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Development of brachytherapy for early stage oral cancer using I-125 seeds

Research Project

Project/Area Number 26293399
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Miura Masahiko  東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (10272600)

Co-Investigator(Kenkyū-buntansha) 林 良雄  東京薬科大学, 薬学部, 教授 (10322562)
吉村 亮一  東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (40302864)
戒田 篤志  東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (40632097)
岡本 裕之  国立研究開発法人国立がん研究センター, その他部局等, その他 (90595729)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Keywords小線源治療 / 口腔癌
Outline of Final Research Achievements

Low dose-rate brachtytherapy is a definitive radiotherapy for early stage oral cancer. Au-198 grains are often used for the therapy; however, their supply has been insufficient since The Great East Japan Earthquake. The objective of this study was to examine whether Au-198 grains could be replaced by I-125 seeds usually used for the prostate cancer treatment. For this purpose, three dimensional absorption dose distribution was simulated and temporo-spatial kinetics of G2 arrest was analyzed. When applied to mold therapy using transient treatment instead of eternal implant, we tentatively propose that Au-198 grains could be replaced by I-125 seeds when ten times more number of I-125 seeds are used compared with that of Au-198 grains.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (29 results)

All 2017 2016 2015 2014

All Journal Article (14 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 14 results,  Open Access: 13 results,  Acknowledgement Compliant: 6 results) Presentation (14 results) (of which Int'l Joint Research: 3 results,  Invited: 10 results) Book (1 results)

  • [Journal Article] Effect of dose rate on early and late compoications in low daose rate brachytherapy for mobile tongue carcinoma using Ir-192 sources2017

    • Author(s)
      Kaida A, Watanabe H, Toda K, Yuasa-Nakagawa K, Yoshimura R, Miura M
    • Journal Title

      Oral Radiol

      Volume: 印刷中 Issue: 3 Pages: 187-192

    • DOI

      10.1007/s11282-016-0263-7

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Estimation of whole-body radiation exposure from brachytherapy for oral cancer using a Monte Carlo simulation2017

    • Author(s)
      Ozaki Y, Watanabe H, Kaida A, Miura M, Nakagawa K, Toda K, Yoshimura R, Sumi Y, Kurabayashi T
    • Journal Title

      J Radiat Res

      Volume: 24 Issue: 4 Pages: 1-6

    • DOI

      10.1093/jrr/rrx002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Radiosensitivitiy of quiescent and proliferating cells grown as multicellular tumor spheroids2017

    • Author(s)
      Onozato Y, Kaida A, Haraada H, Miura M
    • Journal Title

      Cancer Sci

      Volume: 108 Issue: 4 Pages: 704-712

    • DOI

      10.1111/cas.13178

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Temporo-spatial cell-cycle kinetics in HeLa cells irradiated by Ir-192 high dose-rate remote afterloading system (HDR-RALS)2016

    • Author(s)
      Asahina T, Kaida A, Goto T, Yoshimura R, Sasai K, Miura M
    • Journal Title

      Radiat Oncol

      Volume: 99 Issue: 1

    • DOI

      10.1186/s13014-016-0669-8

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Kinetic analysis of radiation-induced cell-cycle alterations in HeLa cells expressing fluorescent ubiquitination-based cell cycle indicator (Fucci)2016

    • Author(s)
      Manila NG, Kaida A, Miura M
    • Journal Title

      Radiat Environ Med

      Volume: 5 Pages: 16-21

    • NAID

      40020922454

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] KPU-300, a novel benzophenone-diketopiperazine-type anti-microtubule agent with a 2-pyridyl structure, is a potent radiosensitizer that synchronizes the cell cycle in early M phase.2015

    • Author(s)
      Okuyama K, Kaida A, Hayashi Y, Hayashi Y, Harada K, Miura M
    • Journal Title

      PLoS One

      Volume: 10 Issue: 12 Pages: e0145995-e0145995

    • DOI

      10.1371/journal.pone.0145995

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Visualizing cell-cycle kinetics after hypoxia/reoxygenation in HeLa cells expressing fluorescent ubiquitination-based cell cycle indicator (Fucci).2015

