Application of theorems of non-equilibrium stochastic models to medical and cosmetic problems
| Project/Area Number |
26310204
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 特設分野 |
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| Research Field |
Mathematical Sciences in Search of New Cooperation
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
丹羽 伸介 東北大学, 学際科学フロンティア研究所, 助教 (30714985)
池田 一穂 国立研究開発法人理化学研究所, 生命システム研究センター, 研究員 (20642565)
岡田 康志 国立研究開発法人理化学研究所, 生命システム研究センター, チームリーダー (50272430)
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| Project Period (FY) |
2014-07-18 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Keywords | 非平衡統計力学 / 分子モーター / 医療 / 生物物理 / １分子計測 / 揺らぎの定理 |
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| Outline of Final Research Achievements |
Organelle transport by kinesin and dynein is deeply related to medical and cosmetic issues. For example, deficit of the transport is a problem as to Alzheimer disease, and melanin pigment produced by sunburn is also transported by kinesin and dynein as melanosomes. The theorems of non-equilibrium statistical mechanics were applied to the in vivo transport because the transport was represented by non-equilibrium stochastic processes. Concretely, we investigated synaptic vesicle precursor transport and melanosome transport. The physical reasons of mis-location of synapses and the effect of dynein inhibitor called ciliobrevin on force and number of motors were clarified.
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Report
(5 results)
Research Products
(17 results)
