japanese guidelines for allergic rhinitis 20172017

    • Author(s)
      Okubo K, Kurono Y, Ichimura K, Enomoto T, Okamoto Y, Kawauchi H, Suzaki H, Fujieda S, Masuyama K
    • Journal Title

      Allergol. Int.

      Volume: 66(2) Issue: 2 Pages: 205-219

    • DOI

      10.1016/j.alit.2016.11.001

    • NAID

      130005628190

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Complementary and alternative medicine for allergic rhinitis in Japan2017

    • Author(s)
      Yonekura S, Okamoto Y, Sakurai D, Sakurai T, Iinuma T, Yamamoto H, Hanazawa T, Horiguchi S, Kurono Y, Honda K, Majima Y, Masuyama K, Takeda N, Fujieda S, Okano M, Ogino S, Okubo.
    • Journal Title

      Allergol. Int.

      Volume: in press Issue: 3 Pages: 425-431

    • DOI

      10.1016/j.alit.2016.10.006

    • NAID

      130005858792

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Toll-like receptor ligands induce cytokine and chemokine production in human inner ear endolymphatic sac fibroblasts.2017

    • Author(s)
      Yamada T, Ogi K, Sakashita M, Kanno M, Kubo S, Ito Y, Imoto Y, Tokunaga T, Okamoto M, Narita N, Fujieda S.
    • Journal Title

      Auris Nasus Larynx.

      Volume: 44(4) Pages: 398-403

    • DOI

      10.1016/j.anl.2016.10.007

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] House dust mite sublingual tablet is effective and safe in patients with allergic rhinitis.2017

    • Author(s)
      Okamoto Y, Fujieda S, Okano M, Yoshida Y, Kakudo S, Masuyama K.
    • Journal Title

      Allergy

      Volume: 72 Pages: 435-443

    • DOI

      10.1111/all.12996

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Guiding principles of sublingual immunotherapy for allergic rhinitis in Japanese patients.2016

    • Author(s)
      Masuyama K, Goto M, Takeno S, Ohta N, Okano M, Kamijo A, Suzuki M, Terada T, Sakurai D, Horiguchi S, Honda K, Matsune S, Yamada T, Sakashita M, Yuta A, Fuchiwaki T, Miyanohara I, Nakayama T, Okamoto Y, Fujieda S.
    • Journal Title

      Auris Nasus Larynx

      Volume: 43(1) Pages: 1-9

    • DOI

      10.1016/j.anl.2015.08.015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Murine allergic rhinitis and nasal Th2 activation are mediated via TSLP- and IL-33-signaling pathways.2016

    • Author(s)
      Akasaki S, Matsushita K, Kato Y, Fukuoka A, Iwasaki N, Nakahira M, Fujieda S, Yasuda K, Yoshimoto T.
    • Journal Title

      Int Immunol.

      Volume: 28 Pages: 65-7

    • DOI

      10.1093/intimm/dxv055

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Nitrite/Nitrate in Nasal Lavage Fluid Reflects Nasal Symptoms After a Single Nasal Allergen Provocation in Patients With Seasonal Allergic Rhinitis.2015

    • Author(s)
      Imoto Y, Yamada T, Tsukahara H, Kimura Y, Kato Y, Sakashita M, Fujieda S.
    • Journal Title

      J Investig Allergol Clin Immunol.

      Volume: 25 Pages: 382-4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Peripheral basophil reactivity, CD203c expression by Cryj1 stimulation, is useful for diagnosing seasonal allergic rhinitis by Japanese cedar pollen2015

    • Author(s)
      Imoto Y, Takabayashi T, Sakashita M, Tokunaga T, Ninomiya T, Ito Y, Narita N, Yamada T, Fujieda S
    • Journal Title

      Immun Inflamm Dis.