    • Author(s)
      Goto T, Kaida A, Miura M
    • Journal Title

      Exp Cell Res

      Volume: 339 Issue: 2 Pages: 389-396

    • DOI

      10.1016/j.yexcr.2015.10.019

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Unusual prolongation of radiation-induced G2 arrest in tumor xenografts derived from HeLa cells2015

    • Author(s)
      Kaida A, Miura M
    • Journal Title

      Cancer Science

      Volume: 106 Issue: 10 Pages: 1370-6

    • DOI

      10.1111/cas.12748

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effect of X-Irradiation at Different Stages in the Cell Cycle on Individual Cell–Based Kinetics in an Asynchronous Cell Population2015

    • Author(s)
      Tsuchida E, Kaida A, Pratama E, Ikeda MA, Suzuki K, Harada K, Miura M
    • Journal Title

      PLoS One

      Volume: 10 Issue: 6 Pages: e0128090-e0128090

    • DOI

      10.1371/journal.pone.0128090

    • NAID

      120006986960

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of Chk1 inhibitor or paclitaxel on cisplatin-induced cell-cycle kinetics and survival in parental and cisplatin-resistant HeLa cells expressing fluorescent ubiquitination based cell cycle indicator (Fucci).2015

    • Author(s)
      Yamada C, Kaida A, Okuyama K, Harada K, Miura M
    • Journal Title

      Integr Cancer Sci Therap

      Volume: 2 Pages: 87-92

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effect of X-irradiation at different stages in the cell cycle on individual cell-based kinetics in an asynchronous cell populatin.2015

    • Author(s)
      Tsuchida E, Kaida A, Pratama E, Ikeda M-A, Suzuki K, Harada K, Miura M
    • Journal Title

      PLOS One

      Volume: in press

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The complexity of DNA double strand break is a crucial factor for activating ATR signaling pathway for G2/M checkpoint regulation regardless of ATM function2015

    • Author(s)
      Xue L, Furusawa Y, Okayasu R, Miura M, Cui X, Liu C, Hirayama R, Matsumoto Y, Yajima H, Yu D.
    • Journal Title

      DNA Repair

      Volume: 25 Pages: 72-83

    • DOI

      10.1016/j.dnarep.2014.11.004

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Development of a new benzophenone-diketopiperazine-type potent antimicrotubule agent possessing a 2-pyridine structure.2014

    • Author(s)
      Hayashi Y, Takeno H, Chinen T, Muguruma K, Okuyama K, Taguchi A, Takayama K, Yakushiji F, Miura M, Usui T, Hayashi Y.
    • Journal Title

      ACS Med Chem Lett.

      Volume: 5 Issue: 10 Pages: 1094-1098

    • DOI

      10.1021/ml5001883

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Chk1 inhibition on the temporal duration of radiation-induced G2 arrest in HeLa cells2014

    • Author(s)
      Nahar F, Goto T, Kaida A, Deguchi S, Miura M
    • Journal Title

      Jounal of Radiation Research

      Volume: in press Issue: 5 Pages: 1021-1027

    • DOI

      10.1093/jrr/rru038

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Oral Cancer and brachytherapy2017

    • Author(s)
      Masahiko Miura
    • Organizer
      The 39th Annual Scientific Conference on Dental Research
    • Place of Presentation
      University of Medicine and Pharmacy at Ho Chi Minh City(Ho chi Minj City, Vietnam)
    • Year and Date
      2017-04-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Fucciによる腫瘍微小環境下での静止期、増殖期細胞の可能性、分離とその放射線感受性2017

    • Author(s)
      三浦雅彦、戒田篤志、小野里祐祐
    • Organizer
      第19回癌治療増感研究シンポジウム
    • Place of Presentation
      奈良県文化会館(奈良市、奈良県)
    • Year and Date
      2017-02-03
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 放射線療法「口腔癌取扱い規約」改訂についてのコンセンサスミーティング2017

    • Author(s)
      三浦雅彦
    • Organizer
      第35回日本口腔腫瘍学会総会・学術大会
    • Place of Presentation
      福岡国際会議場(福岡市、福岡県)
    • Year and Date
      2017-01-26
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Cell cycle kinetics and radiosensitivity2016

