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The analysis of inflammasome activation in extracellular histones

Research Project

Project/Area Number 26293387
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Emergency medicine
Research InstitutionOsaka Institute of Technology

Principal Investigator

Kawahara Ko-ihi  大阪工業大学, 工学部, 教授 (10381170)

Co-Investigator(Kenkyū-buntansha) 丸山 征郎  鹿児島大学, 医歯(薬)学総合研究科, 教授 (20082282)
伊藤 隆史  鹿児島大学, 医歯(薬)学総合研究科, 講師 (20381171)
森元 陽子  鹿児島大学, 医学部・歯学部附属病院, 助教 (30437967)
三浦 直樹  鹿児島大学, 獣医学部, 准教授 (80508036)
中島 利博  東京医科大学, 医学部, 教授 (90260752)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Keywords敗血症 / インフラマソーム / ヒストン / オートファジー / DAMPs
Outline of Final Research Achievements

Recently, extracellular histones are damage-associated molecular patterns (DAMPs), which is released by necrotic cells. However, extracellular histones remain unclear as DAMPs. In this study, we focused whether extracellular histones activate inflammasome (IL-1β release) in macrophage cell lines, which are ASC in the presence or absence. Therefore, histones induced IL-1βin macrophage cell-lines in the presence or absence ASC, suggesting that sepsis might enhance in extracellular histones.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(9 results)

All 2016 2015 2014

All Journal Article Presentation

  • [Journal Article] “DAMP and DIC: The role of extracellular DNA and DNA-binding proteins in the pathogenesis of DIC”2016

    • Author(s)
      Liaw P, Ito T, Iba T, Thachil J, Zeerleder S
    • Journal Title

      Blood Rev.

      Volume: 30

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A natural therapeutic approach for the treatment of periodontitis by MK6152015

    • Author(s)
      Yoko Morimoto-Yamashita, Yoshiko Kawakami, Syoko Tatsuyama, Keiko Miyashita, Makiko Emoto, Kiyoshi Kikuchi, Ko-ichi Kawahara, Masayuki Tokuda
    • Journal Title

      Med Hypotheses.

      Volume: 85 Pages: 618-621

    • DOI

      10.1016/j.mehy.2015.07.028

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] GM2 gangliosidosis variant 0 (Sandhoff disease) in a mixed-breed dog.2015

    • Author(s)
      Kohyama, M., Yabuki, A., Kawasaki, Y., Kawaguchi, H., Miura, N., Kitano, Y., Onitsuka, T., Rahmann, MM., Miyoshi, N., Yamato, O.
    • Journal Title

      J Am Anim Hosp Assoc

      Volume: 51

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diagnostic imaging of intra-abdominal cyst in heifer using the computed tomography2015

    • Author(s)
      Otomaru, K., Fujikawa, T., Saito, Y., Ando, T., Obi, T., Miura, N., Kubota, C.
    • Journal Title

      J. Vet. Med. Sci.

      Volume: 77 Issue: 9 Pages: 1191-1193

    • DOI

      10.1292/jvms.15-0153

    • NAID

      130005100727

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1β2015

    • Author(s)
      Fujita H, Yagishita N, Aratani S, Saito-Fujita T, Morota S, Yamano Y, Hansson MJ, Inazu M, Kokuba H, Sudo K, Sato E, Kawahara K, Nakajima F, Hasegawa D, Higuchi I, Sato T, Araya N, Usui C, Nishioka K, Nakatani Y, Maruyama I, Usui M, Hara N, Uchino H, Elmer E, Nishioka K, Nakajima T.
    • Journal Title

      EMBO J

      Volume: 34 Pages: 1042-1042

    • DOI

      10.15252/embj.201489897

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cleavage of host cytokeratin-6 by lysine-specific gingipain induces gingival inflammation in periodontitis patients.2015

    • Author(s)
      Tancharoen S, Matsuyama T, Kawahara K, Tanaka K, Lee LJ, Machigashira M, Noguchi K, Ito T, Imamura T, Potempa J, Kikuchi K,Maruyama I.
    • Journal Title

      PLOS ONE.

      Volume: 10

    • DOI

      10.1371/journal.pone.0117775

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] HMGB1 promotes the development of pulmonary arterial hypertension in rats.2014

    • Author(s)
      Sadamura-Takenaka Y, Ito T, Noma S, Oyama Y, Yamada S, Kawahara K, Inoue H, Maruyama I.
    • Journal Title

      PLoS One

      Volume: 9

    • DOI

      10.1371/journal.pone.0102482

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 細胞外ヒストンにおけるIL-1β放出機構の解明2015

    • Author(s)
      大池加恵、勝野涼太、藤本靖真、安田 哲 丸山征郎、川原幸一
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 細胞外ヒストンによる炎症性サイトカインIL-1β放出機構の解明2015

    • Author(s)
      大池加恵、勝野涼太、藤本靖真、安田哲、丸山征郎、菊池清志、川原幸一
    • Organizer
      西日本生理学会
    • Place of Presentation
      久留米
    • Year and Date
      2015-10-09
    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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