      Volume: 3 Pages: 300-308

    • DOI

      10.1002/iid3.69

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Long-term sublingual immunotherapy for Japanese cedar pollinosis and the levels of IL-17A and complement components 3a and 5a.2015

    • Author(s)
      Sakashita M, Yamada T, Imoto Y, Hirota T, Tamari M, Ito Y, Kubo S, Osawa Y, Takahashi N, Fujieda S.
    • Journal Title

      Cytokine

      Volume: 75 Pages: 181-5

    • DOI

      10.1016/j.cyto.2015.03.019

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Synergistic suppression of Poly(I:C)-induced CCL3 by a corticosteroid and a long acting &beta;2 agonist in nasal epithelial cells2015

    • Author(s)
      Tanaka S, Tamari M, Nakayama T, et al.
    • Journal Title

      Allergol. Int.

      Volume: 64(2) Issue: 2 Pages: 196-199

    • DOI

      10.1016/j.alit.2014.10.006

    • NAID

      130005290257

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Association and management of eosinophilic inflammation in upper and lower airways2015

    • Author(s)
      Okano M, Kariya S, Ohta N, et al.
    • Journal Title

      Allergol. Int.

      Volume: 64(2) Issue: 2 Pages: 131-138

    • DOI

      10.1016/j.alit.2015.01.004

    • NAID

      130005290337

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Regulation of upper airway inflammation facilitates comfortable breathing.2015

    • Author(s)
      Fujieda S, Izuhara K.
    • Journal Title

      Allergol Int.

      Volume: 64(2) Pages: 119-120

    • NAID

      130005290286

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Factors associated with the development and remission of allergic diseases in an epidemiological survey of high school students in Japan.2015

    • Author(s)
      Tokunaga T, Ninomiya T, Osawa Y, Imoto Y, Ito Y, Takabayashi T, Narita N, Kijima A, Murota H, Katayama I, Fujieda S.
    • Journal Title

      Am J Rhinol Allergy

      Volume: 29 Pages: 94-9

    • DOI

      10.2500/ajra.2015.29.4135

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ishii-Mizuno Y, Umeki Y, Takahashi Y, Kato Y, Takabayashi T, Fujieda S, Takakura Y, Nishikawa M. Nasal delivery of Japanese cedar pollen Cryj1 by using self-gelling immunostimulatory DNA for effective induction of immune responses in mice2015

    • Author(s)
      Ishii-Mizuno Y, Umeki Y, Takahashi Y, Kato Y, Takabayashi T, Fujieda S, Takakura Y, Nishikawa M
    • Journal Title

      J Control Release

      Volume: 200 Pages: 52-59

    • DOI

      10.1016/j.jconrel.2014.12.040

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 粘膜アレルギー:花粉症2015

    • Author(s)
      藤枝重治、坂下雅文、意元義政、高林哲司、山田武千代
    • Journal Title

      炎症と免疫

      Volume: 23(1) Pages: 61-67

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dectin-1-mediated signaling leads to characteristic gene expressions and cytokine secretion via spleen tyrosine kinase (Syk) in rat mast cells.2014

    • Author(s)
      Kimura Y, Chihara K, Honjoh C, Takeuchi K, Yamauchi S, Yoshiki H, Fujieda S, Sada K
    • Journal Title

      J. Biol. Chem.

      Volume: 289 Pages: 31565-31575

    • DOI

      10.1074/jbc.m114.581322

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Nasal sensitization with ragweed pollen induces local-allergic-rhinitis-like symptoms in mice.2014

    • Author(s)
      Kato Y, Akasaki S, Muto-Haenuki Y, Fujieda S, Matsushita K, Yoshimoto T.
    • Journal Title

      PLoS ONE.

