| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Outline of Final Research Achievements |
In this study, we developed an oncolytic adenovirus (AdΔE4), which has mutation in E4 region, targeting oral and other cancer cells. The replication rate of AdΔE4 in cancer cells was higher than that in normal cells. The cytolytic activity of AdΔE4 was also higher in cancer cells. AdΔE4 reduced the volume of tumor formed in nude mice. Furthermore, an oncolytic adenovirus synergistically killed oral cancer cells with cisplatin. These results indicate that AdΔE4 has potential as an oncolytic virus and it suggests the possibility of clinical application.
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