Epidemiological studies on paragonimus westermaniasis in Asia based on the PK gene
| Project/Area Number |
26305011
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 海外学術 |
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| Research Field |
Parasitology (including sanitary zoology)
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| Research Institution | Kochi University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | ウエステルマン肺吸虫 / フォスファーゲンキナーゼ遺伝子 / イントロン / ミトコンドリアDNA / 人獣共通感染症 / 東南アジア / 尿検査 / ウエステルマン肺吸虫の起源 / フォスファーゲンキナーゼ / ＤＮＡ / 分子系統 / アジア / インド / スリランカ / PKD1イントロン3 / タイ / フィリピン / PCR |
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| Outline of Final Research Achievements |
In this study, nucleotide sequences of Pk intron (nuclear DNA) in Paragonimus westermani were used to construct phylogenetic trees. As a result, it was discovered that the India and Sri Lankan clades have been diverged from the other Asian clades of P. westermani considerably long time ago. In addition, it became clear that two clades from Malaysia and Philippines was included in the East Asia clade. Phylogenetic tree obtained from this intron region became quite different from the tree using mitochondrial DNA (cox1). Furthermore, it was considered that a lot of mutation of the Pk intron position has been created by the recombination events between different alleles, indicating a single event of triploid origin. Both of the India and Sri Lankan clades could be separate species from P. westermani.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Morphological and molecular characteristics of Malayfilaria sofiani Uni, Mat Udin & Takaoka n. g., n. sp. (Nematoda: Filarioidea) from the common treeshrew Tupaia glis Diard & Duvaucel (Mammalia: Scandentia) in Peninsular Malaysia2017
Author(s)
Uni S, Mat Udin AS, Agatsuma T, Saijuntha W, Junker K, Ramli R, Omar H, Lim YA, Sivanandam S, Lefoulon E, Martin C, Belabut DM, Kasim S, Abdullah Halim MR, Zainuri NA, Bhassu S, Fukuda M, Matsubayashi M, Harada M, Low VL, Chen CD, Suganuma N, Hashim R, Takaoka H, Azirun MS
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Journal Title
Parasites & Vectors
Volume: 10
Pages: 1-14
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Onchocerca takaokai n. sp. (Nematoda: Filarioidea) in Japanese wild boars (Sus scrofa leucomystax): Description and molecular identification of intradermal females.2015
Author(s)
Shigehiko Uni, Masako Fukuda, Takeshi Agatsuma, Odile Bain, Yasushi Otsuka, Jun Nakatani, Makoto Matsubayashi, Masashi Harada, Hasmahzaiti Omar, Rosli Ramli, Rosli Hashim, Mohd Sofian Azirun, Hiroyuki Takaoka
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Journal Title
Parasitology International
Volume: 64
Pages: 493-502
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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