| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Outline of Final Research Achievements |
We found that mice lacking Fcα/μR, an Fc receptor for IgA/M showed attenuated inflammatory cytokine and chomokine productions and survived during lipopolysaccharide (LPS)-induced septic shock. Analyses using mixed bone marrow chimeric mice showed that Fcα/μR on marginal zone (MZ) B cells enhances systemic inflammatory responses by producing IL-6. IL-6 production from MZ B cells starts at 4-hr after LPS injection, following to that from macrophages. Thus, we tried to neutralize IL-6 by antibody injection for the treatment of septic shock. Although IL-6 is shown to be pro- and/or anti-inflammatory, we found that neutralization of delayed IL-6 leads to the attenuation of systemic inflammatory responses and the improvement of survival of mice.
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