| Project/Area Number |
26340035
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Radiation Effects Research Foundation |
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Principal Investigator |
TAGA Masataka 公益財団法人放射線影響研究所, 分子生物科学部, 研究員 (70359462)
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| Co-Investigator(Kenkyū-buntansha) |
濱谷 清裕 公益財団法人放射線影響研究所, 分子生物科学部, 顧問 (80344414)
伊藤 玲子 公益財団法人放射線影響研究所, 分子生物科学部, 副主任研究員 (30283790)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 放射線 / 肺がん / 融合遺伝子 |
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| Outline of Final Research Achievements |
The molecular mechanisms for development of radiation-associated lung cancer among atomic bomb (A-bomb) survivors have thus far remained unclear. Recently, researchers reported anaplastic lymphoma kinase (ALK) fusion genes (e.g. EML4-ALK) in spontaneous lung adenocarcinoma. In addition, we have found ALK fusion genes in papillary thyroid cancer cases exposed to A-bomb radiation. In this study, we examined the possible involvement of ALK fusion genes in the development of human lung adenocarcinoma following radiation exposure. Using archival lung adenocarcinoma tissues from A-bomb survivors, we established a series of analytical methods for ALK fusion genes. An in vitro experimental system was also developed to assess EML4-ALK induction in an X-irradiated human lung cell line. However, no evidence for links between ALK fusion genes and radiation-associated lung adenocarcinoma has been obtained.
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