      Volume: 9

    • DOI

      10.1371/journal.pone.0103540

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effect of Asian sand dust on Japanese cedar pollinosis.2014

    • Author(s)
      Ogi K, Takabayashi T, Sakashita M, Susuki D, Yamada T, Manabe Y, Fujieda S.
    • Journal Title

      Auris Nasus Larynx

      Volume: 41 Pages: 518-22

    • DOI

      10.1016/j.anl.2014.05.020

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Present state of Japanese cedar pollinosis : the national affliction2014

    • Author(s)
      Yamada T, Saito H, Fujieda S
    • Journal Title

      J Allergy Clin Immunol.

      Volume: 133(3) Pages: 632-9

    • DOI

      10.1016/j.jaci.2013.11.002

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Guiding principles of subcutaneous immunotherapy for allergic rhinitis in Japan. Auris Nasus Larynx2014

    • Author(s)
      Okamoto Y, Ohta N, Okano M, et al
    • Journal Title

      Auris Nasus Larynx

      Volume: 41(1) Pages: 1-5

    • DOI

      10.1016/j.anl.2013.06.003

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 舌下免疫療法の歴史とオーバービュー2014

    • Author(s)
      藤枝重治
    • Journal Title

      アレルギー・免疫

      Volume: 21(7) Pages: 1085-1092

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 舌下免疫療法2014

    • Author(s)
      藤枝重治、坂下雅文、大澤陽子、意元義政
    • Journal Title

      耳喉頭頸

      Volume: 86(1) Pages: 46-52

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] アレルギー性鼻炎の発症因子と先制医療2016

    • Author(s)
      藤枝重治
    • Organizer
      日本アレルギー学会第3回総合アレルギー講習会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-12-17
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] アレルゲン免疫療法の期待と展望2016

    • Author(s)
      藤枝重治
    • Organizer
      第65回日本アレルギー学会学術大会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2016-06-17
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] S. Fujieda, T. Ninomiya, Y. Imoto, Y. Kato, T. Tokunaga.2015

    • Author(s)
      Apolipoprotein A-IV is a new target molecule for allergic rhinitis.
    • Organizer
      13th Japan-Taiwan conference on Otolaryngology-Head and Neck Surgery
    • Place of Presentation
      東京
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] S. Fujieda2015

    • Author(s)
      Apolipoprotein A-IV is a new target molecule for allergic rhinitis.
    • Organizer
      2015 Annual CORLAS Meeting
    • Place of Presentation
      サンフランシスコ
    • Year and Date
      2015-08-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Apolipoprotein A-IV is a new target molecule for allergic rhinitis.2015

    • Author(s)
      S. Fujieda, T. Ninomiya, Y. Imoto, Y. Kato, S.
    • Organizer
      European Academy of Allergy and Clinical Immunology Congress 2015
    • Place of Presentation
      バルセロナ
    • Year and Date
      2015-06-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 舌下免疫療法の実際と対応2015

    • Author(s)
      藤枝重治
    • Organizer
      第116回日本耳鼻咽喉科学会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] Apolipoprotein A-IV is a new target molecule for allergic rhinitis2015

    • Author(s)
      S. Fujieda
    • Organizer
      2015 International Congress of Korean Society of Otorhinolaryngology-
    • Place of Presentation
      ソウル
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 花粉症と口腔アレルギー症候群2015

    • Author(s)
      藤枝重治
    • Organizer
      第78回日本皮膚科学会東京支部学術大会 モーニングセミナー
    • Place of Presentation
      東京 京王プラザ
    • Year and Date
      2015-02-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 小児アレルギー性鼻炎の問題点2014

    • Author(s)
      藤枝重治
    • Organizer
      第51回小児アレルギー学会 ランチョンセミナー
    • Place of Presentation
      四日市市 都ホテル
    • Year and Date
      2014-11-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Sublingeal immunotherapy for seasonal allergic rhinitis caused by Japnese cedar pollen.2014

    • Author(s)
      Fujieda S
    • Organizer
      15th Korea -Japan Joint meeting of Otolaryngology-Head and Neck Surgery
    • Place of Presentation
      Seoul (Korea)
    • Year and Date
      2014-04-04
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi