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Visualization and decoding of decision-making information from neuronal activities

Research Project

Project/Area Number 26330266
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Intelligent informatics
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

MATSUMOTO Narihisa  国立研究開発法人産業技術総合研究所, 情報・人間工学領域, 主任研究員 (00392663)

Co-Investigator(Renkei-kenkyūsha) SHIDARA Munetaka  筑波大学, 医学医療系, 教授 (10357189)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords意思決定 / 前頭葉 / ニューロン / 行動選択 / 報酬量 / 負荷量
Outline of Final Research Achievements

We studied the role of orbitofrontal cortex (OFC) in this type of decision making during a choice task varying reward amount and work or time to reward. We recorded neurons and found them coding for aspects of choice-related values. Neuronal activity in OFC represented reward value in various combinations of difference in or sum of value of offered alternatives. We then reversibly inactivated a small regions of OFC rich in neurons coding for choice-related values. During the period of pharmacological OFC inactivation by muscimol the monkeys were both slower to choose and more likely to choose the less valuable option, especially when the difference in value between the two options was small. Thus, OFC neurons code for information that could be used to guide choices, and inactivating this tissue suggests that these signals have a direct influence on the choice behavior.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2016 2015

All Presentation (6 results) (of which Int'l Joint Research: 2 results)

  • [Presentation] 行動決定課題遂行中のアカゲザル眼窩前頭皮質における報酬価値の情報処理に関連したニューロン活動2016

    • Author(s)
      瀬戸川 剛, 水挽 貴至, 秋澤 文香, 久保木 亮介, Barry J. Richmond, 松本 有央, 設楽 宗孝
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2016-03-24
    • Related Report
      2015 Research-status Report
  • [Presentation] The role of the monkey orbitofrontal cortex during value-based decision-making2016

    • Author(s)
      T. Setogawa, T. Mizuhiki, F. Akizawa, R. Kuboki, B. J. Richmond, N. Matsumoto, & M. Shidara
    • Organizer
      Society for Neuroscience, 46th annual meeting
    • Place of Presentation
      San Diego Convention Center, San Diego, USA
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 報酬価値に基づく意思決定におけるサル眼窩前頭皮質の役割2016

    • Author(s)
      瀬戸川 剛, 秋澤 文香, 水挽 貴至, 久保木 亮介, Barry J. Richmond, 松本 有央, 設楽 宗孝
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Related Report
      2016 Research-status Report
  • [Presentation] Representation of reward value by single unit in the monkey orbitofrontal cortex during decision-making2015

    • Author(s)
      T. Setogawa, T. Mizuhiki, F. Akizawa, R. Kuboki, B. J. Richmond, N. Matsumoto, & M. Shidara
    • Organizer
      Society for Neuroscience, 45th Annual Meeting
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2015-10-18
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 行動決定課題遂行中のサル眼窩前頭皮質単一ニューロンにおける報酬価値表現2015

    • Author(s)
      瀬戸川 剛, 水挽 貴至, 秋澤 文香, 久保木 亮介, 松本 有央, 設楽 宗孝
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場(兵庫)
    • Year and Date
      2015-07-29
    • Related Report
      2015 Research-status Report
  • [Presentation] 行動決定中のアカゲザル眼窩前頭皮質における報酬価値の情報処理に関連したニューロン活動2015

    • Author(s)
      瀬戸川 剛, 水挽 貴至, 秋澤 文香, 久保木 亮介, 松本 有央, 設楽 宗孝
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県)
    • Year and Date
      2015-03-23
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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