Investigation for metabolic features in divergency of ageing
| Project/Area Number |
26310103
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 特設分野 |
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| Research Field |
Neo-Gerontology
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| Research Institution | Kyoto University |
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Principal Investigator |
Kondoh Hirohsi 京都大学, 医学(系)研究科(研究院), 准教授 (80402890)
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| Co-Investigator(Kenkyū-buntansha) |
横出 正之 京都大学, 医学(系)研究科(研究院), 教授 (20252447)
高折 晃史 京都大学, 医学(系)研究科(研究院), 教授 (20324626)
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| Project Period (FY) |
2014-07-18 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | 老化 / 代謝 / 内科 |
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| Outline of Final Research Achievements |
Enhanced glycolysis, the Warburg effect, is well-known property of cancer, while it is not clear how it is coupled with the other hallmark of cancer, immortalization. Several recent reports established the significance of phosphoglycerate mutase PGAM both in the Warburg effect and cancerous proliferation. Moreover, the recent analysis of PGAM-TG and KO mice disclosed the impact of PGAM on the Warburg effect. Interestingly, cooperative manner are observed on the impact of PGAM in vivo and in vitro. Ｗe develop standard experimental procedures to identify and precisely quantify human age-related blood metabolites. To this end, our intent was to increase the reproducibility and accuracy of measuring blood metabolites, which are highly unstable. The combination of comprehensive CV (coefficient of variation) analysis and RBC (red blood cell) metabolomics enabled us to identify 51 previously unreported metabolite CVs. Ultimately, we identified 14 age-related metabolites.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Disruptive chemicals, senescence and immortality.2015
Author(s)
Amancio Carnero, Carmen Blanco-Aparicio , Hiroshi Kondoh , Matilde Lleonart , Juan Fernando Martinez-Leal , Chiara Mondello , A. Ivana Scovassi , John Pierce Wise Sr., Sandra S. Wise and Hemad Yasaey.
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Journal Title
Carcinogenesis
Volume: ３６
Issue: Suppl 1
Pages: S19-S37
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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