    • Author(s)
      Masahiko Miura
    • Organizer
      The 29th Annual Meeting of JASTRO
    • Place of Presentation
      国立京都国際会館(京都市、京都府)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Temporo-spatial cell cycle kinetics in HeLa cells by Ir-192 HDR-RALS.2015

    • Author(s)
      朝比奈泰斗、戒田篤志、笹井啓介、吉村亮一、三浦雅彦
    • Organizer
      日本放射腺腫瘍学会第28回学術大会
    • Place of Presentation
      ベイシア文化ホール( 群馬県、前橋市)
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] Brachytherapy using Au-198 grains for oral or oropharyngeal carcinomas in patients with past histories of cancer treatments in those regions.2015

    • Author(s)
      吉村亮一、三浦雅彦、渡邊裕、林敬二、中川恵子、戸田一真、戒田篤志、桑原博文、渋谷均
    • Organizer
      日本放射線腫瘍学会第28回学術大会
    • Place of Presentation
      ベイシア文化ホール( 群馬県、前橋市)
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] Radiobiology for stereotactic radiotherapy.2015

    • Author(s)
      三浦雅彦、戒田篤志
    • Organizer
      日本放射線腫瘍学会第28回学術大会ワークショップ
    • Place of Presentation
      ベイシア文化ホール( 群馬県、前橋市)
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 口腔癌に対するTS-1を用いた導入化学療法併用低線量率小腺源治療の安全性について2015

    • Author(s)
      吉村亮一、三浦雅彦、中川恵子、渡邊裕、戒田篤志、後藤達明、桑原宏文、長野拓也、林啓二、戸田一真
    • Organizer
      日本放射線腫瘍学会第17回小腺源治療部会
    • Place of Presentation
      大宮ソニックシティービル( 埼玉県、さいたま市)
    • Year and Date
      2015-06-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Basics of Radiation Biology with a Focus on 4Rs.2015

    • Author(s)
      Masahiko Miura
    • Organizer
      12th International Stereotactic Radiosurgery Society Congress.
    • Place of Presentation
      パシフィコ横浜会議センター( 神奈川県、横浜市)
    • Year and Date
      2015-06-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Visualizing Cell cycle kinetics in HeLa cell in vitro and in vivo following X irradiation2015

    • Author(s)
      Miura M
    • Organizer
      15th International Congress of Radiation Research
    • Place of Presentation
      Kyoto International Conference Center (kyoto)
    • Year and Date
      2015-05-25 – 2015-05-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Visualizing Cell cycle kinetics in HeLa cell in vitro and in vivo following X irradiation.2015

    • Author(s)
      Masahiko Miura
    • Organizer
      15th International Congress of Radiation Research.
    • Place of Presentation
      国立京都国際会館( 京都府、京都市)
    • Year and Date
      2015-05-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 口腔癌に対する放射線治療向上のための物理学的、生物学的アプローチの可能性.2015

    • Author(s)
      三浦雅彦
    • Organizer
      第69回日本口腔科学学会総会・学術大会シンポジウム
    • Place of Presentation
      大阪国際会議場( 大阪府、大阪市)
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 分子標的薬の併用において考慮すべき放射線生物学2015

    • Author(s)
      三浦雅彦
    • Organizer
      第10回新潟Radiology Update学術講演会
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2015-02-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 腫瘍微小環境が照射後の腫瘍細胞動態に及ぼす影響の可視化2015

    • Author(s)
      三浦雅彦
    • Organizer
      第5回国際放射線神経生物学会大会
    • Place of Presentation
      高崎シティーギャラリー(群馬県高崎市)
    • Year and Date
      2015-02-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Book] 新版 放射線医科学-生体と放射線・電磁波・超音波-2016

    • Author(s)
      大西武雄、松本英樹、近藤隆、島田義也、田内広、平岡真寛、三浦雅彦、宮川清、宮越順二他
    • Total Pages
      192
    • Publisher
      医療科学社
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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